# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	RNA processing	9	2.31713e-33	3.3879015188888885e-30	2.063624	317	0.1250987	16	6.597411043875e-28	1.972186	269	893	0.09379358	
GO Biological Process	ncRNA metabolic process	12	8.412156e-32	9.224630067e-29	2.560243	198	0.07813733	18	1.2401165879444444e-20	2.087985	177	555	0.06171548	
GO Biological Process	ncRNA processing	14	5.140932e-31	4.832108870571429e-28	2.907224	157	0.06195738	21	3.582370442714286e-20	2.298088	139	396	0.04846583	
GO Biological Process	mitochondrion organization	25	3.1504e-25	1.6582445439999999e-22	2.251575	199	0.07853197	24	6.164980534166667e-18	2.024742	167	540	0.05822873	
GO Biological Process	ribonucleoprotein complex biogenesis	27	1.169434e-24	5.699474817037037e-22	2.396111	172	0.06787687	23	4.583350072043478e-18	2.134288	148	454	0.05160391	
GO Biological Process	ribosome biogenesis	31	3.073323e-23	1.3045760437741937e-20	2.748855	127	0.05011839	30	3.2083159671333334e-14	2.209383	109	323	0.03800558	
GO Biological Process	rRNA processing	36	1.393421e-20	5.093340816388889e-18	2.987472	98	0.03867403	42	2.0694886720714288e-11	2.234318	86	252	0.02998605	
GO Biological Process	rRNA metabolic process	40	1.138116e-19	3.744117111e-17	2.893929	98	0.03867403	47	1.0621449237659574e-10	2.173931	86	259	0.02998605	
GO Biological Process	translation	49	1.146629e-17	3.0792838797959184e-15	2.318553	129	0.05090766	36	1.88103628325e-12	2.04156	116	372	0.0404463	
GO Biological Process	mitochondrial translation	51	5.198804e-17	1.3413933693333335e-14	4.153181	52	0.02052092	66	7.48456006969697e-8	2.631066	43	107	0.01499303	
GO Biological Process	mitochondrial translational elongation	53	1.546234e-16	3.8390364539622636e-14	4.718333	44	0.01736385	87	0.0000011268892665977012	2.695853	35	85	0.01220363	
GO Biological Process	RNA splicing, via transesterification reactions	55	1.044794e-15	2.4997171356363635e-13	2.304233	115	0.04538279	37	4.4130875956756754e-12	2.182357	96	288	0.0334728	
GO Biological Process	mitochondrial translational termination	57	1.300589e-15	3.0025352019298247e-13	4.535897	43	0.01696922	90	0.000002240979162111111	2.633879	35	87	0.01220363	
GO Biological Process	translational elongation	59	1.783741e-15	3.9783470879661014e-13	3.796922	52	0.02052092	86	0.000001083362261616279	2.455152	42	112	0.01464435	
GO Biological Process	mRNA splicing, via spliceosome	60	2.06979e-15	4.539394435e-13	2.290544	114	0.04498816	38	5.905343652631579e-12	2.182357	95	285	0.03312413	
GO Biological Process	peptide biosynthetic process	61	7.690358e-15	1.6589741134754098e-12	2.107129	131	0.05169692	41	1.5685691685121952e-11	1.970802	118	392	0.04114365	
GO Biological Process	translational termination	62	7.777131e-15	1.650633335951613e-12	4.049303	46	0.01815312	79	7.561752722151899e-7	2.618828	38	95	0.01324965	
GO Biological Process	macromolecular complex disassembly	70	2.334147e-12	4.387862910428571e-10	2.504134	75	0.02959747	117	0.0001454537375555556	1.885282	55	191	0.01917713	
GO Biological Process	protein folding	73	5.058217e-12	9.117955822328766e-10	2.3232	84	0.03314917	111	0.00004183375319009008	1.854038	64	226	0.0223152	
GO Biological Process	cellular protein complex disassembly	76	2.983268e-11	5.165371527894737e-9	2.88332	53	0.02091555	102	0.000014813434626470588	2.234318	43	126	0.01499303	
GO Cellular Component	intracellular ribonucleoprotein complex	5	1.512364e-36	5.226729983999999e-34	2.262369	286	0.112865	15	1.44258048e-25	1.962513	244	814	0.08507671	
GO Cellular Component	ribonucleoprotein complex	6	1.874793e-36	5.39940384e-34	2.259489	286	0.112865	14	1.117408608e-25	1.96332	245	817	0.08542538	
GO Cellular Component	Golgi stack	13	2.497229e-20	3.3193936246153845e-18	3.023323	95	0.03749013	49	0.00011291460832653061	2.06207	40	127	0.013947	
GO Cellular Component	organelle inner membrane	14	1.369167e-18	1.6899432685714285e-16	2.079567	172	0.06787687	22	9.412345309090908e-11	1.7522	148	553	0.05160391	
GO Cellular Component	mitochondrial inner membrane	15	2.342875e-17	2.698992e-15	2.114131	154	0.06077348	24	2.73385368e-10	1.778379	135	497	0.04707113	
GO Cellular Component	ribosome	16	6.623118e-17	7.15296744e-15	2.792902	88	0.0347277	26	1.1345443200000001e-9	2.136121	77	236	0.02684798	
GO Cellular Component	organelle subcompartment	17	9.310861e-17	9.46421635764706e-15	2.085487	153	0.06037885	38	0.000003684593482105263	1.750003	85	318	0.02963738	
GO Cellular Component	ribosomal subunit	18	2.736555e-16	2.6270927999999998e-14	3.161062	70	0.02762431	33	8.346925963636364e-9	2.229543	63	185	0.02196653	
GO Cellular Component	preribosome	21	2.305952e-15	1.8974690742857145e-13	4.364844	44	0.01736385	36	1.9164864000000002e-7	2.842807	33	76	0.01150628	
GO Cellular Component	Golgi subcompartment	22	6.291438e-15	4.941638574545455e-13	2.035222	143	0.05643252	39	0.000014666922830769232	1.735633	79	298	0.02754533	
GO Cellular Component	large ribosomal subunit	29	1.49263e-13	8.894016e-12	3.593719	48	0.01894238	37	0.0000026362190529729727	2.334173	41	115	0.01429568	
GO Cellular Component	spliceosomal complex	30	1.971344e-13	1.1354941440000001e-11	2.581033	78	0.03078137	27	1.4629952e-9	2.287955	65	186	0.02266388	
GO Cellular Component	mitochondrial large ribosomal subunit	32	2.968877e-13	1.60319358e-11	5.871667	28	0.01104972	42	0.00001600169965714286	2.952601	23	51	0.008019526	
GO Cellular Component	mitochondrial ribosome	33	3.474013e-13	1.8191195345454546e-11	4.487087	36	0.01420679	41	0.000016158426848780487	2.46478	32	85	0.0111576	
GO Cellular Component	spliceosomal tri-snRNP complex	35	7.844412e-12	3.8728982674285715e-10	6.721188	22	0.008681926	50	0.00017503872768	3.386416	15	29	0.005230126	
GO Cellular Component	catalytic step 2 spliceosome	40	3.991189e-10	1.724193648e-8	3.050958	43	0.01696922	46	0.000033485762504347825	2.318754	34	96	0.01185495	
GO Cellular Component	spliceosomal snRNP complex	41	5.476722e-10	2.308237955121951e-8	4.081952	29	0.01144436	65	0.0018716332209230769	2.323154	22	62	0.007670851	
GO Cellular Component	small nuclear ribonucleoprotein complex	42	5.595593e-10	2.3021868342857143e-8	3.751494	32	0.01262826	59	0.0004484555389830509	2.372127	25	69	0.008716876	
GO Cellular Component	preribosome, large subunit precursor	46	1.714795e-9	6.441664695652174e-8	5.889361	19	0.007498027	72	0.0027924408	3.142594	12	25	0.0041841	
GO Cellular Component	U4/U6 x U5 tri-snRNP complex	47	3.913937e-9	1.4389964119148935e-7	5.947447	18	0.007103394	55	0.00035601984	3.54633	13	24	0.004532775	
GO Molecular Function	structural constituent of ribosome	8	1.253747e-10	6.6166497925e-8	2.706605	55	0.02170481	9	0.00018839685175555556	2.020701	50	162	0.01743375	
GO Molecular Function	rRNA binding	13	3.990238e-9	0.0000012959065258461537	4.579732	23	0.009076559	35	0.04666055484571428	2.182357	20	60	0.006973501	
GO Molecular Function	ribonucleoprotein complex binding	15	8.700592e-9	0.0000024489266282666667	2.703826	44	0.01736385	10	0.0006430236882000001	2.16338	38	115	0.01324965	
GO Molecular Function	ATP-dependent helicase activity	19	8.637311e-7	0.00019193014232631579	2.361917	41	0.01617995	13	0.00334960814	2.159859	32	97	0.0111576	
GO Molecular Function	RNA methyltransferase activity	22	0.000004988729	0.0009573824471818183	2.86259	25	0.009865825	23	0.01338379139826087	2.370491	21	58	0.007322176	
GO Molecular Function	RNA-dependent ATPase activity	29	0.00002312385	0.0033665136103448274	2.405998	29	0.01144436	19	0.008243128350526315	2.310731	24	68	0.008368201	
GO Molecular Function	ATP-dependent RNA helicase activity	31	0.00004086397	0.00556540907548387	2.370049	28	0.01104972	26	0.014234080029230768	2.247502	23	67	0.008019526	
GO Molecular Function	translation factor activity, RNA binding	32	0.00004148986	0.00547406840375	2.188789	33	0.01302289	11	0.0020994988881818184	2.283862	30	86	0.01046025	
GO Molecular Function	RNA helicase activity	33	0.00004849178	0.006204008944242424	2.346092	28	0.01104972	28	0.017113967471428574	2.214451	23	68	0.008019526	
GO Molecular Function	exonuclease activity	37	0.00008722389	0.00995295306972973	2.304575	27	0.01065509	17	0.008286387772941176	2.239787	26	76	0.009065551	
Human Phenotype	Increased serum lactate	1	1.330613e-9	0.000008879180549	3.020743	41	0.01617995	10	0.0017251086310999999	2.226004	34	100	0.01185495	
Mouse Phenotype	abnormal fibroblast physiology	23	1.270659e-13	5.2820742169565214e-11	2.05771	126	0.04972376	17	0.022960870854705884	1.630298	63	253	0.02196653	
Mouse Phenotype	increased retina tumor incidence	59	0.00002455923	0.003979844034406779	8.51007	7	0.002762431	18	0.044026253774999996	6.547071	5	5	0.001743375