# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process cellular response to stress 1 0 0 2.189864 3112 0.2766468 28 0.0000015910716087142858 1.377929 284 1590 0.1166804 GO Biological Process DNA repair 1 0 0 3.539664 1327 0.117966 52 0.0005557756792115385 1.567728 101 497 0.04149548 GO Biological Process negative regulation of transcription, DNA-templated 1 0 0 2.411612 3385 0.3009156 85 0.0037474525304705885 1.314813 196 1150 0.08052588 GO Biological Process negative regulation of RNA metabolic process 1 0 0 2.276701 3408 0.3029603 86 0.0037596135166279073 1.29902 212 1259 0.08709942 GO Biological Process negative regulation of nucleic acid-templated transcription 1 0 0 2.370542 3392 0.3015379 91 0.004162907491758242 1.305127 202 1194 0.08299096 GO Biological Process negative regulation of transcription from RNA polymerase II promoter 1 0 0 2.820693 3122 0.2775358 97 0.005003574090206186 1.376198 142 796 0.05834018 GO Biological Process negative regulation of cellular macromolecule biosynthetic process 1 0 0 2.161089 3418 0.3038492 99 0.005314316646868687 1.279082 224 1351 0.09202958 GO Biological Process negative regulation of RNA biosynthetic process 1 0 0 2.35325 3393 0.3016268 104 0.005822609503461538 1.294244 203 1210 0.08340181 GO Biological Process regulation of establishment or maintenance of cell polarity 1 0 0 13.35938 513 0.04560405 112 0.006015170410446428 3.689525 11 23 0.00451931 GO Biological Process regulation of morphogenesis of an epithelium 1 0 0 5.811094 1483 0.1318339 119 0.0077831161328571425 1.820266 42 178 0.01725555 GO Biological Process negative regulation of macromolecule biosynthetic process 1 0 0 2.083617 3434 0.3052716 129 0.011071900993798449 1.252592 233 1435 0.0957272 GO Biological Process regulation of establishment of cell polarity 1 0 0 13.73163 509 0.04524847 133 0.01173824354736842 3.673553 10 21 0.004108463 GO Biological Process negative regulation of centriole replication 1 0 0 45.44173 356 0.03164726 145 0.017716261180689655 6.428718 5 6 0.002054232 GO Biological Process negative regulation of gene expression 1 0 0 2.3165 3980 0.3538092 152 0.020230144480263158 1.233899 238 1488 0.09778143 GO Biological Process negative regulation of nucleobase-containing compound metabolic process 1 0 0 2.060048 3433 0.3051827 156 0.020465357609615386 1.239533 228 1419 0.09367297 GO Biological Process Wnt signaling pathway, planar cell polarity pathway 1 0 0 7.997397 747 0.0664059 159 0.022821868878616352 2.02602 26 99 0.010682 GO Biological Process regulation of establishment of planar polarity 1 0 0 6.472195 750 0.06667259 179 0.029180339798882685 1.928615 28 112 0.0115037 GO Biological Process regulation of organ morphogenesis 1 0 0 6.251884 2410 0.2142413 195 0.03749613861487179 1.58007 51 249 0.02095316 GO Biological Process negative regulation of centrosome duplication 1 0 0 36.75872 358 0.03182505 203 0.04022383483152709 4.628677 6 10 0.002465078 GO Biological Process cellular response to DNA damage stimulus 310 3.268952e-267 1.3876173989677416e-265 2.637398 1608 0.142946 62 0.001031151550032258 1.438643 138 740 0.0566968 GO Cellular Component organelle subcompartment 1 0 0 4.218864 1374 0.1221442 37 0.005267009383783784 1.576855 65 318 0.02670501 GO Cellular Component Golgi subcompartment 1 0 0 4.382652 1367 0.1215219 42 0.007113065142857143 1.579135 61 298 0.02506163 GO Cellular Component Golgi stack 1 0 0 6.509378 908 0.08071829 64 0.040585239 1.76157 29 127 0.01191454 GO Cellular Component proteasome accessory complex 29 1.397407e-287 8.326618262068966e-286 23.67671 296 0.02631345 23 0.000015011902330434783 4.500103 14 24 0.005751849 GO Cellular Component proteasome regulatory particle 30 3.379589e-287 1.946643264e-285 23.78993 295 0.02622455 24 0.0000150140232 4.775619 13 21 0.005341002 GO Cellular Component perinuclear region of cytoplasm 31 4.64352e-283 2.5883879225806452e-281 2.575344 1762 0.1566361 62 0.03835730787096774 1.3131 112 658 0.04601479 GO Cellular Component nuclear envelope 39 5.984097e-207 2.651415286153846e-205 2.762416 1175 0.1044537 61 0.03820675986885246 1.391421 79 438 0.03245686 GO Cellular Component nucleolus 40 1.209433e-203 5.22475056e-202 2.156315 1797 0.1597475 22 0.000010812747927272728 1.451646 175 930 0.07189811 GO Cellular Component proteasome complex 49 6.809561e-155 2.4014125322448977e-153 7.476568 304 0.02702462 36 0.00430192128 2.382407 21 68 0.008627773 GO Cellular Component endopeptidase complex 50 7.906656e-155 2.7325403136e-153 7.472346 304 0.02702462 38 0.00515043587368421 2.34788 21 69 0.008627773 GO Cellular Component peptidase complex 55 1.143478e-124 3.5925999709090916e-123 5.588431 310 0.02755801 29 0.0019353373572413794 2.279273 26 88 0.010682 GO Cellular Component trans-Golgi network 95 1.009742e-66 1.8366675536842104e-65 2.447624 477 0.04240377 59 0.03530409437288135 1.613739 41 196 0.0168447 GO Cellular Component SMN-Sm protein complex 138 5.15136e-8 6.450398608695652e-7 2.915811 35 0.003111388 55 0.020252722385454548 3.630335 8 17 0.003286771 Mouse Phenotype Single KO embryonic lethality 1 0 0 2.229039 3691 0.3281181 1 0.0000012016767727999998 1.415543 289 1575 0.1187346 Mouse Phenotype Single KO abnormal embryonic growth/weight/body size 1 0 0 2.508071 2550 0.2266868 4 0.00002160047248175 1.531617 163 821 0.06696795 Mouse Phenotype Single KO abnormal embryo size 1 0 0 2.791938 2106 0.1872166 7 0.00007573587257714286 1.588272 126 612 0.05176664 Mouse Phenotype Single KO decreased embryo size 1 0 0 2.782991 1826 0.1623255 8 0.0001218607836875 1.641049 107 503 0.04396056 Mouse Phenotype Single KO abnormal embryo morphology 1 0 0 2.262501 3400 0.3022491 9 0.00011318275837777779 1.399643 213 1174 0.08751027 Mouse Phenotype Single KO embryo phenotype 1 0 0 2.091106 3930 0.3493644 11 0.00013536868020909093 1.332942 273 1580 0.1121611 Mouse Phenotype Single KO embryonic lethality during organogenesis 1 0 0 3.190157 3134 0.2786025 16 0.00629443023 1.418633 137 745 0.05628595 Mouse Phenotype Single KO abnormal prenatal body size 205 3.864355e-292 1.726141401707317e-290 2.332123 2145 0.1906836 10 0.00012001155042999999 1.511827 146 745 0.05998357 Mouse Phenotype Single KO abnormal prenatal growth/weight/body size 209 1.285916e-289 5.634034838277512e-288 2.095916 2599 0.2310428 5 0.000021241749296 1.474595 190 994 0.07806081 Mouse Phenotype Single KO embryonic lethality prior to tooth bud stage 265 5.064813e-251 1.750131797773585e-249 2.432727 1736 0.1543248 14 0.0016466012748571428 1.437295 147 789 0.06039441 Mouse Phenotype Single KO embryonic lethality during organogenesis, complete penetrance 266 1.607164e-250 5.532631860150376e-249 2.360026 1828 0.1625033 18 0.012066295906111111 1.456301 111 588 0.04560394 Mouse Phenotype Single KO abnormal gastrulation 279 6.57721e-245 2.1586921853046593e-243 2.970912 1237 0.1099653 13 0.0014801057826923079 1.736374 70 311 0.02875924 Mouse Phenotype Single KO embryonic lethality prior to organogenesis 350 1.158506e-190 3.030982697714286e-189 2.318484 1468 0.1305005 15 0.0036299758178 1.441754 134 717 0.05505341 Mouse Phenotype Single KO abnormal developmental patterning 403 3.5221e-159 8.002945334987593e-158 2.296302 1262 0.1121878 23 0.04203174476521739 1.508521 79 404 0.03245686 Mouse Phenotype Single KO abnormal extraembryonic tissue morphology 427 8.276587e-148 1.7749111746838407e-146 2.005901 1565 0.1391235 24 0.04360258166666667 1.403779 111 610 0.04560394 Mouse Phenotype Single KO abnormal germ layer development 644 1.010967e-74 1.437488325931677e-73 2.767166 431 0.03831452 20 0.0450725899785 1.974902 32 125 0.01314708 Mouse Phenotype Single KO absent fibroblast proliferation 895 5.792165e-19 5.926129039664805e-18 4.35292 56 0.00497822 21 0.04556122036190476 5.785846 6 8 0.002465078 Mouse Phenotype abnormal prenatal growth/weight/body size 1 0 0 2.126354 3109 0.2763801 3 0.00008231721422 1.417338 219 1192 0.08997535 Mouse Phenotype abnormal embryonic growth/weight/body size 1 0 0 2.48143 3056 0.2716686 4 0.0000673178775825 1.459493 189 999 0.07764996 Mouse Phenotype abnormal embryo size 201 3.673082e-307 1.7471809453731343e-305 2.387642 2153 0.1913948 7 0.0007040687619428572 1.490054 141 730 0.05792933 Mouse Phenotype abnormal embryo development 229 7.916487e-282 3.305219747030568e-280 2.078958 2580 0.2293537 9 0.0006650460564333334 1.394705 192 1062 0.0788825 Mouse Phenotype decreased embryo size 273 4.208259e-251 1.473815542087912e-249 2.33041 1874 0.1665926 10 0.00075957680013 1.525529 123 622 0.0505341 Mouse Phenotype abnormal prenatal body size 325 1.885378e-223 5.546492017846153e-222 2.036906 2198 0.1953951 6 0.00061926007405 1.445373 166 886 0.06820049 Mouse Phenotype embryonic lethality prior to tooth bud stage 341 1.080337e-214 3.029062186803519e-213 2.236187 1755 0.1560139 13 0.005801296345153846 1.396037 154 851 0.06327034 Mouse Phenotype abnormal gastrulation 437 3.200385e-171 7.00203226201373e-170 2.387857 1256 0.1116544 11 0.004023153198818182 1.637021 80 377 0.03286771 Mouse Phenotype embryonic lethality prior to organogenesis 476 6.883632e-156 1.3826555788235294e-154 2.105296 1477 0.1313006 15 0.008027249876 1.407166 141 773 0.05792933