# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	DNA replication-dependent nucleosome assembly	1	1.12843e-35	1.484901037e-31	32.29151	31	0.01290054	185	0.00006607581306	3.417363	17	32	0.005823912	
GO Biological Process	chromosome organization	2	5.405023e-32	3.55623488285e-28	2.361316	230	0.09571369	19	7.108380987368421e-19	2.003258	180	578	0.06166495	
GO Biological Process	chromatin silencing	3	2.111757e-31	9.262870121000002e-28	7.110756	61	0.02538494	96	8.560239284791666e-9	2.785285	42	97	0.01438849	
GO Biological Process	negative regulation of gene expression, epigenetic	4	6.385381e-31	2.100630714475e-27	5.609984	73	0.03037869	102	1.853961189215686e-8	2.595644	46	114	0.01575882	
GO Biological Process	RNA processing	6	1.796849e-29	3.9407893318333334e-26	2.018234	294	0.1223471	16	2.9640663948749996e-20	1.81527	252	893	0.08633094	
GO Biological Process	ncRNA metabolic process	9	1.215753e-28	1.7775659696666666e-25	2.508919	184	0.07657095	81	2.1215508398765433e-9	1.703792	147	555	0.05035971	
GO Biological Process	chromatin assembly or disassembly	11	8.70808e-28	1.0417238610909092e-24	3.720669	100	0.04161465	77	9.223329376753246e-10	2.349013	65	178	0.0222679	
GO Biological Process	ribonucleoprotein complex biogenesis	12	1.418353e-27	1.5553422605833332e-24	2.541426	173	0.07199334	23	6.808335009999999e-17	2.082829	147	454	0.05035971	
GO Biological Process	mRNA metabolic process	13	1.796995e-27	1.8189736311538462e-24	2.146935	239	0.09945901	15	2.205619467e-20	1.971778	202	659	0.06920178	
GO Biological Process	ncRNA processing	14	3.043505e-26	2.860677306785714e-23	2.77281	142	0.0590928	76	8.218119280657895e-10	1.868077	115	396	0.03939705	
GO Biological Process	rRNA processing	16	7.186842e-26	5.910728367375e-23	3.375359	105	0.04369538	74	7.313912681216217e-10	2.118701	83	252	0.0284344	
GO Biological Process	chromatin assembly	18	1.137429e-25	8.315237894999999e-23	3.789195	90	0.03745318	106	2.3071910568867927e-8	2.320651	57	158	0.01952724	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	19	1.267464e-25	8.778188829473683e-23	5.049799	66	0.02746567	69	4.982575251739131e-10	2.725713	50	118	0.01712915	
GO Biological Process	chromatin silencing at rDNA	20	4.315462e-25	2.8393582228999996e-22	14.16697	31	0.01290054	194	0.00009680621839690722	3.216341	18	36	0.006166495	
GO Biological Process	rRNA metabolic process	21	7.756416e-25	4.860318006857143e-22	3.26967	105	0.04369538	83	3.241662574819277e-9	2.061439	83	259	0.0284344	
GO Biological Process	nucleosome organization	22	1.823906e-24	1.0909445024545455e-21	3.60296	91	0.03786933	123	7.236060281219512e-8	2.219464	59	171	0.0202124	
GO Biological Process	nucleosome assembly	24	4.80642e-24	2.6353200324999997e-21	3.865757	82	0.03412401	121	6.75727809e-8	2.35563	52	142	0.01781432	
GO Biological Process	ribosome biogenesis	25	2.587037e-23	1.3617127953200002e-20	2.807411	123	0.05118602	66	3.802235230151515e-10	1.991543	100	323	0.03425831	
GO Biological Process	nuclear-transcribed mRNA catabolic process	27	7.912098e-23	3.8561221326666667e-20	3.43188	90	0.03745318	64	3.25016813921875e-10	2.306669	71	198	0.0243234	
GO Biological Process	DNA packaging	28	2.398243e-22	1.1270885584642856e-19	3.193743	97	0.04036621	139	3.196037092805755e-7	2.068802	64	199	0.02192532	
GO Cellular Component	intracellular ribonucleoprotein complex	13	1.267767e-36	1.6851549046153847e-34	2.302287	276	0.1148564	18	1.19692032e-19	1.825491	231	814	0.07913669	
GO Cellular Component	ribonucleoprotein complex	14	1.564256e-36	1.9307388342857145e-34	2.299355	276	0.1148564	19	1.9001824673684208e-19	1.818788	231	817	0.07913669	
GO Cellular Component	nucleosome	17	4.268168e-30	4.338467237647059e-28	7.007167	59	0.02455264	33	5.556289745454546e-11	2.879391	47	105	0.0161014	
GO Cellular Component	DNA packaging complex	18	6.545851e-28	6.28401696e-26	5.978464	62	0.02580108	31	1.281436861935484e-11	2.871733	50	112	0.01712915	
GO Cellular Component	nuclear nucleosome	20	2.137223e-25	1.846560672e-23	13.6785	32	0.01331669	62	0.0002654922890322581	2.894707	18	40	0.006166495	
GO Cellular Component	protein-DNA complex	22	2.107142e-23	1.6550642618181818e-21	3.309296	97	0.04036621	27	5.88128128e-15	2.547597	80	202	0.02740665	
GO Cellular Component	ribosomal subunit	24	1.618085e-22	1.1650212e-20	3.761966	79	0.03287557	40	4.12319376e-8	2.155818	62	185	0.02124015	
GO Cellular Component	ribosome	27	9.534845e-20	6.1023008e-18	3.045561	91	0.03786933	39	1.2842589046153845e-8	2.044285	75	236	0.02569373	
GO Cellular Component	nuclear chromosome part	28	1.151003e-19	7.1033328e-18	2.006314	198	0.082397	24	1.49930208e-15	1.939817	155	514	0.05310038	
GO Cellular Component	mitochondrial matrix	34	2.208257e-16	1.1223141458823528e-14	2.137129	141	0.05867665	79	0.0030893358987341773	1.41689	100	454	0.03425831	
GO Cellular Component	nuclear chromosome, telomeric region	36	3.272713e-16	1.5709022400000003e-14	3.672137	57	0.02372035	56	0.000067207752	2.046763	42	132	0.01438849	
GO Cellular Component	nuclear chromatin	38	4.250559e-16	1.932885776842105e-14	2.125911	140	0.05826051	32	2.33679006e-11	2.035659	100	316	0.03425831	
GO Cellular Component	chromosome, telomeric region	39	8.847178e-16	3.919980406153846e-14	3.248409	65	0.02704952	61	0.0001255617773114754	1.887434	49	167	0.01678657	
GO Cellular Component	chromosomal region	40	4.151646e-15	1.793511072e-13	2.153411	127	0.0528506	35	1.7104410514285714e-10	1.931627	106	353	0.03631381	
GO Cellular Component	large ribosomal subunit	41	2.234763e-14	9.418708448780488e-13	3.789632	48	0.01997503	58	0.00007026596193103448	2.125582	38	115	0.01301816	
GO Cellular Component	spliceosomal complex	43	2.88838e-13	1.1607257302325582e-11	2.617056	75	0.03121099	38	2.264613574736842e-9	2.24798	65	186	0.0222679	
GO Cellular Component	cytosolic ribosome	44	3.526719e-13	1.3850387345454546e-11	3.255963	53	0.02205576	42	4.942931657142858e-7	2.412256	42	112	0.01438849	
GO Cellular Component	small ribosomal subunit	52	5.518067e-10	1.8336961107692306e-8	3.752769	32	0.01331669	72	0.00114578736	2.23357	25	72	0.008564577	
GO Cellular Component	cytosolic part	58	4.343656e-9	1.2941099255172414e-7	2.093981	76	0.03162713	60	0.00008505791999999999	1.742185	65	240	0.0222679	
GO Cellular Component	catalytic step 2 spliceosome	59	8.213946e-9	2.405711642033898e-7	2.918	39	0.01622971	63	0.0003216035657142857	2.144227	32	96	0.01096266	
GO Molecular Function	structural constituent of ribosome	6	9.329726e-19	6.565017195333333e-16	3.580668	69	0.02871411	8	2.96259587125e-7	2.263351	57	162	0.01952724	
GO Molecular Function	rRNA binding	11	2.921922e-10	1.1214867894545454e-7	5.03937	24	0.009987516	56	0.036894256110714285	2.144227	20	60	0.006851662	
GO Molecular Function	nucleosome binding	13	1.016167e-9	3.3001977492307693e-7	3.3414	36	0.01498127	64	0.04756757200625	2.046763	21	66	0.007194245	
GO Molecular Function	ribonuclease activity	14	3.987185e-9	0.0000012024210764285715	2.949502	40	0.01664586	37	0.007164545721621622	2.014274	31	99	0.01062008	
GO Molecular Function	exonuclease activity	15	7.383424e-9	0.0000020781877418666665	3.150271	35	0.01456513	12	0.0004889579121666667	2.454576	29	76	0.009934909	
GO Molecular Function	chromatin DNA binding	16	8.598884e-9	0.0000022690305155	2.542881	49	0.02039118	48	0.0152625036125	1.917434	31	104	0.01062008	
GO Molecular Function	ribonucleoprotein complex binding	19	1.551992e-8	0.0000034486895915789476	2.721625	42	0.01747815	58	0.03928126234137931	1.789964	32	115	0.01096266	
GO Molecular Function	nuclease activity	20	1.892531e-8	0.000003995132941	2.115687	68	0.02829796	32	0.003989384951875	1.699199	56	212	0.01918465	
GO Molecular Function	structure-specific DNA binding	21	5.238584e-8	0.000010532048403809523	2.156419	61	0.02538494	29	0.003277374087586207	1.89741	41	139	0.01404591	
GO Molecular Function	ATP-dependent RNA helicase activity	22	8.971744e-8	0.000017217592349090908	2.945547	33	0.01373283	42	0.011602096209523809	2.208234	23	67	0.007879411	
GO Molecular Function	RNA helicase activity	23	1.125465e-7	0.000020659622739130435	2.915773	33	0.01373283	45	0.01398022416	2.17576	23	68	0.007879411	
GO Molecular Function	RNA-dependent ATPase activity	24	1.401515e-7	0.000024654984708333335	2.887115	33	0.01373283	45	0.01398022416	2.17576	23	68	0.007879411	
GO Molecular Function	3'-5' exonuclease activity	26	1.689201e-7	0.00002743002546923077	3.471755	25	0.01040366	18	0.0015739766115555557	2.701727	21	50	0.007194245	
GO Molecular Function	ATP-dependent helicase activity	32	0.000001456921	0.00019222251443749998	2.369181	39	0.01622971	50	0.022093295356	1.923173	29	97	0.009934909	
GO Molecular Function	protein carboxyl O-methyltransferase activity	72	0.0004282988	0.025114965744444447	6.385647	6	0.002496879	54	0.03697403208518518	5.360569	5	6	0.001712915	
Mouse Phenotype Single KO	chromosome breakage	17	0.00003613679	0.01946497564882353	2.53463	25	0.01040366	40	0.011951679772	2.412256	21	56	0.007194245	
Mouse Phenotype Single KO	absent inner cell mass proliferation	21	0.0001004715	0.04381035835714286	2.76383	19	0.007906783	37	0.006947311955675675	2.80399	17	39	0.005823912	
Mouse Phenotype	embryonic lethality between somite formation and embryo turning, complete penetrance	12	0.00001382255	0.0110131167125	2.037292	44	0.01831045	58	0.0035822742687931035	2.144227	30	90	0.01027749	
Mouse Phenotype	absent inner cell mass proliferation	14	0.0000146776	0.0100237524	2.989291	21	0.008739076	37	0.0008120940268378379	2.980999	19	41	0.006509078