# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	RNA catabolic process	25	5.770082e-27	3.03714036152e-24	2.103667	257	0.02963903	144	2.232891311736111e-9	1.503842	152	241	0.01930159	
GO Biological Process	mRNA catabolic process	31	5.739208e-26	2.4362012281290324e-23	2.17875	228	0.02629455	151	6.78801263384106e-9	1.522422	136	213	0.01726984	
GO Biological Process	rRNA processing	34	7.567839e-26	2.9289762764999997e-23	2.129184	239	0.02756314	165	1.9454712208484847e-8	1.466584	155	252	0.01968254	
GO Biological Process	rRNA metabolic process	35	1.002994e-25	3.770970870285714e-23	2.105664	244	0.02813978	168	3.093156889821429e-8	1.454564	158	259	0.02006349	
GO Biological Process	viral gene expression	36	1.405705e-24	5.138242248611111e-22	2.70771	141	0.0162611	179	8.881251696089385e-8	1.633395	87	127	0.01104762	
GO Biological Process	multi-organism metabolic process	38	1.988416e-23	6.885675301052633e-21	2.414516	165	0.01902895	167	3.0955294637125745e-8	1.605808	99	147	0.01257143	
GO Biological Process	nuclear-transcribed mRNA catabolic process	40	7.135206e-23	2.34730439385e-20	2.15578	204	0.0235267	187	2.1687249383422462e-7	1.493249	124	198	0.01574603	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	48	8.337089e-21	2.2855782114791665e-18	2.629278	124	0.01430054	272	0.00003254264240808824	1.535703	76	118	0.009650794	
GO Biological Process	viral transcription	52	1.862883e-20	4.7141687301923076e-18	2.590511	125	0.01441587	192	3.4354948347395835e-7	1.645856	78	113	0.009904762	
GO Biological Process	macromolecular complex disassembly	57	4.462374e-20	1.030182095894737e-17	2.01978	207	0.02387268	283	0.000050883063106007074	1.410655	113	191	0.01434921	
GO Biological Process	protein targeting to ER	60	6.792076e-20	1.4896154680666666e-17	2.711305	112	0.01291662	194	4.877761840824742e-7	1.676149	71	101	0.009015873	
GO Biological Process	cotranslational protein targeting to membrane	64	1.019219e-19	2.0956098157812502e-17	2.754551	108	0.01245531	234	0.000006034486836324786	1.630138	67	98	0.008507937	
GO Biological Process	response to topologically incorrect protein	69	4.449849e-19	8.486313476956523e-17	2.036082	192	0.02214277	242	0.000008307581205785124	1.457122	110	180	0.01396825	
GO Biological Process	translational initiation	70	5.215289e-19	9.803998278714286e-17	2.278819	148	0.01706839	217	0.0000030714476476497692	1.534007	92	143	0.01168254	
GO Biological Process	protein localization to endoplasmic reticulum	71	5.657861e-19	1.0486168013943662e-16	2.381299	135	0.01556914	182	1.2851245695054947e-7	1.634455	85	124	0.01079365	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	72	5.937743e-19	1.0852050019027778e-16	2.777755	102	0.01176335	223	0.000004383693665470852	1.6587	64	92	0.008126984	
GO Biological Process	nucleosome organization	83	5.363563e-18	8.503509098433735e-16	2.018926	184	0.02122016	484	0.003252986364049587	1.3386	96	171	0.01219048	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	85	6.535351e-18	1.0117492212823528e-15	2.023545	182	0.02098951	377	0.0006252242301856764	1.399862	91	155	0.01155556	
GO Biological Process	cellular response to topologically incorrect protein	87	1.107556e-17	1.675210276321839e-15	2.164283	153	0.01764502	258	0.000014592316022868217	1.509536	88	139	0.0111746	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	93	4.007107e-17	5.6698409691397855e-15	2.440139	115	0.0132626	211	0.0000018647756102843601	1.635004	72	105	0.009142857	
GO Cellular Component	ribosomal subunit	25	8.216192e-28	5.679031910400001e-26	2.48102	188	0.02168147	44	2.338496901818182e-8	1.533737	119	185	0.01511111	
GO Cellular Component	large ribosomal subunit	37	3.053743e-17	1.4261805145945945e-15	2.4724	113	0.01303195	86	0.0002826559925581395	1.472096	71	115	0.009015873	
GO Cellular Component	mitochondrial ribosome	42	7.757502e-16	3.191657965714286e-14	2.877574	79	0.009110829	88	0.0003657490690909091	1.542835	55	85	0.006984127	
GO Cellular Component	chromosome, telomeric region	45	5.749949e-15	2.207980416e-13	2.035913	147	0.01695306	113	0.003418899992920354	1.327829	93	167	0.01180952	
GO Cellular Component	small ribosomal subunit	51	2.496202e-13	8.45771971764706e-12	2.567518	79	0.009110829	72	0.00005109756000000001	1.65582	50	72	0.006349206	
GO Cellular Component	cytosolic ribosome	52	6.389936e-13	2.1234248861538464e-11	2.06003	121	0.01395456	68	0.00003701797835294118	1.532816	72	112	0.009142857	
GO Cellular Component	methyltransferase complex	60	1.792994e-11	5.16382272e-10	2.07271	104	0.011994	64	0.000030624885	1.598321	61	91	0.007746032	
GO Cellular Component	BLOC complex	65	8.113364e-11	2.156906614153846e-9	3.54003	38	0.004382424	154	0.021451201246753246	1.762369	17	23	0.00215873	
GO Cellular Component	mediator complex	67	1.422909e-10	3.6698309731343287e-9	2.449874	66	0.007611579	84	0.0002652936685714286	1.854519	28	36	0.003555556	
GO Cellular Component	mitochondrial large ribosomal subunit	68	1.499928e-10	3.8115817411764705e-9	2.941589	48	0.005535694	134	0.011062550256716418	1.542835	33	51	0.004190476	
GO Cellular Component	Cajal body	83	3.039145e-9	6.327280192771084e-8	2.203321	70	0.008072887	94	0.0007784437787234041	1.64739	38	55	0.004825397	
GO Cellular Component	histone methyltransferase complex	84	3.575472e-9	7.355256685714285e-8	2.011594	86	0.009918118	81	0.00020922888533333336	1.624144	47	69	0.005968254	
GO Cellular Component	vesicle coat	91	1.54721e-8	2.937998769230769e-7	2.063548	74	0.008534194	73	0.0000555868010958904	1.776598	38	51	0.004825397	
GO Cellular Component	cytosolic small ribosomal subunit	92	1.833345e-8	3.443500173913044e-7	2.439117	51	0.005881675	106	0.0019766901735849057	1.679905	31	44	0.003936508	
GO Cellular Component	cytosolic large ribosomal subunit	94	2.752617e-8	5.060129974468085e-7	2.176499	63	0.007265598	185	0.04913615636756757	1.407176	36	61	0.004571429	
GO Cellular Component	intraciliary transport particle B	97	5.374714e-8	9.574748239175258e-7	3.487021	27	0.003113828	146	0.01811151123287671	1.816671	16	21	0.002031746	
GO Cellular Component	mitochondrial small ribosomal subunit	99	6.236579e-8	0.0000010885665163636365	3.132191	31	0.003575136	145	0.018203550455172416	1.703129	20	28	0.002539683	
GO Cellular Component	preribosome	101	6.846496e-8	0.0000011713608998019802	2.029325	70	0.008072887	175	0.03552048164571429	1.380431	44	76	0.005587302	
GO Cellular Component	spindle pole centrosome	115	4.404274e-7	0.000006617900410434783	5.573828	14	0.001614577	179	0.04109522842458101	1.986984	10	12	0.001269841	
GO Cellular Component	spliceosomal snRNP complex	126	0.000001503275	0.000020616342857142857	2.097865	51	0.005881675	127	0.00941555905511811	1.499853	39	62	0.004952381	
GO Molecular Function	unfolded protein binding	7	1.529983e-21	9.22798318e-19	2.781088	117	0.01349325	106	0.01682566575471698	1.394638	62	106	0.007873016	
GO Molecular Function	structural constituent of ribosome	8	5.399749e-19	2.84971753475e-16	2.229109	155	0.01787568	21	0.0000016639095005714288	1.530714	104	162	0.01320635	
GO Molecular Function	rRNA binding	9	1.852382e-16	8.689729782222223e-14	3.5496	61	0.007034944	54	0.00006222065386296296	1.748546	44	60	0.005587302	
GO Molecular Function	ribonucleoprotein complex binding	10	1.982554e-14	8.370342988e-12	2.172946	121	0.01395456	41	0.00003913009325853659	1.555031	75	115	0.00952381	
GO Molecular Function	protein binding involved in protein folding	13	3.919351e-11	1.2728846093846153e-8	3.366938	42	0.004843732	48	0.000047397702475000004	2.11945	24	27	0.003047619	
GO Molecular Function	protein phosphatase activator activity	17	3.779956e-10	9.38763190117647e-8	3.928601	31	0.003575136	123	0.032787705315447155	2.384381	8	8	0.001015873	
GO Molecular Function	ribosomal small subunit binding	32	5.996034e-8	0.000007911017358750001	3.137909	31	0.003575136	126	0.033868548920634914	2.043755	12	14	0.00152381	
GO Molecular Function	small ribosomal subunit rRNA binding	35	8.886965e-8	0.000010720218922857143	6.381015	14	0.001614577	123	0.032787705315447155	2.384381	8	8	0.001015873	
GO Molecular Function	nucleoside-diphosphatase activity	45	0.000001917394	0.00017989416595555555	3.71472	19	0.002191212	126	0.033868548920634914	2.043755	12	14	0.00152381	
GO Molecular Function	ATPase activator activity	59	0.000004311431	0.0003085230793559322	2.325129	37	0.004267097	91	0.003628144614945055	1.969706	19	23	0.002412698	
GO Molecular Function	phosphatase activator activity	63	0.000005098204	0.00034166059187301585	2.443722	33	0.003805789	129	0.037395759519379845	2.167619	10	11	0.001269841	
GO Molecular Function	JUN kinase binding	133	0.0002086028	0.006621962568421053	2.411243	22	0.002537193	123	0.032787705315447155	2.384381	8	8	0.001015873	
Mouse Phenotype Single KO	abnormal embryonic erythropoiesis	12	1.480873e-18	1.1300295050833333e-15	3.177188	81	0.009341483	286	0.027880289084265732	1.726621	21	29	0.002666667	
Mouse Phenotype Single KO	abnormal embryonic erythrocyte morphology	21	2.388747e-17	1.041607441857143e-14	2.928706	85	0.009802791	246	0.014725520594308943	1.703129	25	35	0.003174603	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	26	1.328027e-15	4.677208938076923e-13	2.195875	129	0.01487718	110	0.0009092268334545454	1.709556	38	53	0.004825397	
Mouse Phenotype Single KO	extramedullary hematopoiesis	28	1.454134e-15	4.755537513571428e-13	2.0335	154	0.01776035	175	0.005248666818285714	1.422262	68	114	0.008634921	
Mouse Phenotype Single KO	abnormal circulating interferon level	41	6.319182e-14	1.4113353554634146e-11	2.308685	102	0.01176335	249	0.015029122996787148	1.430629	54	90	0.006857143	
Mouse Phenotype Single KO	abnormal platelet aggregation	43	8.392131e-14	1.7871335713255816e-11	2.096653	125	0.01441587	345	0.04681517577101449	1.406173	46	78	0.00584127	
Mouse Phenotype Single KO	abnormal interferon level	48	4.620547e-13	8.814656016458333e-11	2.115309	115	0.0132626	311	0.0341240168778135	1.35932	61	107	0.007746032	
Mouse Phenotype Single KO	increased circulating interferon-gamma level	61	5.948849e-12	8.930100048032786e-10	2.77336	61	0.007034944	158	0.003469414592025317	1.718972	31	43	0.003936508	
Mouse Phenotype Single KO	abnormal circulating interferon-gamma level	63	1.515317e-11	2.2025012331746027e-9	2.299674	83	0.009572137	172	0.004483049455058139	1.54481	46	71	0.00584127	
Mouse Phenotype Single KO	abnormal platelet volume	104	3.305113e-9	2.910088436634616e-7	2.054167	82	0.00945681	294	0.030735579511904768	1.505925	36	57	0.004571429	
Mouse Phenotype Single KO	increased mean platelet volume	117	8.482342e-9	6.638701341367521e-7	2.132546	71	0.008188214	266	0.022116733418421054	1.608071	29	43	0.00368254	
Mouse Phenotype Single KO	impaired macrophage chemotaxis	148	7.987929e-8	0.000004942261206283784	2.096341	64	0.007380925	334	0.0432833569491018	1.589587	26	39	0.003301587	
Mouse Phenotype Single KO	increased embryonic neuroepithelium apoptosis	151	9.969956e-8	0.000006046019012715232	2.785164	36	0.00415177	178	0.005601547819662921	2.103866	15	17	0.001904762	
Mouse Phenotype Single KO	polyploidy	224	0.000002962491	0.00012110504503125001	2.225774	42	0.004843732	225	0.01255644874977778	1.834139	20	26	0.002539683	
Mouse Phenotype Single KO	abnormal choroid pigmentation	322	0.00005358409	0.0015238183606521738	2.164095	33	0.003805789	295	0.03137473774237288	2.043755	12	14	0.00152381	
Mouse Phenotype Single KO	abnormal Kupffer cell morphology	327	0.00005729804	0.0016045203433639145	2.327701	28	0.003229155	327	0.042851819678899075	1.816671	16	21	0.002031746	
Mouse Phenotype	increased circulating interferon-gamma level	14	6.278748e-19	4.287936402e-16	3.225982	81	0.009341483	196	0.0009210984472959183	1.696579	37	52	0.004698413	
Mouse Phenotype	abnormal circulating interferon-gamma level	15	2.201629e-18	1.4033183246e-15	2.620482	109	0.01257064	224	0.0021106709941071428	1.507367	55	87	0.006984127	
Mouse Phenotype	abnormal circulating interferon level	17	1.51134e-17	8.49995396470588e-15	2.343187	128	0.01476185	391	0.02017065341432225	1.3656	63	110	0.008	
Mouse Phenotype	abnormal embryonic erythropoiesis	19	2.586801e-17	1.3017054926842106e-14	2.92459	85	0.009802791	304	0.008609422604605264	1.769057	23	31	0.002920635	
Mouse Phenotype	abnormal interferon level	26	2.634192e-16	9.686734504615384e-14	2.118296	147	0.01695306	519	0.04202706110982659	1.300571	72	132	0.009142857	
Mouse Phenotype	decreased erythroid progenitor cell number	28	3.280598e-16	1.1202070527857143e-13	2.044402	159	0.01833699	202	0.0010723849525247524	1.568672	50	76	0.006349206	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	36	1.783269e-15	4.7360652525e-13	2.638788	89	0.0102641	354	0.014066559130508475	1.650725	27	39	0.003428571	
Mouse Phenotype	abnormal embryonic hematopoiesis	55	1.044852e-13	1.816332722181818e-11	2.018878	136	0.01568447	169	0.00033563958388757397	1.680793	43	61	0.005460317	
Mouse Phenotype	abnormal DNA repair	63	3.275806e-13	4.971425581904762e-11	2.088931	120	0.01383923	291	0.006818892057731959	1.387632	71	122	0.009015873	
Mouse Phenotype	abnormal platelet dense granule morphology	68	2.708031e-12	3.807571233970588e-10	2.698148	66	0.007611579	488	0.034430845930327865	1.669067	21	30	0.002666667	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	116	2.969933e-9	2.447890466637931e-7	2.742995	46	0.00530504	197	0.0009382791695939086	2.00288	21	25	0.002666667	
Mouse Phenotype	increased spleen white pulp amount	142	2.164662e-8	0.0000014574882663380282	2.356917	54	0.006227655	511	0.04087842035225049	1.612964	23	34	0.002920635	
Mouse Phenotype	polyploidy	192	2.774517e-7	0.0000138162276234375	2.291336	48	0.005535694	262	0.004279321138167939	1.828025	23	30	0.002920635	
Mouse Phenotype	increased neural tube apoptosis	201	4.178905e-7	0.00001987786602238806	2.107556	56	0.006458309	369	0.016646631189430897	1.608071	29	43	0.00368254	
Mouse Phenotype	decreased cardiomyocyte apoptosis	247	0.00000265962	0.00010294990615384617	2.523136	33	0.003805789	337	0.011292990754005935	1.986984	15	18	0.001904762	
Mouse Phenotype	abnormal Kupffer cell morphology	367	0.00005729804	0.0014927154235422344	2.327701	28	0.003229155	467	0.031329267783725905	1.816671	16	21	0.002031746