# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 22 1.982769e-26 1.1859662395909091e-23 2.377882 194 0.01641981 448 0.0066324032921875 1.380732 69 113 0.008309249 GO Biological Process nuclear-transcribed mRNA catabolic process 26 1.241891e-24 6.285401411153846e-22 2.016429 260 0.02200592 316 0.0013034072784810127 1.324743 116 198 0.01396917 GO Biological Process liver regeneration 32 2.945414e-23 1.2112094633124999e-20 3.128772 106 0.008971646 476 0.008259381810294118 1.679748 26 35 0.003131021 GO Biological Process regulation of DNA-templated transcription in response to stress 40 1.318067e-21 4.3361109132500005e-19 2.134653 197 0.01667372 454 0.007203369929074889 1.368121 72 119 0.00867052 GO Biological Process triglyceride homeostasis 42 1.607095e-21 5.035181691666666e-19 3.651485 79 0.006686416 649 0.029054078485362095 1.625237 23 32 0.00276975 GO Biological Process cellular response to unfolded protein 69 1.527539e-19 2.913171840724638e-17 2.102783 183 0.01548879 677 0.03349849893648449 1.308132 70 121 0.008429672 GO Biological Process mitochondrial transmembrane transport 84 8.10055e-18 1.2689897315476189e-15 2.356366 129 0.01091832 452 0.007028181142035398 1.443898 53 83 0.006382466 GO Biological Process cellular response to epidermal growth factor stimulus 101 9.795654e-17 1.2762476335247525e-14 2.350335 121 0.01024122 444 0.006537548278153153 1.666147 28 38 0.003371869 GO Biological Process protein-lipid complex assembly 108 3.987767e-16 4.858798699351852e-14 3.258233 67 0.005670758 707 0.036975505741159834 1.63742 21 29 0.002528902 GO Biological Process platelet-derived growth factor receptor signaling pathway 119 9.943944e-16 1.0995996562689075e-13 2.264668 122 0.01032586 342 0.0020780619694444444 1.781551 26 33 0.003131021 GO Biological Process negative regulation of response to endoplasmic reticulum stress 123 1.638394e-15 1.7528151744715447e-13 2.550472 95 0.008040626 580 0.019798178333793104 1.58284 28 40 0.003371869 GO Biological Process protein targeting to ER 124 1.772818e-15 1.881331617903226e-13 2.220781 125 0.01057977 425 0.005483822831529412 1.410451 63 101 0.007586705 GO Biological Process cotranslational protein targeting to membrane 126 2.954348e-15 3.085417883492063e-13 2.246176 120 0.01015658 386 0.003766951248704663 1.430555 62 98 0.007466281 GO Biological Process response to epidermal growth factor 138 8.183585e-15 7.803463406884057e-13 2.195929 122 0.01032586 604 0.02188300305794702 1.561304 29 42 0.003492293 GO Biological Process viral gene expression 145 1.486839e-14 1.3493320276551724e-12 2.029462 144 0.0121879 466 0.007809338445708155 1.353159 76 127 0.009152216 GO Biological Process plasma lipoprotein particle assembly 146 1.519478e-14 1.3695076028767123e-12 3.368901 57 0.004824376 753 0.04809317417662682 1.652415 19 26 0.002288054 GO Biological Process RNA phosphodiester bond hydrolysis, endonucleolytic 149 1.80694e-14 1.5958069436241612e-12 2.360059 102 0.008633094 757 0.04808719270805813 1.389023 43 70 0.005178227 GO Biological Process protein-lipid complex subunit organization 171 1.509159e-13 1.1613463907017545e-11 2.407549 91 0.007702074 468 0.00786500495940171 1.587651 33 47 0.003973988 GO Biological Process SRP-dependent cotranslational protein targeting to membrane 172 1.515632e-13 1.1595465981395348e-11 2.198477 110 0.009310199 598 0.020807046008026756 1.376382 56 92 0.006743738 GO Biological Process regulation of exit from mitosis 218 3.144381e-12 1.8980233751834863e-10 3.59234 43 0.003639441 561 0.01860580564973262 1.884333 15 18 0.001806358 GO Cellular Component PcG protein complex 35 2.466913e-24 1.217950189714286e-22 2.764671 135 0.01142615 69 0.0010517071304347826 1.671321 34 46 0.004094412 GO Cellular Component high-density lipoprotein particle 43 1.062302e-13 4.268971758139534e-12 3.709496 47 0.003977994 119 0.02347241142857143 1.674963 20 27 0.002408478 GO Cellular Component mitochondrial outer membrane translocase complex 51 1.817927e-12 6.159564423529412e-11 5.065826 30 0.002539145 125 0.025953343488 2.055636 10 11 0.001204239 GO Cellular Component cleavage furrow 52 2.39082e-12 7.94487876923077e-11 2.132919 106 0.008971646 105 0.010747154468571428 1.521961 35 52 0.004214836 GO Cellular Component endopeptidase complex 83 3.598138e-9 7.491063209638554e-8 2.012621 86 0.007278883 96 0.0062806445999999995 1.474695 45 69 0.005419075 GO Cellular Component cytoplasmic stress granule 91 1.191306e-8 2.2621722725274724e-7 2.044928 77 0.006517139 103 0.01051478269514563 1.577581 30 43 0.003612717 GO Cellular Component proteasome accessory complex 168 0.00001850345 0.0001903212 2.360867 31 0.002623783 128 0.029799684000000003 1.6959 18 24 0.00216763 GO Cellular Component CD40 receptor complex 227 0.0001010549 0.0007692637321585902 2.96931 17 0.001438849 125 0.025953343488 2.055636 10 11 0.001204239 GO Cellular Component nuclear pore outer ring 336 0.003306299 0.01700382342857143 2.450612 13 0.001100296 149 0.045083079302013426 2.035079 9 10 0.001083815 GO Molecular Function protein transmembrane transporter activity 39 1.191573e-10 1.2899541553846153e-8 3.141088 44 0.00372408 99 0.033827623545454544 1.884333 15 18 0.001806358 GO Molecular Function thyroid hormone receptor binding 101 5.389892e-7 0.000022530815865346537 2.259769 47 0.003977994 82 0.011540023492682927 1.776657 22 28 0.002649326 GO Molecular Function apolipoprotein binding 226 0.00006803675 0.001271022825221239 2.059527 36 0.003046974 91 0.02096050872307692 1.978549 14 16 0.001685934 Human Phenotype Abnormal CSF metabolite level 26 1.393026e-15 3.575254806923077e-13 2.619402 91 0.007702074 139 0.03233658508417266 1.471574 41 63 0.00493738 Human Phenotype Increased serum lactate 29 5.890722e-15 1.3554754450344826e-12 2.117423 134 0.01134152 87 0.008956968477011495 1.424556 63 100 0.007586705 Human Phenotype Increased CSF lactate 35 4.32277e-14 8.241669774285714e-12 2.60635 82 0.00694033 150 0.038516760638666665 1.481475 38 58 0.004576108 Human Phenotype Severe short stature 48 2.792294e-11 3.881870387916667e-9 2.403076 74 0.006263225 81 0.00800872040493827 1.766562 25 32 0.003010597 Mouse Phenotype Single KO abnormal cellular replicative senescence 132 2.51198e-11 1.7425909742424241e-9 2.141924 95 0.008040626 447 0.04512618765100671 1.432093 38 60 0.004576108 Mouse Phenotype Single KO increased respiratory quotient 172 8.973003e-10 4.7770807250581396e-8 2.0562 88 0.007448159 185 0.0015414497821621622 1.661289 36 49 0.00433526 Mouse Phenotype Single KO increased hepatocyte apoptosis 180 1.213276e-9 6.172204628888888e-8 2.042794 88 0.007448159 360 0.02554886939166667 1.561304 29 42 0.003492293 Mouse Phenotype Single KO abnormal sublingual gland morphology 181 1.281936e-9 6.485462956906078e-8 3.728807 31 0.002623783 406 0.03293813497536946 2.261199 8 8 0.0009633911 Mouse Phenotype Single KO absent segment of posterior cerebral artery 197 3.351716e-9 1.557952457461929e-7 2.634669 49 0.00414727 420 0.03681990455714286 1.74729 17 22 0.002047206 Mouse Phenotype Single KO increased muscle cell glucose uptake 233 2.614051e-8 0.0000010273332621030043 2.059889 72 0.006093948 333 0.017986484633333334 1.830495 17 21 0.002047206 Mouse Phenotype Single KO abnormal pharyngeal muscle morphology 253 5.015202e-8 0.0000018151859570750988 3.31855 29 0.002454507 433 0.03970314476674365 2.055636 10 11 0.001204239 Mouse Phenotype Single KO abnormal hypoglossal nerve topology 636 0.0001625195 0.002339923052672956 2.089199 31 0.002623783 347 0.02093207074495677 1.884333 15 18 0.001806358 Mouse Phenotype Single KO abnormal nucleotide metabolism 926 0.002152829 0.021288828458963283 2.133858 19 0.001608125 356 0.02315276971966292 2.072766 11 12 0.001324663 Mouse Phenotype decreased circulating free fatty acid level 24 1.23997e-25 4.9397304875000005e-23 2.081417 251 0.02124418 549 0.016155853875409836 1.330117 70 119 0.008429672 Mouse Phenotype abnormal cellular replicative senescence 93 1.193253e-15 1.2267410680645162e-13 2.110822 142 0.01201862 461 0.0077629015132321035 1.426709 53 84 0.006382466 Mouse Phenotype absent type I pneumocytes 106 1.80579e-14 1.628788508490566e-12 3.902025 47 0.003977994 726 0.04350927957438016 2.261199 7 7 0.0008429672 Mouse Phenotype early cellular replicative senescence 120 8.04369e-14 6.4088100075e-12 2.100084 125 0.01057977 550 0.016140447347454543 1.424865 46 73 0.005539499 Mouse Phenotype decreased circulating total protein level 156 6.877338e-12 4.2150146550000003e-10 2.032119 114 0.009648752 722 0.04259172570498615 1.41804 37 59 0.004455684 Mouse Phenotype increased respiratory quotient 192 8.596088e-11 4.28058319625e-9 2.030997 102 0.008633094 356 0.002828911902808989 1.574764 39 56 0.004696532 Mouse Phenotype absent segment of posterior cerebral artery 270 3.351716e-9 1.1868798768888888e-7 2.634669 49 0.00414727 617 0.02616958820421394 1.74729 17 22 0.002047206 Mouse Phenotype decreased type I pneumocyte number 284 6.02617e-9 2.028739836971831e-7 2.239816 65 0.005501481 412 0.004717223352669903 2.099685 13 14 0.001565511 Mouse Phenotype abnormal pharyngeal muscle morphology 301 1.098076e-8 3.487941739534884e-7 3.313498 32 0.002708421 546 0.015761966913186813 2.072766 11 12 0.001324663 Mouse Phenotype decreased liver cholesterol level 302 1.245135e-8 3.9419654751655626e-7 2.125427 70 0.005924672 595 0.023025828610084037 1.625237 23 32 0.00276975 Mouse Phenotype increased circulating interferon-gamma level 349 5.170194e-8 0.0000014163961270487105 2.046023 70 0.005924672 615 0.026193206775609757 1.478477 34 52 0.004094412 Mouse Phenotype abnormal infrahyoid muscle morphology 396 1.709924e-7 0.000004128430142424242 3.286213 27 0.002285231 751 0.049490231280958724 2.035079 9 10 0.001083815 Mouse Phenotype abnormal circulating lactate dehydrogenase level 479 0.000001822249 0.00003637269872442588 3.900003 18 0.001523487 637 0.028178863629513346 2.055636 10 11 0.001204239 Mouse Phenotype increased circulating lactate dehydrogenase level 510 0.000003059407 0.00005735488299411764 3.938421 17 0.001438849 751 0.049490231280958724 2.035079 9 10 0.001083815 Mouse Phenotype abnormal hypoglossal nerve topology 774 0.0001625195 0.0020075567693798447 2.089199 31 0.002623783 535 0.014175487085046729 1.884333 15 18 0.001806358 Mouse Phenotype abnormal nucleotide metabolism 947 0.0007337928 0.007408440296515311 2.238245 21 0.001777402 626 0.02722612353354633 1.938171 12 14 0.001445087