# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	16	1.084543e-43	8.919688335625001e-41	2.025851	460	0.06182796	49	3.4984651675510206e-21	1.535928	329	555	0.0453981	
GO Biological Process	ncRNA processing	18	2.457436e-38	1.7965222402222222e-35	2.169557	344	0.04623656	52	4.752200770769231e-18	1.589934	243	396	0.03353112	
GO Biological Process	rRNA metabolic process	24	6.878868e-29	3.7716260005000004e-26	2.293139	228	0.03064516	128	1.956748440234375e-8	1.500581	150	259	0.02069822	
GO Biological Process	regulation of gene expression, epigenetic	25	7.844941e-29	4.12926314476e-26	2.193833	250	0.03360215	385	0.008695272378441558	1.285054	123	248	0.01697254	
GO Biological Process	ribosome biogenesis	26	8.875604e-29	4.4920797321538464e-26	2.078887	282	0.03790323	97	7.111183290309279e-11	1.508076	188	323	0.02594177	
GO Biological Process	rRNA processing	28	1.890457e-28	8.884472736785714e-26	2.304965	222	0.02983871	129	3.257275832170543e-8	1.501137	146	252	0.02014627	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	29	2.453889e-27	1.1134732879655173e-24	3.105697	127	0.01706989	399	0.010462562596240602	1.421612	62	113	0.008555264	
GO Biological Process	regulation of hematopoietic stem cell differentiation	34	3.207152e-25	1.241262152e-22	3.15344	114	0.01532258	415	0.012861102435903613	1.433856	57	103	0.007865324	
GO Biological Process	viral gene expression	49	2.388452e-21	6.414212217959184e-19	2.708099	121	0.01626344	254	0.000273731911980315	1.509718	74	127	0.01021112	
GO Biological Process	macromolecular complex disassembly	50	3.283123e-21	8.6405231114e-19	2.149274	189	0.02540323	154	0.0000012154156543506495	1.519332	112	191	0.01545467	
GO Biological Process	nucleosome organization	53	9.704809e-21	2.409539276056604e-18	2.212305	173	0.02325269	491	0.031563188120162934	1.303078	86	171	0.01186698	
GO Biological Process	multi-organism metabolic process	58	9.667245e-20	2.1932978785344826e-17	2.387649	140	0.0188172	243	0.00020241477052674898	1.480573	84	147	0.011591	
GO Biological Process	viral transcription	60	2.091133e-19	4.586203191166667e-17	2.680986	111	0.01491935	273	0.0007226787835897436	1.513329	66	113	0.009107217	
GO Biological Process	chromatin assembly or disassembly	68	7.156285e-18	1.3848463869852942e-15	2.066952	172	0.02311828	541	0.04891847304436229	1.280945	88	178	0.01214296	
GO Biological Process	mRNA catabolic process	70	2.173771e-17	4.086378941285714e-15	2.004662	180	0.02419355	209	0.000055181479478468904	1.423227	117	213	0.01614461	
GO Biological Process	response to topologically incorrect protein	71	2.426879e-17	4.497929684647887e-15	2.063986	167	0.02244624	198	0.000041262975368181816	1.468235	102	180	0.01407479	
GO Biological Process	translational initiation	73	2.670199e-17	4.8133080330136984e-15	2.31491	129	0.01733871	261	0.00043976722570881224	1.467631	81	143	0.01117704	
GO Biological Process	cellular protein complex disassembly	74	3.334652e-17	5.929822387567567e-15	2.334647	126	0.01693548	172	0.000007173174405465116	1.603954	78	126	0.01076307	
GO Biological Process	nuclear-transcribed mRNA catabolic process	77	6.903734e-17	1.1798212429350648e-14	2.04446	166	0.02231183	240	0.00019259287600416664	1.413274	108	198	0.01490272	
GO Biological Process	endoplasmic reticulum unfolded protein response	78	7.09038e-17	1.196183466923077e-14	2.397198	117	0.01572581	245	0.00021989956560816324	1.545511	68	114	0.009383193	
GO Cellular Component	spliceosomal complex	27	7.088887e-23	4.5368876799999994e-21	2.197694	195	0.02620968	34	1.3773054494117647e-8	1.588034	114	186	0.01573065	
GO Cellular Component	ribosomal subunit	29	2.086944e-22	1.2435307696551725e-20	2.414728	157	0.02110215	71	0.00032191544788732395	1.400542	100	185	0.01379881	
GO Cellular Component	ribosome	37	1.244425e-19	5.81180108108108e-18	2.06462	191	0.02567204	54	0.0000222045216	1.40529	128	236	0.01766248	
GO Cellular Component	chromosome, telomeric region	41	2.23403e-16	9.415619121951218e-15	2.195215	136	0.01827957	97	0.008093223389690722	1.334289	86	167	0.01186698	
GO Cellular Component	catalytic step 2 spliceosome	42	4.683211e-16	1.9268068114285713e-14	2.489079	103	0.01384409	50	0.00000751011264	1.673356	62	96	0.008555264	
GO Cellular Component	large ribosomal subunit	43	7.270747e-16	2.9218257711627906e-14	2.524479	99	0.01330645	75	0.0007521484032	1.487011	66	115	0.009107217	
GO Cellular Component	mitochondrial ribosome	44	7.482408e-16	2.938545687272727e-14	3.056526	72	0.009677419	116	0.01919085517241379	1.432672	47	85	0.006485442	
GO Cellular Component	methyltransferase complex	47	1.773747e-13	6.521350672340425e-12	2.299517	99	0.01330645	65	0.00020224873550769233	1.594463	56	91	0.007727335	
GO Cellular Component	peptidase complex	51	1.39236e-11	4.717643294117647e-10	2.289541	84	0.01129032	80	0.0016470328319999998	1.531047	52	88	0.007175383	
GO Cellular Component	spliceosomal snRNP complex	52	1.723806e-11	5.72833993846154e-10	2.780556	58	0.007795699	82	0.001899164511219512	1.629825	39	62	0.005381537	
GO Cellular Component	histone methyltransferase complex	55	7.378558e-11	2.3182087680000002e-9	2.235383	82	0.01102151	85	0.002948594145882353	1.577132	42	69	0.005795502	
GO Cellular Component	mitochondrial large ribosomal subunit	57	1.148533e-10	3.4818684631578946e-9	3.142604	44	0.005913978	109	0.017164810568807337	1.574923	31	51	0.004277632	
GO Cellular Component	small nuclear ribonucleoprotein complex	61	3.33571e-10	9.449355540983605e-9	2.475595	62	0.008333333	85	0.002948594145882353	1.577132	42	69	0.005795502	
GO Cellular Component	preribosome	64	9.856707e-10	2.6613108899999998e-8	2.297517	68	0.009139785	81	0.0018485179733333332	1.568239	46	76	0.006347454	
GO Cellular Component	proteasome accessory complex	67	1.116714e-9	2.8801220776119403e-8	3.749146	31	0.004166667	79	0.0013184696870886076	2.051211	19	24	0.002621775	
GO Cellular Component	integral component of mitochondrial membrane	68	3.354893e-9	8.525375152941177e-8	2.273498	65	0.008736559	120	0.020150582400000002	1.497924	37	64	0.005105561	
GO Cellular Component	intrinsic component of mitochondrial membrane	69	4.344098e-9	1.0879132382608694e-7	2.257756	65	0.008736559	133	0.02664820258646617	1.474879	37	65	0.005105561	
GO Cellular Component	endopeptidase complex	70	4.689413e-9	1.1576150948571428e-7	2.304178	62	0.008333333	130	0.024986667323076923	1.46448	39	69	0.005381537	
GO Cellular Component	proteasome complex	72	1.076625e-8	2.5839e-7	2.268295	61	0.008198925	137	0.035464614306569345	1.447914	38	68	0.005243549	
GO Cellular Component	proteasome regulatory particle	82	4.721145e-8	9.948949463414634e-7	3.414052	28	0.003763441	83	0.0018971320597590362	2.097479	17	21	0.002345798	
GO Molecular Function	structural constituent of ribosome	8	1.515779e-16	7.9995236725e-14	2.229192	133	0.01787634	61	0.002298744726557377	1.407459	88	162	0.01214296	
GO Molecular Function	unfolded protein binding	10	1.09486e-12	4.62249892e-10	2.382448	86	0.01155914	62	0.003901275089032258	1.491049	61	106	0.008417276	
GO Molecular Function	ribonucleoprotein complex binding	11	2.503977e-11	9.610718994545456e-9	2.092954	100	0.01344086	82	0.015536074409756096	1.419419	63	115	0.008693252	
GO Molecular Function	RNA methyltransferase activity	13	6.119796e-8	0.000019875214393846154	2.22294	57	0.00766129	42	0.00007116525796666666	1.831571	41	58	0.005657513	
GO Molecular Function	tRNA binding	24	0.000001261354	0.00022189319116666664	2.093393	52	0.006989247	34	0.00001252022924117647	1.943252	39	52	0.005381537	
GO Molecular Function	O-methyltransferase activity	40	0.00001178818	0.001244242399	2.723256	25	0.003360215	69	0.005575721275942029	2.097479	17	21	0.002345798	
Human Phenotype	Increased CSF lactate	1	1.675466e-10	0.0000011180384618	2.725671	54	0.007258065	43	0.013679904505116278	1.652881	37	58	0.005105561	
Human Phenotype	Abnormal CSF metabolite level	2	7.242319e-10	0.00000241639973435	2.55982	56	0.007526882	51	0.019472206529411763	1.603954	39	63	0.005381537	
Human Phenotype	Increased serum lactate	3	1.425783e-9	0.000003171416653	2.082772	83	0.01115591	49	0.019257501753061224	1.476872	57	100	0.007865324	
Human Phenotype	Abnormality of mitochondrial metabolism	11	3.510728e-7	0.00021297352676363635	2.018423	63	0.008467742	36	0.010216513142500001	1.614683	43	69	0.00593349	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	11	4.778971e-8	0.000039782761315454546	3.038211	33	0.004435484	100	0.029191096665000003	1.943252	18	24	0.002483786	
Mouse Phenotype Single KO	increased skin tumor incidence	19	0.000003881827	0.0018708363073157899	2.133933	45	0.006048387	124	0.049164073308870966	1.64882	28	44	0.003863668	
Mouse Phenotype	abnormal DNA repair	4	6.48871e-12	1.55096390775e-8	2.109952	104	0.01397849	157	0.041166968214649685	1.380453	65	122	0.008969229	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	12	9.69253e-8	0.000077225232775	2.787903	36	0.00483871	145	0.03190439102689655	1.813702	21	30	0.002897751	
Mouse Phenotype	increased incidence of tumors by ionizing radiation induction	31	0.000007900211	0.0024365779797096776	2.940515	23	0.003091398	96	0.0060120544018750005	2.181897	16	19	0.00220781