# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of gene expression, epigenetic	21	6.646133e-85	4.164593530809524e-82	2.09615	858	0.03210597	380	0.00012611602914473685	1.201218	195	248	0.01586527	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	53	4.416264e-57	1.0964833580377358e-54	2.373531	438	0.01638976	343	0.00003298031729825073	1.311391	97	113	0.007891953	
GO Biological Process	regulation of DNA-templated transcription in response to stress	56	1.078982e-55	2.5354150246428575e-53	2.261181	472	0.01766203	304	0.000006857786878289473	1.322298	103	119	0.008380116	
GO Biological Process	endoplasmic reticulum unfolded protein response	60	1.213082e-54	2.6604910063333336e-52	2.378623	417	0.01560395	308	0.000008220640920129871	1.32669	99	114	0.008054674	
GO Biological Process	cellular response to topologically incorrect protein	70	3.804171e-50	7.151298026999999e-48	2.157189	470	0.01758719	336	0.000024289677222916665	1.285908	117	139	0.00951916	
GO Biological Process	mitochondrial membrane organization	75	8.365256e-47	1.4677120493866665e-44	2.039506	500	0.01870977	300	0.000005683367713666666	1.31826	107	124	0.008705557	
GO Biological Process	cellular response to unfolded protein	77	2.960327e-46	5.059083505584416e-44	2.169219	427	0.01597815	318	0.00001245089683018868	1.313067	104	121	0.008461476	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	103	1.948678e-39	2.489578039029126e-37	3.573832	155	0.00580003	683	0.0100196826090776	1.464049	23	24	0.001871288	
GO Biological Process	IRE1-mediated unfolded protein response	116	6.240703e-37	7.079431963534483e-35	2.756551	212	0.007932944	889	0.04248483063667041	1.264306	48	58	0.003905297	
GO Biological Process	mitochondrial transmembrane transport	128	2.077603e-34	2.1358732716406249e-32	2.277374	282	0.01055231	712	0.013156153811797753	1.251612	68	83	0.005532503	
GO Biological Process	viral gene expression	140	2.401871e-32	2.2575871777857144e-30	2.062428	331	0.01238587	180	6.492978843944445e-10	1.395382	116	127	0.0094378	
GO Biological Process	cotranslational protein targeting to membrane	142	9.247604e-32	8.569663453239436e-30	2.234388	270	0.01010328	298	0.000004916118500335571	1.356226	87	98	0.00707835	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	167	2.529984e-27	1.9935364943712576e-25	2.015812	293	0.01096393	290	0.0000027209581238620687	1.333504	103	118	0.008380116	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	172	1.016231e-26	7.774757981976744e-25	2.079301	265	0.00991618	647	0.007391672666460587	1.273086	65	78	0.005288422	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	198	8.184799e-24	5.43958434550505e-22	2.076488	235	0.008793594	338	0.000027288024639349114	1.345043	81	92	0.006590188	
GO Biological Process	protein targeting to ER	203	1.229596e-23	7.970568356650246e-22	2.002941	255	0.009541985	306	0.000007689422947058824	1.346194	89	101	0.007241071	
GO Biological Process	tRNA transport	215	7.274044e-23	4.4520532556279066e-21	2.540088	147	0.005500674	408	0.00022409044869362745	1.484055	34	35	0.002766252	
GO Biological Process	protein transmembrane transport	223	2.429274e-22	1.4334895321076232e-20	2.093875	215	0.008045203	847	0.033705061770956314	1.260961	52	63	0.004230738	
GO Biological Process	intracellular protein transmembrane transport	229	9.572689e-22	5.500742993493449e-20	2.146394	197	0.007371651	828	0.028000492576086958	1.282179	47	56	0.003823936	
GO Biological Process	positive regulation of intrinsic apoptotic signaling pathway	232	1.198492e-21	6.797825960344828e-20	2.118955	202	0.007558749	375	0.00011285997066933332	1.41454	50	54	0.004068017	
GO Cellular Component	methyltransferase complex	42	7.590196e-36	3.122823497142857e-34	2.153362	333	0.01246071	67	0.000006059693659701492	1.359824	81	91	0.006590188	
GO Cellular Component	histone methyltransferase complex	52	7.034828e-31	2.3377274584615387e-29	2.1554	284	0.01062715	110	0.0007521226821818181	1.328438	60	69	0.004881621	
GO Cellular Component	preribosome	69	7.402029e-24	1.8537255234782607e-22	2.116429	225	0.008419398	88	0.00011643664581818183	1.346791	67	76	0.005451143	
GO Cellular Component	intrinsic component of mitochondrial membrane	83	4.926424e-21	1.0256458640963855e-19	2.050081	212	0.007932944	185	0.03125952934054054	1.245666	53	65	0.004312098	
GO Cellular Component	spliceosomal snRNP complex	88	3.401784e-20	6.679866763636364e-19	2.228905	167	0.006249065	118	0.0015366737898305086	1.33058	54	62	0.004393459	
GO Cellular Component	integral component of mitochondrial membrane	89	4.179693e-20	8.115179217977528e-19	2.025425	208	0.007783266	193	0.03777951469430052	1.241259	52	64	0.004230738	
GO Cellular Component	small nuclear ribonucleoprotein complex	91	1.150971e-19	2.1855800967032967e-18	2.08986	188	0.007034875	110	0.0007521226821818181	1.328438	60	69	0.004881621	
GO Cellular Component	mitochondrial ribosome	93	1.219192e-19	2.2653373935483873e-18	2.127353	180	0.006735519	176	0.023955892363636364	1.222163	68	85	0.005532503	
GO Cellular Component	BLOC-1 complex	99	5.068125e-19	8.846181818181819e-18	3.365524	77	0.002881305	200	0.04401703296	1.442831	17	18	0.001383126	
GO Cellular Component	BLOC complex	104	1.123489e-17	1.8667201846153846e-16	2.811085	93	0.003480018	198	0.04249959272727273	1.394859	21	23	0.001708567	
GO Cellular Component	MLL1 complex	113	2.920611e-16	4.466208679646018e-15	2.555849	100	0.003741955	182	0.028943420835164834	1.369665	26	29	0.002115369	
GO Cellular Component	endoribonuclease complex	143	1.349906e-12	1.6312150825174822e-11	2.277885	94	0.003517438	149	0.006852241353020134	1.422344	27	29	0.002196729	
GO Cellular Component	preribosome, large subunit precursor	181	2.003596e-9	1.912825352486188e-8	2.174961	74	0.002769047	136	0.0044896756235294115	1.466595	24	25	0.001952648	
GO Cellular Component	spliceosomal tri-snRNP complex	193	7.829698e-9	7.010216654922279e-8	2.114713	73	0.002731627	149	0.006852241353020134	1.422344	27	29	0.002196729	
GO Molecular Function	unfolded protein binding	11	5.285507e-33	2.028673686727273e-30	2.213494	287	0.01073941	162	0.03560626306172839	1.210633	84	106	0.006834269	
GO Molecular Function	rRNA binding	12	5.694884e-33	2.0036500206666668e-30	3.039788	161	0.006024547	168	0.043687798404761904	1.273086	50	60	0.004068017	
GO Molecular Function	ribonucleoprotein complex binding	14	1.144002e-31	3.449983174285714e-29	2.010251	345	0.01290974	105	0.003448652641142857	1.248731	94	115	0.007647872	
GO Molecular Function	RNA polymerase II core binding	40	7.759311e-15	8.189952760499999e-13	2.106178	135	0.005051639	111	0.00418183774954955	1.473142	27	28	0.002196729	
GO Molecular Function	RNA polymerase core enzyme binding	41	1.312471e-14	1.351525015121951e-12	2.019712	147	0.005500674	130	0.013353689103076924	1.396757	32	35	0.002603531	
GO Molecular Function	ubiquitin-specific protease binding	332	0.000008626146	0.00010969755545783132	2.107314	43	0.001609041	152	0.03144742811842105	1.527703	16	16	0.001301766	
Human Phenotype	Exercise intolerance	15	8.356839e-19	3.7176791098e-16	2.080211	181	0.006772938	169	0.0397247243668639	1.265811	58	70	0.0047189	
Mouse Phenotype Single KO	extramedullary hematopoiesis	25	6.17827e-45	2.2629767356e-42	2.043665	477	0.01784912	280	0.03820297129642857	1.206081	90	114	0.007322431	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	28	9.819248e-42	3.2112447834285716e-39	2.154023	390	0.01459362	292	0.042148698852739724	1.297106	45	53	0.003661216	
Mouse Phenotype Single KO	decreased erythroid progenitor cell number	34	4.876196e-40	1.3132743168235293e-37	2.133123	382	0.01429427	126	0.000667370953626984	1.407883	47	51	0.003823936	
Mouse Phenotype Single KO	decreased mean corpuscular hemoglobin	46	1.078715e-33	2.147346359782609e-31	2.153476	312	0.0116749	194	0.007525378363402061	1.306297	59	69	0.00480026	
Mouse Phenotype Single KO	abnormal erythrocyte physiology	172	3.683187e-16	1.9608687999418607e-14	2.017911	165	0.006174225	210	0.01438380687904762	1.357958	40	45	0.003254414	
Mouse Phenotype Single KO	polyploidy	272	1.733045e-12	5.834372450367646e-11	2.046192	119	0.004452926	202	0.010868193975742573	1.468945	25	26	0.002034009	
Mouse Phenotype Single KO	increased mammary adenocarcinoma incidence	356	1.050224e-10	2.70137673258427e-9	2.512923	64	0.002394851	276	0.03720017978985507	1.458262	21	22	0.001708567	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	25	9.083762e-52	3.4739939392800005e-49	2.809086	292	0.01092651	346	0.014444092845953757	1.371016	35	39	0.002847612	
Mouse Phenotype	abnormal embryonic erythropoiesis	30	4.163889e-50	1.3270314242999999e-47	2.936092	263	0.009841341	427	0.035396859590163934	1.379861	28	31	0.00227809	
Mouse Phenotype	decreased erythroid progenitor cell number	42	2.844167e-44	6.474543020714285e-42	2.019213	484	0.01811106	182	0.0003115017927692308	1.346791	67	76	0.005451143	
Mouse Phenotype	microcytic anemia	71	4.497688e-33	6.056675347605633e-31	3.03394	162	0.006061967	355	0.01591292980056338	1.422344	27	29	0.002196729	
Mouse Phenotype	pancytopenia	120	6.270387e-24	4.99593084225e-22	2.452275	165	0.006174225	251	0.0028310338122310755	1.475024	28	29	0.00227809	
Mouse Phenotype	abnormal erythrocyte osmotic lysis	164	1.613218e-19	9.404864206097562e-18	2.435685	134	0.005014219	494	0.04942419599392713	1.347973	30	34	0.00244081	
Mouse Phenotype	increased liver iron level	172	6.181912e-19	3.4363523623255813e-17	2.303888	145	0.005425834	454	0.03938934040969163	1.353109	31	35	0.002522171	
Mouse Phenotype	increased body temperature	196	1.994479e-17	9.729190672959183e-16	2.028846	177	0.00662326	454	0.03938934040969163	1.353109	31	35	0.002522171	
Mouse Phenotype	absent hypoglossal nerve	200	3.594163e-17	1.71818962215e-15	3.164999	75	0.002806466	441	0.03751435044217687	1.527703	15	15	0.001220405	
Mouse Phenotype	abnormal DNA replication	356	8.718243e-12	2.341435992219101e-10	2.071508	108	0.004041311	404	0.02853930100990099	1.41454	25	27	0.002034009