# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	17	2.56985e-45	1.9892150676470587e-42	2.627749	284	0.01723824	271	0.00014398878854612545	1.375486	87	114	0.008350931	
GO Biological Process	cellular response to topologically incorrect protein	20	3.178307e-42	2.09116709065e-39	2.374964	319	0.01936267	254	0.00008966848261811023	1.348529	104	139	0.009982722	
GO Biological Process	cellular response to unfolded protein	24	3.850554e-40	2.11122667025e-37	2.414455	293	0.01778452	233	0.0000438248070193133	1.385286	93	121	0.008926857	
GO Biological Process	regulation of DNA-templated transcription in response to stress	27	1.615431e-39	7.873132047777778e-37	2.354572	303	0.0183915	682	0.03555870515542522	1.241963	82	119	0.007870993	
GO Biological Process	IRE1-mediated unfolded protein response	28	6.162237e-39	2.8960313101071427e-36	3.416814	162	0.00983308	358	0.001448933079162011	1.460534	47	58	0.004511423	
GO Biological Process	response to topologically incorrect protein	30	7.129348e-39	3.127169677733334e-36	2.109743	378	0.02294385	212	0.000014293026481603772	1.331745	133	180	0.01276637	
GO Biological Process	response to unfolded protein	33	2.556003e-36	1.019225559909091e-33	2.115464	350	0.02124431	196	0.000006080323405663266	1.363036	121	160	0.01161451	
GO Biological Process	liver regeneration	44	7.910144e-33	2.365672384e-30	3.175175	150	0.009104704	431	0.004471553378422273	1.544881	30	35	0.002879631	
GO Biological Process	nuclear-transcribed mRNA catabolic process	45	7.951633e-33	2.3252341921555557e-30	2.00226	360	0.02185129	253	0.00008935767183794466	1.292603	142	198	0.01363026	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	55	6.422533e-30	1.5366202135818182e-27	2.410528	216	0.01311077	386	0.002421491566554404	1.313585	86	118	0.008254943	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	79	6.518555e-26	1.085793230949367e-23	2.163037	233	0.01414264	631	0.02477291234548336	1.284662	67	94	0.006431177	
GO Biological Process	regulation of mitochondrial membrane permeability	105	9.680607e-23	1.213210547742857e-20	2.185005	198	0.01201821	309	0.000668809794789644	1.432013	58	73	0.005567287	
GO Biological Process	response to epidermal growth factor	122	2.429672e-21	2.6206601514754096e-19	2.246033	174	0.01056146	539	0.012044447348237475	1.459054	34	42	0.003263582	
GO Biological Process	cellular response to epidermal growth factor stimulus	131	1.568136e-20	1.5751985972519084e-18	2.270598	163	0.009893778	576	0.015611890144618053	1.470347	31	38	0.002975619	
GO Biological Process	translational elongation	133	3.692344e-20	3.653199601203007e-18	2.111385	188	0.01141123	509	0.009612995925540276	1.287401	80	112	0.007679017	
GO Biological Process	cotranslational protein targeting to membrane	148	4.567866e-19	4.061388425270271e-17	2.188056	163	0.009893778	515	0.01015695173262136	1.305792	71	98	0.006815128	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	154	9.620396e-19	8.220440971688311e-17	2.169905	163	0.009893778	644	0.02885517371273292	1.474659	27	33	0.002591668	
GO Biological Process	viral gene expression	155	9.635682e-19	8.180383189548386e-17	2.001207	198	0.01201821	679	0.03481611708394698	1.234688	87	127	0.008350931	
GO Biological Process	mitochondrial genome maintenance	173	2.186368e-17	1.663029856184971e-15	3.136109	77	0.004673748	572	0.014843869618006992	1.630708	19	21	0.001823767	
GO Biological Process	mitochondrial transmembrane transport	182	3.945e-17	2.8523217032967032e-15	2.095952	160	0.009711684	632	0.02496578782278481	1.302912	60	83	0.005759263	
GO Cellular Component	DNA-directed RNA polymerase III complex	66	2.378054e-14	6.226177745454546e-13	4.466605	40	0.002427921	119	0.025156833882352944	1.612639	17	19	0.001631791	
GO Molecular Function	unfolded protein binding	9	1.329681e-26	6.2376813133333336e-24	2.402004	192	0.01165402	121	0.030696110317355373	1.275256	75	106	0.007199079	
GO Molecular Function	RNA polymerase III activity	36	3.128158e-13	3.668634187777778e-11	4.409447	37	0.002245827	129	0.036381203100775195	1.689714	15	16	0.001439816	
GO Molecular Function	5'-3' RNA polymerase activity	54	5.003336e-11	3.9118675170370376e-9	2.356729	75	0.004552352	103	0.021303978355339804	1.441889	36	45	0.003455558	
GO Molecular Function	DNA-directed 5'-3' RNA polymerase activity	56	7.082755e-11	5.339891358928571e-9	2.369496	73	0.004430956	126	0.03686050607936508	1.425123	34	43	0.003263582	
GO Molecular Function	S-acyltransferase activity	93	1.253403e-8	5.690180070967741e-7	2.196282	65	0.003945372	98	0.012407359418367347	1.562046	26	30	0.002495681	
GO Molecular Function	thyroid hormone receptor binding	103	3.040306e-8	0.000001246230284660194	2.172277	63	0.003823976	114	0.026344365233333333	1.544881	24	28	0.002303705	
GO Molecular Function	5S rRNA binding	541	0.001536389	0.011990081992606285	2.320577	17	0.001031866	140	0.0461432935	1.802361	11	11	0.001055865	
Human Phenotype	Abnormal CSF metabolite level	60	5.950245e-12	6.6176641475e-10	2.12621	103	0.006251897	119	0.010767973367226891	1.401837	49	63	0.004703398	
Human Phenotype	Increased CSF lactate	109	6.678991e-10	4.0888905452293574e-8	2.051491	90	0.005462822	183	0.038335145207650266	1.367309	44	58	0.004223459	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	23	1.461759e-26	5.8197074621739135e-24	2.083681	261	0.01584219	252	0.026938313327380954	1.298475	67	93	0.006431177	
Mouse Phenotype Single KO	increased hepatocyte apoptosis	124	7.331926e-14	5.414390837258065e-12	2.097591	126	0.007647951	309	0.04705548188996763	1.416141	33	42	0.003167595	
Mouse Phenotype Single KO	decreased bone ossification	187	5.139003e-12	2.5164625920320855e-10	2.050851	113	0.006858877	188	0.010509313553191488	1.602099	24	27	0.002303705	
Mouse Phenotype Single KO	abnormal rostral-caudal body axis extension	193	7.669498e-12	3.638839025181347e-10	2.475291	74	0.004491654	227	0.018981690521145376	1.802361	13	13	0.00124784	
Mouse Phenotype Single KO	abnormal pancreatic islet number	581	0.000007776084	0.00012255697278485368	2.039318	47	0.002852807	298	0.04375933639597315	1.567271	20	23	0.001919754	
Mouse Phenotype	extramedullary hematopoiesis	5	7.096942e-52	1.3570772492400002e-48	2.079654	526	0.03192716	294	0.004581143393877551	1.246204	121	175	0.01161451	
Mouse Phenotype	decreased circulating free fatty acid level	35	1.641665e-31	4.484559732857143e-29	2.016013	339	0.02057663	216	0.0010322821365277778	1.332839	88	119	0.008446919	
Mouse Phenotype	spleen atrophy	356	1.541302e-9	4.1394349500000004e-8	2.062003	85	0.005159332	513	0.032086529625731	1.525075	22	26	0.00211173	
Mouse Phenotype	increased liver adenoma incidence	522	1.900369e-7	0.000003480733335057471	2.086217	61	0.00370258	582	0.048329162932989694	1.480511	23	28	0.002207717