# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mitochondrial transport	21	2.067912e-15	1.295793048e-12	2.038811	150	0.03134141	179	0.0016740299039664805	1.472784	90	239	0.01874609	
GO Biological Process	regulation of cellular amino acid metabolic process	26	9.951272e-15	5.0364918556923075e-12	3.889867	48	0.01002925	322	0.03453442238695652	1.759977	27	60	0.005623828	
GO Biological Process	nuclear-transcribed mRNA catabolic process	42	3.400874e-13	1.0655262134761905e-10	2.144316	112	0.02340159	209	0.00529775673444976	1.481462	75	198	0.01562175	
GO Biological Process	mRNA catabolic process	43	3.854025e-13	1.179421278488372e-10	2.077544	120	0.02507313	201	0.004570335433930348	1.468943	80	213	0.0166632	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	47	9.89945e-13	2.7716353734042553e-10	3.718936	43	0.008984538	269	0.017686777092565057	2.380645	14	23	0.002916059	
GO Biological Process	spliceosomal snRNP assembly	48	1.19676e-12	3.280867675e-10	4.199612	37	0.007730882	338	0.0404036583372781	1.95553	19	38	0.003957509	
GO Biological Process	RNA 3'-end processing	57	5.390724e-12	1.2445006511578947e-9	2.64928	66	0.01379022	196	0.004238521956530612	1.68139	46	107	0.009581337	
GO Biological Process	viral gene expression	62	7.480873e-12	1.5877549646290322e-9	2.505024	72	0.01504388	188	0.0034110983782978726	1.632175	53	127	0.01103937	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	63	1.264702e-11	2.641621209206349e-9	2.573867	67	0.01399916	282	0.02144927265886525	1.557795	47	118	0.009789627	
GO Biological Process	protein targeting to ER	67	2.279813e-11	4.4776207861194034e-9	2.675387	61	0.01274551	301	0.028652957441860468	1.587658	41	101	0.008539888	
GO Biological Process	cotranslational protein targeting to membrane	68	2.343599e-11	4.535208711911764e-9	2.726312	59	0.01232762	261	0.015719575021839082	1.63626	41	98	0.008539888	
GO Biological Process	negative regulation of G2/M transition of mitotic cell cycle	72	3.205016e-11	5.8576118811111105e-9	2.580933	64	0.01337234	262	0.01569510594389313	1.669891	38	89	0.007915018	
GO Biological Process	mitochondrial translation	73	3.487277e-11	6.286175074383562e-9	2.621821	62	0.01295445	92	0.000011805014707282609	1.937254	53	107	0.01103937	
GO Biological Process	negative regulation of cell cycle G2/M phase transition	75	3.969764e-11	6.9650832634666665e-9	2.545311	65	0.01358128	249	0.01261713986064257	1.676169	39	91	0.008123308	
GO Biological Process	multi-organism metabolic process	77	4.822999e-11	8.242317381948053e-9	2.227009	84	0.01755119	185	0.002525204987027027	1.596351	60	147	0.0124974	
GO Biological Process	positive regulation of endoplasmic reticulum unfolded protein response	86	1.479291e-10	2.263487240581395e-8	3.776201	34	0.007104053	345	0.044815625371014495	2.707657	9	13	0.001874609	
GO Biological Process	viral transcription	88	2.111663e-10	3.1576560701136364e-8	2.440536	65	0.01358128	197	0.00426133641538071	1.661335	48	113	0.009997917	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	97	5.295884e-10	7.184385315051547e-8	2.421886	63	0.01316339	273	0.01893423927252747	1.601672	43	105	0.008956467	
GO Biological Process	mitochondrial translational elongation	99	5.680075e-10	7.549909790404041e-8	2.782056	49	0.01023819	118	0.00007152080429915254	1.978536	43	85	0.008956467	
GO Biological Process	mitochondrial translational termination	106	9.595628e-10	1.1912157438867926e-7	2.736684	49	0.01023819	126	0.00015049363455555556	1.933053	43	87	0.008956467	
GO Cellular Component	ribosomal subunit	33	2.959624e-14	1.5497667490909092e-12	2.367032	99	0.02068533	33	0.000006039956945454546	1.691269	80	185	0.0166632	
GO Cellular Component	spliceosomal complex	34	8.30115e-14	4.218937411764706e-12	2.119914	121	0.02528207	42	0.0002807763428571429	1.57704	75	186	0.01562175	
GO Cellular Component	catalytic step 2 spliceosome	36	1.743971e-12	8.3710608e-11	2.629661	70	0.01462599	48	0.0011980882800000001	1.751829	43	96	0.008956467	
GO Cellular Component	ribosome	38	2.528969e-12	1.1500153768421053e-10	2.016454	120	0.02507313	28	0.000001554889577142857	1.640657	99	236	0.0206207	
GO Cellular Component	mitochondrial ribosome	44	3.939655e-10	1.5472099636363637e-8	2.969672	45	0.009402424	40	0.0002372277456	1.886511	41	85	0.008539888	
GO Cellular Component	large ribosomal subunit	45	1.042634e-9	4.0037145599999997e-8	2.418058	61	0.01274551	43	0.00036698134772093023	1.73447	51	115	0.01062279	
GO Cellular Component	mitochondrial large ribosomal subunit	51	7.676119e-9	2.600849731764706e-7	3.441906	31	0.006477225	54	0.0027788060799999997	1.993874	26	51	0.005415538	
GO Cellular Component	Bcl-2 family protein complex	53	9.529066e-9	3.106835103396227e-7	6.445676	16	0.003343084	88	0.029926623272727274	3.352337	6	7	0.00124974	
GO Cellular Component	PcG protein complex	56	5.243619e-8	0.0000016180310057142859	2.426677	48	0.01002925	57	0.003047064252631579	2.040553	24	46	0.004998959	
GO Cellular Component	methyltransferase complex	59	1.416756e-7	0.000004149414183050848	2.130363	59	0.01232762	82	0.023852384780487807	1.590211	37	91	0.007706728	
GO Cellular Component	small ribosomal subunit	68	0.000001309502	0.00003327675670588235	2.355282	40	0.00835771	93	0.03790975587096774	1.629608	30	72	0.006248698	
GO Cellular Component	U2-type spliceosomal complex	122	0.0002014136	0.0028528090229508196	2.226146	26	0.005432511	86	0.02810963720930233	1.95553	18	36	0.003749219	
GO Molecular Function	structural constituent of ribosome	13	9.187455e-12	2.983802693076923e-9	2.266811	87	0.01817802	22	0.00013808177660000001	1.689964	70	162	0.0145803	
GO Molecular Function	NF-kappaB binding	30	9.371066e-8	0.000013188213550666667	3.297105	28	0.005850397	56	0.02855836192857143	2.234892	16	28	0.003332639	
GO Molecular Function	signal sequence binding	40	0.000001153704	0.00012177345719999999	2.285458	43	0.008984538	59	0.04538262864067796	1.912074	22	45	0.004582379	
GO Molecular Function	cytoskeletal adaptor activity	163	0.001077213	0.0279017993006135	2.670976	14	0.002925198	53	0.012081627403773585	3.199958	9	11	0.001874609	
Human Phenotype	Increased serum lactate	6	4.735009e-15	5.266119176166666e-12	2.88666	74	0.01546176	17	0.001145777259235294	1.838198	47	100	0.009789627	
Human Phenotype	Abnormal CNS myelination	19	1.167788e-9	4.101394381052632e-7	2.133472	79	0.01650648	68	0.02684571451764706	1.564424	50	125	0.0104145	
Human Phenotype	Death in infancy	22	4.436433e-9	0.0000013456507913181818	2.775252	44	0.009193481	48	0.010210030601041666	1.95553	28	56	0.005832118	
Human Phenotype	Lipid accumulation in hepatocytes	71	0.000007029748	0.0006606973014647888	2.04409	47	0.009820309	31	0.004550841777096774	1.90121	35	72	0.007290148	
Human Phenotype	Hepatic steatosis	98	0.00002260851	0.0015394549717346938	2.036535	42	0.008775595	45	0.009064238409333333	1.923472	30	61	0.006248698	
Human Phenotype	Severe muscular hypotonia	116	0.00007171244	0.004125319932068965	2.188253	31	0.006477225	76	0.04444161806315789	2.005672	20	39	0.004165799	
Mouse Phenotype Single KO	absent subcutaneous adipose tissue	75	0.000002439867	0.00029789149491999995	3.164124	23	0.004805683	88	0.011073466448863638	2.675989	13	19	0.002707769	
Mouse Phenotype	increased keratinocyte apoptosis	2	6.377167e-24	3.04860468435e-20	9.639834	37	0.007730882	252	0.044578807488095236	2.707657	9	13	0.001874609	
Mouse Phenotype	abnormal mitochondrial ATP synthesis coupled electron transport	37	5.994949e-10	1.5491272267297297e-7	3.016905	43	0.008984538	139	0.00581935767733813	2.091962	23	43	0.004790669	
Mouse Phenotype	abnormal oxidative phosphorylation	45	2.473219e-9	5.254765968666666e-7	2.756176	46	0.009611366	140	0.005930393957785714	1.993874	26	51	0.005415538	
Mouse Phenotype	abnormal keratinocyte proliferation	64	6.70207e-8	0.0000100122642609375	2.076684	66	0.01379022	126	0.004446373402380952	1.84689	34	72	0.007081858	
Mouse Phenotype	absent subcutaneous adipose tissue	180	0.0001022444	0.005430881713333334	2.478091	23	0.004805683	166	0.013404919415060241	2.542189	13	20	0.002707769	
Mouse Phenotype	ovary hypoplasia	181	0.0001067934	0.005641169598895028	3.384421	14	0.002925198	150	0.00806483098	3.476498	8	9	0.00166632