# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	90	5.223106e-104	7.63676131711111e-102	2.790094	603	0.01830323	526	0.006863491734030419	1.213643	95	114	0.007368339	
GO Biological Process	cellular response to insulin stimulus	100	1.115166e-97	1.4674469394e-95	2.139248	946	0.02871452	511	0.005796694008806262	1.190682	121	148	0.009384938	
GO Biological Process	mitochondrial transport	101	1.526829e-97	1.9892616644554455e-95	2.053535	1040	0.03156776	336	0.0006489960054464286	1.176066	193	239	0.01496936	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	107	1.82004e-92	2.2383090056074767e-90	2.2796	779	0.02364547	457	0.003771689016849015	1.193285	127	155	0.009850306	
GO Biological Process	cellular response to unfolded protein	110	1.128168e-88	1.3495966101818181e-86	2.521964	612	0.01857642	473	0.004327127106765328	1.215649	101	121	0.007833708	
GO Biological Process	response to topologically incorrect protein	116	5.854513e-86	6.641339359224138e-84	2.193796	786	0.02385795	721	0.026151002981969484	1.148915	142	180	0.01101373	
GO Biological Process	response to unfolded protein	125	2.259818e-83	2.37895560496e-81	2.22762	737	0.02237062	398	0.0016872182153517589	1.201507	132	160	0.01023811	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	131	1.899995e-82	1.908552229389313e-80	2.562612	552	0.0167552	498	0.005349960561646586	1.239465	80	94	0.006204917	
GO Biological Process	mitochondrial membrane organization	164	5.705615e-72	4.5780602307926826e-70	2.187099	661	0.02006374	328	0.0005070880828353659	1.244963	106	124	0.008221516	
GO Biological Process	mRNA catabolic process	165	7.900833e-72	6.30103402709091e-70	2.014581	801	0.02431325	395	0.0015687210353164556	1.176037	172	213	0.01334057	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	167	1.91712e-71	1.5106216814371259e-69	2.391287	544	0.01651237	346	0.0007717148794508671	1.25016	97	113	0.007523462	
GO Biological Process	nuclear-transcribed mRNA catabolic process	183	1.882816e-67	1.3538784559562842e-65	2.03594	732	0.02221885	424	0.002472807313561321	1.176866	160	198	0.01240983	
GO Biological Process	cellular response to epidermal growth factor stimulus	189	2.582914e-65	1.7983367897354498e-63	2.723738	391	0.01186827	832	0.04086941831971154	1.303069	34	38	0.00263709	
GO Biological Process	response to epidermal growth factor	195	2.514365e-64	1.6967450787179488e-62	2.633679	408	0.01238428	647	0.017179011450695517	1.31767	38	42	0.002947336	
GO Biological Process	regulation of mitochondrial membrane permeability	198	6.078931e-63	4.040032981262626e-61	2.4723	448	0.01359842	565	0.009919976198230089	1.256869	63	73	0.004886372	
GO Biological Process	regulation of DNA-templated transcription in response to stress	199	6.348591e-63	4.198045676834171e-61	2.203375	567	0.0172105	297	0.0002201515764175084	1.260557	103	119	0.007988831	
GO Biological Process	regulation of membrane permeability	230	1.227331e-55	7.021934186521739e-54	2.271276	468	0.01420549	709	0.024895194724964737	1.222633	68	81	0.00527418	
GO Biological Process	multi-organism metabolic process	250	1.051795e-52	5.536228162e-51	2.079791	540	0.01639095	357	0.0008955186051260503	1.218597	123	147	0.00954006	
GO Biological Process	viral gene expression	253	2.840762e-52	1.4775330892490119e-50	2.254226	446	0.01353771	337	0.0006779372324332343	1.238489	108	127	0.008376638	
GO Biological Process	insulin receptor signaling pathway	288	6.235128e-48	2.8488906025e-46	2.000724	539	0.0163606	836	0.04076247374760766	1.207723	68	82	0.00527418	
GO Cellular Component	PcG protein complex	112	2.559577e-31	3.949061657142857e-30	2.144552	292	0.008863257	97	0.00475253443298969	1.329731	42	46	0.003257582	
GO Cellular Component	MLL1 complex	118	6.689533e-29	9.796197477966102e-28	2.985449	144	0.004370921	127	0.02460017537007874	1.355932	27	29	0.00209416	
GO Cellular Component	ESCRT complex	126	6.558992e-27	8.995189028571429e-26	3.006572	132	0.004006678	136	0.031343213647058825	1.352345	26	28	0.002016598	
GO Cellular Component	cleavage furrow	128	1.306012e-26	1.7631162000000002e-25	2.027772	281	0.008529367	117	0.011765452800000001	1.288329	46	52	0.003567828	
GO Cellular Component	endopeptidase complex	130	1.892284e-26	2.515282116923077e-25	2.11499	252	0.007649112	141	0.03469904885106383	1.224196	58	69	0.004498565	
GO Cellular Component	proteasome complex	138	1.680027e-25	2.103685982608696e-24	2.090992	249	0.007558051	146	0.04146139528767123	1.220782	57	68	0.004421004	
GO Cellular Component	mitochondrial nucleoid	219	1.474107e-15	1.1631310027397258e-14	2.073124	148	0.004492336	144	0.037986612	1.282994	37	42	0.002869774	
GO Molecular Function	cadherin binding	7	3.795033e-192	2.2889470465714284e-189	2.121555	1884	0.05718622	36	2.8400338500000004e-10	1.250372	261	304	0.02024354	
GO Molecular Function	ribonuclease activity	50	2.74255e-38	2.3158092199999995e-36	2.08144	387	0.01174685	135	0.032566975570370374	1.206288	82	99	0.00636004	
GO Molecular Function	phosphotyrosine binding	58	1.764323e-34	1.2843054665517241e-32	2.203307	304	0.0092275	142	0.043437065830985916	1.33154	32	35	0.002481967	
GO Molecular Function	RNA polymerase core enzyme binding	101	1.759667e-23	7.355756508910891e-22	2.217875	199	0.00604037	83	0.0016461160886746989	1.414761	34	35	0.00263709	
GO Molecular Function	RNA polymerase II core binding	104	2.646065e-23	1.0742006182692307e-21	2.303269	182	0.005524359	117	0.013236060213675214	1.404358	27	28	0.00209416	
GO Molecular Function	H4 histone acetyltransferase activity	165	1.945194e-17	4.977338829090909e-16	2.946257	85	0.002580058	146	0.048317117438356164	1.456372	17	17	0.001318545	
GO Molecular Function	O-methyltransferase activity	436	7.739127e-9	7.49417298027523e-8	2.017185	82	0.002488997	119	0.013153335880672268	1.456372	21	21	0.001628791	
Mouse Phenotype Single KO	abnormal lymph node secondary follicle morphology	143	3.252632e-43	2.082821763916084e-41	2.950548	224	0.006799211	330	0.028363169284848482	1.398117	24	25	0.001861475	
Mouse Phenotype Single KO	absent somites	313	1.400633e-26	4.097634626517572e-25	2.17694	237	0.007193808	233	0.007659500376394849	1.375462	34	36	0.00263709	
Mouse Phenotype	extramedullary hematopoiesis	41	3.562656e-98	8.307940003902438e-96	2.058221	1041	0.03159812	344	0.007466337764825581	1.173419	141	175	0.01093617	
Mouse Phenotype	abnormal thymus development	178	2.305154e-48	1.2381785052808989e-46	2.551252	322	0.009773866	513	0.03369644919883041	1.355932	27	29	0.00209416	
Mouse Phenotype	absent somites	258	1.02668e-37	3.8046850697674424e-36	2.197404	336	0.01019882	213	0.0008890446222535211	1.367206	46	49	0.003567828	
Mouse Phenotype	increased body temperature	416	1.41031e-26	3.2413398822115387e-25	2.185021	235	0.007133101	498	0.02804817263855422	1.33154	32	35	0.002481967