# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 16 3.95862e-51 3.25571753625e-48 2.574405 330 0.03943123 138 0.0000033488749126811596 1.473912 130 248 0.01946691 GO Biological Process DNA replication-dependent nucleosome assembly 21 5.907595e-49 3.701811552619048e-46 17.04832 57 0.00681085 312 0.0013145727124038462 2.02096 23 32 0.003444145 GO Biological Process negative regulation of gene expression, epigenetic 22 6.407093e-49 3.8323153085e-46 3.861509 175 0.0209105 276 0.0006210781005797101 1.553873 63 114 0.009433962 GO Biological Process DNA conformation change 49 4.466632e-39 1.199518581387755e-36 2.180617 348 0.04158203 133 0.000002190474843157895 1.450913 145 281 0.02171309 GO Biological Process gene silencing 74 2.813063e-33 5.002310272567568e-31 2.561069 214 0.02557056 194 0.00005063839597010309 1.499611 96 180 0.01437556 GO Biological Process chromatin silencing 83 5.675962e-32 8.998793247951806e-30 3.815672 114 0.0136217 368 0.0032978556579347828 1.536328 53 97 0.007936508 GO Biological Process nucleosome organization 86 3.632219e-31 5.557717421046511e-29 2.455568 216 0.02580954 135 0.0000027998647985185185 1.578538 96 171 0.01437556 GO Biological Process chromatin assembly or disassembly 88 9.037401e-31 1.3513995427159091e-28 2.393036 224 0.02676544 136 0.0000032276617741911763 1.56385 99 178 0.0148248 GO Biological Process chromatin assembly 93 3.810599e-30 5.3917927140860215e-28 2.478212 205 0.02449516 154 0.000006274089863766234 1.583845 89 158 0.01332734 GO Biological Process regulation of megakaryocyte differentiation 95 4.44728e-30 6.160185002105263e-28 3.146572 138 0.01648943 198 0.00005783872301010101 1.775855 48 76 0.007187781 GO Biological Process nucleosome assembly 108 4.768006e-27 5.80946212537037e-25 2.477148 183 0.02186641 178 0.000024109032676404496 1.584096 80 142 0.01197963 GO Biological Process chromatin silencing at rDNA 111 6.589998e-27 7.812412944324324e-25 6.954589 53 0.006332895 612 0.033525799246732026 1.718304 22 36 0.0032944 GO Biological Process DNA packaging 121 2.225139e-24 2.4198846364462816e-22 2.127115 225 0.02688493 202 0.00006187883599950495 1.469468 104 199 0.01557353 GO Biological Process regulation of gene silencing 144 1.085114e-20 9.915982726388888e-19 2.329391 155 0.01852073 321 0.0017813576063862926 1.481009 69 131 0.01033243 GO Biological Process mRNA catabolic process 147 3.932541e-20 3.520292994489796e-18 2.029654 205 0.02449516 146 0.000005026317092260274 1.504891 114 213 0.01707098 GO Biological Process multi-organism metabolic process 183 9.686106e-18 6.964998298032787e-16 2.213577 146 0.01744533 409 0.005167346258435208 1.415449 74 147 0.01108116 GO Biological Process platelet aggregation 187 1.144096e-17 8.050887306951873e-16 3.114371 79 0.009439599 527 0.019834031343643265 1.714494 25 41 0.003743636 GO Biological Process Arp2/3 complex-mediated actin nucleation 193 4.709495e-17 3.2109971349740934e-15 3.867632 57 0.00681085 400 0.00463104358025 2.219818 15 19 0.002246181 GO Biological Process mitochondrial membrane organization 197 1.100757e-16 7.352721504060915e-15 2.071 159 0.01899869 471 0.009630004852016986 1.428561 63 124 0.009433962 GO Biological Process actin nucleation 213 1.326296e-15 8.193769513615024e-14 3.14065 68 0.008125224 268 0.0005509309954477612 2.133067 22 29 0.0032944 GO Cellular Component nucleosome 26 1.075055e-35 7.144980923076923e-34 4.058052 119 0.01421914 54 0.000161039392 1.606726 60 105 0.008984726 GO Cellular Component ficolin-1-rich granule lumen 30 1.522101e-28 8.767301759999999e-27 2.729651 163 0.01947664 59 0.0005586184677966102 1.519263 67 124 0.01003294 GO Cellular Component DNA packaging complex 31 2.432731e-28 1.356051344516129e-26 3.322457 120 0.01433863 62 0.0008966380180645161 1.53141 61 112 0.009134471 GO Cellular Component protein-DNA complex 42 1.504471e-21 6.189823542857143e-20 2.066934 211 0.02521209 47 0.000043317430468085106 1.461564 105 202 0.01572327 GO Cellular Component ribosomal subunit 67 1.700511e-15 4.3857955343283574e-14 2.05097 150 0.01792329 78 0.01096386756923077 1.337491 88 185 0.0131776 GO Cellular Component Arp2/3 protein complex 98 1.002993e-10 1.7685427591836735e-9 3.664259 36 0.004301589 63 0.00097509888 2.59548 12 13 0.001796945 GO Cellular Component small ribosomal subunit 102 2.017199e-10 3.417372423529412e-9 2.357111 70 0.008364201 68 0.0016849786447058824 1.640199 42 72 0.006289308 GO Cellular Component cytosolic small ribosomal subunit 154 9.671241e-8 0.0000010851886005194806 2.378479 48 0.005735452 77 0.009603631542857143 1.725404 27 44 0.004043127 GO Cellular Component eukaryotic translation initiation factor 4F complex 171 0.000001403312 0.000014180837052631579 4.17887 17 0.002031306 90 0.0301758144 2.499351 8 9 0.001197963 GO Cellular Component CRD-mediated mRNA stability complex 377 0.007994696 0.03664412384084881 2.381028 11 0.001314374 96 0.036371808 2.81177 6 6 0.0008984726 GO Molecular Function nucleosome binding 46 1.806612e-11 1.6581556226086958e-9 2.265297 85 0.01015653 85 0.02604229934588235 1.576295 37 66 0.005540581 GO Molecular Function nucleosomal DNA binding 61 2.533866e-9 1.753767582295082e-7 2.469004 56 0.006691361 83 0.020696976491566266 1.711512 28 46 0.004192872 GO Molecular Function carbohydrate derivative transporter activity 138 0.000002679983 0.00008199194366666667 2.145435 46 0.005496475 89 0.04150380648539326 1.747857 23 37 0.003444145 GO Molecular Function 1-acylglycerol-3-phosphate O-acyltransferase activity 151 0.00000569152 0.00015913640688741722 2.239111 39 0.004660055 87 0.03912227007126437 2.071831 14 19 0.002096436 GO Molecular Function mitogen-activated protein kinase binding 245 0.000110791 0.0019092228653061225 2.029933 35 0.004182101 91 0.045581565679120875 1.874513 18 27 0.002695418 Mouse Phenotype Single KO abnormal platelet activation 11 4.764196e-46 3.965976615636364e-43 3.32589 199 0.02377823 226 0.006245937026991151 1.554743 47 85 0.007038035 Mouse Phenotype Single KO abnormal platelet aggregation 12 9.730616e-46 7.425270892666668e-43 3.371429 194 0.02318079 193 0.002548021126528497 1.622175 45 78 0.006738544 Mouse Phenotype Single KO abnormal platelet physiology 27 4.136083e-34 1.4027448900370368e-31 2.584709 216 0.02580954 314 0.019567039214012736 1.431447 56 110 0.008385744 Mouse Phenotype Single KO cortical renal glomerulopathies 72 2.493011e-20 3.170625239861111e-18 2.007221 213 0.02545107 209 0.004800449907177033 1.447852 69 134 0.01033243 Mouse Phenotype Single KO decreased erythroid progenitor cell number 77 9.566006e-20 1.1376093109350649e-17 2.425043 136 0.01625045 305 0.017554890704590164 1.653982 30 51 0.004492363 Mouse Phenotype Single KO abnormal pre-B cell morphology 93 1.184767e-17 1.1665496149462364e-15 2.098145 164 0.01959613 146 0.0006726826278767123 1.659961 49 83 0.007337526 Mouse Phenotype Single KO decreased platelet aggregation 94 1.287281e-17 1.2540034167021278e-15 2.620359 104 0.01242681 313 0.019588534452076676 1.593336 34 60 0.005091345 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 98 1.841e-17 1.720207857142857e-15 2.310388 131 0.01565301 299 0.01671460897959866 1.64462 31 53 0.004642108 Mouse Phenotype Single KO abnormal thymus development 124 4.697918e-16 3.469260897258064e-14 3.949505 52 0.006213407 374 0.03731690510427808 2.108827 12 16 0.001796945 Mouse Phenotype Single KO extramedullary hematopoiesis 138 3.386296e-15 2.2469791646376813e-13 2.038475 149 0.0178038 197 0.0030022047235533 1.504544 61 114 0.009134471 Mouse Phenotype Single KO decreased pre-B cell number 150 2.046166e-14 1.2491161374666666e-12 2.155944 123 0.0146971 230 0.006615008837391303 1.667999 35 59 0.00524109 Mouse Phenotype Single KO abnormal platelet volume 204 1.238255e-11 5.558186781862745e-10 2.258066 87 0.01039551 236 0.0068564861139830515 1.677196 34 57 0.005091345 Mouse Phenotype Single KO increased mean platelet volume 228 7.24975e-11 2.9116649451754387e-9 2.333979 75 0.008961644 252 0.009069663295634921 1.76553 27 43 0.004043127 Mouse Phenotype Single KO increased circulating interleukin-18 level 236 1.431468e-10 5.5542171508474575e-9 8.704216 16 0.001911817 404 0.04579986879207921 2.81177 6 6 0.0008984726 Mouse Phenotype Single KO increased thymus tumor incidence 291 3.643286e-9 1.1464457010996565e-7 2.059659 81 0.009678576 277 0.01274108946931408 1.698778 29 48 0.004342618 Mouse Phenotype Single KO decreased single-positive T cell number 298 6.999262e-9 2.1507463803355706e-7 2.170038 69 0.008244713 359 0.03542032178551532 1.687062 24 40 0.00359389 Mouse Phenotype Single KO abnormal nitric oxide homeostasis 308 1.07723e-8 3.20266075e-7 2.30515 59 0.007049827 412 0.04951232128883495 1.645914 24 41 0.00359389 Mouse Phenotype Single KO increased T cell derived lymphoma incidence 319 1.448227e-8 4.1571832724137934e-7 2.012963 79 0.009439599 311 0.019630025784887463 1.675097 28 47 0.004192872 Mouse Phenotype Single KO decreased inguinal fat pad weight 324 1.923401e-8 5.435982394135803e-7 2.46041 50 0.005974429 191 0.0024710428183246074 2.082793 20 27 0.002994909 Mouse Phenotype Single KO decreased spleen iron level 372 1.502462e-7 0.0000036983990682795696 2.886907 33 0.003943123 374 0.03731690510427808 2.108827 12 16 0.001796945 Mouse Phenotype abnormal platelet aggregation 18 1.687599e-49 8.963963355000002e-47 3.353126 212 0.02533158 258 0.0025691559508139537 1.555447 52 94 0.007786763 Mouse Phenotype abnormal platelet activation 19 2.464218e-49 1.240020436736842e-46 3.321724 214 0.02557056 322 0.007731532342546584 1.490238 53 100 0.007936508 Mouse Phenotype abnormal platelet physiology 29 2.292289e-38 7.557439699655172e-36 2.579157 245 0.0292747 232 0.0011825844297413794 1.49109 70 132 0.01048218 Mouse Phenotype decreased pre-B cell number 81 3.58074e-20 4.2265994e-18 2.023501 207 0.02473414 197 0.0003979091641370559 1.595139 59 104 0.008834981 Mouse Phenotype decreased platelet aggregation 86 2.071947e-19 2.3034750310465115e-17 2.615874 116 0.01386068 420 0.021276072812142856 1.523042 39 72 0.005840072 Mouse Phenotype decreased erythroid progenitor cell number 115 7.509257e-17 6.243130971913043e-15 2.091531 157 0.01875971 338 0.009736834710355028 1.553873 42 76 0.006289308 Mouse Phenotype abnormal embryonic erythrocyte morphology 144 1.803687e-15 1.197573014375e-13 2.672572 87 0.01039551 529 0.04324395115689981 1.658223 23 39 0.003444145 Mouse Phenotype abnormal embryonic hematopoiesis 147 3.865381e-15 2.5140753565306127e-13 2.107111 137 0.01636994 348 0.011192145063793105 1.613311 35 61 0.00524109 Mouse Phenotype increased respiratory quotient 256 2.194912e-10 8.197481887500001e-9 2.220733 79 0.009439599 498 0.03662824859638554 1.556516 31 56 0.004642108 Mouse Phenotype abnormal platelet volume 278 5.486026e-10 1.886758798057554e-8 2.066767 89 0.01063448 406 0.019839918063546794 1.557288 36 65 0.005390836 Mouse Phenotype increased mean platelet volume 297 2.179127e-9 7.01502802929293e-8 2.14182 76 0.009081133 487 0.03221650608418891 1.606726 28 49 0.004192872 Mouse Phenotype decreased cellular sensitivity to ultraviolet irradiation 317 5.938183e-9 1.7910084436277603e-7 3.776544 28 0.00334568 373 0.014468105070241285 2.249416 12 15 0.001796945 Mouse Phenotype abnormal granulocyte differentiation 323 7.825145e-9 2.316291372910217e-7 2.043309 79 0.009439599 347 0.011210903470893372 1.711512 28 46 0.004192872 Mouse Phenotype increased keratinocyte apoptosis 333 1.231315e-8 3.535316130630631e-7 3.873828 26 0.003106703 558 0.04929451127419355 2.1629 10 13 0.001497454 Mouse Phenotype decreased inguinal fat pad weight 334 1.274265e-8 3.6476789416167666e-7 2.208477 64 0.00764727 214 0.0006733620186448598 2.044924 24 33 0.00359389 Mouse Phenotype decreased DN1 thymic pro-T cell number 487 0.000001271374 0.00002496017826283367 2.571027 34 0.004062612 525 0.042131338697142855 2.300539 9 11 0.001347709 Mouse Phenotype decreased CD4-positive, alpha-beta memory T cell number 547 0.000006149652 0.00010748962115539306 2.988098 23 0.002748238 558 0.04929451127419355 2.1629 10 13 0.001497454 Mouse Phenotype decreased transitional stage T1 B cell number 625 0.00002633654 0.000402885854304 2.591236 25 0.002987215 395 0.016924073750886077 2.150177 13 17 0.001946691