# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	multi-organism metabolic process	25	1.81116e-18	9.533221776e-16	2.139192	165	0.0168591	298	0.0002974360121979866	1.461615	84	147	0.01144258	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	31	2.958485e-18	1.255829165e-15	2.219545	150	0.01532645	356	0.0008995085801685393	1.493951	66	113	0.008990601	
GO Biological Process	viral gene expression	35	2.329276e-17	8.757412252571429e-15	2.279856	134	0.01369163	346	0.000758555879450867	1.470246	73	127	0.009944149	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	36	7.521195e-17	2.7492056945833333e-14	2.329464	124	0.01266987	582	0.013323501065979381	1.387295	64	118	0.008718158	
GO Biological Process	regulation of DNA-templated transcription in response to stress	38	8.153702e-17	2.8235411741578944e-14	2.0799	159	0.01624604	313	0.00041966270792971247	1.504603	70	119	0.009535486	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	43	8.624997e-16	2.639449663325581e-13	2.267976	122	0.01246552	741	0.030418990807017543	1.358138	60	113	0.008173273	
GO Biological Process	protein targeting to ER	51	4.187458e-15	1.0804462710196079e-12	2.337795	109	0.01113722	451	0.004130437953436808	1.468851	58	101	0.007900831	
GO Biological Process	viral transcription	52	4.605824e-15	1.1655391926153845e-12	2.221674	121	0.01236334	317	0.00044080200848580436	1.516587	67	113	0.009126822	
GO Biological Process	translational initiation	54	9.176588e-15	2.236198546148148e-12	2.018968	148	0.0151221	714	0.025576949256302522	1.32363	74	143	0.01008037	
GO Biological Process	cotranslational protein targeting to membrane	56	3.019841e-14	7.096087092678572e-12	2.327469	103	0.01052416	493	0.005837044129817444	1.461615	56	98	0.007628389	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	61	5.032425e-14	1.0856013209016392e-11	2.364501	98	0.01001328	668	0.021002551964071855	1.417925	51	92	0.006947282	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	63	1.167799e-13	2.4392169906349207e-11	2.047175	131	0.0133851	658	0.020411968820668695	1.414968	52	94	0.007083504	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	74	3.382318e-12	6.01458413e-10	2.163937	101	0.01031981	521	0.007388440053550864	1.508461	46	78	0.006266176	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	81	1.180234e-11	1.9173702723456792e-9	2.049098	109	0.01113722	581	0.01284804897969019	1.412894	58	105	0.007900831	
GO Biological Process	negative regulation of ubiquitin-protein transferase activity	83	1.552912e-11	2.4620203624096384e-9	2.151022	96	0.00980893	589	0.013382189151103565	1.461615	48	84	0.006538619	
GO Biological Process	regulation of mitochondrial membrane permeability	86	2.319119e-11	3.548521735e-9	2.024835	109	0.01113722	258	0.00005780723198062015	1.716897	49	73	0.00667484	
GO Biological Process	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	115	3.457319e-10	3.956074845304347e-8	2.174376	81	0.008276285	443	0.0037550736270880354	1.563116	44	72	0.005993734	
GO Biological Process	negative regulation of ubiquitin protein ligase activity	117	3.737055e-10	4.2030689525641024e-8	2.136314	84	0.008582814	553	0.010679782531283906	1.494833	45	77	0.006129955	
GO Biological Process	regulation of ubiquitin protein ligase activity	118	4.242441e-10	4.73104077279661e-8	2.007704	97	0.009911107	564	0.012082255492375888	1.445728	52	92	0.007083504	
GO Biological Process	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	123	5.878255e-10	6.288777036178862e-8	2.160319	80	0.008174109	480	0.005502345381875	1.549106	43	71	0.005857513	
GO Cellular Component	PcG protein complex	22	2.441795e-18	1.9179189818181818e-16	2.645316	107	0.01093287	52	0.000012040474707692309	1.946172	35	46	0.004767743	
GO Cellular Component	histone methyltransferase complex	33	9.73607e-12	5.098160290909091e-10	2.113789	102	0.01042199	81	0.004321418666666667	1.556938	42	69	0.005721291	
GO Cellular Component	methyltransferase complex	34	1.167118e-11	5.9317056e-10	2.012934	114	0.0116481	92	0.006790557286956522	1.461615	52	91	0.007083504	
GO Cellular Component	nuclear ubiquitin ligase complex	35	1.186532e-11	5.858077988571429e-10	2.93829	54	0.005517523	130	0.030563242338461534	1.598641	25	40	0.003405531	
GO Cellular Component	endopeptidase complex	45	1.993937e-9	7.65671808e-8	2.147145	76	0.007765403	107	0.018339877682242992	1.482798	40	69	0.005448849	
GO Cellular Component	proteasome complex	50	4.246612e-9	1.4676291072000002e-7	2.12009	75	0.007663227	123	0.02412606907317073	1.466988	39	68	0.005312628	
GO Cellular Component	anaphase-promoting complex	78	4.087756e-7	0.000009055951753846154	3.138534	27	0.002758762	134	0.03502413564179104	1.827019	15	21	0.002043318	
GO Cellular Component	pre-autophagosomal structure membrane	92	0.000004341003	0.00008153536069565218	2.822641	26	0.002656585	144	0.046858260000000006	1.918369	12	16	0.001634655	
GO Cellular Component	NuRD complex	105	0.00002008179	0.0003304888868571429	2.313742	32	0.003269643	144	0.046858260000000006	1.918369	12	16	0.001634655	
GO Cellular Component	pronucleus	182	0.0009220318	0.008754235991208791	2.246912	20	0.002043527	116	0.022605740689655176	2.046261	12	15	0.001634655	
GO Molecular Function	unfolded protein binding	9	3.66063e-13	1.7172422066666666e-10	2.211249	105	0.01072852	91	0.004113036211428571	1.471956	61	106	0.008309495	
GO Molecular Function	nucleosome binding	12	3.091041e-11	1.0875312585e-8	2.14219	94	0.009604578	132	0.02500319255909091	1.511443	39	66	0.005312628	
GO Molecular Function	DNA polymerase binding	14	7.694379e-11	2.320404867e-8	4.972032	26	0.002656585	128	0.0238059613984375	2.078234	13	16	0.001770876	
GO Molecular Function	signal sequence binding	20	3.037375e-10	6.411898625e-8	2.157278	83	0.008480638	147	0.04048992779591837	1.591536	28	45	0.003814194	
GO Molecular Function	NF-kappaB binding	39	8.378451e-9	9.070210287692309e-7	2.64884	46	0.004700112	120	0.018623822525	1.827019	20	28	0.002724424	
GO Molecular Function	peroxisome proliferator activated receptor binding	42	1.874815e-8	0.0000018846354595238093	3.310104	31	0.003167467	142	0.041014470338028165	2.302043	9	10	0.001225991	
GO Molecular Function	protein phosphatase activator activity	56	2.445638e-7	0.00001843836363571428	3.143792	28	0.002860938	121	0.019000088647933882	2.557826	8	8	0.00108977	
GO Molecular Function	peroxiredoxin activity	180	0.000361447	0.008477940188888889	3.153232	13	0.001328293	121	0.019000088647933882	2.557826	8	8	0.00108977	
Human Phenotype	Abnormal CSF metabolite level	50	0.0000010511	0.000140279806	2.015454	58	0.005926229	188	0.04389439059042553	1.502215	37	63	0.005040185	
Mouse Phenotype Single KO	early cellular replicative senescence	30	1.395184e-7	0.00004258566629333333	2.037184	66	0.00674364	191	0.00530126057172775	1.672425	34	52	0.004631522	
Mouse Phenotype Single KO	increased embryonic epiblast cell apoptosis	249	0.001084284	0.03987465296385542	2.123335	22	0.00224788	222	0.00877533459009009	2.557826	9	9	0.001225991	
Mouse Phenotype	early cellular replicative senescence	2	3.137995e-11	1.50011850975e-7	2.068764	102	0.01042199	128	0.0000071250700816406245	1.786974	51	73	0.006947282	
Mouse Phenotype	polychromatophilia	5	6.381853e-11	1.22033793066e-7	2.442248	69	0.007050169	528	0.03999163490909091	1.655064	22	34	0.002996867	
Mouse Phenotype	decreased embryonic epiblast cell proliferation	119	0.00002647547	0.0021271594005882353	2.590703	25	0.002554409	413	0.01260596320387409	2.557826	8	8	0.00108977