# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	negative regulation of gene expression, epigenetic	17	1.656069e-59	1.2818948218235296e-56	3.16155	280	0.01712015	542	0.006444503712730627	1.309068	79	114	0.007947686	
GO Biological Process	regulation of gene expression, epigenetic	23	2.182168e-55	1.2484847266086956e-52	2.127713	533	0.03258942	213	0.000002537637779201878	1.317754	173	248	0.01740443	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	86	1.021228e-32	1.5625975874418605e-30	2.033664	345	0.02109447	646	0.015413346510681115	1.243106	102	155	0.01026157	
GO Biological Process	endoplasmic reticulum unfolded protein response	104	1.407733e-28	1.781188321826923e-26	2.236926	240	0.01467441	497	0.003327418630382294	1.325638	80	114	0.00804829	
GO Biological Process	cellular response to topologically incorrect protein	110	2.928759e-27	3.5035945164545454e-25	2.062405	275	0.01681443	415	0.0011459304288915664	1.318247	97	139	0.009758551	
GO Biological Process	cellular response to unfolded protein	130	1.230605e-24	1.2456562457692308e-22	2.058629	248	0.01516356	407	0.0010837539010810813	1.342619	86	121	0.008651911	
GO Biological Process	retrograde transport, endosome to Golgi	157	1.267735e-22	1.0625557238853503e-20	2.209879	192	0.01173953	638	0.014359678310971786	1.34931	55	77	0.005533199	
GO Biological Process	erythrocyte homeostasis	172	5.367183e-21	4.1062070405232558e-19	2.023027	218	0.01332926	552	0.007005129285326086	1.373843	56	77	0.005633803	
GO Biological Process	platelet aggregation	180	1.006358e-20	7.357036067777777e-19	2.582119	128	0.007826353	780	0.040828766710256405	1.428294	31	41	0.003118712	
GO Biological Process	viral gene expression	186	2.533619e-20	1.7924673344623654e-18	2.056615	202	0.01235096	197	8.791274071573605e-7	1.45768	98	127	0.009859155	
GO Biological Process	regulation of membrane permeability	193	1.009219e-19	6.88099109896373e-18	2.013864	206	0.01259554	462	0.0021408402734415586	1.399285	60	81	0.006036217	
GO Biological Process	erythrocyte differentiation	197	1.673935e-19	1.118137597208122e-17	2.03187	199	0.01216753	547	0.006774457681718465	1.396243	51	69	0.005130785	
GO Biological Process	positive regulation of mRNA metabolic process	204	3.035615e-19	1.9581204796568625e-17	2.276817	151	0.009232651	556	0.00738166885323741	1.453103	40	52	0.004024145	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	211	1.408306e-18	8.782890357345971e-17	2.057238	183	0.01118924	231	0.000007718032630303029	1.440789	90	118	0.009054326	
GO Biological Process	cotranslational protein targeting to membrane	216	2.56119e-18	1.560310148611111e-16	2.163544	160	0.009782941	445	0.0017316135095505618	1.368586	71	98	0.007142857	
GO Biological Process	viral transcription	217	2.913949e-18	1.7670347876036867e-16	2.032665	185	0.01131153	227	0.0000059586792488986786	1.454389	87	113	0.008752515	
GO Biological Process	platelet formation	228	9.430334e-18	5.442708995877193e-16	3.18607	77	0.00470804	663	0.01705505241357466	1.690188	17	19	0.001710262	
GO Biological Process	regulation of viral transcription	237	3.304871e-17	1.834970358185654e-15	2.185311	146	0.008926934	586	0.009844452246245734	1.394979	48	65	0.004828974	
GO Biological Process	regulation of mitochondrial membrane permeability	238	3.49586e-17	1.932858056302521e-15	2.000943	180	0.01100581	383	0.0008046755986161879	1.449122	56	73	0.005633803	
GO Biological Process	platelet morphogenesis	246	9.100363e-17	4.867954338089431e-15	3.001093	79	0.004830327	601	0.01098726797953411	1.700131	18	20	0.001810865	
GO Cellular Component	ficolin-1-rich granule lumen	64	2.873361e-22	7.758074700000001e-21	2.013773	235	0.01436869	82	0.00011739642146341462	1.371073	90	124	0.009054326	
GO Cellular Component	cytoplasmic stress granule	80	1.824145e-17	3.9401532e-16	2.378987	124	0.007581779	137	0.01421942189781022	1.449724	33	43	0.00331992	
GO Cellular Component	PcG protein complex	82	3.822496e-17	8.055211082926831e-16	2.174754	147	0.008988077	118	0.005017034196610169	1.478375	36	46	0.00362173	
GO Cellular Component	ESC/E(Z) complex	100	1.804954e-14	3.1189605119999997e-13	2.599239	85	0.005197187	145	0.01744537555862069	1.679142	16	18	0.001609658	
GO Cellular Component	platelet dense tubular network membrane	127	1.280037e-10	1.7416566425196849e-9	3.29414	41	0.002506879	165	0.03413192727272727	1.889034	9	9	0.0009054326	
GO Cellular Component	nuclear ubiquitin ligase complex	166	2.156161e-8	2.2444856674698794e-7	2.149037	66	0.004035463	120	0.00514143216	1.511227	32	40	0.003219316	
GO Cellular Component	endoribonuclease complex	178	8.886635e-8	8.627025438202247e-7	2.217394	56	0.003424029	106	0.0027947905811320757	1.628478	25	29	0.002515091	
GO Cellular Component	INO80-type complex	198	5.434308e-7	0.0000047426688	2.631507	35	0.002140018	126	0.008851508571428572	1.642638	20	23	0.002012072	
GO Cellular Component	ribonuclease P complex	253	0.00001197791	0.00008180959873517787	2.603545	27	0.001650871	113	0.0039060935362831865	1.889034	13	13	0.001307847	
GO Cellular Component	CCR4-NOT complex	260	0.00001562024	0.00010381451815384616	2.164319	38	0.002323448	171	0.04217416421052632	1.652905	14	16	0.001408451	
GO Cellular Component	Ino80 complex	264	0.00001782774	0.00011669066181818182	2.720476	24	0.001467441	171	0.04217416421052632	1.652905	14	16	0.001408451	
GO Cellular Component	multimeric ribonuclease P complex	292	0.00005742309	0.00033981883397260276	2.720327	21	0.001284011	150	0.019866827519999998	1.889034	10	10	0.001006036	
GO Molecular Function	ribonucleoprotein complex binding	12	2.540239e-27	8.937407548333333e-25	2.218391	233	0.01424641	96	0.004106062120833333	1.330537	81	115	0.008148893	
GO Molecular Function	rRNA binding	15	4.225068e-21	1.1892158064e-18	3.054242	99	0.006053195	88	0.001976113816818182	1.479743	47	60	0.00472837	
GO Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase activity	47	9.250376e-13	8.309593079148936e-11	2.43844	83	0.005074901	128	0.028343400871875	1.690188	17	19	0.001710262	
GO Molecular Function	mRNA 5'-UTR binding	136	1.676815e-8	5.205524213235295e-7	2.400282	53	0.003240599	133	0.033960402992481195	1.631439	19	22	0.001911469	
GO Molecular Function	ribonuclease P activity	336	0.00003800643	0.00047756889124999995	2.654381	23	0.001406298	130	0.029635023427692305	1.889034	11	11	0.00110664	
Mouse Phenotype Single KO	abnormal mean corpuscular hemoglobin	15	2.808247e-45	1.7143411852666666e-42	2.037216	481	0.02940997	215	0.016741087203255813	1.241365	115	175	0.01156942	
Mouse Phenotype Single KO	abnormal erythropoiesis	30	2.440557e-39	7.449393483e-37	2.051683	409	0.02500764	108	0.0005493531030277778	1.391016	81	110	0.008148893	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	33	9.42846e-38	2.616254794545455e-35	2.43669	270	0.01650871	132	0.0012363073813636365	1.532613	43	53	0.004325956	
Mouse Phenotype Single KO	abnormal platelet physiology	34	1.006382e-37	2.710423521764706e-35	2.149256	351	0.02146133	161	0.00495261065689441	1.339497	78	110	0.007847082	
Mouse Phenotype Single KO	decreased erythroid progenitor cell number	38	1.257964e-34	3.0313621968421055e-32	2.37234	260	0.01589728	121	0.0008233860883471074	1.555675	42	51	0.004225352	
Mouse Phenotype Single KO	abnormal platelet volume	75	1.919992e-24	2.3441822325333335e-22	2.377352	179	0.01094467	175	0.007098700005142857	1.458202	44	57	0.004426559	
Mouse Phenotype Single KO	increased mean platelet volume	84	1.714606e-22	1.869124659761905e-20	2.452333	154	0.009416081	273	0.0378137141025641	1.449724	33	43	0.00331992	
Mouse Phenotype Single KO	absent hypoglossal nerve	127	6.178593e-18	4.454911504015748e-16	3.999367	58	0.003546316	268	0.03506252884701492	1.763099	14	15	0.001408451	
Mouse Phenotype Single KO	abnormal spleen iron level	169	2.501948e-15	1.355641292071006e-13	2.678669	86	0.005258331	247	0.030024820568825907	1.563339	24	29	0.002414487	
Mouse Phenotype Single KO	abnormal cellular hemoglobin content	193	5.520128e-14	2.619057621554404e-12	3.995607	44	0.002690309	256	0.0326395112640625	1.889034	11	11	0.00110664	
Mouse Phenotype	abnormal platelet physiology	22	7.49621e-47	3.2577847186363637e-44	2.213995	411	0.02512993	256	0.002289013202109375	1.3166	92	132	0.009255533	
Mouse Phenotype	abnormal mean corpuscular hemoglobin	23	1.811791e-46	7.53153641347826e-44	2.003287	515	0.03148884	270	0.002935305258555556	1.262778	123	184	0.01237425	
Mouse Phenotype	abnormal erythropoiesis	26	7.246588e-45	2.6647933795384617e-42	2.003006	497	0.03038826	146	0.00004877861758561644	1.369233	108	149	0.01086519	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	31	3.992873e-43	1.2314793146129033e-40	3.159579	201	0.01228982	456	0.03720306709210526	1.453103	30	39	0.003018109	
Mouse Phenotype	decreased erythroid progenitor cell number	59	1.283035e-34	2.079169090677966e-32	2.160961	317	0.01938245	258	0.002313573003488372	1.416776	57	76	0.005734406	
Mouse Phenotype	abnormal embryonic hematopoiesis	66	1.027705e-31	1.4887708340909092e-29	2.195807	279	0.017059	227	0.0011560200888105726	1.486453	48	61	0.004828974	
Mouse Phenotype	decreased mean corpuscular volume	76	4.315597e-27	5.429134594342106e-25	2.024438	286	0.01748701	357	0.01599226958655462	1.300939	73	106	0.007344064	
Mouse Phenotype	microcytic anemia	87	2.017422e-25	2.217077211724138e-23	3.304964	108	0.006603485	376	0.020593949006648935	1.563339	24	29	0.002414487	
Mouse Phenotype	pancytopenia	99	4.138239e-23	3.996535664545454e-21	2.889902	119	0.007276062	308	0.005321866791233767	1.628478	25	29	0.002515091	
Mouse Phenotype	poikilocytosis	103	9.062649e-23	8.412425930970874e-21	3.063901	107	0.006542342	299	0.004646671581270904	1.549977	32	39	0.003219316	
Mouse Phenotype	abnormal erythrocyte physiology	119	2.46507e-21	1.9805490983193276e-19	2.447428	146	0.008926934	382	0.020619029843717277	1.408189	41	55	0.004124748	
Mouse Phenotype	abnormal platelet volume	120	2.799518e-21	2.2305159665e-19	2.186464	184	0.01125038	333	0.012587090954054053	1.394979	48	65	0.004828974	
Mouse Phenotype	abnormal DNA repair	129	2.014957e-20	1.493411153255814e-18	2.002725	217	0.01326811	168	0.0002520243177142857	1.378066	89	122	0.008953722	
Mouse Phenotype	abnormal erythrocyte osmotic lysis	135	5.302503e-20	3.755350458e-18	2.940373	99	0.006053195	428	0.028854092754672895	1.500115	27	34	0.002716298	
Mouse Phenotype	hemolysis	143	2.705742e-19	1.8090628854545458e-17	2.799175	103	0.006297768	462	0.03889845251948052	1.469249	28	36	0.002816901	
Mouse Phenotype	absent hypoglossal nerve	163	6.178593e-18	3.6241428020245403e-16	3.999367	58	0.003546316	403	0.02434574606203474	1.763099	14	15	0.001408451	
Mouse Phenotype	abnormal spleen iron level	221	1.824616e-14	7.893734649773756e-13	2.475214	93	0.005686334	384	0.02091226488203125	1.53484	26	32	0.002615694	
Mouse Phenotype	abnormal cellular hemoglobin content	232	5.520128e-14	2.2749113710344824e-12	3.995607	44	0.002690309	394	0.02214305274822335	1.889034	11	11	0.00110664	
Mouse Phenotype	anisocytosis	241	3.532264e-13	1.4013268092946057e-11	2.089977	120	0.007337206	470	0.04127971921276596	1.406728	35	47	0.003521127	
Mouse Phenotype	increased circulating interleukin-1 beta level	252	9.876828e-13	3.747315575714286e-11	2.256158	97	0.005930908	294	0.004426856821428571	1.574195	30	36	0.003018109