# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	27	1.680073e-34	8.188178002592593e-32	2.836593	187	0.0195873	558	0.018002766585663084	1.367287	64	113	0.008228336	
GO Biological Process	positive regulation of nuclease activity	34	3.749912e-32	1.4513262355294116e-29	6.958888	64	0.006703677	742	0.04869489723450135	1.931293	12	15	0.001542813	
GO Biological Process	activation of signaling protein activity involved in unfolded protein response	38	5.539566e-31	1.9182933945789476e-28	8.085038	55	0.005760972	578	0.019693037703979236	2.414117	8	8	0.001028542	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	39	1.165524e-30	3.9325975169230774e-28	2.965772	154	0.01613072	217	0.000022692907741935484	1.554855	76	118	0.009771149	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	44	1.137983e-29	3.403345067500001e-27	5.034212	78	0.008170106	579	0.020075620398272886	1.810588	18	24	0.00231422	
GO Biological Process	regulation of DNA-templated transcription in response to stress	48	2.114742e-29	5.797477078750001e-27	2.547895	190	0.01990154	635	0.027952264908661414	1.338922	66	119	0.008485472	
GO Biological Process	mRNA catabolic process	61	5.075278e-27	1.094845626262295e-24	2.143738	247	0.025872	285	0.0003370779428245614	1.360066	120	213	0.01542813	
GO Biological Process	protein targeting to ER	63	1.250969e-26	2.612936677936508e-24	2.946235	134	0.01403582	120	3.3212285211666666e-8	1.744857	73	101	0.009385446	
GO Biological Process	rRNA processing	64	1.460649e-26	3.0032312798437502e-24	2.087551	258	0.0270242	211	0.000018915607236018956	1.379495	144	252	0.01851376	
GO Biological Process	cotranslational protein targeting to membrane	66	3.154425e-26	6.289254329545454e-24	2.988264	129	0.0135121	98	3.799763299387755e-9	1.798271	73	98	0.009385446	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	67	3.197755e-26	6.280486275373135e-24	3.067028	124	0.01298837	118	2.6953367817796607e-8	1.784347	68	92	0.008742607	
GO Biological Process	nuclear-transcribed mRNA catabolic process	70	7.994956e-26	1.502937514342857e-23	2.178725	227	0.0237771	298	0.0004997611569127517	1.365561	112	198	0.01439959	
GO Biological Process	multi-organism metabolic process	72	9.645196e-26	1.7627935300555555e-23	2.418911	182	0.01906358	115	1.9813941119130438e-8	1.625834	99	147	0.01272821	
GO Biological Process	rRNA metabolic process	74	1.2039e-25	2.1408270405405405e-23	2.0457	261	0.02733843	226	0.0000440330359119469	1.360853	146	259	0.01877089	
GO Biological Process	RNA catabolic process	75	1.207706e-25	2.1189604338666666e-23	2.014724	271	0.02838588	315	0.0007509394311746032	1.322255	132	241	0.01697094	
GO Biological Process	viral gene expression	78	4.88514e-25	8.2414817e-23	2.633675	151	0.01581649	126	6.02572019484127e-8	1.653765	87	127	0.01118539	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	81	2.339264e-24	3.8002932069135806e-22	2.171112	215	0.02252016	355	0.0015003254237183098	1.38617	89	155	0.01144253	
GO Biological Process	endoplasmic reticulum unfolded protein response	87	1.756256e-23	2.6563876671264365e-21	2.490856	156	0.01634021	600	0.022867183840000003	1.355294	64	114	0.008228336	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	91	2.179842e-23	3.1521473492307695e-21	2.659488	138	0.0144548	124	4.555435680483871e-8	1.724369	75	105	0.009642582	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	95	8.181918e-23	1.1333248311789473e-20	2.467102	154	0.01613072	526	0.015076984291064638	1.412515	55	94	0.007071227	
GO Cellular Component	catalytic step 2 spliceosome	43	2.622378e-17	1.0538300427906976e-15	2.35406	125	0.01309312	61	0.0006868856655737705	1.508823	60	96	0.007714065	
GO Cellular Component	Bcl-2 family protein complex	54	2.13569e-14	6.834207999999999e-13	6.058645	30	0.003142348	115	0.031394304	2.414117	7	7	0.0008999743	
GO Cellular Component	large ribosomal subunit	66	2.192628e-12	5.7406987636363646e-11	2.126309	107	0.01120771	81	0.004116482133333333	1.406485	67	115	0.00861404	
GO Cellular Component	spliceosomal snRNP complex	81	2.770042e-10	5.909422933333333e-9	2.428415	65	0.006808421	103	0.020833455844660197	1.47962	38	62	0.004885575	
GO Cellular Component	U2 snRNP	106	1.122128e-8	1.829280362264151e-7	3.663427	28	0.002932858	60	0.00056392848	2.159999	17	19	0.002185652	
GO Cellular Component	cytosolic large ribosomal subunit	112	3.678189e-8	5.674920171428572e-7	2.102301	67	0.007017911	75	0.002731163904	1.583027	40	61	0.00514271	
GO Cellular Component	small nuclear ribonucleoprotein complex	116	4.966379e-8	7.398192165517242e-7	2.084821	67	0.007017911	138	0.05029077286956522	1.399488	40	69	0.00514271	
GO Cellular Component	signal recognition particle, endoplasmic reticulum targeting	126	1.918679e-7	0.0000026313312	5.982047	14	0.001466429	115	0.031394304	2.414117	7	7	0.0008999743	
GO Cellular Component	very-low-density lipoprotein particle	130	2.773907e-7	0.000003687162535384616	2.919808	31	0.003247093	90	0.009712335360000001	1.931293	16	20	0.002057084	
GO Cellular Component	chylomicron	195	0.00003269094	0.00028969202215384617	2.920619	20	0.002094899	96	0.0159212358	2.069243	12	14	0.001542813	
GO Cellular Component	pyruvate dehydrogenase complex	366	0.004215039	0.019900512000000002	2.481609	12	0.001256939	115	0.031394304	2.414117	7	7	0.0008999743	
GO Molecular Function	structural constituent of ribosome	15	3.564248e-15	1.0032170037333332e-12	2.011512	154	0.01613072	66	0.006517181551515152	1.356078	91	162	0.01169967	
GO Molecular Function	rRNA binding	24	1.280808e-13	2.2531547400000003e-11	3.1182	59	0.006179952	73	0.011011733646575343	1.569176	39	60	0.005014142	
GO Molecular Function	microtubule plus-end binding	142	0.00001089756	0.0003240105515492957	2.56417	28	0.002932858	84	0.022966433504761904	2.21294	11	12	0.001414245	
GO Molecular Function	MAP kinase phosphatase activity	167	0.00002602192	0.0006578715343712575	2.161769	36	0.003770818	95	0.0393096242968421	2.069243	12	14	0.001542813	
Mouse Phenotype Single KO	absent hypoglossal nerve	88	3.94087e-15	4.100743930681818e-13	4.725055	40	0.004189798	247	0.015540885963967613	2.092235	13	15	0.001671381	
Mouse Phenotype Single KO	abnormal osteoblast differentiation	89	5.237724e-15	5.388970636853933e-13	2.208968	122	0.01277888	339	0.04112541057817109	1.555764	29	45	0.003728465	
Mouse Phenotype Single KO	salivary gland inflammation	152	4.627907e-11	2.7880094999342106e-9	2.931994	51	0.005341992	303	0.028798801265346532	1.682566	23	33	0.002957058	
Mouse Phenotype Single KO	abnormal inferior vena cava valve morphology	452	0.000005186148	0.00010506539211504425	2.730736	27	0.002828114	308	0.030235908581168834	2.194652	10	11	0.001285678	
Mouse Phenotype	absent hypoglossal nerve	110	3.94087e-15	3.425332551818182e-13	4.725055	40	0.004189798	376	0.010659454644414893	2.092235	13	15	0.001671381	
Mouse Phenotype	salivary gland inflammation	151	3.420044e-13	2.1654993830463577e-11	3.009651	60	0.006284697	423	0.01576358460567376	1.651764	26	38	0.003342762	
Mouse Phenotype	thin hypoglossal nerve	203	5.002219e-11	2.355971224581281e-9	3.602756	38	0.003980308	573	0.04581557782198953	1.931293	12	15	0.001542813	
Mouse Phenotype	abnormal blood uric acid level	268	3.080377e-9	1.0989359886940298e-7	2.503082	54	0.005656227	479	0.02605109023590814	1.839327	16	21	0.002057084	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	294	7.31926e-9	2.3802532265306126e-7	2.312821	60	0.006284697	426	0.01606065533028169	1.748154	21	29	0.002699923	
Mouse Phenotype	increased respiratory mucosa goblet cell number	431	5.746837e-7	0.000012748377855452436	2.764876	32	0.003351838	533	0.037478402476547844	2.414117	7	7	0.0008999743	
Mouse Phenotype	abnormal inferior vena cava valve morphology	528	0.000005186148	0.00009391053224999999	2.730736	27	0.002828114	455	0.021370389975824175	2.194652	10	11	0.001285678	
Mouse Phenotype	abnormal mitophagy	954	0.0007748664	0.007765720807547169	2.559891	16	0.001675919	533	0.037478402476547844	2.414117	7	7	0.0008999743