# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	translation	13	1.209755e-27	1.224551234230769e-24	2.090997	265	0.0459113	30	1.1503843434666666e-18	1.749119	204	372	0.03465262	
GO Biological Process	rRNA processing	22	1.870797e-25	1.1189917146818182e-22	2.408965	180	0.03118503	78	5.343432953717949e-13	1.759326	139	252	0.02361135	
GO Biological Process	ncRNA processing	23	3.762661e-25	2.1527328738695653e-22	2.048612	252	0.04365904	93	3.3844353722580645e-12	1.578676	196	396	0.0332937	
GO Biological Process	rRNA metabolic process	24	3.901656e-25	2.139245471e-22	2.372429	183	0.03170478	77	5.32677858064935e-13	1.748722	142	259	0.02412094	
GO Biological Process	nuclear-transcribed mRNA catabolic process	27	2.237645e-23	1.0905618724074073e-20	2.476519	156	0.02702703	59	1.1890416641525423e-14	1.916964	119	198	0.02021403	
GO Biological Process	ribosome biogenesis	28	3.860206e-23	1.8141589555000002e-20	2.090504	220	0.03811504	65	3.338912024e-14	1.698471	172	323	0.02921692	
GO Biological Process	mRNA catabolic process	29	4.044242e-23	1.8351096716551725e-20	2.382997	166	0.02875953	64	2.57904269046875e-14	1.871814	125	213	0.02123323	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	31	1.157902e-22	4.915107231612903e-20	3.185353	100	0.01732502	95	4.699245118947369e-12	2.08133	77	118	0.01307967	
GO Biological Process	macromolecular complex disassembly	37	2.64024e-21	9.389977881081082e-19	2.330632	159	0.02754678	184	0.000005813129137119565	1.586435	95	191	0.01613725	
GO Biological Process	telomere organization	38	4.583696e-21	1.587285675368421e-18	2.961026	103	0.01784477	211	0.00005698023492748815	1.6902	62	117	0.01053168	
GO Biological Process	DNA replication-dependent nucleosome assembly	39	4.852601e-21	1.6373173476666668e-18	12.14261	28	0.004851005	375	0.009639314897599999	1.993481	20	32	0.003397316	
GO Biological Process	chromatin assembly or disassembly	41	7.994887e-21	2.565968732512195e-18	2.354464	152	0.02633403	173	0.00000219404114433526	1.630623	91	178	0.01545779	
GO Biological Process	RNA catabolic process	45	3.199868e-20	9.357125113777778e-18	2.16421	176	0.03049203	80	7.005863114125e-13	1.773454	134	241	0.02276202	
GO Biological Process	protein-DNA complex subunit organization	47	6.330476e-20	1.7723985890212764e-17	2.010916	206	0.03568954	157	9.583473398726115e-8	1.582027	124	250	0.02106336	
GO Biological Process	chromatin assembly	51	1.313945e-19	3.39023573627451e-17	2.401334	137	0.02373527	180	0.000004265353873666667	1.655347	82	158	0.013929	
GO Biological Process	regulation of gene expression, epigenetic	52	2.192207e-19	5.547548444807692e-17	2.081268	184	0.03187803	210	0.000054884152488095235	1.466173	114	248	0.0193647	
GO Biological Process	translational initiation	54	5.544252e-19	1.351052075333333e-16	2.613783	113	0.01957727	119	3.8587772281512604e-10	1.895898	85	143	0.01443859	
GO Biological Process	protein localization to endoplasmic reticulum	57	1.139251e-18	2.63007086122807e-16	2.729356	103	0.01784477	83	1.0678818632168675e-12	2.08351	81	124	0.01375913	
GO Biological Process	cotranslational protein targeting to membrane	60	5.025499e-18	1.1021756890166666e-15	3.103522	81	0.01403326	87	1.5909881387356321e-12	2.213171	68	98	0.01155087	
GO Biological Process	negative regulation of gene expression, epigenetic	61	7.069871e-18	1.5251218440819671e-15	2.879444	90	0.01559252	292	0.0024597780711986305	1.566806	56	114	0.009512485	
GO Cellular Component	ribosomal subunit	30	4.11895e-21	2.3725152e-19	2.577262	130	0.02252252	35	3.308892397714286e-11	1.810297	105	185	0.01783591	
GO Cellular Component	ribosome	33	3.000246e-18	1.5710379054545456e-16	2.173592	156	0.02702703	34	2.7765620894117648e-11	1.716421	127	236	0.02157296	
GO Cellular Component	chromosome, telomeric region	36	5.487112e-17	2.6338137600000002e-15	2.413475	116	0.02009702	99	0.0026737588363636364	1.432442	75	167	0.01273994	
GO Cellular Component	protein-DNA complex	39	3.215388e-16	1.4246642215384616e-14	2.102098	148	0.02564103	46	6.938494747826088e-8	1.642155	104	202	0.01766604	
GO Cellular Component	nucleosome	43	1.842097e-15	7.402659572093023e-14	3.213892	65	0.01126126	71	0.00005645660754929577	1.701104	56	105	0.009512485	
GO Cellular Component	nuclear chromosome, telomeric region	44	9.927347e-15	3.8987399127272727e-13	2.494333	93	0.01611227	96	0.0021499542	1.498131	62	132	0.01053168	
GO Cellular Component	DNA packaging complex	47	9.105129e-14	3.3475878536170216e-12	2.810111	70	0.01212751	67	0.000021674089934328356	1.708698	60	112	0.01019195	
GO Cellular Component	mitochondrial ribosome	49	3.078758e-13	1.0857334334693877e-11	3.119013	57	0.00987526	111	0.012857137297297297	1.538499	41	85	0.006964498	
GO Cellular Component	large ribosomal subunit	51	9.199609e-13	3.117043990588235e-11	2.530894	77	0.01334026	50	2.2799667455999999e-7	1.830536	66	115	0.01121114	
GO Cellular Component	small ribosomal subunit	56	5.167811e-10	1.5946388228571428e-8	2.636472	54	0.009355509	81	0.00037648	1.771983	40	72	0.006794632	
GO Cellular Component	mitochondrial intermembrane space	57	6.14288e-10	1.8622625684210527e-8	2.545352	57	0.00987526	127	0.02869867842519685	1.513001	37	78	0.006285035	
GO Cellular Component	cytosolic ribosome	62	2.708377e-9	7.5485088e-8	2.071648	81	0.01403326	41	5.596515746341464e-9	1.936525	68	112	0.01155087	
GO Cellular Component	small-subunit processome	66	1.556701e-8	4.0757262545454544e-7	3.335618	31	0.005370755	144	0.0483429	1.731481	19	35	0.00322745	
GO Cellular Component	cytoplasmic stress granule	71	4.272784e-8	0.0000010399113735211267	2.500647	46	0.007969508	74	0.00012474205491891892	2.076929	28	43	0.004756243	
GO Cellular Component	vesicle coat	74	7.650765e-8	0.000001786557016216216	2.26214	54	0.009355509	106	0.006649089690566039	1.751137	28	51	0.004756243	
GO Cellular Component	cytosolic large ribosomal subunit	78	1.557451e-7	0.000003450352984615385	2.387364	46	0.007969508	54	0.00000126054496	2.091521	40	61	0.006794632	
GO Cellular Component	ESCRT III complex	79	1.767392e-7	0.000003865890349367089	4.87091	17	0.002945253	132	0.031233469090909093	2.392178	9	12	0.001528792	
GO Cellular Component	small nuclear ribonucleoprotein complex	80	1.957932e-7	0.00000422913312	2.367513	46	0.007969508	118	0.020519794983050847	1.571672	34	69	0.005775437	
GO Cellular Component	organelle envelope lumen	85	3.188798e-7	0.000006482638757647059	2.023116	63	0.01091476	109	0.00823217456146789	1.557697	42	86	0.007134364	
GO Cellular Component	spliceosomal snRNP complex	87	4.122909e-7	0.000008188950289655172	2.471782	40	0.006930007	123	0.023323939902439025	1.594785	31	62	0.00526584	
GO Molecular Function	structural constituent of ribosome	9	1.0002e-17	4.692049333333333e-15	2.484507	115	0.01992377	8	9.733113815e-11	1.890116	96	162	0.01630712	
GO Molecular Function	mRNA 5'-UTR binding	100	0.0001791677	0.007564460294000001	2.566496	20	0.003465003	48	0.0070176975724999995	2.319687	16	22	0.002717853	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	145	0.0007140659	0.020791629171034484	2.075037	25	0.004331254	73	0.03627518109041096	1.979733	18	29	0.003057585	
Human Phenotype	Increased serum lactate	3	1.788615e-10	3.978475965e-7	2.328857	72	0.01247401	12	0.00015586743352500001	1.786159	56	100	0.009512485	
Human Phenotype	Abnormal CSF metabolite level	6	3.076092e-8	0.00003421126986	2.592512	44	0.007623008	64	0.00606649207265625	1.771983	35	63	0.005945303	
Human Phenotype	11 pairs of ribs	11	4.319249e-7	0.0002620213507	3.127428	27	0.004677755	140	0.04572654184285715	2.453516	10	13	0.001698658	
Human Phenotype	Increased CSF lactate	13	7.840586e-7	0.00040246331059999997	2.47235	38	0.006583507	78	0.012190638491025642	1.759763	32	58	0.005435706	
Human Phenotype	Abnormality of the mitochondrion	15	0.000001164645	0.000518111739	2.098265	52	0.009009009	68	0.008351585299411764	1.707094	38	71	0.006454901	
Human Phenotype	Abnormality of mitochondrial metabolism	17	0.000001320419	0.0005183032933529412	2.106146	51	0.008835759	73	0.00910410644589041	1.710349	37	69	0.006285035	
Human Phenotype	Junctional split	18	0.000001801332	0.000667793802	4.603789	15	0.002598753	139	0.045514876751798564	3.18957	6	6	0.001019195	
Human Phenotype	Hypoalbuminemia	19	0.000002208402	0.0007756140287368421	2.932363	26	0.004504505	81	0.014771550518518518	2.168908	17	25	0.002887719	
Human Phenotype	Exercise intolerance	21	0.000002645258	0.0008405622206666667	2.234875	42	0.007276507	134	0.04280148849402986	1.594785	35	70	0.005945303	
Human Phenotype	Deviation of the thumb	30	0.00001060003	0.0023578000063333338	2.354305	33	0.005717256	143	0.045799057553846154	2.182338	13	19	0.002208255	
Human Phenotype	CNS hypomyelination	63	0.00008909122	0.009436598588253969	2.564261	22	0.003811504	100	0.020363246723999997	2.020061	19	30	0.00322745	
Mouse Phenotype Single KO	increased papilloma incidence	13	1.631473e-10	1.1491844816153846e-7	2.756533	53	0.009182259	80	0.007866420432375	2.093155	21	32	0.003567182	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	33	5.292482e-8	0.00001468583565878788	2.353738	51	0.008835759	153	0.049496451799346405	1.647945	31	60	0.00526584	
Mouse Phenotype Single KO	abnormal keratinocyte proliferation	66	0.000003815397	0.0005293574292272727	2.336803	37	0.006410256	155	0.04991619531935484	1.876218	20	34	0.003397316	
Mouse Phenotype	spontaneous skin ulceration	7	2.029238e-14	2.7716492168571425e-11	3.256995	59	0.01022176	231	0.022779744733766233	1.834003	23	40	0.003906914	
Mouse Phenotype	abnormal keratinocyte physiology	11	3.157723e-12	2.744635418454546e-9	2.018153	119	0.02061677	111	0.0015189086956756755	1.608898	57	113	0.009682351	
Mouse Phenotype	abnormal keratinocyte proliferation	12	8.976895e-12	7.15234109125e-9	2.269823	87	0.01507277	45	0.00003837719535333333	1.949182	44	72	0.007474095	
Mouse Phenotype	abnormal foot pad morphology	19	2.966878e-10	1.492964239894737e-7	2.651149	55	0.00952876	295	0.04652709942711864	1.962812	16	26	0.002717853	
Mouse Phenotype	increased skin papilloma incidence	20	3.169902e-10	1.5153716511000002e-7	2.674255	54	0.009355509	224	0.020293115792410714	1.822612	24	42	0.004076779	
Mouse Phenotype	increased skin tumor incidence	30	5.639258e-9	0.0000017972315245999997	2.079232	77	0.01334026	233	0.024527994571673824	1.541028	43	89	0.00730423	
Mouse Phenotype	increased papilloma incidence	39	3.634783e-8	0.000008910810323846154	2.005761	75	0.01299376	103	0.001300860377475728	1.860583	35	60	0.005945303	
Mouse Phenotype	abnormal Mullerian duct morphology	40	4.25722e-8	0.000010175820105000001	2.078388	68	0.01178101	212	0.01849836573537736	1.812256	25	44	0.004246645	
Mouse Phenotype	abnormal cellular replicative senescence	50	2.194069e-7	0.000041954987418000004	2.008235	66	0.01143451	236	0.02474065534194915	1.556814	41	84	0.006964498	
Mouse Phenotype	early cellular replicative senescence	55	3.200287e-7	0.00005563262546727273	2.063409	60	0.01039501	216	0.019572956073611113	1.616631	37	73	0.006285035	
Mouse Phenotype	decreased keratinocyte proliferation	62	4.73169e-7	0.00007296723885483872	2.491066	39	0.006756757	177	0.009685455050847457	2.168908	17	25	0.002887719	
Mouse Phenotype	increased keratinocyte proliferation	83	0.000001603745	0.0001847398306626506	2.127384	49	0.008489258	174	0.009012182115517242	1.822612	28	49	0.004756243	
Mouse Phenotype	increased lung adenoma incidence	110	0.000004734273	0.0004114944013909091	2.025412	50	0.008662509	113	0.0015478159061946902	1.879568	33	56	0.005605572	
Mouse Phenotype	abnormal lung adenoma incidence	115	0.000005391518	0.0004482461182434783	2.015404	50	0.008662509	124	0.0023450010254032257	1.846593	33	57	0.005605572	
Mouse Phenotype	pancytopenia	186	0.00004978244	0.002558978004516129	2.201964	32	0.005544006	173	0.008754018440462428	2.089718	19	29	0.00322745	
Mouse Phenotype	ruffled hair	196	0.00006735866	0.003285796674795919	2.165546	32	0.005544006	290	0.045954484934482766	1.822612	20	35	0.003397316	
Mouse Phenotype	abnormal epidermal-dermal junction morphology	231	0.0001427672	0.0059090787844155845	2.881172	17	0.002945253	183	0.010935521752459017	2.870613	9	10	0.001528792	
Mouse Phenotype	decreased white fat cell number	361	0.001141602	0.03023506017174515	2.205499	20	0.003465003	273	0.035557078824175824	2.339018	11	15	0.001868524