# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	10	3.868053e-57	5.0899709427e-54	2.880882	309	0.01989313	277	0.000027805997867509026	1.421088	86	113	0.008552108	
GO Biological Process	regulation of DNA-templated transcription in response to stress	15	4.352582e-52	3.818375102533333e-49	2.653966	322	0.02073006	219	0.0000038457189517351595	1.443583	92	119	0.009148767	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	22	2.231427e-45	1.3346976315e-42	9.807527	72	0.004635293	648	0.02105395324382716	1.867243	11	11	0.001093874	
GO Biological Process	liver regeneration	23	2.104517e-44	1.2040582262173915e-41	3.726959	166	0.01068692	420	0.001928132187595238	1.600494	30	35	0.002983294	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	27	1.441424e-39	7.0250734874074075e-37	2.190938	353	0.02272581	252	0.000011862431197619048	1.373327	114	155	0.01133652	
GO Biological Process	endoplasmic reticulum unfolded protein response	33	3.948738e-37	1.5745891921818181e-34	2.492696	254	0.01635228	553	0.0101915122443038	1.293967	79	114	0.007856006	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	43	5.210309e-33	1.594475723976744e-30	2.392678	243	0.01564411	419	0.0018801902678997613	1.370636	69	94	0.006861575	
GO Biological Process	nuclear-transcribed mRNA catabolic process	50	3.603135e-32	9.482730693e-30	2.023402	343	0.02208202	126	9.921491229999998e-10	1.433439	152	198	0.01511535	
GO Biological Process	cellular response to unfolded protein	57	4.022875e-31	9.287195109649123e-29	2.254973	258	0.0166098	638	0.020615638101724138	1.265405	82	121	0.008154336	
GO Biological Process	cellular response to topologically incorrect protein	64	1.435969e-30	2.95248688609375e-28	2.171547	275	0.01770424	767	0.048743029087353326	1.22244	91	139	0.009049324	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	68	4.900152e-30	9.482514730588236e-28	2.578404	191	0.0122964	408	0.0015180951305392156	1.412402	59	78	0.005867144	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	83	1.61721e-27	2.5639598060240966e-25	2.377765	203	0.01306895	458	0.0037286371277292576	1.321942	80	113	0.007955449	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	84	2.714213e-27	4.251943912738095e-25	2.379165	201	0.01294019	199	6.347059159497488e-7	1.471641	93	118	0.00924821	
GO Biological Process	cotranslational protein targeting to membrane	108	1.774624e-24	2.1622478903703704e-22	2.434652	171	0.01100882	152	2.5878662544736842e-8	1.562387	82	98	0.008154336	
GO Biological Process	protein targeting to ER	115	1.043963e-23	1.1945660101739131e-21	2.364897	175	0.01126634	170	1.0898879825294117e-7	1.534467	83	101	0.008253779	
GO Biological Process	regulation of hematopoietic stem cell differentiation	117	1.386433e-23	1.5593223800854703e-21	2.34515	177	0.01139509	647	0.02105749144976816	1.287129	71	103	0.007060461	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	119	2.222217e-23	2.4573238237815124e-21	3.011245	113	0.007274834	456	0.003499713965131579	1.704874	21	23	0.002088305	
GO Biological Process	regulation of cellular amino acid metabolic process	129	1.194875e-22	1.2188651259689921e-20	2.896469	116	0.007467971	569	0.011900627262741652	1.400433	45	60	0.00447494	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	138	8.303287e-22	7.917605335724638e-20	2.386752	157	0.01010751	186	3.097375324623656e-7	1.542505	76	92	0.007557677	
GO Biological Process	negative regulation of response to endoplasmic reticulum stress	161	2.603353e-20	2.1277964054037266e-18	2.573036	126	0.008111762	699	0.028934344293276106	1.447114	31	40	0.003082737	
GO Cellular Component	ribosomal subunit	41	7.418798e-26	3.126751937560976e-24	2.018537	274	0.01763986	41	1.561903375609756e-8	1.413049	140	185	0.01392204	
GO Cellular Component	large ribosomal subunit	45	1.910788e-21	7.33742592e-20	2.210715	181	0.01165261	55	0.000008882491810909091	1.428847	88	115	0.008750994	
GO Cellular Component	mitochondrial ribosome	46	5.302004e-21	1.991709328695652e-19	2.602695	128	0.00824052	52	0.0000030128437661538457	1.515762	69	85	0.006861575	
GO Cellular Component	endopeptidase complex	57	2.509916e-17	7.609008505263158e-16	2.314117	130	0.008369278	116	0.0148359168	1.353075	50	69	0.004972156	
GO Cellular Component	proteasome complex	61	1.306869e-16	3.7020813639344266e-15	2.279803	128	0.00824052	122	0.01935901062295082	1.345514	49	68	0.004872713	
GO Cellular Component	mitochondrial large ribosomal subunit	66	2.67915e-15	7.014501818181819e-14	2.77102	81	0.005214704	102	0.003466757647058823	1.464505	40	51	0.003977725	
GO Cellular Component	PcG protein complex	82	1.583983e-13	3.337954419512195e-12	2.040607	131	0.008433657	124	0.01927400051612903	1.420729	35	46	0.003480509	
GO Cellular Component	mitochondrial small ribosomal subunit	252	0.00001918787	0.00013157396571428573	2.143305	38	0.002446404	127	0.021443405102362204	1.533807	23	28	0.002287192	
GO Cellular Component	prespliceosome	259	0.00002991615	0.00019959500849420849	2.233394	33	0.002124509	137	0.0264574962919708	1.600494	18	21	0.001789976	
GO Molecular Function	structural constituent of ribosome	13	2.061778e-23	6.6960205507692314e-21	2.007028	250	0.01609477	13	9.768646004615385e-7	1.417722	123	162	0.0122315	
GO Molecular Function	unfolded protein binding	18	2.315461e-20	5.431042412222223e-18	2.229215	168	0.01081568	89	0.02156582419775281	1.303547	74	106	0.007358791	
GO Molecular Function	rRNA binding	24	1.018628e-17	1.7919364233333333e-15	2.891036	89	0.005729737	62	0.004120412551290322	1.462674	47	60	0.004673827	
Human Phenotype	Increased serum lactate	14	4.053249e-17	1.9319521840714283e-14	2.043291	170	0.01094444	40	0.000167474116075	1.437777	77	100	0.00765712	
Mouse Phenotype Single KO	increased skin tumor incidence	139	4.118559e-15	2.7132118534532373e-13	2.384927	105	0.006759802	195	0.014660361695897437	1.485307	35	44	0.003480509	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	255	1.407857e-10	5.0555868819607846e-9	2.535713	62	0.003991502	264	0.044665279265151514	1.612619	19	22	0.001889419	
Mouse Phenotype Single KO	heterochrony	480	6.147968e-7	0.000011728529786666666	2.114414	54	0.003476469	202	0.017417851554950493	1.757406	16	17	0.00159109	
Mouse Phenotype Single KO	abnormal inferior vena cava valve morphology	767	0.00006585625	0.0007862394801173403	2.11352	34	0.002188888	245	0.038750106718367344	1.867243	11	11	0.001093874	
Mouse Phenotype	decreased circulating free fatty acid level	16	1.172459e-45	7.006175311875e-43	2.308579	366	0.02356274	419	0.03742456068973747	1.25529	80	119	0.007955449	
Mouse Phenotype	abnormal pancreatic islet cell apoptosis	26	6.251011e-42	2.2986890835e-39	6.121277	94	0.006051632	422	0.0390232441563981	1.659772	16	18	0.00159109	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	259	1.309411e-12	4.83369828996139e-11	2.633608	71	0.004570914	341	0.017973112668914954	1.556036	25	30	0.002486078	
Mouse Phenotype	absent segment of posterior cerebral artery	329	1.407857e-10	4.091343701215806e-9	2.535713	62	0.003991502	397	0.031012271531486148	1.612619	19	22	0.001889419	
Mouse Phenotype	abnormal cerebral artery morphology	502	6.022438e-8	0.0000011470225043426294	2.11532	64	0.00412026	452	0.04929353347566372	1.556036	20	24	0.001988862	
Mouse Phenotype	heterochrony	603	6.147968e-7	0.000009748046774129353	2.114414	54	0.003476469	306	0.012005344638235296	1.757406	16	17	0.00159109	
Mouse Phenotype	abnormal vertebral transverse process morphology	791	0.000014992	0.00018121177243994943	2.037954	44	0.002832679	379	0.026154708332453824	1.867243	11	11	0.001093874	
Mouse Phenotype	abnormal inferior vena cava valve morphology	925	0.00006585625	0.0006807044391891892	2.11352	34	0.002188888	379	0.026154708332453824	1.867243	11	11	0.001093874