# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process DNA replication-dependent nucleosome assembly 3 4.288058e-30 1.8808851740666666e-26 26.61875 28 0.01063426 124 0.000001600501578548387 3.605415 20 32 0.006144393 GO Biological Process mRNA metabolic process 5 7.549232e-28 1.98680687776e-24 2.098765 256 0.0972275 28 3.784527930035714e-17 1.820762 208 659 0.06390169 GO Biological Process ribonucleoprotein complex biogenesis 9 1.155045e-25 1.6888041283333335e-22 2.399867 179 0.06798329 72 5.2406083027777776e-12 1.829708 144 454 0.04423963 GO Biological Process chromatin silencing 14 1.049417e-23 9.863770216428573e-21 5.744902 54 0.02050893 118 8.192275961355932e-7 2.438301 41 97 0.01259601 GO Biological Process nucleosome organization 15 1.916815e-23 1.681557905666667e-20 3.396635 94 0.03570072 69 1.1921144312608695e-12 2.462646 73 171 0.02242704 GO Biological Process protein-DNA complex subunit organization 16 2.915492e-23 2.39780995175e-20 2.739127 128 0.04861375 40 1.4795084788000001e-15 2.33054 101 250 0.03102919 GO Biological Process chromatin silencing at rDNA 18 7.986821e-23 5.838809863277778e-20 12.51237 30 0.01139385 132 0.000003719928675833333 3.365054 21 36 0.006451613 GO Biological Process chromatin assembly or disassembly 21 3.617936e-22 2.267067610666667e-19 3.225875 95 0.03608052 60 1.0239805246833334e-13 2.495433 77 178 0.02365591 GO Biological Process ribosome biogenesis 22 7.467186e-22 4.466395480636363e-19 2.645498 127 0.04823395 113 6.075081759115045e-7 1.750245 98 323 0.03010753 GO Biological Process chromosome organization 23 1.015376e-21 5.809275123478261e-19 2.023871 216 0.0820357 57 6.177991206842106e-14 1.786489 179 578 0.05499232 GO Biological Process negative regulation of gene expression, epigenetic 24 1.3487e-21 7.394809708333334e-19 4.418575 63 0.02392708 105 2.0296078160952384e-7 2.378309 47 114 0.01443932 GO Biological Process ncRNA processing 25 2.546125e-21 1.3401783550000002e-18 2.477134 139 0.05279149 143 0.000011268806272027971 1.602407 110 396 0.03379416 GO Biological Process protein-DNA complex assembly 26 2.845971e-21 1.4403897072692308e-18 2.77485 114 0.04329662 41 2.1759395029756095e-15 2.423366 92 219 0.02826421 GO Biological Process ncRNA metabolic process 27 3.668318e-21 1.7878295022962964e-18 2.190203 176 0.0668439 144 0.000014207964202083332 1.496734 144 555 0.04423963 GO Biological Process nucleosome assembly 28 4.770483e-21 2.2419566356071426e-18 3.485047 81 0.03076339 66 6.385671917575757e-13 2.640585 65 142 0.01996928 GO Biological Process regulation of gene expression, epigenetic 30 1.72083e-20 7.54813399e-18 2.752381 111 0.04215724 125 0.0000015906809743999998 1.837598 79 248 0.02427035 GO Biological Process chromatin assembly 31 2.646169e-20 1.1232560603548388e-17 3.266076 85 0.03228257 70 1.6293323411428572e-12 2.519227 69 158 0.02119816 GO Biological Process rRNA metabolic process 33 1.660133e-19 6.619906105151514e-17 2.841958 100 0.03797949 142 0.000011210291103521128 1.759554 79 259 0.02427035 GO Biological Process rRNA processing 34 1.797988e-19 6.95874238e-17 2.875144 98 0.0372199 145 0.000014570316362758621 1.762647 77 252 0.02365591 GO Biological Process gene silencing 38 1.712272e-18 5.929417696842105e-16 3.119206 82 0.03114318 153 0.00002821674049215686 1.89084 59 180 0.01812596 GO Cellular Component nucleosome 13 1.666965e-37 2.2157811692307694e-35 7.587373 70 0.02658564 21 1.2276164571428574e-16 3.1865 58 105 0.01781874 GO Cellular Component nuclear nucleosome 15 6.452567e-36 7.433357183999999e-34 16.38478 42 0.01595139 34 9.009207529411764e-8 3.461198 24 40 0.007373272 GO Cellular Component intracellular ribonucleoprotein complex 16 1.506624e-35 1.62715392e-33 2.21537 291 0.1105203 24 5.12036424e-16 1.686661 238 814 0.07311828 GO Cellular Component ribonucleoprotein complex 17 1.867894e-35 1.8986593129411764e-33 2.212549 291 0.1105203 25 8.006978304e-16 1.680467 238 817 0.07311828 GO Cellular Component DNA packaging complex 18 1.6806e-34 1.6133759999999997e-32 6.424269 73 0.02772503 20 4.329854784e-17 3.141861 61 112 0.0187404 GO Cellular Component protein-DNA complex 23 8.644569e-25 6.494702274782608e-23 3.26931 105 0.03987847 22 1.7125037672727273e-16 2.513081 88 202 0.02703533 GO Cellular Component nuclear chromatin 26 1.952068e-22 1.2973744246153845e-20 2.314389 167 0.06342575 23 2.690794267826087e-16 2.172376 119 316 0.03655914 GO Cellular Component nuclear chromosome part 27 4.7819e-22 3.060416e-20 2.025259 219 0.08317509 26 1.240299913846154e-15 1.874255 167 514 0.05130568 GO Cellular Component chromatin 28 2.505187e-21 1.546058262857143e-19 2.019742 213 0.08089632 18 5.05409952e-19 2.005976 169 486 0.05192012 GO Cellular Component ribosomal subunit 31 9.553224e-21 5.325151958709678e-19 3.476808 80 0.03038359 39 0.0000011889738830769233 1.964464 63 185 0.01935484 GO Cellular Component ribosome 33 1.073373e-18 5.620571345454546e-17 2.871155 94 0.03570072 33 6.313148509090909e-8 1.931036 79 236 0.02427035 GO Cellular Component large ribosomal subunit 38 2.028642e-12 9.224982568421052e-11 3.386542 47 0.01785036 55 0.0023689217978181817 1.856005 37 115 0.01136713 GO Cellular Component cytosolic ribosome 39 3.323618e-12 1.472618436923077e-10 3.027612 54 0.02050893 42 0.00000388488096 2.214755 43 112 0.01321045 GO Cellular Component spliceosomal complex 40 8.212027e-12 3.5475956640000003e-10 2.420295 76 0.02886441 38 6.030174315789473e-7 1.984917 64 186 0.01966206 GO Cellular Component nuclear chromosome, telomeric region 42 5.597982e-11 2.3031697371428575e-9 2.939794 50 0.01898975 50 0.0011878987392 1.835484 42 132 0.01290323 GO Cellular Component cytosolic part 45 9.717144e-11 3.731383296e-9 2.162522 86 0.03266236 44 0.000007321170763636364 1.778671 74 240 0.02273425 GO Cellular Component chromosome, telomeric region 46 2.54715e-10 9.568424347826087e-9 2.599771 57 0.02164831 62 0.0047846592 1.658059 48 167 0.01474654 GO Cellular Component small ribosomal subunit 47 3.574324e-10 1.3141344408510639e-8 3.639014 34 0.01291303 51 0.001226977242352941 2.163249 27 72 0.008294931 GO Cellular Component catalytic step 2 spliceosome 51 3.697748e-9 1.2528840282352943e-7 2.867958 42 0.01595139 47 0.0005791950842553191 2.043068 34 96 0.01044547 GO Cellular Component cytosolic small ribosomal subunit 53 1.62995e-8 5.314252075471698e-7 3.937502 25 0.009494873 64 0.0053480628 2.359908 18 44 0.005529954 GO Molecular Function structural constituent of ribosome 7 1.043853e-14 6.295924808571429e-12 3.078444 65 0.02468667 11 0.000012747300367272728 2.029715 57 162 0.01751152 GO Molecular Function chromatin DNA binding 9 8.050125e-12 3.7764030833333335e-9 2.794377 59 0.0224079 26 0.00035075515361538464 2.107781 38 104 0.01167435 GO Molecular Function structure-specific DNA binding 11 1.667802e-10 6.401327312727274e-8 2.322944 72 0.02734523 15 0.00002879147865333333 2.075059 50 139 0.01536098 GO Molecular Function nucleosome binding 14 9.821469e-10 2.961874437e-7 3.218937 38 0.01443221 42 0.01693276325238095 2.097696 24 66 0.007373272 GO Molecular Function ribonucleoprotein complex binding 20 1.783835e-7 0.00003765675685 2.483883 42 0.01595139 35 0.0037902003782857145 1.906167 38 115 0.01167435 GO Molecular Function recombinase activity 63 0.0003472793 0.023273225469841268 4.263501 9 0.003418154 53 0.04375999441509434 4.326498 6 8 0.001843318 Human Phenotype Increased serum lactate 9 0.000004659665 0.003454882727222222 2.410819 34 0.01291303 63 0.026470964819047618 1.845972 32 100 0.009831029 Mouse Phenotype Single KO increased mammary adenocarcinoma incidence 38 4.284032e-7 0.00010323389743157895 5.579277 14 0.005317129 147 0.02798764167755102 2.884332 11 22 0.003379416 Mouse Phenotype Single KO abnormal lymph node cortex morphology 42 8.744926e-7 0.00019066020805238095 2.702599 32 0.01215344 162 0.03947384298333333 2.163249 18 48 0.005529954 Mouse Phenotype Single KO abnormal class switch recombination 51 0.000001920209 0.0003447716433921569 2.476283 35 0.01329282 179 0.04917142741620112 1.952471 22 65 0.006758833 Mouse Phenotype Single KO absent inner cell mass proliferation 54 0.000004236015 0.0007183183213888888 3.053434 23 0.008735283 103 0.010365670658252427 2.514546 17 39 0.005222734 Mouse Phenotype Single KO abnormal cell cycle checkpoint function 56 0.000006234394 0.0010194347474642858 2.639781 28 0.01063426 119 0.018655463760504202 2.218717 20 52 0.006144393 Mouse Phenotype Single KO increased adenocarcinoma incidence 71 0.00001667751 0.0021509290009859156 2.003674 45 0.01709077 129 0.022563430072868217 1.843594 31 97 0.00952381 Mouse Phenotype Single KO abnormal inner cell mass proliferation 86 0.00004926712 0.0052458025330232565 2.19945 32 0.01215344 126 0.02029151228968254 2.073113 23 64 0.007066052 Mouse Phenotype Single KO abnormal B cell apoptosis 106 0.0001417745 0.012247444306603775 2.235274 27 0.01025446 143 0.027332191406293706 2.366631 16 39 0.004915515 Mouse Phenotype Single KO abnormal mortality induced by ionizing radiation 138 0.0003968076 0.02633019705217391 2.24563 23 0.008735283 125 0.0202959850336 2.307465 18 45 0.005529954 Mouse Phenotype Single KO absent B cells 146 0.0005482085 0.03438318653767123 2.014794 28 0.01063426 138 0.025351101415942028 2.257303 18 46 0.005529954 Mouse Phenotype Single KO decreased T cell apoptosis 150 0.0006239024 0.03808716184533333 2.318495 20 0.007595898 166 0.04346176980722891 2.499754 13 30 0.003993856 Mouse Phenotype Single KO increased mortality induced by ionizing radiation 158 0.0006983492 0.04047331407848101 2.243714 21 0.007975693 169 0.04466376056923077 2.251186 16 41 0.004915515 Mouse Phenotype abnormal B cell activation 13 6.675312e-13 4.909435233230769e-10 2.16206 106 0.04025826 104 0.00015326981688461538 1.772809 63 205 0.01935484 Mouse Phenotype abnormal B cell proliferation 24 1.247673e-11 4.970417313749999e-9 2.125218 98 0.0372199 107 0.00017961893279439255 1.8008 59 189 0.01812596 Mouse Phenotype abnormal follicular B cell morphology 46 1.495944e-9 3.1092870834782605e-7 2.45034 58 0.0220281 129 0.0009335004641860465 2.016232 36 103 0.01105991 Mouse Phenotype abnormal spleen germinal center morphology 49 4.778503e-9 9.323932078163265e-7 2.226205 66 0.02506646 177 0.004843030020338983 1.768495 42 137 0.01290323 Mouse Phenotype decreased B cell proliferation 51 1.719423e-8 0.000003223412412352941 2.150534 66 0.02506646 238 0.01863029544579832 1.740545 35 116 0.01075269 Mouse Phenotype abnormal spleen secondary B follicle morphology 52 2.515248e-8 0.000004624670409230769 2.128162 66 0.02506646 191 0.007678238869633508 1.730599 42 140 0.01290323 Mouse Phenotype abnormal class switch recombination 74 4.069825e-7 0.000052583238952702705 2.298394 46 0.01747057 181 0.005702798431491713 1.943789 31 92 0.00952381 Mouse Phenotype absent inner cell mass proliferation 79 5.63604e-7 0.0000682103524556962 3.247819 25 0.009494873 134 0.001154375161791045 2.673283 19 41 0.005837174 Mouse Phenotype abnormal plasma cell morphology 87 0.000001653968 0.00018176537986206896 2.066563 52 0.01974934 242 0.019532720015702477 1.821683 30 95 0.00921659 Mouse Phenotype arrested B cell differentiation 91 0.000002404465 0.00025262736115384615 2.147922 46 0.01747057 216 0.012688894429166667 2.003008 25 72 0.007680492 Mouse Phenotype abnormal B cell apoptosis 100 0.000005426512 0.00051882881232 2.061146 47 0.01785036 80 0.00002019139785 2.494557 32 74 0.009831029 Mouse Phenotype abnormal inner cell mass proliferation 106 0.00001104819 0.0009965258923584905 2.310715 34 0.01291303 162 0.0033826646846296295 2.1851 25 66 0.007680492 Mouse Phenotype abnormal cell cycle checkpoint function 108 0.00001190349 0.0010537895175 2.302136 34 0.01291303 141 0.0017003933361702127 2.238586 26 67 0.007987711 Mouse Phenotype decreased T cell apoptosis 140 0.00007967649 0.005441335149214285 2.36176 26 0.009874668 253 0.024752782782213434 2.228802 17 44 0.005222734 Mouse Phenotype absent brachial lymph nodes 143 0.00008223651 0.0054983445602097905 4.656098 10 0.003797949 301 0.04463748199335548 3.845776 6 9 0.001843318 Mouse Phenotype abnormal common lymphocyte progenitor cell morphology 161 0.0001521339 0.009034485825465838 2.35557 24 0.009115078 200 0.009212893551 2.692043 14 30 0.004301075 Mouse Phenotype abnormal brachial lymph node morphology 165 0.0001628249 0.009434962841818183 3.427887 13 0.004937334 204 0.009656066335294117 3.845776 8 12 0.002457757 Mouse Phenotype decreased B cell apoptosis 174 0.0002056941 0.01130253615 2.788116 17 0.006456513 299 0.042347075969899665 2.746983 10 21 0.003072197 Mouse Phenotype increased salivary gland tumor incidence 181 0.000255245 0.013482858812154698 3.269282 13 0.004937334 151 0.002536139462781457 3.525294 11 18 0.003379416 Mouse Phenotype decreased mortality induced by ionizing radiation 207 0.0004316744 0.019938352359420288 5.318587 7 0.002658564 246 0.021350257121951217 4.326498 6 8 0.001843318