# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	negative regulation of gene expression, epigenetic	3	1.304829e-56	5.7234149369999995e-53	4.853227	158	0.02628077	126	9.623727080396827e-9	2.026151	65	114	0.01230129	
GO Biological Process	chromatin silencing	5	1.644011e-55	4.326708149800001e-52	5.963905	128	0.02129075	170	0.0000027680459638235295	1.941635	53	97	0.01003028	
GO Biological Process	regulation of gene expression, epigenetic	7	3.829693e-54	7.199275741e-51	2.975555	274	0.04557552	104	1.0939081761153846e-9	1.719464	120	248	0.02271007	
GO Biological Process	nucleosome organization	16	1.583111e-45	1.3020098530625e-42	3.228368	204	0.03393214	116	3.7062051244827584e-9	1.849513	89	171	0.0168433	
GO Biological Process	gene silencing	17	1.597867e-45	1.2368430501764706e-42	3.298582	198	0.03293413	145	3.635796306827586e-8	1.776779	90	180	0.01703255	
GO Biological Process	chromosome organization	18	1.611792e-45	1.178309496e-42	2.002538	488	0.08117099	80	7.608913766125e-11	1.487822	242	578	0.04579864	
GO Biological Process	chromatin assembly or disassembly	19	3.076984e-45	2.131054339789474e-42	3.137894	211	0.03509647	124	7.426701889032259e-9	1.816707	91	178	0.0172218	
GO Biological Process	viral gene expression	20	5.236846e-44	3.4455828257e-41	4.071463	147	0.0244511	69	1.4441495211014493e-11	2.126539	76	127	0.01438304	
GO Biological Process	mRNA catabolic process	21	6.889835e-44	4.3173018459523815e-41	3.004548	218	0.03626081	71	2.0824784716901408e-11	1.851854	111	213	0.02100681	
GO Biological Process	RNA catabolic process	24	3.372413e-43	1.8490659444583335e-40	2.809772	238	0.03958749	62	3.0271685222580646e-12	1.828387	124	241	0.02346707	
GO Biological Process	ncRNA processing	27	3.76437e-42	1.8346424011111113e-39	2.3961	307	0.05106454	91	2.885602404945055e-10	1.579359	176	396	0.0333081	
GO Biological Process	ribonucleoprotein complex biogenesis	28	5.993277e-42	2.8166261443928573e-39	2.178412	371	0.06170991	45	5.143344285333333e-14	1.635889	209	454	0.03955337	
GO Biological Process	viral life cycle	29	7.530657e-42	3.4171005332068965e-39	2.455292	291	0.04840319	99	8.271194456161617e-10	1.657532	139	298	0.02630583	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	30	8.777121e-42	3.8499378413000006e-39	4.159143	136	0.02262142	120	6.725093369166666e-9	2.017698	67	118	0.01267979	
GO Biological Process	DNA replication-dependent nucleosome assembly	32	9.169185e-41	3.77054079421875e-38	18.73587	45	0.00748503	386	0.02636538262720207	1.998876	18	32	0.00340651	
GO Biological Process	viral transcription	33	9.442808e-41	3.765391226424243e-38	4.065037	136	0.02262142	66	1.270289310969697e-11	2.201319	70	113	0.01324754	
GO Biological Process	ncRNA metabolic process	34	9.500673e-41	3.6770398825588236e-38	2.109185	387	0.06437126	123	7.322328759512196e-9	1.447034	226	555	0.04277063	
GO Biological Process	chromatin assembly	35	2.166623e-40	8.145883444857144e-38	3.146885	187	0.03110446	151	5.5896242467549664e-8	1.821761	81	158	0.0153293	
GO Biological Process	nuclear-transcribed mRNA catabolic process	36	9.797769e-40	3.5813567297500006e-37	3.002553	197	0.0327678	85	1.531900340647059e-10	1.848568	103	198	0.01949281	
GO Biological Process	translation	38	1.160615e-38	4.019087575e-36	2.302971	304	0.05056554	82	9.179391029756098e-11	1.614385	169	372	0.03198335	
GO Cellular Component	nucleosome	19	1.163973e-63	1.0586028126315789e-61	6.50348	137	0.02278776	23	1.7645577182608694e-14	2.369039	70	105	0.01324754	
GO Cellular Component	DNA packaging complex	20	8.506067e-55	7.349241888e-53	5.35732	139	0.02312043	24	1.1913012e-13	2.28443	72	112	0.01362604	
GO Cellular Component	nuclear nucleosome	25	1.903122e-45	1.3154379264e-43	11.27631	66	0.01097804	63	0.00016621818514285714	2.220974	25	40	0.004731264	
GO Cellular Component	protein-DNA complex	29	1.877049e-38	1.1184623006896553e-36	2.836364	208	0.03459747	25	5.8696088832e-13	1.917514	109	202	0.02062831	
GO Cellular Component	ribosomal subunit	30	9.510348e-38	5.477960448e-36	3.216691	169	0.02811045	40	2.29346424e-9	1.805592	94	185	0.01778955	
GO Cellular Component	ribosome	35	5.354635e-32	2.6436597942857145e-30	2.621904	196	0.03260146	39	5.856258461538461e-10	1.731607	115	236	0.02176382	
GO Cellular Component	chromosome, telomeric region	37	4.311077e-28	2.0133894745945945e-26	2.89641	145	0.02411843	82	0.0018249441717073172	1.489515	70	167	0.01324754	
GO Cellular Component	nuclear chromosome, telomeric region	42	2.762281e-25	1.1364813257142857e-23	3.064261	119	0.01979375	111	0.01627214010810811	1.453728	54	132	0.01021953	
GO Cellular Component	cytosolic ribosome	43	4.528469e-25	1.8198126586046514e-23	2.995699	122	0.02029275	43	4.534923013953488e-9	2.030605	64	112	0.01211204	
GO Cellular Component	vesicle coat	47	5.512131e-23	2.0265877378723404e-21	3.539287	88	0.01463739	115	0.018681212660869567	1.74194	25	51	0.004731264	
GO Cellular Component	melanosome	53	2.52931e-21	8.246505056603773e-20	2.539786	135	0.02245509	76	0.0009026805978947369	1.658327	49	105	0.009273278	
GO Cellular Component	large ribosomal subunit	54	7.197598e-21	2.30323136e-19	3.060993	97	0.0161344	57	0.00006866053389473683	1.730428	56	115	0.01059803	
GO Cellular Component	intrinsic component of endoplasmic reticulum membrane	55	5.128481e-20	1.611275485090909e-18	2.458109	134	0.02228876	125	0.026682324480000002	1.411342	56	141	0.01059803	
GO Cellular Component	integral component of endoplasmic reticulum membrane	58	2.531345e-18	7.541662344827587e-17	2.394978	128	0.02129075	137	0.0351714345109489	1.400672	54	137	0.01021953	
GO Cellular Component	cytosolic part	61	3.012018e-18	8.53240508852459e-17	2.026337	184	0.03060546	50	0.000020224435968	1.525069	103	240	0.01949281	
GO Cellular Component	small ribosomal subunit	62	4.982592e-18	1.388696609032258e-16	3.374964	72	0.01197605	66	0.00023410485818181818	1.875489	38	72	0.007191522	
GO Cellular Component	cytosolic large ribosomal subunit	67	1.157517e-16	2.9853572776119403e-15	3.338435	67	0.01114438	56	0.00004929749485714286	2.038927	35	61	0.00662377	
GO Cellular Component	myelin sheath	68	3.189094e-16	8.104050635294118e-15	2.056884	156	0.0259481	70	0.00032690476800000006	1.557424	71	162	0.01343679	
GO Cellular Component	methyltransferase complex	70	3.519928e-15	8.689193691428571e-14	2.587009	90	0.01497006	61	0.0001413688131147541	1.796304	46	91	0.008705526	
GO Cellular Component	cytosolic small ribosomal subunit	71	5.047295e-15	1.2284120788732392e-13	3.655852	53	0.008815702	59	0.00012531997830508474	2.180592	27	44	0.005109765	
GO Molecular Function	unfolded protein binding	7	2.043426e-40	1.2324777960000002e-37	4.31966	126	0.02095808	84	0.02693818953333333	1.54211	46	106	0.008705526	
GO Molecular Function	structural constituent of ribosome	8	1.170568e-31	6.17767262e-29	3.090552	149	0.02478377	17	1.0228045836470588e-7	1.82065	83	162	0.0157078	
GO Molecular Function	nucleosomal DNA binding	9	9.583224e-30	4.4955968586666665e-27	4.909965	80	0.01330672	68	0.003076696818235294	2.008533	26	46	0.004920515	
GO Molecular Function	nucleosome binding	10	3.754866e-29	1.5853044252e-26	3.821184	103	0.0171324	46	0.0005233416813043479	1.938304	36	66	0.00681302	
GO Molecular Function	chromatin DNA binding	16	1.759243e-18	4.642202466250001e-16	2.489121	120	0.01996008	55	0.0009312726396363636	1.708441	50	104	0.009462528	
GO Molecular Function	ribonucleoprotein complex binding	19	1.00482e-16	2.2328158105263158e-14	2.590083	100	0.0166334	87	0.029034509590804596	1.514125	49	115	0.009273278	
GO Molecular Function	protein binding involved in protein folding	21	1.575195e-15	3.1668920428571427e-13	4.740454	41	0.006819694	88	0.03340940565909091	2.105812	16	27	0.003028009	
GO Molecular Function	rRNA binding	23	2.870951e-15	5.270067444347826e-13	4.028479	48	0.007984032	78	0.014760869794871794	1.776779	30	60	0.005677517	
GO Molecular Function	structure-specific DNA binding	24	4.697805e-15	8.264221962499999e-13	2.048831	145	0.02411843	36	0.00025618005316666666	1.661736	65	139	0.01230129	
Mouse Phenotype Single KO	abnormal platelet activation	8	3.736841e-19	4.277281629625e-16	2.628983	113	0.01879574	82	0.007261017465731707	1.714069	41	85	0.007759273	
Mouse Phenotype Single KO	abnormal platelet aggregation	9	1.275812e-18	1.2980678315555556e-15	2.636898	109	0.01813041	68	0.0047434862475	1.776779	39	78	0.007380772	
Mouse Phenotype Single KO	increased integument system tumor incidence	10	2.540953e-17	2.3267506621e-14	2.899701	86	0.01430472	130	0.019640257616923076	1.683264	36	76	0.00681302	
Mouse Phenotype Single KO	abnormal erythropoiesis	11	3.9411e-17	3.280786609090909e-14	2.115194	155	0.02578177	49	0.0011615052754285716	1.712169	53	110	0.01003028	
Mouse Phenotype Single KO	decreased erythroid progenitor cell number	18	2.151272e-14	1.0943998724444445e-11	2.407725	97	0.0161344	60	0.0024014644564999995	2.020651	29	51	0.005488266	
Mouse Phenotype Single KO	abnormal embryonic erythropoiesis	45	2.589328e-11	5.268994776888889e-9	2.941788	52	0.008649368	112	0.011555553511607143	2.205657	18	29	0.00340651	
Mouse Phenotype Single KO	abnormal embryonic erythrocyte morphology	54	1.017748e-10	1.7258367474074076e-8	2.733189	55	0.00914837	90	0.008178323241222222	2.132135	21	35	0.003974262	
Mouse Phenotype Single KO	microcytic anemia	75	8.954851e-10	1.0933276080933332e-7	3.439564	35	0.00582169	105	0.00959498367047619	2.42288	15	22	0.002838759	
Mouse Phenotype Single KO	decreased platelet aggregation	90	2.962072e-9	3.0137437004444443e-7	2.279793	65	0.01081171	160	0.040184418552500004	1.717553	29	60	0.005488266	
Mouse Phenotype Single KO	decreased mean corpuscular hemoglobin	93	3.565165e-9	3.5103457962365593e-7	2.178343	71	0.01180971	173	0.04969627757687862	1.648027	32	69	0.006056018	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	102	7.490532e-9	6.724588384705883e-7	2.013177	82	0.01363939	109	0.010865948227522935	1.877351	28	53	0.005299016	
Mouse Phenotype Single KO	pancytopenia	219	0.0000214592	0.0008972689242009132	2.755347	23	0.003825682	169	0.046839978511834315	2.443071	11	16	0.002081756	
Mouse Phenotype	abnormal platelet activation	13	1.535465e-18	1.129275451153846e-15	2.528076	117	0.01946108	229	0.020445125496943235	1.563565	44	100	0.008327025	
Mouse Phenotype	abnormal platelet aggregation	15	1.76528e-17	1.1251894719999999e-14	2.487981	113	0.01879574	224	0.018785495483035715	1.58776	42	94	0.007948524	
Mouse Phenotype	decreased erythroid progenitor cell number	24	2.0216e-15	8.053549e-13	2.243906	121	0.02012641	133	0.0011724244542857143	1.823536	39	76	0.007380772	
Mouse Phenotype	abnormal platelet physiology	29	2.605929e-14	8.591478334137931e-12	2.036954	139	0.02312043	238	0.022468635223109247	1.480649	55	132	0.01040878	
Mouse Phenotype	microcytic anemia	34	2.399546e-13	6.747664501764706e-11	3.746166	45	0.00748503	145	0.0020319907580689653	2.328193	19	29	0.003595761	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	69	4.319213e-10	5.984926883043478e-8	2.522997	59	0.009813706	126	0.0010349888733333333	2.186805	24	39	0.004542014	
Mouse Phenotype	abnormal embryonic erythropoiesis	81	8.074486e-10	9.530884030370371e-8	2.6301	53	0.008815702	178	0.0063205891028089885	2.177987	19	31	0.003595761	
Mouse Phenotype	decreased mean corpuscular hemoglobin	100	3.942244e-9	3.7691794884e-7	2.043626	82	0.01363939	190	0.008055932540526316	1.707554	37	77	0.007002271	
Mouse Phenotype	pancytopenia	207	0.000003506058	0.00016193922965217393	2.378319	36	0.005988024	145	0.0020319907580689653	2.328193	19	29	0.003595761	
Mouse Phenotype	absent inner cell mass proliferation	257	0.00001562684	0.0005813549308949416	2.162057	38	0.006320692	296	0.04795338930405406	1.820115	21	41	0.003974262