# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process DNA replication-dependent nucleosome assembly 7 1.049259e-65 1.9724570258571426e-62 18.10526 75 0.007233099 302 0.000050406769539735095 2.08962 26 32 0.003561156 GO Biological Process chromatin assembly or disassembly 26 6.56154e-49 3.3208963407692304e-46 2.629891 305 0.0294146 130 6.557908105461539e-9 1.618236 112 178 0.01534036 GO Biological Process chromatin silencing at rDNA 29 1.321198e-47 5.99504982137931e-45 8.684527 82 0.007908188 187 4.6521223806951873e-7 2.21464 31 36 0.004245994 GO Biological Process chromatin silencing 30 6.28559e-47 2.7570692936666665e-44 4.16029 154 0.01485196 247 0.000009330050651821862 1.67037 63 97 0.008628955 GO Biological Process chromatin assembly 32 9.801063e-46 4.03038087553125e-43 2.683206 275 0.02652136 168 8.925099582738095e-8 1.611469 99 158 0.01355979 GO Biological Process negative regulation of gene expression, epigenetic 36 8.08643e-43 2.955814788055556e-40 3.312597 186 0.01793808 208 9.930249556730768e-7 1.66944 74 114 0.0101356 GO Biological Process protein heterotetramerization 39 6.529905e-41 2.2032569203846153e-38 4.958055 111 0.01070499 304 0.00005197454381907895 1.92888 33 44 0.004519929 GO Biological Process DNA packaging 46 9.706062e-39 2.776566736043478e-36 2.31963 304 0.02931816 212 0.0000012788003099056604 1.499163 116 199 0.01588823 GO Biological Process regulation of gene expression, epigenetic 50 3.416685e-36 8.992031583000001e-34 2.134515 339 0.03269361 226 0.0000032775103832300885 1.431104 138 248 0.01890152 GO Biological Process nucleosome organization 52 1.456248e-35 3.685147583076923e-33 2.394834 261 0.02517118 184 3.415789619619565e-7 1.56416 104 171 0.01424462 GO Biological Process nucleosome assembly 55 8.355848e-35 1.9991746151272727e-32 2.523769 231 0.02227794 167 7.767145451916167e-8 1.648151 91 142 0.01246405 GO Biological Process positive regulation of gene expression, epigenetic 65 7.095399e-33 1.4364362375538463e-30 3.441945 134 0.01292314 318 0.00008164795351572327 1.671696 52 80 0.007122312 GO Biological Process telomere organization 89 1.740737e-29 2.573748110449438e-27 2.720467 170 0.01639502 234 0.000004443159968717948 1.626634 74 117 0.0101356 GO Biological Process regulation of gene silencing by miRNA 91 5.553243e-29 8.030233476593408e-27 2.638158 176 0.01697367 344 0.00022455470097383718 1.552809 64 106 0.008765922 GO Biological Process gene silencing 97 2.866982e-28 3.8893418698969073e-26 2.25061 233 0.02247083 428 0.0009071820749065421 1.385936 97 180 0.01328585 GO Biological Process regulation of posttranscriptional gene silencing 99 8.579557e-28 1.1403877834646465e-25 2.573174 176 0.01697367 400 0.0006879916680250001 1.510071 64 109 0.008765922 GO Biological Process regulation of gene silencing by RNA 99 8.579557e-28 1.1403877834646465e-25 2.573174 176 0.01697367 400 0.0006879916680250001 1.510071 64 109 0.008765922 GO Biological Process regulation of hematopoietic stem cell differentiation 108 2.655757e-26 3.235843181759259e-24 2.81841 142 0.01369467 332 0.00014917878709939757 1.573067 63 103 0.008628955 GO Biological Process regulation of hematopoietic progenitor cell differentiation 115 2.867208e-25 3.280833919304348e-23 2.649527 151 0.01456264 360 0.00031366669666666667 1.524896 67 113 0.009176825 GO Biological Process regulation of gene silencing 121 4.437457e-24 4.825826170495868e-22 2.292499 189 0.01822741 432 0.0009730194095138889 1.452795 74 131 0.0101356 GO Cellular Component nucleosome 23 4.951504e-55 3.7200864834782606e-53 4.541416 165 0.01591282 33 8.458769454545454e-12 1.910509 78 105 0.01068347 GO Cellular Component nuclear nucleosome 26 2.017546e-46 1.3408921107692309e-44 8.222113 83 0.008004629 63 0.0004521663085714286 1.864584 29 40 0.003972059 GO Cellular Component DNA packaging complex 27 5.321937e-46 3.40603968e-44 3.776605 169 0.01629858 31 8.431307767741936e-12 1.882954 82 112 0.01123134 GO Cellular Component protein-DNA complex 30 2.046373e-38 1.178710848e-36 2.340305 296 0.02854663 36 1.81342992e-10 1.616949 127 202 0.01739488 GO Cellular Component chromosome, telomeric region 40 6.288568e-31 2.7166613759999996e-29 2.466913 213 0.020542 80 0.0022630060800000002 1.370621 89 167 0.01219011 GO Cellular Component nuclear chromosome, telomeric region 42 1.192951e-29 4.908141257142858e-28 2.657547 178 0.01716655 70 0.0011158727862857142 1.441789 74 132 0.0101356 GO Cellular Component actin filament bundle 46 1.479789e-22 5.5588595478260875e-21 2.427881 157 0.01514129 48 0.0000080072964 1.862367 42 58 0.005752637 GO Cellular Component ribosomal subunit 48 8.593256e-21 3.0935721600000003e-19 2.118878 192 0.01851673 49 0.000009638135118367346 1.473595 106 185 0.01451856 GO Cellular Component stress fiber 51 3.238898e-18 1.0974148517647059e-16 2.356837 132 0.01273025 47 0.000004675743727659575 1.92888 39 52 0.005341734 GO Cellular Component large ribosomal subunit 65 6.269618e-12 1.6667538313846155e-10 2.04923 112 0.01080143 68 0.001087943209411765 1.476012 66 115 0.009039858 GO Cellular Component small ribosomal subunit 68 1.669333e-11 4.2420697411764705e-10 2.282959 84 0.00810107 106 0.023042081207547166 1.46452 41 72 0.005615669 GO Cellular Component cytosolic large ribosomal subunit 105 3.772302e-8 6.208131291428572e-7 2.051203 71 0.006847333 75 0.0014854127616 1.644291 39 61 0.005341734 GO Cellular Component U1 snRNP 270 0.0006084057 0.00389379648 2.137577 24 0.002314592 94 0.008172746961702127 2.0304 15 19 0.002054513 GO Cellular Component prespliceosome 302 0.00134245 0.007681303311258277 2.129066 21 0.002025268 96 0.010303469999999999 1.959497 16 21 0.002191481 GO Cellular Component THO complex part of transcription export complex 323 0.002279928 0.01219726186996904 2.372916 15 0.00144662 127 0.04696035930708661 2.571839 6 6 0.0008218052 GO Cellular Component U2-type prespliceosome 332 0.002808574 0.014618120096385542 2.185784 17 0.001639502 133 0.04808948643609023 1.92888 12 16 0.00164361 GO Molecular Function nucleosomal DNA binding 12 2.026962e-29 7.13152797e-27 3.772041 106 0.01022278 93 0.012083899694623656 1.677287 30 46 0.004109026 GO Molecular Function chromatin DNA binding 14 2.058452e-24 6.207703102857142e-22 2.297102 191 0.01842029 49 0.00020236812853061223 1.58267 64 104 0.008765922 GO Molecular Function structure-specific DNA binding 15 2.413735e-24 6.793859446666667e-22 2.03995 249 0.02401389 26 0.000005273476109230769 1.59121 86 139 0.01177921 GO Molecular Function cAMP response element binding 16 7.565418e-24 1.99632467475e-21 4.936153 63 0.006075803 108 0.03873151386111111 2.176172 11 13 0.001506643 GO Molecular Function nucleosome binding 17 1.057208e-21 2.625607162352941e-19 2.688765 125 0.01205516 95 0.01261189618105263 1.558691 40 66 0.005478702 GO Molecular Function histone acetyltransferase binding 37 2.679725e-12 3.0577835e-10 2.384469 83 0.008004629 106 0.03615798070566038 1.809813 19 27 0.002602383 GO Molecular Function protein phosphatase activator activity 53 4.980359e-10 3.967372773207547e-8 3.603193 34 0.003279005 103 0.021365435099029127 2.571839 8 8 0.00109574 GO Molecular Function insulin-like growth factor binding 62 2.109449e-9 1.4364667222580648e-7 2.132371 77 0.007425981 82 0.0057818796853658545 1.92888 21 28 0.002876318 Human Phenotype Mitral valve prolapse 39 1.883478e-12 3.2226791523076926e-10 2.107319 110 0.01060854 241 0.03502641086721992 1.630923 26 41 0.003561156 Human Phenotype Achalasia 747 0.005026338 0.04490060706024096 2.425233 12 0.001157296 248 0.03609097431451613 2.571839 7 7 0.0009587728 Mouse Phenotype Single KO chromosome breakage 65 2.830656e-12 3.987741075692308e-10 2.232107 95 0.009161925 179 0.0017525976204469274 1.699251 37 56 0.005067799 Mouse Phenotype Single KO heart inflammation 75 1.000463e-11 1.2214986254666665e-9 2.269064 87 0.008390394 420 0.043091839090476196 1.68777 21 32 0.002876318 Mouse Phenotype Single KO abnormal osteocyte morphology 123 1.228214e-9 9.143703738211384e-8 3.092288 40 0.003857653 395 0.03324705014177216 2.057472 12 15 0.00164361 Mouse Phenotype Single KO abnormal rostral-caudal body axis extension 128 1.771669e-9 1.267435393203125e-7 2.657376 50 0.004822066 349 0.02599547670343839 2.176172 11 13 0.001506643 Mouse Phenotype Single KO abnormal ureter physiology 169 1.148261e-8 6.221672175739646e-7 2.427781 53 0.00511139 387 0.03173740483204134 2.571839 7 7 0.0009587728 Mouse Phenotype Single KO delayed cellular replicative senescence 360 0.000003445843 0.00008764884541944444 3.902207 17 0.001639502 307 0.015546963391530945 2.571839 8 8 0.00109574 Mouse Phenotype Single KO pale placenta 738 0.0002409962 0.002990246888075881 2.201303 26 0.002507474 349 0.02599547670343839 2.176172 11 13 0.001506643 Mouse Phenotype tumor regression 36 2.629726e-21 6.984113968333333e-19 9.505756 33 0.003182563 488 0.010212080589344263 2.571839 8 8 0.00109574 Mouse Phenotype impaired wound healing 135 1.137994e-11 8.059526395555555e-10 2.043144 110 0.01060854 645 0.02748955002790698 1.515548 33 56 0.004519929 Mouse Phenotype abnormal rostral-caudal body axis extension 252 1.24528e-8 4.7246516190476186e-7 2.053089 76 0.00732954 601 0.021320282301164725 1.870429 16 22 0.002191481 Mouse Phenotype abnormal terminal bronchiole morphology 274 2.59056e-8 9.039541664233577e-7 2.388801 52 0.005014948 465 0.00915961071483871 2.204434 12 14 0.00164361 Mouse Phenotype pancytopenia 299 4.90558e-8 0.0000015686371364548496 2.221661 58 0.005593596 768 0.04132345119921875 1.684998 19 29 0.002602383 Mouse Phenotype abnormal osteocyte morphology 573 0.000007147534 0.00011926277936125655 2.122876 43 0.004146977 462 0.009200544091558441 2.0304 15 19 0.002054513 Mouse Phenotype abnormal malleus manubrium morphology 577 0.00000735624 0.00012189429920277296 2.061056 46 0.004436301 745 0.03940954365100671 2.28608 8 9 0.00109574 Mouse Phenotype pale lung 828 0.00007320751 0.0008453345448188405 2.938078 18 0.001735944 777 0.04246916217374517 2.571839 6 6 0.0008218052 Mouse Phenotype abnormal branching involved in terminal bronchiole morphogenesis 834 0.00007494674 0.0008591915841007193 2.00501 38 0.00366477 494 0.01083615095708502 2.338036 10 11 0.001369675 Mouse Phenotype impaired branching involved in terminal bronchiole morphogenesis 894 0.0001202338 0.0012858561093959731 2.189773 29 0.002796798 397 0.004877627236775818 2.571839 9 9 0.001232708 Mouse Phenotype pale placenta 992 0.0002422149 0.0023344925996975803 2.163498 27 0.002603916 609 0.022515574118226602 2.057472 12 15 0.00164361 Mouse Phenotype increased liver adenocarcinoma incidence 1154 0.0006977768 0.005781147300519931 2.500715 17 0.001639502 603 0.021267437661691542 2.571839 7 7 0.0009587728 Mouse Phenotype increased fibroblast cell migration 1407 0.00225889 0.01534985592750533 2.375288 15 0.00144662 777 0.04246916217374517 2.571839 6 6 0.0008218052 Mouse Phenotype abnormal conotruncus septation 1524 0.003729978 0.023400472216535434 2.123478 17 0.001639502 603 0.021267437661691542 2.571839 7 7 0.0009587728