# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	cellular protein complex disassembly	2	4.432931e-24	2.9166469514500004e-20	4.002416	79	0.02903344	101	0.00001166032149	2.161809	46	126	0.01450646	
GO Biological Process	translational termination	3	1.468222e-23	6.440111099333334e-20	5.000695	61	0.02241823	121	0.00008404233517024793	2.243928	36	95	0.01135289	
GO Biological Process	mitochondrial translational elongation	4	3.197518e-23	1.0519034840500001e-19	5.492583	55	0.02021316	156	0.0009308954963461538	2.159597	31	85	0.009776096	
GO Biological Process	ncRNA processing	5	5.951642e-23	1.56635314156e-19	2.517734	146	0.05365674	23	2.0335558157826085e-14	2.018685	135	396	0.04257332	
GO Biological Process	ncRNA metabolic process	6	6.047622e-23	1.3263442983e-19	2.227747	185	0.06798971	22	8.400908966363638e-15	1.856463	174	555	0.05487228	
GO Biological Process	mitochondrial translational termination	7	6.732895e-23	1.2656880757857145e-19	5.403006	55	0.02021316	164	0.0015164584051829267	2.109951	31	87	0.009776096	
GO Biological Process	translational elongation	8	6.755945e-23	1.1112685031875e-19	4.487974	66	0.02425579	144	0.0002953025811111111	2.061942	39	112	0.01229896	
GO Biological Process	macromolecular complex disassembly	9	1.199825e-22	1.7542774638888887e-19	3.140477	101	0.03711871	103	0.000012031948258446602	1.922154	62	191	0.01955219	
GO Biological Process	translation	10	1.314414e-22	1.7296373826000001e-19	2.477234	148	0.05439177	42	7.618287125476192e-10	1.8624	117	372	0.03689688	
GO Biological Process	protein complex disassembly	11	1.38229e-22	1.6535958281818182e-19	3.407764	90	0.03307607	120	0.00008387298772166666	1.936583	52	159	0.01639861	
GO Biological Process	mitochondrion organization	12	2.239475e-22	2.4557709604166667e-19	2.11791	201	0.0738699	49	3.2274649618367344e-9	1.677751	153	540	0.04824976	
GO Biological Process	mitochondrial translation	13	1.670521e-21	1.6909527568461537e-18	4.537174	61	0.02241823	152	0.0005947995261381579	2.047613	37	107	0.01166824	
GO Biological Process	peptide biosynthetic process	19	4.040311e-19	2.798234339421053e-16	2.246928	150	0.05512679	51	5.475392814901961e-9	1.797591	119	392	0.03752759	
GO Biological Process	protein folding	24	1.771304e-18	9.711912223333333e-16	2.678667	104	0.03822124	83	0.0000014273148748674698	1.912689	73	226	0.02302113	
GO Biological Process	protein refolding	27	2.229705e-17	1.0866921516666667e-14	13.98597	21	0.007717751	178	0.002531764247022472	3.383701	12	21	0.003784295	
GO Biological Process	ribonucleoprotein complex biogenesis	29	6.401067e-17	2.904539332862069e-14	2.062783	159	0.0584344	26	3.844932765038462e-12	1.865134	143	454	0.04509618	
GO Biological Process	ribosome biogenesis	32	1.265519e-16	5.2040514128125e-14	2.35837	117	0.0429989	36	2.0565305556944444e-10	1.961603	107	323	0.0337433	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	33	2.750624e-16	1.096832158060606e-13	3.744448	56	0.02058067	97	0.000007998863654948454	2.253305	43	113	0.01356039	
GO Biological Process	regulation of hematopoietic stem cell differentiation	40	4.596914e-16	1.51226978315e-13	3.933032	52	0.01911062	100	0.0000116268147283	2.299602	40	103	0.01261432	
GO Biological Process	DNA replication-dependent nucleosome assembly	49	3.989822e-15	1.0714707693469388e-12	15.63871	17	0.006247703	202	0.005121805912079207	2.775692	15	32	0.004730369	
GO Cellular Component	ribonucleoprotein complex	7	2.382227e-39	5.880697508571429e-37	2.266068	308	0.1131937	15	8.607794687999999e-21	1.804709	249	817	0.07852412	
GO Cellular Component	intracellular ribonucleoprotein complex	9	4.602564e-39	8.83692288e-37	2.26159	307	0.1128262	16	1.044527508e-20	1.804086	248	814	0.07820877	
GO Cellular Component	mitochondrial ribosome	13	4.72597e-27	6.2819047384615395e-25	6.50022	56	0.02058067	52	0.00036672712615384617	2.159597	31	85	0.009776096	
GO Cellular Component	mitochondrial large ribosomal subunit	14	3.127481e-26	3.86020512e-24	8.592788	44	0.01617053	51	0.0003242892197647059	2.554362	22	51	0.006937874	
GO Cellular Component	ribosomal subunit	15	3.477059e-26	4.005571968e-24	3.826964	91	0.03344359	39	0.0000011078340923076923	1.984495	62	185	0.01955219	
GO Cellular Component	ribosome	17	1.172853e-24	1.1921705788235292e-22	3.192088	108	0.03969129	34	1.0899177035294119e-7	1.932007	77	236	0.02428256	
GO Cellular Component	nuclear nucleosome	19	8.659105e-24	7.875228126315789e-22	12.07991	32	0.01176038	76	0.010056064168421053	2.36859	16	40	0.005045727	
GO Cellular Component	large ribosomal subunit	21	1.829706e-21	1.5055866514285715e-19	4.392599	63	0.02315325	48	0.00024095163599999997	2.008153	39	115	0.01229896	
GO Cellular Component	mitochondrial matrix	25	3.225567e-20	2.2295119104000004e-18	2.208619	165	0.06063947	38	0.0000010343225936842104	1.604277	123	454	0.03878903	
GO Cellular Component	nucleosome	26	1.068354e-19	7.100445046153847e-18	5.139392	49	0.01800809	53	0.0003685957675471698	2.03022	36	105	0.01135289	
GO Cellular Component	DNA packaging complex	31	8.00095e-17	4.459884387096774e-15	4.257878	50	0.0183756	56	0.00068475672	1.956202	37	112	0.01166824	
GO Cellular Component	vesicle coat	36	5.67193e-15	2.7225264e-13	4.087722	46	0.01690555	58	0.0010618789406896551	2.438255	21	51	0.006622517	
GO Cellular Component	membrane coat	44	3.244298e-12	1.2741243054545452e-10	2.892165	58	0.02131569	71	0.0038819933746478876	1.912143	31	96	0.009776096	
GO Cellular Component	protein-DNA complex	62	2.97189e-8	8.282945032258064e-7	2.078922	69	0.02535832	80	0.010758804479999998	1.553655	53	202	0.01671397	
GO Cellular Component	spliceosomal complex	65	5.988383e-8	0.0000015919885883076922	2.064676	67	0.0246233	42	0.000018953473371428572	1.878318	59	186	0.01860612	
GO Cellular Component	spliceosomal snRNP complex	67	1.383065e-7	0.0000035670691343283584	3.408171	26	0.009555311	111	0.03477779027027027	1.910154	20	62	0.006307159	
GO Cellular Component	spliceosomal tri-snRNP complex	68	1.914772e-7	0.000004865773552941176	4.836713	17	0.006247703	65	0.002422635529846154	2.858644	14	29	0.004415011	
GO Cellular Component	catalytic step 2 spliceosome	69	1.967104e-7	0.000004926312626086956	2.576977	39	0.01433297	49	0.0003125460401632653	2.097189	34	96	0.01072217	
GO Cellular Component	peptidase complex	73	6.158869e-7	0.000014578802235616438	2.608445	35	0.01286292	112	0.03450735771428571	1.749527	26	88	0.008199306	
GO Cellular Component	small ribosomal subunit	77	0.000001102779	0.00002474807937662337	2.899914	28	0.01029033	95	0.022918718652631575	1.891583	23	72	0.007253232	
GO Molecular Function	rRNA binding	3	1.196293e-16	1.6835830153333336e-13	6.304769	34	0.01249541	10	0.00014352051478	2.664664	27	60	0.008514664	
GO Molecular Function	ribonucleoprotein complex binding	4	1.568792e-12	1.655859956e-9	3.090281	54	0.01984564	9	0.000016134687304444442	2.265608	44	115	0.01387575	
GO Molecular Function	nuclease activity	9	9.232643e-11	4.331135416222222e-8	2.225629	81	0.02976847	15	0.00030591429840000003	1.787615	64	212	0.02018291	
GO Molecular Function	structural constituent of ribosome	18	2.464259e-8	0.000005780056387777778	2.383107	52	0.01911062	51	0.028179142952941178	1.644854	45	162	0.01419111	
GO Molecular Function	endonuclease activity	19	3.241432e-8	0.000007202803107368421	2.318296	54	0.01984564	42	0.01656067437142857	1.754511	40	135	0.01261432	
GO Molecular Function	ribonuclease activity	23	2.810551e-7	0.00005159194053043479	2.539677	39	0.01433297	20	0.0005100938071	2.153264	36	99	0.01135289	
GO Molecular Function	endoribonuclease activity	28	3.014193e-7	0.00004544972445	3.182085	27	0.009922822	16	0.000291653649	2.643516	25	56	0.007883948	
GO Molecular Function	Hsp70 protein binding	31	3.801602e-7	0.000051775366593548396	3.42297	24	0.008820287	58	0.04076436358965517	2.400598	15	37	0.004730369	
GO Molecular Function	heat shock protein binding	36	0.000002648451	0.0003106044478333333	2.14012	46	0.01690555	44	0.017070486354545455	1.861035	33	105	0.01040681	
GO Molecular Function	peptidyl-prolyl cis-trans isomerase activity	40	0.000007206908	0.0007606891394	2.800844	25	0.009187799	33	0.008692614389090908	2.537775	18	42	0.005676443	
GO Molecular Function	cis-trans isomerase activity	46	0.00001203096	0.0011042328939130433	2.715152	25	0.009187799	41	0.014476527468292682	2.422422	18	44	0.005676443	
GO Molecular Function	RNA-dependent ATPase activity	49	0.00001351386	0.0011643983044897959	2.395174	31	0.01139287	18	0.00044147178811111107	2.438255	28	68	0.008830022	
GO Molecular Function	ATP-dependent RNA helicase activity	54	0.00002321477	0.0018150510914814815	2.364823	30	0.01102536	24	0.0008220179465833333	2.386266	27	67	0.008514664	
GO Molecular Function	RNA helicase activity	56	0.0000278679	0.0021010406035714287	2.340919	30	0.01102536	25	0.0010994907068	2.351174	27	68	0.008514664	
GO Molecular Function	translation factor activity, RNA binding	58	0.00003178807	0.0023139522679310343	2.161902	35	0.01286292	31	0.005548305889677419	2.065631	30	86	0.009460738	
GO Molecular Function	ATP-dependent helicase activity	65	0.00005098299	0.003311541288923077	2.038649	38	0.01396545	22	0.0007802728096363637	2.136615	35	97	0.01103753	
GO Molecular Function	protein phosphatase activator activity	67	0.00005598502	0.003527891857313433	4.442317	11	0.004042631	56	0.03571663476071429	4.441107	6	8	0.001892148	
GO Molecular Function	ribosome binding	72	0.00008639927	0.005066357193611111	2.504718	23	0.008452775	54	0.03157607998888889	2.153264	20	55	0.006307159	
GO Molecular Function	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	76	0.0001243456	0.0069077253052631585	2.80924	18	0.006615215	49	0.018910932526530613	2.493253	16	38	0.005045727	
GO Molecular Function	endoribonuclease activity, producing 5'-phosphomonoesters	82	0.0002427287	0.012497567943902438	2.853164	16	0.005880191	29	0.0026084680689655174	3.062832	15	29	0.004730369	
Human Phenotype	Increased serum lactate	4	9.561448e-9	0.000015950885626	2.813144	41	0.01506799	1	0.007220793243	2.190946	37	100	0.01166824	
Mouse Phenotype	abnormal plasma cell morphology	1	9.559542e-17	9.1398781062e-13	2.999592	78	0.02866593	82	0.014987625384146344	1.932271	31	95	0.009776096	
Mouse Phenotype	abnormal spleen germinal center morphology	3	2.065027e-14	6.581241049e-11	2.6438	81	0.02976847	22	0.0006211833850909091	1.988233	46	137	0.01450646	
Mouse Phenotype	abnormal spleen secondary B follicle morphology	5	7.763305e-14	1.4844991821000002e-10	2.558567	82	0.03013598	20	0.0005303357626500001	1.987924	47	140	0.01482182	
Mouse Phenotype	abnormal plasma cell number	11	3.06136e-12	2.6608784509090913e-9	2.751552	63	0.02315325	100	0.044616722013	1.92448	26	80	0.008199306	
Mouse Phenotype	abnormal spleen B cell follicle morphology	15	2.523521e-11	1.6084922853999998e-8	2.126528	95	0.03491363	46	0.003770193286956522	1.718148	56	193	0.01766004	
Mouse Phenotype	abnormal germinal center B cell number	119	0.00001146118	0.0009208432099159663	2.116889	41	0.01506799	50	0.0040607230614	2.264094	26	68	0.008199306	
Mouse Phenotype	abnormal translation	190	0.000286702	0.014427146431578946	6.894716	6	0.002205072	101	0.044845851567326726	4.441107	6	8	0.001892148