# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of gene expression, epigenetic	1	2.228963e-40	2.9330924117e-36	2.380185	300	0.03645643	117	7.3790363411965825e-9	1.576162	136	248	0.02081739	
GO Biological Process	negative regulation of gene expression, epigenetic	3	3.578351e-36	1.5695840269666668e-32	3.388616	151	0.01834974	293	0.001385238498634812	1.537937	61	114	0.009337211	
GO Biological Process	chromatin silencing	8	2.057961e-31	3.385088599875e-28	3.812507	112	0.0136104	467	0.014126276668736617	1.481535	50	97	0.007653452	
GO Biological Process	gene silencing	14	4.024283e-28	3.782538571214285e-25	2.422072	199	0.02418277	190	0.000035685109485789475	1.516927	95	180	0.01454156	
GO Biological Process	RNA catabolic process	28	8.454398e-23	3.973265117214286e-20	2.026907	235	0.02855754	101	2.178643126138614e-10	1.633868	137	241	0.02097046	
GO Biological Process	mRNA catabolic process	29	6.69356e-22	3.037260553103448e-19	2.094392	208	0.02527646	112	1.6102727045535715e-9	1.646242	122	213	0.01867442	
GO Biological Process	nuclear-transcribed mRNA catabolic process	35	1.397358e-20	5.2536668348571425e-18	2.11568	190	0.02308908	119	1.1532757701680672e-8	1.640313	113	198	0.0172968	
GO Biological Process	positive regulation of gene expression, epigenetic	36	1.47468e-20	5.390365033333333e-18	3.074769	95	0.01154454	444	0.011335583450900901	1.54487	43	80	0.006581968	
GO Biological Process	ribonucleoprotein complex export from nucleus	49	1.179989e-17	3.1688725002040816e-15	2.388053	124	0.01506866	258	0.0006092045756589148	1.540559	67	125	0.01025563	
GO Biological Process	ribonucleoprotein complex localization	51	2.848013e-17	7.348431973921568e-15	2.340762	126	0.0153117	251	0.0005669085934661355	1.53893	68	127	0.01040869	
GO Biological Process	regulation of gene silencing	54	1.259604e-16	3.06946834e-14	2.170329	142	0.01725605	432	0.009926918099074075	1.426118	65	131	0.009949487	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	58	2.90146e-16	6.582812437931034e-14	2.435361	109	0.01324584	212	0.00012480293539622643	1.607591	66	118	0.01010256	
GO Biological Process	multi-organism metabolic process	64	6.788785e-16	1.395837840859375e-13	2.143301	139	0.01689148	244	0.0004610875309467214	1.505521	77	147	0.01178632	
GO Biological Process	viral gene expression	69	9.873801e-16	1.8830340196956524e-13	2.327035	115	0.01397497	280	0.0011127217502499998	1.516298	67	127	0.01025563	
GO Biological Process	regulation of megakaryocyte differentiation	76	6.127734e-15	1.060984890868421e-12	2.388484	103	0.01251671	223	0.00023726160873542598	1.739634	46	76	0.007041176	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	78	7.020111e-15	1.1843287262692308e-12	2.182212	124	0.01506866	409	0.006946903140831296	1.475241	58	113	0.008878004	
GO Biological Process	mRNA export from nucleus	80	1.036368e-14	1.704695814e-12	2.356538	104	0.01263823	321	0.0018850784021495327	1.545548	57	106	0.008724935	
GO Biological Process	viral transcription	87	4.102678e-14	6.205418368045978e-12	2.292909	105	0.01275975	275	0.0010353065756727273	1.551547	61	113	0.009337211	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	88	4.712652e-14	7.047021325909091e-12	3.669044	49	0.005954551	435	0.010417172609655174	2.035876	17	24	0.002602174	
GO Biological Process	translational initiation	92	8.062048e-14	1.1531357568695653e-11	2.076731	128	0.01555475	185	0.000029308407645405405	1.587832	79	143	0.01209245	
GO Cellular Component	nucleosome	20	6.64592e-31	5.74207488e-29	3.814959	110	0.01336736	63	0.00015505686857142858	1.615014	59	105	0.009031073	
GO Cellular Component	DNA packaging complex	23	2.257474e-27	1.6960500313043478e-25	3.294508	117	0.01421801	69	0.0003762742539130435	1.5654	61	112	0.009337211	
GO Cellular Component	protein-DNA complex	26	4.803679e-22	3.192598966153846e-20	2.092136	210	0.0255195	53	0.000005537535758490565	1.508232	106	202	0.01622532	
GO Cellular Component	ficolin-1-rich granule lumen	38	1.084919e-16	4.9335264e-15	2.248123	132	0.01604083	129	0.016166511627906978	1.390731	60	124	0.009184142	
GO Cellular Component	nuclear chromosome, telomeric region	41	8.364237e-16	3.525219886829268e-14	2.276335	121	0.0147041	151	0.02872961356291391	1.349992	62	132	0.00949028	
GO Cellular Component	chromosome, telomeric region	42	9.099667e-15	3.7438629942857144e-13	2.057705	141	0.01713452	123	0.013193576429268293	1.34243	78	167	0.01193938	
GO Cellular Component	PcG protein complex	55	3.626713e-10	1.1394472843636363e-8	2.234652	76	0.00923563	75	0.0005715652608	1.874463	30	46	0.004592071	
GO Cellular Component	intrinsic component of mitochondrial membrane	63	1.460776e-9	4.006699885714286e-8	2.229707	71	0.008628023	77	0.0006404809558441559	1.724506	39	65	0.005969692	
GO Cellular Component	integral component of mitochondrial membrane	67	2.519122e-9	6.497078829850747e-8	2.213631	70	0.008506501	80	0.00107897184	1.706543	38	64	0.005816623	
GO Cellular Component	nuclear pore outer ring	76	1.500326e-8	3.4112675368421046e-7	5.142467	19	0.002308908	169	0.047157753940828405	2.299342	8	10	0.001224552	
GO Cellular Component	small ribosomal subunit	85	3.723098e-8	7.568839228235294e-7	2.157492	63	0.007655851	158	0.029993202227848105	1.477008	37	72	0.005663554	
GO Cellular Component	cytosolic small ribosomal subunit	123	0.000004354253	0.00006117194458536585	2.166971	43	0.005225422	120	0.01208251584	1.698377	26	44	0.003979795	
GO Cellular Component	oxoglutarate dehydrogenase complex	130	0.000007640129	0.00010155494547692307	5.04908	12	0.001458257	140	0.0218617056	2.874177	6	6	0.0009184142	
GO Cellular Component	U2-type prespliceosome	187	0.0002398324	0.002216205279144385	2.75421	17	0.002065865	130	0.016226318769230766	2.155633	12	16	0.001836828	
GO Cellular Component	dihydrolipoyl dehydrogenase complex	201	0.000336119	0.0028896200597014927	2.771565	16	0.001944343	106	0.00833882753207547	2.58676	9	10	0.001377621	
GO Cellular Component	GATOR2 complex	205	0.0003699391	0.0031183159258536585	2.746816	16	0.001944343	142	0.023574093971830985	2.3516	9	11	0.001377621	
GO Cellular Component	CRD-mediated mRNA stability complex	272	0.002583415	0.016412283529411764	2.641676	12	0.001458257	140	0.0218617056	2.874177	6	6	0.0009184142	
GO Cellular Component	Bcl-2 family protein complex	300	0.004560401	0.026267909760000003	2.577311	11	0.001336736	113	0.009418023589380533	2.874177	7	7	0.001071483	
GO Molecular Function	nucleosomal DNA binding	22	1.023306e-11	1.963817241818182e-9	2.735207	61	0.007412808	111	0.02947692758018018	1.687017	27	46	0.004132864	
GO Molecular Function	nucleosome binding	23	1.850971e-11	3.3977389399999997e-9	2.276732	84	0.0102078	66	0.0010332846036363635	1.741926	40	66	0.006122761	
GO Molecular Function	polyubiquitin binding	44	1.2215e-7	0.000011720847727272726	2.29032	51	0.006197594	96	0.021001450620833334	1.724506	27	45	0.004132864	
GO Molecular Function	K63-linked polyubiquitin binding	49	2.5161e-7	0.000021679539183673472	2.76899	34	0.004131729	103	0.027815364003883496	2.052984	15	21	0.002296036	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	105	0.00002179577	0.0008763975327619048	2.154105	37	0.004496294	106	0.02863604559056604	1.883082	19	29	0.002908312	
Human Phenotype	Aplasia cutis congenita	34	2.732441e-9	5.362817292058824e-7	2.750424	46	0.005589987	142	0.03188867863802817	2.052984	15	21	0.002296036	
Human Phenotype	Aplasia/Hypoplasia of the patella	45	9.371684e-8	0.00001389716607377778	2.703467	38	0.004617815	100	0.016169179475	2.235471	14	18	0.002142966	
Human Phenotype	Upper limb amyotrophy	106	0.00005015483	0.003157388496132075	3.450503	15	0.001822822	157	0.044231194191082804	2.258282	11	14	0.001683759	
Human Phenotype	Basal cell carcinoma	109	0.0000529493	0.0032415658614678897	2.338634	28	0.003402601	51	0.0010706405876666667	2.3516	18	22	0.002755243	
Mouse Phenotype Single KO	embryonic lethality between somite formation and embryo turning, complete penetrance	13	3.340011e-14	2.3526523636153846e-11	2.171429	119	0.01446105	59	0.00021627064681355932	1.786651	46	74	0.007041176	
Mouse Phenotype Single KO	absent inner cell mass proliferation	23	2.189291e-10	8.716233776956522e-8	2.548682	60	0.007291287	154	0.03454871287467533	1.768724	24	39	0.003673657	
Mouse Phenotype Single KO	abnormal chromosome number	26	3.210786e-10	1.1308141308461538e-7	2.090215	89	0.01081541	166	0.042725651816265066	1.567733	36	66	0.005510485	
Mouse Phenotype Single KO	abnormal DNA replication	80	0.000001700198	0.000194608913575	2.623168	32	0.003888686	120	0.011351230863333334	2.124392	17	23	0.002602174	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	87	0.000003373691	0.00035509067226436783	2.580427	31	0.003767165	105	0.00594859301447619	2.155633	18	24	0.002755243	
Mouse Phenotype Single KO	increased hemangiosarcoma incidence	115	0.0000258067	0.0020548865382608696	2.189706	35	0.004253251	105	0.00594859301447619	2.155633	18	24	0.002755243	
Mouse Phenotype Single KO	pale placenta	157	0.0001186896	0.006922552020382165	2.453715	23	0.002794993	138	0.021647884541304348	2.431996	11	13	0.001683759	
Mouse Phenotype	early cellular replicative senescence	15	1.18494e-13	7.55280756e-11	2.339834	97	0.01178758	181	0.007792088224309391	1.614264	41	73	0.00627583	
Mouse Phenotype	abnormal cellular replicative senescence	27	1.927206e-11	6.82445058e-9	2.11293	99	0.01203062	284	0.048385830750000004	1.471305	43	84	0.006581968	
Mouse Phenotype	absent inner cell mass proliferation	32	7.24561e-11	2.1648524128125e-8	2.577195	62	0.00753433	228	0.022913531965789477	1.752547	25	41	0.003826726	
Mouse Phenotype	abnormal DNA replication	56	4.97545e-8	0.000008494692401785715	2.616173	42	0.005103901	138	0.0024836221717391303	2.12902	20	27	0.003061381	
Mouse Phenotype	increased number of Howell-Jolly bodies	65	1.332639e-7	0.000019602094583076925	2.902547	33	0.004010208	222	0.019270949182432433	2.299342	12	15	0.001836828	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	93	0.000002539244	0.00026105066541935485	2.450581	35	0.004253251	118	0.0015218381443220337	2.10773	22	30	0.003367519	
Mouse Phenotype	polyploidy	102	0.000004554569	0.00042692386479411767	2.162908	43	0.005225422	164	0.005224662084878049	2.011924	21	30	0.00321445	
Mouse Phenotype	pale placenta	133	0.00001483964	0.0010667804363909774	2.62516	26	0.003159558	222	0.019270949182432433	2.299342	12	15	0.001836828