# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of immune response 4 6.325724e-204 2.0810050529e-200 2.055635 2040 0.1398314 90 2.388057305111111e-12 1.294365 491 914 0.06300526 GO Biological Process positive regulation of immune response 13 1.325901e-136 1.3421177891538461e-133 2.077884 1367 0.09370073 229 5.837274937117905e-8 1.292094 318 593 0.04080585 GO Biological Process lymphocyte activation 19 5.130975e-127 3.5536052644736847e-124 2.205659 1119 0.07670162 251 3.831675366932271e-7 1.363982 197 348 0.0252791 GO Biological Process regulation of lymphocyte activation 29 5.989865e-119 2.7179528805172417e-116 2.053315 1230 0.0843101 94 2.6152700561702125e-12 1.451706 241 400 0.03092519 GO Biological Process innate immune response 31 6.563266e-117 2.7860005578709675e-114 2.117401 1128 0.07731853 882 0.027459834180272112 1.137699 297 629 0.03811113 GO Biological Process adaptive immune response 37 8.216093e-114 2.9220423726216217e-111 2.563271 752 0.05154569 348 0.00005621210950287356 1.344611 149 267 0.01911972 GO Biological Process regulation of immune effector process 45 1.171405e-107 3.4254485322222225e-105 2.295351 877 0.06011378 444 0.0004032077641891892 1.264639 190 362 0.02438085 GO Biological Process positive regulation of cytokine production 49 7.137662e-105 1.9168264134285713e-102 2.112637 1020 0.06991569 154 1.4633380501948054e-10 1.42321 228 386 0.02925703 GO Biological Process cytokine-mediated signaling pathway 52 2.90825e-104 7.35955033653846e-102 2.03092 1111 0.07615327 209 6.131878041291867e-9 1.324323 299 544 0.03836777 GO Biological Process leukocyte differentiation 56 2.028894e-101 4.7675385975e-99 2.118532 981 0.06724244 304 0.000007642426882236842 1.352825 169 301 0.02168613 GO Biological Process immune response-activating signal transduction 58 3.913137e-101 8.878098238448275e-99 2.13055 966 0.06621427 295 0.0000045475139840677965 1.31827 209 382 0.02681894 GO Biological Process activation of immune response 63 9.139654e-98 1.909027095015873e-95 2.052329 1018 0.0697786 322 0.00001539589514068323 1.281053 235 442 0.03015527 GO Biological Process immune response-regulating signaling pathway 64 5.343036e-97 1.0985782925625001e-94 2.027301 1040 0.07128659 232 6.937838854741379e-8 1.350234 232 414 0.02977031 GO Biological Process leukocyte cell-cell adhesion 77 7.415856e-91 1.2673408974545455e-88 2.181876 825 0.05654946 327 0.000018467235971865445 1.367537 147 259 0.01886308 GO Biological Process regulation of innate immune response 79 7.771008e-90 1.294413851544304e-87 2.078209 910 0.06237576 305 0.000008422942152786885 1.297407 224 416 0.02874374 GO Biological Process positive regulation of cell activation 80 8.040956e-90 1.32263675005e-87 2.059739 929 0.06367811 73 4.249596301643836e-13 1.537622 194 304 0.02489414 GO Biological Process regulation of leukocyte cell-cell adhesion 85 1.799838e-88 2.786360969647059e-86 2.004362 977 0.06696826 85 2.050667597647059e-12 1.506851 202 323 0.0259207 GO Biological Process leukocyte aggregation 96 2.847343e-86 3.9029360976041663e-84 2.218801 756 0.05181986 347 0.000056235157149855906 1.373821 130 228 0.01668164 GO Biological Process regulation of T cell activation 97 3.444971e-86 4.673440555567011e-84 2.04151 911 0.06244431 89 2.360637366179775e-12 1.517653 194 308 0.02489414 GO Biological Process lymphocyte differentiation 98 3.8328e-86 5.146511755102041e-84 2.187854 778 0.05332785 418 0.000177212253 1.358065 124 220 0.01591172 GO Cellular Component ribosomal subunit 30 2.889341e-60 1.664260416e-58 2.753107 351 0.02405922 27 1.1207936e-10 1.614996 124 185 0.01591172 GO Cellular Component nucleosome 31 2.480049e-59 1.382427313548387e-57 4.01026 205 0.01405168 44 6.546233454545454e-8 1.698103 74 105 0.009495701 GO Cellular Component nuclear nucleosome 35 1.591089e-50 7.85543369142857e-49 7.111121 101 0.006923024 116 0.011834158841379313 1.626392 27 40 0.003464648 GO Cellular Component DNA packaging complex 36 1.601914e-49 7.6891872e-48 3.367147 212 0.0145315 42 1.8200925257142856e-8 1.699537 79 112 0.0101373 GO Cellular Component protein-DNA complex 40 9.352819e-46 4.040417808e-44 2.225294 396 0.02714374 30 3.256922304e-10 1.574505 132 202 0.01693828 GO Cellular Component MHC protein complex 41 2.11697e-45 8.922254048780488e-44 9.221572 75 0.00514086 87 0.001630526896551724 2.04805 17 20 0.002181445 GO Cellular Component large ribosomal subunit 45 1.439054e-42 5.52596736e-41 2.912943 224 0.01535403 45 1.230645888e-7 1.655201 79 115 0.0101373 GO Cellular Component ribosome 46 7.340395e-42 2.7574353391304347e-40 2.149902 390 0.02673247 41 1.819283496585366e-8 1.480395 145 236 0.01860644 GO Cellular Component MHC class II protein complex 48 2.593174e-41 9.3354264e-40 13.05572 55 0.003769964 133 0.036380363548872176 1.927576 12 15 0.001539843 GO Cellular Component cytosolic ribosome 53 4.710741e-40 1.535879329811321e-38 2.59043 256 0.01754747 21 5.106009600000001e-16 1.957694 91 112 0.01167715 GO Cellular Component extrinsic component of cytoplasmic side of plasma membrane 61 1.784532e-32 5.055198845901639e-31 2.127009 307 0.02104325 79 0.000989488453670886 1.458945 66 109 0.008469139 GO Cellular Component cytosolic large ribosomal subunit 62 5.53518e-32 1.5427082322580646e-30 3.100548 151 0.01035026 25 1.6878322944e-12 2.132973 54 61 0.006929296 GO Cellular Component uropod 78 2.773377e-23 6.144096738461539e-22 5.238442 58 0.003975598 127 0.02562327382677165 2.038782 11 13 0.001411523 GO Cellular Component small ribosomal subunit 89 4.584074e-20 8.900314462921349e-19 2.511155 130 0.008910823 90 0.00197694912 1.539384 46 72 0.005902733 GO Cellular Component nuclear chromosome, telomeric region 96 5.246902e-19 9.444423600000001e-18 2.037387 192 0.0131606 134 0.03673519092537313 1.296003 71 132 0.00911074 GO Cellular Component cytosolic small ribosomal subunit 104 2.0362e-17 3.383224615384616e-16 2.728836 96 0.0065803 62 0.00004068553703225806 1.861863 34 44 0.00436289 GO Cellular Component I-kappaB/NF-kappaB complex 140 4.524306e-13 5.584286262857143e-12 5.011589 32 0.002193433 131 0.027934241221374046 2.40947 7 7 0.000898242 GO Cellular Component nuclear inclusion body 161 1.677841e-11 1.8008131975155279e-10 2.785877 58 0.003975598 127 0.02562327382677165 2.038782 11 13 0.001411523 GO Cellular Component eukaryotic translation initiation factor 4F complex 296 0.00000548711 0.00003203285837837838 3.102278 22 0.001507985 103 0.006112776512621358 2.40947 9 9 0.001154883 GO Cellular Component methylosome 483 0.00849611 0.030396020869565214 2.177053 13 0.0008910823 139 0.04826755269064748 2.007892 10 12 0.001283203 GO Molecular Function antigen binding 10 3.587098e-44 1.5144727756e-41 3.439607 183 0.0125437 84 0.004156126245 1.581215 42 64 0.005389452 GO Molecular Function non-membrane spanning protein tyrosine kinase activity 13 6.944541e-40 2.2553732386153847e-37 2.864307 215 0.01473713 46 0.00003631570738695652 1.842536 39 51 0.005004491 GO Molecular Function chemokine receptor activity 14 2.219539e-39 6.69349547e-37 4.995706 106 0.007265748 121 0.03870185276033058 1.760767 19 26 0.002438085 GO Molecular Function structural constituent of ribosome 15 4.490217e-37 1.2638464116e-34 2.376228 278 0.01905545 10 3.7349610572e-9 1.63606 110 162 0.01411523 GO Molecular Function C-C chemokine binding 17 3.56599e-36 8.856241047058823e-34 8.048819 65 0.004455412 104 0.014791659271153845 2.40947 9 9 0.001154883 GO Molecular Function cytokine receptor activity 18 3.941136e-35 9.244153440000001e-33 2.408005 256 0.01754747 58 0.0002645358157931034 1.571394 60 92 0.007699217 GO Molecular Function MHC class II protein complex binding 28 9.43339e-31 1.4224204492857143e-28 6.214055 67 0.004592501 131 0.04551499705343511 1.957694 13 16 0.001668164 GO Molecular Function chemokine binding 30 2.070903e-30 2.914450822e-28 3.827232 108 0.007402838 117 0.032759659952136755 1.807103 18 24 0.002309765 GO Molecular Function peptide antigen binding 57 2.903199e-21 2.150404592631579e-19 5.194936 53 0.003632874 76 0.0024310337107894737 2.141751 16 18 0.002053125 GO Molecular Function nucleosome binding 63 1.615026e-20 1.0823237733333334e-18 2.339083 153 0.01048735 126 0.04462248553968254 1.460285 40 66 0.005132811 GO Molecular Function rRNA binding 65 2.390167e-20 1.552505396e-18 3.147275 91 0.006237576 108 0.020387443792592594 1.525998 38 60 0.004876171 GO Molecular Function phosphotyrosine binding 116 2.350041e-14 8.553338881034483e-13 2.111325 129 0.008842278 120 0.038717182516666664 1.652208 24 35 0.003079687 GO Molecular Function MAP kinase kinase kinase activity 192 2.633392e-10 5.790719283333333e-9 2.143222 85 0.005826307 121 0.03870185276033058 1.760767 19 26 0.002438085 GO Molecular Function phosphatidylinositol-3,4-bisphosphate binding 262 1.02081e-7 0.0000016449846641221373 2.008768 70 0.004798136 117 0.032759659952136755 1.807103 18 24 0.002309765 Human Phenotype Abnormality of leukocytes 2 6.205187e-56 2.07036064255e-52 2.041386 592 0.04057852 11 0.01006706979090909 1.312552 140 257 0.01796484 Human Phenotype Abnormality of lymphocytes 3 2.677336e-46 5.955287709333334e-43 2.362462 354 0.02426486 20 0.0156676734965 1.40408 81 139 0.01039394 Human Phenotype Decreased antibody level in blood 5 2.06271e-40 2.752892766e-37 2.64516 249 0.01706765 6 0.00795708539 1.586724 54 82 0.006929296 Human Phenotype Recurrent bacterial infections 6 3.640636e-39 4.0489940046666666e-36 2.783584 221 0.0151484 10 0.007168083216 1.58598 52 79 0.006672655 Human Phenotype Abnormality of B cell physiology 7 1.266735e-38 1.2075603792857143e-35 2.456127 272 0.01864418 14 0.014001617483571429 1.477505 65 106 0.008340819 Human Phenotype Abnormal immunoglobulin level 8 2.739471e-38 2.2850612478750002e-35 2.453959 270 0.01850709 23 0.019011237737391305 1.459583 63 104 0.008084178 Human Phenotype Abnormality of bone marrow cell morphology 13 2.993752e-30 1.5367159304615384e-27 2.052935 310 0.02124889 16 0.013744449000624999 1.417335 80 136 0.01026562 Human Phenotype Abnormality of cells of the lymphoid lineage 27 2.620374e-20 6.4762058155555555e-18 2.488268 134 0.009185002 42 0.04974497477857143 1.64282 30 44 0.003849609 Human Phenotype Abnormality of the lymph nodes 29 6.893027e-20 1.586109281758621e-17 2.421562 138 0.009459182 1 0.00019655835320999998 1.927576 40 50 0.005132811 Human Phenotype Lymphadenopathy 35 9.986584e-19 1.9040135723428571e-16 2.423604 129 0.008842278 3 0.0012299878238666666 1.905162 34 43 0.00436289 Mouse Phenotype Single KO abnormal lymphocyte physiology 1 0 0 2.490501 2723 0.1866475 1 5.8392888706e-35 1.518832 544 863 0.06980624 Mouse Phenotype Single KO abnormal cell-mediated immunity 1 0 0 2.228355 3388 0.2322298 2 2.8948344595e-34 1.420624 737 1250 0.09457205 Mouse Phenotype Single KO abnormal leukocyte physiology 1 0 0 2.235222 3354 0.2298992 3 3.1121682236666664e-34 1.425851 719 1215 0.09226229 Mouse Phenotype Single KO abnormal immune cell physiology 1 0 0 2.233544 3377 0.2314758 4 3.21324853125e-34 1.42077 730 1238 0.09367381 Mouse Phenotype Single KO abnormal adaptive immunity 1 0 0 2.211992 3421 0.2344917 5 4.8510324654e-34 1.413429 745 1270 0.09559861 Mouse Phenotype Single KO abnormal hematopoietic system physiology 1 0 0 2.088405 3623 0.2483378 6 7.479298718833334e-33 1.387534 797 1384 0.1022713 Mouse Phenotype Single KO abnormal blood cell physiology 1 0 0 2.147132 3480 0.2385359 7 1.2156715467142858e-31 1.389589 763 1323 0.09790838 Mouse Phenotype Single KO abnormal lymphocyte morphology 1 0 0 2.074559 3164 0.2168757 13 5.815271186615385e-26 1.377135 667 1167 0.08558963 Mouse Phenotype Single KO abnormal T cell physiology 14 7.86473e-319 5.14409817e-316 2.750225 1810 0.1240661 11 6.291111233727272e-27 1.583366 345 525 0.0442705 Mouse Phenotype Single KO abnormal lymphocyte cell number 17 2.306479e-295 1.2423781295882353e-292 2.039156 2898 0.1986428 18 2.7858341099999996e-22 1.364993 609 1075 0.07814706 Mouse Phenotype Single KO abnormal immune serum protein physiology 19 1.527654e-282 7.362488251578947e-280 2.171722 2448 0.1677977 26 1.5969276189615385e-20 1.37429 539 945 0.06916463 Mouse Phenotype Single KO abnormal professional antigen presenting cell physiology 21 2.201966e-281 9.601620315238095e-279 2.222337 2331 0.1597779 12 4.806664205916667e-26 1.447385 510 849 0.06544335 Mouse Phenotype Single KO abnormal T cell morphology 22 4.158822e-281 1.7310151388181816e-278 2.204398 2366 0.162177 47 1.0981146487021277e-16 1.359857 469 831 0.06018221 Mouse Phenotype Single KO abnormal B cell physiology 24 1.455507e-261 5.55336566625e-259 2.527008 1724 0.1181712 23 4.696780570869566e-21 1.50703 339 542 0.04350058 Mouse Phenotype Single KO increased lymphocyte cell number 27 2.224509e-244 7.54438107888889e-242 2.321693 1883 0.1290698 50 5.345396918600001e-16 1.413398 359 612 0.04606698 Mouse Phenotype Single KO decreased lymphocyte cell number 28 2.434358e-242 7.961220073571428e-240 2.095909 2291 0.1570361 45 1.390783677488889e-17 1.373873 463 812 0.05941229 Mouse Phenotype Single KO abnormal hemopoiesis 31 7.841124e-233 2.3161668538064517e-230 2.090997 2220 0.1521694 28 4.066669485e-20 1.422735 434 735 0.055691 Mouse Phenotype Single KO abnormal T cell number 32 1.986783e-231 5.6853037284375e-229 2.124013 2136 0.1464117 58 2.58667409637931e-13 1.334428 427 771 0.05479276 Mouse Phenotype Single KO abnormal humoral immune response 35 1.177112e-223 3.0796613097142856e-221 2.505328 1509 0.1034341 38 2.359746369368421e-18 1.496718 305 491 0.03913769 Mouse Phenotype Single KO abnormal immunoglobulin level 36 2.325797e-214 5.915923091388888e-212 2.553642 1402 0.0960998 46 3.633493618695652e-17 1.501244 281 451 0.036058 Mouse Phenotype abnormal leukocyte physiology 1 0 0 2.123738 3936 0.2697923 1 1.1740697658e-38 1.407963 866 1482 0.1111254 Mouse Phenotype abnormal cell-mediated immunity 1 0 0 2.121176 3986 0.2732195 2 1.3650736872e-38 1.400119 885 1523 0.1135635 Mouse Phenotype abnormal immune cell physiology 1 0 0 2.122931 3971 0.2721914 3 9.891093525e-39 1.401671 879 1511 0.1127935 Mouse Phenotype abnormal lymphocyte physiology 1 0 0 2.307634 3204 0.2196175 4 1.1378969174250001e-38 1.477484 669 1091 0.08584627 Mouse Phenotype abnormal adaptive immunity 1 0 0 2.105987 4018 0.275413 5 1.3956268187999998e-38 1.395121 894 1544 0.1147183 Mouse Phenotype abnormal blood cell physiology 1 0 0 2.050943 4069 0.2789088 7 2.354815568142857e-36 1.375124 916 1605 0.1175414 Mouse Phenotype abnormal professional antigen presenting cell physiology 1 0 0 2.177826 2781 0.1906231 9 8.972804093e-32 1.446621 616 1026 0.0790453 Mouse Phenotype abnormal lymphocyte morphology 1 0 0 2.025265 3807 0.26095 10 8.308348375199999e-32 1.371135 824 1448 0.1057359 Mouse Phenotype abnormal lymphocyte cell number 1 0 0 2.004713 3552 0.2434711 17 5.783240807647058e-28 1.361252 761 1347 0.09765174 Mouse Phenotype abnormal immune serum protein physiology 20 3.844e-321 1.837544e-318 2.102177 2929 0.2007677 39 4.2380750515384617e-23 1.354547 651 1158 0.08353651 Mouse Phenotype abnormal T cell physiology 21 9.66773e-319 4.4015786e-316 2.452277 2182 0.1495647 16 5.3337359113124995e-28 1.512843 437 696 0.05607597 Mouse Phenotype decreased lymphocyte cell number 22 3.499426e-315 1.520818727317e-312 2.069428 2975 0.2039208 27 4.628402195555555e-25 1.385165 618 1075 0.07930194 Mouse Phenotype abnormal T cell morphology 25 1.15457e-307 4.4155375080000004e-305 2.082531 2875 0.1970663 40 2.2020223539749996e-22 1.367043 598 1054 0.07673553 Mouse Phenotype abnormal B cell physiology 26 1.748982e-305 6.431544962307692e-303 2.460555 2086 0.1429844 28 6.403903165714285e-25 1.490726 417 674 0.05350956 Mouse Phenotype abnormal hemopoiesis 28 4.738362e-302 1.6179813957857142e-299 2.079921 2836 0.194393 26 2.568108870230769e-25 1.401524 584 1004 0.07493905 Mouse Phenotype abnormal lymphopoiesis 29 2.314625e-296 7.631079181034482e-294 2.358731 2186 0.1498389 19 5.076790357894737e-27 1.521186 411 651 0.05273964 Mouse Phenotype abnormal leukopoiesis 32 1.234669e-286 3.6889594715625e-284 2.233834 2347 0.1608746 24 8.110484755e-26 1.471213 461 755 0.05915565 Mouse Phenotype abnormal definitive hematopoiesis 33 1.739192e-280 5.03891354909091e-278 2.055265 2723 0.1866475 22 3.8051641371818186e-26 1.414147 574 978 0.07365584 Mouse Phenotype abnormal T cell number 35 1.077808e-271 2.9442635108571434e-269 2.044765 2676 0.1834259 51 7.5200939423529405e-19 1.3495 550 982 0.07057616 Mouse Phenotype increased lymphocyte cell number 37 3.735471e-267 9.652658981351352e-265 2.180601 2308 0.1582014 49 1.7640663538163263e-19 1.396707 462 797 0.05928397