# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	61	2.022182e-23	4.3622775308196726e-21	2.201571	201	0.01197426	497	0.0005304236686519114	1.347871	86	118	0.008470403	
GO Biological Process	viral gene expression	74	1.042615e-20	1.854023079054054e-18	2.053408	207	0.0123317	487	0.00042319452082135523	1.339726	92	127	0.009061361	
GO Biological Process	viral transcription	95	9.781988e-19	1.3549597904421052e-16	2.034	190	0.01131896	413	0.00008599091066343826	1.391145	85	113	0.00837191	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	100	9.72481e-18	1.2796877479000001e-15	2.166389	154	0.009174312	515	0.0007004451380194175	1.387053	69	92	0.006796021	
GO Biological Process	cotranslational protein targeting to membrane	110	1.096686e-16	1.3119355521818182e-14	2.081642	158	0.009412606	508	0.0006280891723818897	1.377617	73	98	0.007189993	
GO Biological Process	protein targeting to ER	123	1.887644e-15	2.0194721460162604e-13	2.000794	160	0.009531753	551	0.0013280287291107078	1.355009	74	101	0.007288486	
GO Biological Process	IRE1-mediated unfolded protein response	163	1.066076e-12	8.606438088343558e-11	2.173571	105	0.006255213	861	0.020369658214866432	1.37111	43	58	0.004235201	
GO Biological Process	cellular response to arsenic-containing substance	210	1.845839e-10	1.1566378762380951e-8	2.783427	52	0.00309782	865	0.020570316139884394	1.726111	14	15	0.001378903	
GO Biological Process	response to arsenic-containing substance	236	6.318817e-10	3.5232759704661024e-8	2.195606	77	0.004587156	672	0.0052216341474702384	1.594314	25	29	0.002462326	
GO Biological Process	positive regulation of histone deacetylation	237	6.585096e-10	3.656256466835443e-8	2.308106	69	0.004110568	1029	0.04178460776579203	1.631827	15	17	0.001477396	
GO Biological Process	apoptotic nuclear changes	398	2.39647e-7	0.000007923404203517587	2.282493	49	0.002919099	744	0.010014214779301076	1.618229	21	24	0.002068354	
GO Biological Process	cellular component disassembly involved in execution phase of apoptosis	412	3.453233e-7	0.000011029391516262135	2.232072	50	0.002978673	833	0.017245177543817526	1.56488	22	26	0.002166847	
GO Biological Process	anterograde synaptic vesicle transport	584	0.000007600915	0.0001712678775428082	2.396681	33	0.001965924	1029	0.04178460776579203	1.631827	15	17	0.001477396	
GO Biological Process	polyamine biosynthetic process	788	0.000059625	0.000995692100253807	2.365315	27	0.001608483	1077	0.04957228667595172	1.707142	12	13	0.001181917	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	908	0.0001895435	0.0027469195115638768	2.237372	26	0.00154891	865	0.020570316139884394	1.726111	14	15	0.001378903	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	1004	0.0003400583	0.004456999173007968	2.189187	25	0.001489336	691	0.006409110945586108	1.849404	13	13	0.00128041	
GO Biological Process	histone H4-K20 methylation	1178	0.0009133929	0.010203172471222412	2.153272	22	0.001310616	1063	0.048831006445907814	1.849404	9	9	0.0008864375	
GO Biological Process	phosphatidylglycerol biosynthetic process	1615	0.005700746	0.04644960781052632	2.031572	17	0.001012749	1063	0.048831006445907814	1.849404	9	9	0.0008864375	
GO Cellular Component	PRC1 complex	21	1.12064e-30	9.221266285714287e-29	7.781637	56	0.003336113	128	0.00840726135	1.849404	12	12	0.001181917	
GO Cellular Component	large ribosomal subunit	27	1.911662e-19	1.22346368e-17	2.090904	185	0.01102109	102	0.0018827474823529412	1.318706	82	115	0.008076431	
GO Cellular Component	nuclear ubiquitin ligase complex	31	5.553576e-19	3.095670750967742e-17	2.950436	93	0.005540331	127	0.008006843111811024	1.479523	32	40	0.003151778	
GO Cellular Component	nuclear transcriptional repressor complex	33	2.684635e-18	1.405772509090909e-16	2.617751	109	0.006493506	142	0.014690397295774647	1.530541	24	29	0.002363833	
GO Cellular Component	PcG protein complex	35	2.986886e-17	1.474668288e-15	2.162158	150	0.008936018	51	0.0000016254659011764706	1.688586	42	46	0.004136708	
GO Cellular Component	mitochondrial large ribosomal subunit	42	5.489098e-14	2.2583717485714288e-12	2.595832	82	0.004885023	157	0.02376241039490446	1.377987	38	51	0.003742736	
GO Cellular Component	NuRD complex	84	1.176087e-8	2.419378971428572e-7	2.360779	56	0.003336113	132	0.010157074036363638	1.733816	15	16	0.001477396	
GO Cellular Component	MLL1 complex	94	1.960573e-7	0.000003604117174468085	2.197269	54	0.003216967	142	0.014690397295774647	1.530541	24	29	0.002363833	
GO Cellular Component	intrinsic component of mitochondrial outer membrane	123	0.000003352138	0.00004709345092682927	2.169777	44	0.002621232	180	0.040671484800000005	1.527769	19	23	0.001871368	
GO Molecular Function	protein phosphatase 2A binding	38	2.91526e-11	3.2390072947368424e-9	2.108872	98	0.005838198	114	0.0046847312	1.643915	24	27	0.002363833	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	84	6.075106e-8	0.000003053463991904762	2.026391	71	0.004229715	129	0.00872732892868217	1.594314	25	29	0.002462326	
GO Molecular Function	phosphatase activator activity	128	0.000002550154	0.00008411523584375001	2.027382	53	0.003157393	147	0.03309556869387755	1.849404	11	11	0.001083424	
GO Molecular Function	U6 snRNA binding	139	0.000005008108	0.0001521167768057554	3.619888	18	0.001072322	147	0.03309556869387755	1.849404	11	11	0.001083424	
Human Phenotype	Increased variability in muscle fiber diameter	56	1.857456e-8	0.000002213357837142857	2.15796	66	0.003931848	321	0.014635851402492213	1.664464	18	20	0.001772875	
Human Phenotype	Upper limb amyotrophy	97	7.260473e-7	0.0000499475632257732	3.044771	27	0.001608483	423	0.03703125347281324	1.717304	13	14	0.00128041	
Human Phenotype	Lipomatous tumor	202	0.00004324838	0.001428695246237624	2.221065	32	0.001906351	423	0.03703125347281324	1.717304	13	14	0.00128041	
Human Phenotype	Hand muscle atrophy	456	0.001274145	0.018645547335526317	2.362904	17	0.001012749	365	0.021066734128767126	1.849404	11	11	0.001083424	
Mouse Phenotype Single KO	vertebral transformation	2	3.083974e-25	1.4119974958999998e-21	2.067116	252	0.01501251	149	0.000006716555024161074	1.487564	74	92	0.007288486	
Mouse Phenotype Single KO	thoracic vertebral transformation	3	4.019798e-25	1.2269763428666666e-21	2.696447	146	0.008697724	217	0.0001816645414516129	1.579699	41	48	0.004038215	
Mouse Phenotype Single KO	lumbar vertebral transformation	8	5.746117e-21	6.5771491711249994e-18	2.891758	107	0.00637436	521	0.02304779990786948	1.460056	30	38	0.002954792	
Mouse Phenotype Single KO	abnormal sternebra number	13	3.229785e-18	2.2750108649999997e-15	4.741313	49	0.002919099	400	0.0077045303955	1.849404	13	13	0.00128041	
Mouse Phenotype Single KO	cervical vertebral transformation	20	3.102773e-15	1.4206046180499999e-12	2.351967	109	0.006493506	254	0.0006724042781889763	1.606061	33	38	0.003250271	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	25	9.399707e-14	3.44292467996e-11	2.063053	130	0.007744549	227	0.00028268352834361234	1.510347	49	60	0.00482616	
Mouse Phenotype Single KO	early cellular replicative senescence	39	4.075465e-12	9.56898282179487e-10	2.051604	114	0.006791374	293	0.0016713259517064847	1.493749	42	52	0.004136708	
Mouse Phenotype Single KO	heterochrony	87	5.228449e-9	5.503092815287356e-7	2.28268	63	0.003753128	427	0.0095146891470726	1.740616	16	17	0.001575889	
Mouse Phenotype Single KO	increased embryonic neuroepithelium apoptosis	115	6.636241e-8	0.0000052841790293043485	2.237991	56	0.003336113	641	0.04667711465366615	1.631827	15	17	0.001477396	
Mouse Phenotype	thoracic vertebral transformation	1	9.597255e-32	9.1759355055e-28	2.77853	178	0.01060407	257	0.000011834516514396889	1.589839	49	57	0.00482616	
Mouse Phenotype	sacral vertebral transformation	3	2.423213e-27	7.722779831e-24	5.153307	70	0.004170142	683	0.005850006338653001	1.67327	19	21	0.001871368	
Mouse Phenotype	early cellular replicative senescence	14	1.020211e-18	6.967312407857143e-16	2.093083	177	0.0105445	267	0.000015025652215730338	1.520058	60	73	0.005909583	
Mouse Phenotype	abnormal sternebra number	16	3.229785e-18	1.9299983990625e-15	4.741313	49	0.002919099	651	0.004942825512442396	1.849404	13	13	0.00128041	
Mouse Phenotype	abnormal rib development	24	5.951315e-16	2.3708551131249997e-13	2.349483	115	0.006850947	606	0.003127552983663366	1.569191	28	33	0.002757806	
Mouse Phenotype	lumbar vertebral transformation	32	2.598135e-14	7.7627402296875e-12	2.069249	135	0.008042416	515	0.001435450667300971	1.502641	39	48	0.003841229	
Mouse Phenotype	enlarged liver sinusoidal spaces	37	1.756813e-13	4.5396997548648645e-11	2.001957	137	0.008161563	1017	0.03517378145722713	1.39833	31	41	0.003053285	
Mouse Phenotype	cervical vertebral transformation	46	1.794423e-12	3.7296691963043476e-10	2.010423	124	0.007387108	315	0.00004866336533333333	1.634357	38	43	0.003742736	
Mouse Phenotype	absent uterus	58	2.171064e-11	3.5788867075862066e-9	2.999583	51	0.003038246	1030	0.03661610515339806	1.849404	9	9	0.0008864375	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	80	2.796152e-10	3.341751159e-8	2.279402	74	0.004408436	658	0.0050148694613981765	1.627476	22	25	0.002166847	
Mouse Phenotype	heterochrony	105	5.228449e-9	4.7608762751428573e-7	2.28268	63	0.003753128	691	0.0061389562133140375	1.740616	16	17	0.001575889	
Mouse Phenotype	increased leiomyosarcoma incidence	180	8.365202e-7	0.00004443316462333333	3.496942	22	0.001310616	1030	0.03661610515339806	1.849404	9	9	0.0008864375	
Mouse Phenotype	decreased cellular sensitivity to ultraviolet irradiation	188	9.650444e-7	0.00004907866759787234	2.488082	37	0.002204218	849	0.015227542307420494	1.726111	14	15	0.001378903	
Mouse Phenotype	reduced sympathetic cervical ganglion size	421	0.0001620498	0.003680185600475059	2.15085	29	0.00172763	1045	0.03712092559808612	1.707142	12	13	0.001181917