# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process	34	3.83506e-32	1.4842810158823532e-29	2.343142	245	0.02557144	136	0.0000017404577186764706	1.549236	108	198	0.01633641	
GO Biological Process	rRNA metabolic process	37	4.463057e-31	1.587280190891892e-28	2.171213	278	0.02901576	112	4.069969433303571e-7	1.50238	137	259	0.02072304	
GO Biological Process	rRNA processing	41	4.812435e-30	1.5445568820731707e-27	2.168832	269	0.0280764	134	0.0000014387225707462687	1.487758	132	252	0.01996672	
GO Biological Process	mRNA catabolic process	42	6.30754e-30	1.976212353809524e-27	2.213965	256	0.02671955	153	0.0000055294565233986934	1.506808	113	213	0.01709272	
GO Biological Process	mitochondrial transport	45	5.582446e-29	1.6324312647555553e-26	2.036895	300	0.03131197	331	0.0049518787945619334	1.331003	112	239	0.01694146	
GO Biological Process	cellular response to insulin stimulus	47	2.032135e-28	5.689545630851064e-26	2.10726	271	0.02828515	486	0.024440411063374485	1.36256	71	148	0.01073968	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	56	5.527159e-27	1.298783665732143e-24	2.243906	223	0.02327523	336	0.005599189747321429	1.410971	77	155	0.01164725	
GO Biological Process	liver regeneration	58	1.018418e-26	2.310579734827586e-24	3.639913	100	0.01043732	247	0.000727530743076923	2.028762	25	35	0.003781576	
GO Biological Process	RNA catabolic process	59	1.096985e-26	2.446648409322034e-24	2.037206	275	0.02870264	143	0.0000032821426256643354	1.484952	126	241	0.01905914	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	67	1.566132e-24	3.075929998208955e-22	2.705778	141	0.01471663	173	0.000015190612685549132	1.660834	69	118	0.01043715	
GO Biological Process	response to epidermal growth factor	74	1.02858e-23	1.8290654351351353e-21	2.818935	127	0.0132554	278	0.0015276093761870503	1.893511	28	42	0.004235365	
GO Biological Process	cellular response to epidermal growth factor stimulus	76	1.247603e-23	2.1601589311842104e-21	2.898362	121	0.01262916	275	0.0014824671005090907	1.94334	26	38	0.003932839	
GO Biological Process	protein targeting to ER	85	2.378708e-22	3.682519832e-20	2.738601	125	0.01304665	174	0.000015550912942528736	1.715408	61	101	0.009227046	
GO Biological Process	protein localization to endoplasmic reticulum	120	1.406349e-19	1.54217887425e-17	2.330727	146	0.01523849	170	0.000012495585144705882	1.649187	72	124	0.01089094	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	124	6.046354e-19	6.416449377903226e-17	2.657225	110	0.01148106	530	0.03540302325660377	1.526113	36	67	0.00544547	
GO Biological Process	cotranslational protein targeting to membrane	127	7.61269e-19	7.887825803937007e-17	2.608338	113	0.01179418	164	0.000010434581501829269	1.738939	60	98	0.009075783	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	130	1.033611e-18	1.0462528576153847e-16	2.438815	127	0.0132554	172	0.00001404158637093023	1.70416	63	105	0.009529572	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	138	2.991937e-18	2.85296369442029e-16	2.637156	107	0.01116794	166	0.000011785509557228917	1.75973	57	92	0.008621994	
GO Biological Process	ATP biosynthetic process	146	6.047327e-18	5.450464109109589e-16	3.732085	63	0.006575514	297	0.002744272675690236	1.870419	27	41	0.004084102	
GO Biological Process	multi-organism metabolic process	158	1.2919e-16	1.0759564620253165e-14	2.079238	157	0.0163866	271	0.0013884599884870848	1.468437	76	147	0.01149599	
GO Cellular Component	catalytic step 2 spliceosome	42	2.520269e-20	1.0369106742857143e-18	2.495831	133	0.01388164	66	0.0012244668218181817	1.568064	53	96	0.008016941	
GO Cellular Component	large ribosomal subunit	72	2.69379e-12	6.465096e-11	2.118763	107	0.01116794	96	0.0099229428	1.432482	58	115	0.008773257	
GO Cellular Component	mitochondrial ribosome	77	5.630995e-12	1.2636830337662338e-10	2.472402	75	0.007827993	105	0.020537033142857142	1.470255	44	85	0.006655574	
GO Cellular Component	MLL1 complex	82	3.792595e-11	7.992200195121951e-10	3.20803	45	0.004696796	123	0.040151316292682926	1.762924	18	29	0.002722735	
GO Cellular Component	zonula adherens	85	6.809865e-11	1.3844054964705882e-9	4.813689	27	0.002818077	130	0.04925811544615385	2.485233	7	8	0.001058841	
GO Cellular Component	proton-transporting ATP synthase complex	89	1.081621e-10	2.100046166292135e-9	3.82782	34	0.00354869	112	0.02578004742857143	1.893511	16	24	0.002420209	
GO Cellular Component	spliceosomal snRNP complex	97	3.182327e-10	5.66913510927835e-9	2.419798	65	0.006784261	104	0.01992149723076923	1.557565	34	62	0.005142944	
GO Cellular Component	mitochondrial proton-transporting ATP synthase complex	102	7.306035e-10	1.2377282823529412e-8	3.721904	32	0.003339944	125	0.044607656448	1.852348	15	23	0.002268946	
GO Cellular Component	transcription factor TFIID complex	130	9.440586e-8	0.0000012548717390769232	2.333251	50	0.005218662	120	0.0341919936	1.70416	21	35	0.003176524	
GO Cellular Component	U2 snRNP	150	5.509972e-7	0.000006347487744	3.25931	25	0.002609331	82	0.0026007938341463415	2.242315	15	19	0.002268946	
GO Cellular Component	male pronucleus	222	0.00003247652	0.00025279020972972976	4.043707	13	0.001356852	116	0.02833301793103448	2.840266	6	6	0.0009075783	
GO Cellular Component	death-inducing signaling complex	274	0.0002440695	0.0015392412262773723	2.97684	15	0.001565599	109	0.023090439633027524	2.524681	8	9	0.001210104	
GO Molecular Function	cadherin binding	4	3.520259e-48	3.7156333745e-45	2.013518	520	0.05427408	8	2.0005070935000002e-13	1.644365	176	304	0.0266223	
GO Molecular Function	unfolded protein binding	9	2.547695e-25	1.1951520322222223e-22	2.861138	133	0.01388164	48	0.0026260321045833332	1.554108	58	106	0.008773257	
GO Molecular Function	ribonuclease activity	21	1.431765e-14	2.8785294428571427e-12	2.20079	119	0.01242042	47	0.002398466997021277	1.577926	55	99	0.008319468	
GO Molecular Function	endoribonuclease activity	76	7.654288e-9	4.252158412631579e-7	2.209071	66	0.006888634	62	0.00585035526032258	1.724447	34	56	0.005142944	
Human Phenotype	Increased serum lactate	7	1.394759e-13	1.3296038295714286e-10	2.182447	112	0.0116898	58	0.022434683525862066	1.505341	53	100	0.008016941	
Human Phenotype	Leukodystrophy	78	5.274251e-7	0.00004512189349102564	2.047108	59	0.006158021	61	0.03258411678852459	1.70416	30	50	0.004537891	
Human Phenotype	CNS hypomyelination	157	0.00003468261	0.0014741213791719745	2.24701	32	0.003339944	52	0.014001493923076922	1.988186	21	30	0.003176524	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	39	4.847423e-18	1.1381500618205128e-15	2.924247	89	0.009289218	87	0.020547223895402297	2.044992	18	25	0.002722735	
Mouse Phenotype Single KO	prenatal lethality prior to heart atrial septation	115	7.099413e-12	5.652984768782609e-10	2.203812	94	0.009811084	62	0.004007354279032258	1.762924	36	58	0.00544547	
Mouse Phenotype	abnormal vitelline vein morphology	64	4.847423e-18	7.24159551609375e-16	2.924247	89	0.009289218	122	0.015298987128688523	2.044992	18	25	0.002722735	
Mouse Phenotype	abnormal cellular replicative senescence	96	1.150593e-14	1.1459187159375e-12	2.19972	120	0.01252479	142	0.028371318133098594	1.521571	45	84	0.006806837	
Mouse Phenotype	early cellular replicative senescence	107	8.32807e-14	7.441558623364486e-12	2.237553	108	0.01127231	147	0.030652800146938775	1.55631	40	73	0.006050522	
Mouse Phenotype	prenatal lethality prior to heart atrial septation	149	7.099413e-12	4.555536086778523e-10	2.203812	94	0.009811084	81	0.0032026871222222224	1.762924	36	58	0.00544547