# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	5	2.600748e-36	6.844648586400001e-33	2.295806	283	0.07006685	18	7.174726164388888e-21	1.824724	231	555	0.05393416	
GO Biological Process	ncRNA processing	11	1.782752e-32	2.1326575970909095e-29	2.497757	215	0.053231	20	3.6697240203999995e-19	1.948478	176	396	0.04109269	
GO Biological Process	ribonucleoprotein complex biogenesis	22	2.855499e-23	1.7079777882272727e-20	2.036419	233	0.05768755	27	3.7167049645185185e-16	1.805776	187	454	0.04366099	
GO Biological Process	ribosome biogenesis	25	3.270164e-20	1.7212835230400002e-17	2.227023	164	0.04060411	43	1.801305825744186e-12	1.845927	136	323	0.03175344	
GO Biological Process	rRNA metabolic process	29	1.033653e-17	4.690289595517241e-15	2.352872	127	0.03144343	66	2.1414278712121214e-8	1.777328	105	259	0.02451553	
GO Biological Process	rRNA processing	31	1.405046e-17	5.964193649677419e-15	2.37155	124	0.03070067	65	1.8671819313230767e-8	1.791904	103	252	0.02404856	
GO Biological Process	nucleic acid phosphodiester bond hydrolysis	38	1.622371e-14	5.618099997105263e-12	2.044301	139	0.03441446	87	0.0000028373980310344826	1.646007	104	277	0.02428205	
GO Biological Process	RNA phosphodiester bond hydrolysis	39	1.792507e-14	6.048102464871796e-12	2.698192	79	0.0195593	139	0.0003062938067913669	1.780001	54	133	0.01260799	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	46	1.079553e-13	3.088225636304348e-11	2.927978	65	0.01609309	231	0.004744421054285714	1.707074	44	113	0.01027317	
GO Biological Process	RNA phosphodiester bond hydrolysis, endonucleolytic	50	4.544492e-13	1.19601940456e-10	3.384173	50	0.0123793	210	0.0034676997836190476	1.94152	31	70	0.007237917	
GO Biological Process	regulation of gene expression, epigenetic	54	1.496398e-12	3.646500237407407e-10	2.0044	124	0.03070067	132	0.0001837487868712121	1.573318	89	248	0.02077983	
GO Biological Process	positive regulation of chromosome organization	58	2.137746e-12	4.850103381724137e-10	2.659174	68	0.01683585	60	1.9914019128333335e-9	2.655145	43	71	0.01003969	
GO Biological Process	translational elongation	62	3.980189e-12	8.447630169516128e-10	2.794415	61	0.01510275	218	0.003928560898486239	1.722316	44	112	0.01027317	
GO Biological Process	regulation of hematopoietic stem cell differentiation	63	4.599367e-12	9.606836563968255e-10	2.904382	57	0.0141124	293	0.01803674039453925	1.65999	39	103	0.009105767	
GO Biological Process	multi-organism metabolic process	64	7.06382e-12	1.4523876153125e-9	2.41898	77	0.01906412	162	0.0007639638589320987	1.699948	57	147	0.01330843	
GO Biological Process	mRNA catabolic process	69	1.370847e-11	2.6143443004347827e-9	2.092512	102	0.02525378	169	0.000992534315739645	1.564271	76	213	0.01774457	
GO Biological Process	tRNA metabolic process	74	1.739627e-11	3.0934799585135136e-9	2.16869	93	0.0230255	80	6.780214227e-7	1.832498	79	189	0.01844502	
GO Biological Process	regulation of telomere capping	75	1.790341e-11	3.1412129625333334e-9	3.653064	39	0.009655855	144	0.00039055838894444447	2.866512	17	26	0.00396918	
GO Biological Process	positive regulation of telomere maintenance	76	1.949866e-11	3.376090354473684e-9	2.890806	54	0.01336965	85	0.0000026664143624705884	2.630446	30	50	0.007004436	
GO Biological Process	macromolecular complex disassembly	77	2.043088e-11	3.4915577911688316e-9	2.094735	100	0.0247586	112	0.00005819875576607144	1.698543	74	191	0.01727761	
GO Cellular Component	ribosomal subunit	32	2.994498e-13	1.61702892e-11	2.436499	86	0.0212924	52	0.00038828292923076926	1.611444	68	185	0.01587672	
GO Cellular Component	mitochondrial ribosome	35	4.976114e-13	2.4567785691428574e-11	3.597101	46	0.01138896	80	0.00610677792	1.753631	34	85	0.007938361	
GO Cellular Component	ribosome	37	3.364287e-12	1.5712129556756757e-10	2.110628	106	0.02624412	48	0.000184402152	1.560434	84	236	0.01961242	
GO Cellular Component	endoribonuclease complex	39	6.081141e-12	2.6944132430769233e-10	4.810085	30	0.007427581	71	0.0038700044619718304	2.418801	16	29	0.003735699	
GO Cellular Component	spliceosomal complex	43	7.007398e-11	2.8159962195348837e-9	2.055261	99	0.02451102	30	2.489491584e-7	1.838484	78	186	0.01821153	
GO Cellular Component	vesicle coat	50	2.495729e-9	8.625239424e-8	2.753823	46	0.01138896	82	0.007479028448780488	1.977133	23	51	0.005370068	
GO Cellular Component	peptidase complex	52	3.761062e-9	1.2498298338461537e-7	2.560581	51	0.01262689	59	0.0013032286047457626	1.843305	37	88	0.008638805	
GO Cellular Component	catalytic step 2 spliceosome	53	4.317886e-9	1.4077937750943397e-7	2.448292	55	0.01361723	36	0.0000083953776	2.055036	45	96	0.01050665	
GO Cellular Component	Holliday junction resolvase complex	56	7.010951e-9	2.1633791657142857e-7	29.36629	7	0.001733102	91	0.011703846540659342	4.384077	5	5	0.001167406	
GO Cellular Component	large ribosomal subunit	60	1.20561e-8	3.4721567999999995e-7	2.442525	52	0.01287447	103	0.019894581436893204	1.563019	41	115	0.009572729	
GO Cellular Component	proteasome accessory complex	61	1.320819e-8	3.7415987409836067e-7	4.67831	21	0.005199307	75	0.00428057856	2.557378	14	24	0.003268737	
GO Cellular Component	preribosome	62	4.879364e-8	0.0000013599259664516128	2.613955	42	0.01039861	41	0.000027883716058536583	2.134353	37	76	0.008638805	
GO Cellular Component	membrane coat	64	6.735494e-8	0.0000018185833800000001	2.116364	63	0.01559792	84	0.007689552685714286	1.689696	37	96	0.008638805	
GO Cellular Component	endopeptidase complex	66	8.461946e-8	0.000002215491316363636	2.669857	39	0.009655855	94	0.013210668459574467	1.779046	28	69	0.006537474	
GO Cellular Component	spliceosomal snRNP complex	69	1.184627e-7	0.000002966718052173913	2.914182	33	0.008170339	89	0.011800970211235955	1.838484	26	62	0.006070511	
GO Cellular Component	proteasome complex	72	2.273543e-7	0.000005456503199999999	2.602869	38	0.009408269	104	0.021787139076923076	1.740736	27	68	0.006303993	
GO Cellular Component	proteasome regulatory particle	73	2.520032e-7	0.000005965226432876712	4.267414	19	0.004704135	67	0.003542735283582089	2.713952	13	21	0.003035256	
GO Cellular Component	small nuclear ribonucleoprotein complex	77	8.477766e-7	0.000019025428114285713	2.574276	35	0.008665511	94	0.013210668459574467	1.779046	28	69	0.006537474	
GO Cellular Component	intrinsic component of mitochondrial membrane	86	0.000002819237	0.00005664699460465116	2.367361	37	0.009160683	87	0.01144246444137931	1.821078	27	65	0.006303993	
GO Cellular Component	integral component of mitochondrial membrane	94	0.000005893495	0.00010833999319148936	2.319439	36	0.008913097	100	0.018581356799999997	1.781031	26	64	0.006070511	
GO Molecular Function	nuclease activity	15	2.231243e-14	6.2802052973333325e-12	2.18426	118	0.02921515	9	0.0000054144429155555555	1.757767	85	212	0.0198459	
GO Molecular Function	ribonuclease activity	16	9.838278e-13	2.59607560725e-10	2.807686	64	0.01584551	44	0.006332628655909092	1.771344	40	99	0.009339248	
GO Molecular Function	endoribonuclease activity	21	1.423687e-11	2.862288816190476e-9	3.41406	43	0.0106462	56	0.01829792182142857	1.957177	25	56	0.00583703	
GO Molecular Function	endonuclease activity	25	1.255913e-10	2.1209858744000002e-8	2.255924	78	0.01931171	34	0.0015657920300000002	1.721156	53	135	0.0123745	
GO Molecular Function	O-methyltransferase activity	27	1.427426e-10	2.2320713229629626e-8	5.016348	25	0.006189651	50	0.011598931719999999	2.713952	13	21	0.003035256	
GO Molecular Function	endoribonuclease activity, producing 5'-phosphomonoesters	29	3.243489e-10	4.722072606206896e-8	3.844248	32	0.007922753	53	0.0126668444	2.418801	16	29	0.003735699	
GO Molecular Function	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	31	5.802497e-10	7.90262655935484e-8	3.574785	34	0.008417925	65	0.04841411568615385	2.076668	18	38	0.004202662	
GO Molecular Function	RNA methyltransferase activity	35	8.51741e-9	0.0000010274430005714284	2.873505	40	0.009903441	12	0.00013576498928333334	2.343213	31	58	0.007237917	
GO Molecular Function	rRNA methyltransferase activity	44	3.258662e-7	0.0000312683431	4.407587	18	0.004456549	45	0.006208011912	2.84965	13	20	0.003035256	
GO Molecular Function	exonuclease activity	47	3.927441e-7	0.00003528011894042553	2.356202	44	0.01089379	32	0.0008595220165625	2.018983	35	76	0.008171842	
GO Molecular Function	cAMP-dependent protein kinase regulator activity	48	4.521176e-7	0.000039767510566666664	6.673755	12	0.002971032	67	0.04985759169850746	3.75778	6	7	0.001400887	
GO Molecular Function	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	50	7.388677e-7	0.000062389988588	2.780703	31	0.007675167	63	0.04811801337142857	1.928994	22	50	0.005136587	
GO Molecular Function	deoxyribonuclease activity	52	9.088386e-7	0.00007379070325384616	2.390533	40	0.009903441	58	0.019953812579310344	1.826699	30	72	0.007004436	
GO Molecular Function	endodeoxyribonuclease activity	63	0.000004998281	0.00033496416479365077	2.370503	35	0.008665511	47	0.007311840157872341	2.067961	25	53	0.00583703	
GO Molecular Function	RNA polymerase III regulatory region DNA binding	71	0.00001113692	0.0006622545949295774	6.744672	9	0.002228274	67	0.04985759169850746	3.75778	6	7	0.001400887	
Human Phenotype	Increased serum lactate	25	3.48586e-14	9.304457512e-12	3.004527	65	0.01609309	1	0.0017112067701999998	2.016675	46	100	0.01074014	
Mouse Phenotype Single KO	abnormal DNA repair	40	7.77157e-8	0.0000177910666225	2.367775	49	0.01213172	33	0.02070944345151515	1.791343	38	93	0.008872286	
Mouse Phenotype	abnormal DNA repair	43	1.966857e-8	0.000004373283669069768	2.242278	60	0.01485516	41	0.015458206144390243	1.688948	47	122	0.01097362