# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	24	1.867246e-56	1.0237954214166668e-53	2.185892	513	0.02638075	151	6.380211738013246e-11	1.376687	176	213	0.01561668	
GO Biological Process	nuclear-transcribed mRNA catabolic process	31	1.504703e-51	6.3872215409677415e-49	2.19112	465	0.02391237	169	2.286726637573965e-9	1.363177	162	198	0.01437445	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	44	7.445894e-47	2.2268299805909091e-44	2.465018	331	0.0170215	368	0.00008828541163315216	1.34173	91	113	0.008074534	
GO Biological Process	rRNA processing	47	1.333548e-45	3.733650666382979e-43	2.006067	505	0.02596935	91	2.27992834e-15	1.408255	213	252	0.01889973	
GO Biological Process	endoplasmic reticulum unfolded protein response	50	2.083754e-44	5.4840237772e-42	2.461446	314	0.01614728	393	0.00016832396794402035	1.329961	91	114	0.008074534	
GO Biological Process	regulation of DNA-templated transcription in response to stress	60	5.57831e-42	1.2234163548333334e-39	2.277932	346	0.01779286	311	0.00001641306414598071	1.358085	97	119	0.008606921	
GO Biological Process	cellular response to topologically incorrect protein	61	1.531082e-41	3.302870170163935e-39	2.239184	355	0.01825568	343	0.000045735773352769676	1.3185	110	139	0.009760426	
GO Biological Process	response to topologically incorrect protein	62	1.247237e-40	2.647159948870968e-38	2.038028	431	0.02216394	255	0.000001004990500862745	1.323628	143	180	0.01268855	
GO Biological Process	cellular response to unfolded protein	65	1.428543e-39	2.8920303595384615e-37	2.275958	326	0.01676437	356	0.00006344866898033708	1.335638	97	121	0.008606921	
GO Biological Process	IRE1-mediated unfolded protein response	67	1.053807e-38	2.0697084049253732e-36	3.18069	178	0.009153553	640	0.010852202626874998	1.350119	47	58	0.004170364	
GO Biological Process	response to unfolded protein	69	1.250932e-37	2.3856542301449272e-35	2.038055	398	0.02046693	254	9.29043532480315e-7	1.343297	129	160	0.01144632	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	70	1.54129e-37	2.897405015714286e-35	2.017785	407	0.02092975	704	0.017916982247585225	1.203895	112	155	0.009937888	
GO Biological Process	multi-organism metabolic process	86	1.27495e-34	1.95082175e-32	2.133698	327	0.0168158	181	8.611773051933701e-9	1.405422	124	147	0.01100266	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	87	1.308407e-34	1.9790031854022987e-32	2.401526	254	0.01306181	272	0.0000026389392412867645	1.383714	98	118	0.008695652	
GO Biological Process	protein targeting to ER	97	6.8678e-32	9.316843319587628e-30	2.439538	226	0.01162193	239	4.680428908075314e-7	1.435159	87	101	0.00771961	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	98	6.887746e-32	9.248556083061226e-30	2.523203	212	0.01090198	592	0.0059411729141891885	1.342831	54	67	0.004791482	
GO Biological Process	cotranslational protein targeting to membrane	99	9.784522e-32	1.3005507575555555e-29	2.479262	218	0.01121053	236	3.40037369838983e-7	1.445091	85	98	0.007542147	
GO Biological Process	viral gene expression	103	7.747045e-31	9.897414092718446e-29	2.234922	261	0.01342178	206	4.446295148786408e-8	1.416845	108	127	0.009582964	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	110	2.309571e-29	2.762876799e-27	2.465067	203	0.01043916	251	6.945603301992032e-7	1.448787	80	92	0.007098492	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	124	1.233472e-27	1.3089724232258065e-25	2.22343	235	0.01208475	263	0.0000015531672771863119	1.412222	89	105	0.007897072	
GO Cellular Component	large ribosomal subunit	47	3.992558e-23	1.467902175319149e-21	2.117088	217	0.01115911	60	0.00000128013408	1.390835	96	115	0.00851819	
GO Cellular Component	mitochondrial ribosome	56	1.230938e-18	3.798322971428572e-17	2.306358	142	0.007302273	54	2.86095776e-7	1.470092	75	85	0.006654836	
GO Cellular Component	mitochondrial large ribosomal subunit	79	1.603573e-15	3.507562207594937e-14	2.568665	94	0.004833899	75	0.00004031682048	1.502761	46	51	0.004081633	
GO Cellular Component	endopeptidase complex	84	1.737473e-14	3.574230171428571e-13	2.033308	143	0.007353697	97	0.0008379023901030928	1.376347	57	69	0.005057675	
GO Cellular Component	proteasome complex	87	3.425067e-14	6.802891696551723e-13	2.020229	142	0.007302273	105	0.0010743729737142857	1.372086	56	68	0.004968944	
GO Cellular Component	mitochondrial nucleoid	119	9.07516e-12	1.3178047462184873e-10	2.207017	93	0.004782475	106	0.0010766863154716981	1.467759	37	42	0.003283052	
GO Cellular Component	spliceosomal snRNP complex	122	1.214282e-11	1.719901062295082e-10	2.03596	111	0.005708115	167	0.030364778155688624	1.289888	48	62	0.004259095	
GO Cellular Component	very-low-density lipoprotein particle	148	1.332219e-9	1.5554556972972972e-8	2.543267	55	0.002828345	176	0.03550654145454545	1.499494	18	20	0.001597161	
GO Cellular Component	methylosome	165	7.073134e-9	7.407500334545456e-8	3.643502	29	0.001491309	152	0.024788785263157895	1.666105	12	12	0.001064774	
GO Cellular Component	small-subunit processome	202	4.056698e-7	0.0000034702842297029708	2.012108	63	0.003239741	95	0.0006940994021052631	1.523296	32	35	0.002839397	
GO Cellular Component	platelet dense tubular network	272	0.00001759262	0.00011176487999999999	2.204978	36	0.00185128	178	0.03528179919101124	1.666105	11	11	0.0009760426	
GO Cellular Component	cytosolic proteasome complex	388	0.0008159953	0.0036341233979381446	2.130491	23	0.001182763	152	0.024788785263157895	1.666105	12	12	0.001064774	
GO Molecular Function	unfolded protein binding	10	2.210613e-32	9.333208086e-30	2.437786	230	0.01182763	91	0.002288841774945055	1.304591	83	106	0.007364685	
GO Molecular Function	ribonuclease activity	18	5.197556e-21	1.219115635111111e-18	2.013745	221	0.01136481	135	0.022157484454814816	1.262201	75	99	0.006654836	
GO Molecular Function	rRNA binding	22	2.157302e-18	4.140058656363636e-16	2.698497	104	0.005348144	98	0.0037947719426530612	1.388421	50	60	0.004436557	
GO Molecular Function	snRNA binding	35	2.00406e-14	2.4174689485714288e-12	2.767915	76	0.003908259	96	0.002833084262083334	1.490725	34	38	0.003016859	
GO Molecular Function	SUMO transferase activity	118	1.233767e-8	4.41437650338983e-7	2.357657	56	0.00287977	139	0.025321514860431653	1.578415	18	19	0.001597161	
GO Molecular Function	cAMP response element binding	213	9.995483e-7	0.00001981264282910798	2.130712	51	0.002622647	148	0.03731851474324325	1.666105	13	13	0.001153505	
GO Molecular Function	aminoacyl-tRNA editing activity	228	0.000001335871	0.000024737049833333332	2.656047	32	0.001645583	148	0.03731851474324325	1.666105	13	13	0.001153505	
Human Phenotype	Exercise intolerance	6	2.269903e-21	2.5245104531666668e-18	2.400732	152	0.007816518	61	0.00028580951270491806	1.42809	60	70	0.005323869	
Human Phenotype	Abnormal CSF metabolite level	8	2.537869e-21	2.116899979625e-18	2.483433	142	0.007302273	72	0.0007769666770555555	1.42809	54	63	0.004791482	
Human Phenotype	Progressive external ophthalmoplegia	14	4.186216e-20	1.9953299548571426e-17	4.03874	65	0.00334259	141	0.02228172911276596	1.666105	15	15	0.001330967	
Human Phenotype	Increased serum lactate	15	8.556976e-20	3.806713389866666e-17	2.006562	209	0.01074771	47	0.00008540622202553193	1.382867	83	100	0.007364685	
Human Phenotype	Increased CSF lactate	23	4.756307e-18	1.3799494178695653e-15	2.413973	125	0.006428057	99	0.003384982378181818	1.407571	49	58	0.004347826	
Human Phenotype	Abnormality of mitochondrial metabolism	24	6.798134e-17	1.8901645075833335e-14	2.047061	167	0.008587884	42	0.00003063150087857143	1.472933	61	69	0.0054126	
Human Phenotype	Abnormality of the mitochondrion	26	2.43973e-16	6.261660880769231e-14	2.012159	168	0.008639309	46	0.00006133245691086956	1.454908	62	71	0.005501331	
Human Phenotype	External ophthalmoplegia	55	2.925206e-12	3.549072661454545e-10	2.191976	99	0.005091021	117	0.007757402423931624	1.509907	29	32	0.002573203	
Human Phenotype	Glycosuria	83	2.21043e-10	1.777132456626506e-8	2.163328	84	0.004319654	143	0.02205430233146853	1.493749	26	29	0.00230701	
Human Phenotype	Abnormal mitochondria in muscle tissue	174	5.064135e-7	0.000019421248767241377	2.243782	48	0.002468374	171	0.03971246686549708	1.521226	21	23	0.001863354	
Human Phenotype	Acute encephalopathy	186	8.930598e-7	0.00003203972067419355	2.014061	59	0.003034043	110	0.00488377700290909	1.596684	23	24	0.002040816	
Human Phenotype	Acute necrotizing encephalopathy	216	0.000002491893	0.00007698334254166665	2.196258	44	0.002262676	149	0.0234880687738255	1.582799	19	20	0.001685892	
Mouse Phenotype Single KO	absent hypoglossal nerve	145	1.181148e-12	7.459153266206897e-11	3.131679	54	0.002776921	212	0.020335939028773585	1.666105	15	15	0.001330967	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	165	7.299848e-12	4.051194432484848e-10	2.661552	65	0.00334259	266	0.04550736389097745	1.573543	17	18	0.001508429	
Mouse Phenotype	early cellular replicative senescence	69	1.043699e-22	1.4462037882608695e-20	2.13342	209	0.01074771	149	0.00022089580397315436	1.415048	62	73	0.005501331	
Mouse Phenotype	abnormal cellular replicative senescence	74	3.944427e-22	5.0963062901351345e-20	2.041151	226	0.01162193	164	0.0006475647810365853	1.368586	69	84	0.006122449	
Mouse Phenotype	absent hypoglossal nerve	226	1.181148e-12	4.996883198230088e-11	3.131679	54	0.002776921	297	0.015156319324242426	1.666105	15	15	0.001330967	
Mouse Phenotype	abnormal hypoglossal nerve topology	248	7.299848e-12	2.814268013225806e-10	2.661552	65	0.00334259	386	0.03274357651554404	1.573543	17	18	0.001508429	
Mouse Phenotype	absent segment of posterior cerebral artery	315	3.106342e-10	9.428487575238095e-9	2.319486	71	0.003651136	402	0.037077700701492536	1.514641	20	22	0.001774623	
Mouse Phenotype	increased thyroid tumor incidence	374	3.076106e-9	7.863810017647059e-8	2.021166	86	0.004422503	452	0.050103405172566375	1.466172	22	25	0.001952085	
Mouse Phenotype	heterochrony	510	1.901108e-7	0.000003564018350588235	2.032988	65	0.00334259	437	0.04574008654462243	1.568099	16	17	0.001419698	
Mouse Phenotype	abnormal pharyngeal muscle morphology	522	2.744375e-7	0.000005026622485632184	2.516519	40	0.002056978	441	0.047273724931972794	1.666105	12	12	0.001064774