# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process rRNA processing 101 3.625564e-18 4.723643235247525e-16 2.046973 179 0.02649889 481 0.04541685222661123 1.271657 106 252 0.01706649 GO Biological Process regulation of antigen receptor-mediated signaling pathway 124 2.068139e-16 2.1947291210483872e-14 2.702767 91 0.0134715 211 0.0007743977952606635 1.88236 33 53 0.005313154 GO Biological Process regulation of type I interferon production 128 2.712313e-16 2.7883849036718747e-14 2.320795 120 0.01776462 320 0.0087434029696875 1.474724 60 123 0.00966028 GO Biological Process regulation of T cell receptor signaling pathway 184 3.446125e-13 2.464541243206522e-11 3.189166 55 0.008142117 478 0.0440018240083682 1.763524 21 36 0.003381098 GO Biological Process telomere organization 189 5.546161e-13 3.861477915291005e-11 2.309053 94 0.01391562 338 0.01226205842218935 1.472834 57 117 0.009177266 GO Biological Process type I interferon production 204 1.361941e-12 8.785187068137254e-11 10.82072 17 0.002516654 360 0.015800998224999998 3.023185 7 7 0.001127033 GO Biological Process positive regulation of antigen receptor-mediated signaling pathway 268 9.945852e-11 4.88348755477612e-9 3.318887 41 0.006069578 416 0.025316868973798076 2.116229 14 20 0.002254065 GO Biological Process regulation of toll-like receptor signaling pathway 270 1.276385e-10 6.220722301851852e-9 2.435885 67 0.009918579 473 0.043087545832980974 1.588453 31 59 0.004991145 GO Biological Process intrinsic apoptotic signaling pathway in response to DNA damage 278 1.842384e-10 8.720838509352518e-9 2.36097 70 0.01036269 495 0.04750478751515152 1.533499 35 69 0.005635163 GO Biological Process CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 290 4.677461e-10 2.122438251689655e-8 3.610059 34 0.005033309 396 0.02121472712929293 2.375359 11 14 0.001771051 GO Biological Process recombinational repair 291 4.895009e-10 2.213519705532646e-8 2.07043 89 0.01317543 422 0.026093919692180098 1.511592 43 86 0.006923201 GO Biological Process positive regulation of intrinsic apoptotic signaling pathway 294 5.085024e-10 2.27598064e-8 2.489991 60 0.008882309 465 0.03937212418494623 1.623562 29 54 0.004669135 GO Biological Process mitotic recombination 302 7.235883e-10 3.152880278046357e-8 3.396838 36 0.005329386 341 0.013330942980351907 2.22761 14 19 0.002254065 GO Biological Process double-strand break repair via homologous recombination 310 9.960982e-10 4.2282761979999996e-8 2.048669 88 0.01302739 453 0.03753025231125828 1.493809 42 85 0.006762196 GO Biological Process regulation of interferon-beta production 318 1.201962e-9 4.973779232075471e-8 2.522122 56 0.008290155 427 0.027458031659953162 1.708757 26 46 0.004186121 GO Biological Process positive T cell selection 334 1.850785e-9 7.291760423652695e-8 2.715357 48 0.007105848 208 0.0007255126079807692 2.365971 18 23 0.002898084 GO Biological Process viral gene expression 347 3.078458e-9 1.1674186980403458e-7 2.045997 83 0.01228719 301 0.007156318863122924 1.475885 62 127 0.009982289 GO Biological Process cellular protein complex localization 370 7.256179e-9 2.5806502557027027e-7 2.807859 42 0.006217617 409 0.02387303849584352 1.976698 17 26 0.002737079 GO Biological Process interferon-gamma-mediated signaling pathway 425 4.672836e-8 0.0000014468199746823531 2.142449 63 0.009326425 485 0.045593818707216495 1.55883 33 64 0.005313154 GO Biological Process TRIF-dependent toll-like receptor signaling pathway 443 7.087765e-8 0.000002105370194920993 2.824502 36 0.005329386 452 0.03722200738274336 1.876459 18 29 0.002898084 GO Cellular Component protein-DNA complex 38 5.848617e-18 2.659581625263158e-16 2.075336 171 0.02531458 37 0.001142137478918919 1.421795 95 202 0.01529544 GO Cellular Component nucleosome 42 9.39715e-17 3.866256e-15 3.126444 74 0.01095485 67 0.017874530005970148 1.468404 51 105 0.008211238 GO Cellular Component DNA packaging complex 48 5.856977e-15 2.10851172e-13 2.744204 80 0.01184308 58 0.009194136827586206 1.4846 55 112 0.008855257 GO Cellular Component cleavage furrow 76 1.116674e-9 2.5389640421052632e-8 2.322848 66 0.00977054 45 0.002910191232 1.802283 31 52 0.004991145 GO Cellular Component cell division site part 97 4.187298e-8 7.459433962886598e-7 2.055462 70 0.01036269 55 0.006912458705454545 1.685054 34 61 0.005474159 GO Cellular Component mitochondrial nucleoid 122 0.00000169495 0.000024007160655737705 2.459406 36 0.005329386 78 0.02504485661538462 1.727534 24 42 0.003864112 GO Molecular Function structure-specific DNA binding 12 4.743488e-17 1.6689171946666664e-14 2.062412 164 0.02427831 19 5.418637015789473e-7 1.739962 80 139 0.01288037 GO Molecular Function chromatin DNA binding 33 1.600497e-12 2.0476661618181817e-10 2.086108 113 0.01672835 42 0.00002089440658571429 1.744145 60 104 0.00966028 GO Molecular Function nucleosomal DNA binding 38 3.288743e-12 3.6539665647368424e-10 3.00431 55 0.008142117 80 0.0164573823875 1.774478 27 46 0.004347126 GO Molecular Function MAP kinase kinase kinase activity 107 0.000008095183 0.00031941927687850465 2.178253 40 0.00592154 77 0.009581500012987012 2.092974 18 26 0.002898084 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 51 3.941293e-25 7.076552941372549e-23 2.00352 267 0.03952628 389 0.0194448895 1.285722 111 261 0.01787152 Mouse Phenotype Single KO abnormal interleukin-6 secretion 71 1.54586e-20 1.993723946478873e-18 2.120417 188 0.02783124 186 0.0002703851882849463 1.52122 79 157 0.01271937 Mouse Phenotype Single KO abnormal double-positive T cell morphology 72 2.139481e-20 2.7210038218055556e-18 2.038206 205 0.03034789 82 5.946871828170731e-7 1.737203 77 134 0.01239736 Mouse Phenotype Single KO increased T cell proliferation 73 4.982678e-20 6.250189376164384e-18 2.405461 140 0.02072539 130 0.000039565600819230764 1.685492 63 113 0.01014329 Mouse Phenotype Single KO decreased double-positive T cell number 76 2.499645e-19 3.0117433243421053e-17 2.219281 159 0.02353812 175 0.00020666841440571433 1.656938 57 104 0.009177266 Mouse Phenotype Single KO abnormal dendritic cell physiology 84 2.848491e-18 3.105194296071429e-16 2.038311 182 0.02694301 208 0.0006527734741346153 1.501713 76 153 0.01223635 Mouse Phenotype Single KO abnormal B cell activation 87 1.142509e-17 1.2025235532183908e-15 2.008484 182 0.02694301 99 0.0000032001513620202024 1.650818 83 152 0.01336339 Mouse Phenotype Single KO abnormal dendritic cell morphology 96 5.353795e-16 5.106739668229167e-14 2.198018 132 0.01954108 314 0.00691927416433121 1.48553 57 116 0.009177266 Mouse Phenotype Single KO lacrimal gland inflammation 125 1.236677e-12 9.0594010312e-11 4.008815 39 0.005773501 381 0.017512925932020997 2.267389 12 16 0.001932056 Mouse Phenotype Single KO altered susceptibility to parasitic infection 134 3.47258e-12 2.3730160492537317e-10 2.023377 118 0.01746854 301 0.0053939992993355486 1.498448 57 115 0.009177266 Mouse Phenotype Single KO abnormal marginal zone B cell morphology 139 4.239196e-12 2.792684731798561e-10 2.171579 99 0.01465581 235 0.0015187804096595742 1.630482 48 89 0.007728224 Mouse Phenotype Single KO decreased dendritic cell number 140 4.283411e-12 2.8016567519285715e-10 2.331273 85 0.01258327 346 0.011539646106936415 1.627869 35 65 0.005635163 Mouse Phenotype Single KO abnormal gut-associated lymphoid tissue morphology 162 3.638606e-11 2.056710811234568e-9 2.028614 106 0.01569208 487 0.04241941704106776 1.474724 40 82 0.006440187 Mouse Phenotype Single KO abnormal Peyer's patch morphology 163 3.673719e-11 2.063818704478528e-9 2.036026 105 0.01554404 508 0.046501589326771654 1.473803 39 80 0.006279182 Mouse Phenotype Single KO decreased B cell proliferation 180 1.175239e-10 5.9787019572222225e-9 2.031788 100 0.01480385 146 0.00007195507880821917 1.791517 48 81 0.007728224 Mouse Phenotype Single KO increased IgG2a level 182 1.222215e-10 6.149353162087913e-9 2.186433 84 0.01243523 421 0.027953863182897862 1.556051 35 68 0.005635163 Mouse Phenotype Single KO abnormal Peyer's patch T cell area morphology 190 1.874043e-10 9.031900921578948e-9 6.349705 20 0.00296077 500 0.045017112294 2.645287 7 8 0.001127033 Mouse Phenotype Single KO decreased erythroid progenitor cell number 215 1.281747e-9 5.4590498972093015e-8 2.010343 91 0.0134715 407 0.02396256407125307 1.659788 28 51 0.004508131 Mouse Phenotype Single KO increased bone trabecula number 219 1.669777e-9 6.981802734703196e-8 2.370105 62 0.009178386 291 0.004044587112027491 1.88949 25 40 0.004025117 Mouse Phenotype Single KO abnormal liver sinusoid morphology 232 3.07873e-9 1.2151694228448276e-7 2.099418 78 0.011547 369 0.01576584016775068 1.603204 35 66 0.005635163 Mouse Phenotype abnormal lymph node size 44 1.110238e-38 2.4124967086363635e-36 2.067838 386 0.05714286 120 3.565249095e-7 1.500947 141 284 0.02270166 Mouse Phenotype abnormal interleukin-6 secretion 68 5.267039e-27 7.405611746911765e-25 2.211133 229 0.03390081 231 0.0001412872429090909 1.480101 94 192 0.01513444 Mouse Phenotype abnormal B cell activation 75 9.82121e-25 1.2520078508e-22 2.027345 255 0.03774981 123 3.725565688780488e-7 1.592702 108 205 0.0173885 Mouse Phenotype abnormal dendritic cell physiology 82 6.951526e-23 8.105309766585366e-21 2.099459 216 0.03197631 269 0.0004496740893680298 1.468892 86 177 0.0138464 Mouse Phenotype increased T cell proliferation 83 1.117032e-22 1.2867401146987953e-20 2.275739 179 0.02649889 307 0.0011197908600977199 1.456956 80 166 0.01288037 Mouse Phenotype abnormal spleen germinal center morphology 103 9.431918e-19 8.755200776504853e-17 2.156208 164 0.02427831 341 0.002390208783958944 1.478492 67 137 0.01078731 Mouse Phenotype abnormal spleen secondary B follicle morphology 113 2.35847e-17 1.9955160769911504e-15 2.073816 165 0.02442635 355 0.002662717492732394 1.468404 68 140 0.01094832 Mouse Phenotype abnormal marginal zone B cell morphology 123 1.777393e-16 1.3815979246341465e-14 2.08432 154 0.02279793 249 0.0003166461128915663 1.544217 71 139 0.01143133 Mouse Phenotype abnormal circulating tumor necrosis factor level 137 2.05292e-15 1.4326984029197078e-13 2.116444 138 0.02042931 561 0.02491507977540107 1.366645 66 146 0.01062631 Mouse Phenotype decreased single-positive T cell number 149 1.733167e-14 1.1121348783221478e-12 2.208248 117 0.0173205 229 0.00012671510608296943 1.748348 48 83 0.007728224 Mouse Phenotype small lymph nodes 152 4.231895e-14 2.6619176378289476e-12 2.203763 114 0.01687639 407 0.006130142035872236 1.615126 39 73 0.006279182 Mouse Phenotype abnormal B cell apoptosis 153 4.743016e-14 2.963919998431373e-12 2.11962 124 0.01835677 325 0.0018237375094153846 1.675008 41 74 0.006601191 Mouse Phenotype increased IgG1 level 158 1.367933e-13 8.277726210759494e-12 2.065414 127 0.01880089 658 0.04279869765957447 1.419046 46 98 0.007406215 Mouse Phenotype increased IgG2a level 161 2.16304e-13 1.2845233192546585e-11 2.228187 105 0.01554404 640 0.0389646454359375 1.458242 41 85 0.006601191 Mouse Phenotype decreased erythroid progenitor cell number 162 2.278708e-13 1.3448597029629633e-11 2.063113 125 0.01850481 369 0.0035815816926829266 1.630929 41 76 0.006601191 Mouse Phenotype abnormal follicular B cell morphology 167 5.540999e-13 3.172304876586826e-11 2.041952 124 0.01835677 243 0.00026122261238271607 1.643673 56 103 0.009016261 Mouse Phenotype abnormal germinal center B cell number 182 3.43302e-12 1.8034672648351645e-10 2.142173 103 0.01524796 207 0.0000526236516231884 1.867261 42 68 0.006762196 Mouse Phenotype lacrimal gland inflammation 202 1.127756e-11 5.337858968316832e-10 3.278401 46 0.006809771 434 0.008045347982488479 2.159418 15 21 0.00241507 Mouse Phenotype decreased susceptibility to endotoxin shock 204 1.536228e-11 7.199939170588236e-10 2.297275 83 0.01228719 681 0.047835283519823794 1.455607 39 81 0.006279182 Mouse Phenotype decreased dendritic cell number 237 1.623015e-10 6.5475301329113924e-9 2.05278 96 0.0142117 637 0.03872060909576138 1.473803 39 80 0.006279182