# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	5	1.147278e-73	3.0194062404e-70	2.258447	612	0.06892668	36	6.829645279444443e-36	1.634376	384	555	0.04830796	
GO Biological Process	ncRNA processing	11	2.319272e-66	2.7744818407272724e-63	2.462676	466	0.05248339	43	3.8376111939534886e-32	1.711987	287	396	0.03610517	
GO Biological Process	ribonucleoprotein complex biogenesis	13	1.817468e-62	1.8396970316923077e-59	2.194624	552	0.06216916	31	2.0405338692258063e-40	1.743021	335	454	0.04214367	
GO Biological Process	rRNA processing	15	2.61211e-58	2.2915170326666667e-55	2.818807	324	0.0364906	64	7.860105094687501e-26	1.799759	192	252	0.02415398	
GO Biological Process	rRNA metabolic process	17	3.33134e-57	2.5786531211764708e-54	2.764256	328	0.0369411	66	4.194732311969696e-25	1.778478	195	259	0.02453139	
GO Biological Process	ribosome biogenesis	19	9.710881e-56	6.725551741000001e-53	2.446165	396	0.04459962	50	4.247185681e-30	1.762496	241	323	0.03031828	
GO Biological Process	translation	20	1.099727e-54	7.2356537965e-52	2.2826	445	0.05011826	34	1.721262995e-37	1.790688	282	372	0.03547616	
GO Biological Process	peptide biosynthetic process	25	3.81217e-47	2.0065738012000003e-44	2.10246	458	0.05158239	37	8.752225167837838e-36	1.75356	291	392	0.03660838	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	26	1.815422e-46	9.188130037692308e-44	3.665162	177	0.01993468	120	2.03014749175e-15	1.901758	95	118	0.01195119	
GO Biological Process	viral gene expression	28	3.99651e-43	1.8782169675e-40	3.394429	181	0.02038518	85	1.7657891807058826e-19	1.971587	106	127	0.01333501	
GO Biological Process	cotranslational protein targeting to membrane	29	1.067974e-41	4.846024091724138e-39	3.785957	152	0.01711904	107	7.380394864205607e-17	2.024729	84	98	0.01056737	
GO Biological Process	protein targeting to ER	30	1.919149e-41	8.418027230333333e-39	3.687993	156	0.01756955	106	7.017457589716981e-17	2.011365	86	101	0.01081897	
GO Biological Process	nuclear-transcribed mRNA catabolic process	31	3.087056e-41	1.3104054807741935e-38	2.631598	255	0.02871945	82	1.213994136390244e-19	1.789533	150	198	0.0188703	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	32	1.034649e-40	4.2546706846874995e-38	3.856265	145	0.01633067	116	6.063902020086207e-16	2.028397	79	92	0.009938357	
GO Biological Process	mRNA catabolic process	33	2.010703e-40	8.01783053848485e-38	2.519657	270	0.03040883	80	2.5128031630000002e-20	1.77441	160	213	0.02012832	
GO Biological Process	viral transcription	34	3.790694e-39	1.467110069e-36	3.359608	166	0.0186958	96	7.167115145e-18	1.985907	95	113	0.01195119	
GO Biological Process	multi-organism metabolic process	35	3.928162e-39	1.4768766788e-36	2.915288	204	0.02297556	88	5.594370904431818e-19	1.896175	118	147	0.01484463	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	36	9.774261e-39	3.5727639027499995e-36	3.37761	163	0.01835792	103	3.2980797747572815e-17	2.002232	89	105	0.01119638	
GO Biological Process	translational initiation	38	8.53914e-38	2.9570142963157895e-35	2.932162	195	0.02196193	104	3.3173181049999995e-17	1.866621	113	143	0.01421562	
GO Biological Process	protein localization to endoplasmic reticulum	42	5.86328e-37	1.8370214647619046e-34	3.066234	178	0.0200473	111	2.48472979981982e-16	1.904987	100	124	0.0125802	
GO Cellular Component	ribonucleoprotein complex	14	1.875974e-86	2.3154879085714288e-84	2.031475	901	0.1014754	15	7.857679104e-53	1.624905	562	817	0.07070072	
GO Cellular Component	intracellular ribonucleoprotein complex	15	4.694916e-86	5.408543232e-84	2.02955	899	0.1012501	16	1.09422468e-52	1.62509	560	814	0.07044911	
GO Cellular Component	ribosomal subunit	19	5.386734e-53	4.899092816842105e-51	3.17039	246	0.02770582	26	7.96879163076923e-25	1.902516	149	185	0.0187445	
GO Cellular Component	ribosome	21	2.658076e-45	2.187216822857143e-43	2.599546	287	0.03232346	25	2.2344353280000003e-25	1.811675	181	236	0.02277016	
GO Cellular Component	large ribosomal subunit	22	7.701326e-41	6.049041512727274e-39	3.504203	164	0.01847055	36	2.9556456e-17	1.951369	95	115	0.01195119	
GO Cellular Component	mitochondrial ribosome	31	7.588101e-29	4.229754363870968e-27	3.735028	105	0.01182566	46	4.6382450086956526e-11	1.889747	68	85	0.008554535	
GO Cellular Component	cytosolic ribosome	39	6.264953e-24	2.7758560984615385e-22	2.54381	153	0.01723167	44	8.827817890909092e-13	1.834911	87	112	0.01094477	
GO Cellular Component	cytosolic large ribosomal subunit	40	8.089922e-24	3.4948463040000003e-22	3.34009	99	0.0111499	50	1.7313288192e-10	2.013665	52	61	0.006541703	
GO Cellular Component	catalytic step 2 spliceosome	41	8.983138e-22	3.786064015609756e-20	2.632411	130	0.01464129	49	1.3787242971428572e-10	1.82085	74	96	0.009309347	
GO Cellular Component	spliceosomal complex	42	1.121009e-21	4.612151314285714e-20	2.04928	217	0.02443969	42	8.239297371428572e-14	1.676389	132	186	0.01660586	
GO Cellular Component	mitochondrial large ribosomal subunit	44	9.61871e-19	3.777529745454545e-17	3.830239	64	0.007208019	69	0.00000389829787826087	1.852693	40	51	0.00503208	
GO Cellular Component	small ribosomal subunit	47	8.256309e-16	3.035511053617021e-14	2.729544	86	0.009685775	56	2.757543017142857e-8	1.837254	56	72	0.007044911	
GO Cellular Component	spliceosomal snRNP complex	55	2.077969e-12	6.528600785454546e-11	2.691456	67	0.007545895	70	0.000008598572434285714	1.752588	46	62	0.005786891	
GO Cellular Component	INO80-type complex	56	2.215441e-12	6.836217942857142e-11	4.570217	33	0.003716635	86	0.00025652702511627906	2.054073	20	23	0.00251604	
GO Cellular Component	preribosome	57	5.372074e-12	1.6285866442105264e-10	2.349832	83	0.0093479	76	0.000027649909894736846	1.647312	53	76	0.006667505	
GO Cellular Component	small nuclear ribonucleoprotein complex	59	7.215335e-12	2.1132370983050848e-10	2.475874	74	0.008334272	67	0.0000025526010841791043	1.745962	51	69	0.006415901	
GO Cellular Component	SWI/SNF superfamily-type complex	60	2.234606e-11	6.43566528e-10	2.064565	104	0.01171303	56	2.757543017142857e-8	1.837254	56	72	0.007044911	
GO Cellular Component	mitochondrial small ribosomal subunit	62	6.177365e-11	1.7216914064516127e-9	3.650846	37	0.004167136	82	0.000058166397658536584	2.024729	24	28	0.003019248	
GO Cellular Component	methyltransferase complex	63	6.541502e-11	1.7942405485714287e-9	2.024154	104	0.01171303	64	4.6833849e-7	1.687274	65	91	0.008177129	
GO Cellular Component	Ino80 complex	65	3.441876e-10	9.150094966153847e-9	5.011081	24	0.002703007	154	0.019753272935064934	1.919274	13	16	0.001635426	
GO Molecular Function	structural constituent of ribosome	6	2.384967e-44	1.678221779e-41	3.047645	217	0.02443969	7	6.840050137142857e-22	1.924742	132	162	0.01660586	
GO Molecular Function	rRNA binding	8	2.542972e-24	1.342053473e-21	4.262025	75	0.008446897	48	0.0000011906954766666668	1.850377	47	60	0.005912693	
GO Molecular Function	unfolded protein binding	9	1.77499e-23	8.326675311111112e-21	2.855216	123	0.01385291	76	0.0002587757683947368	1.515363	68	106	0.008554535	
GO Molecular Function	ribonucleoprotein complex binding	10	1.531803e-19	6.467272266e-17	2.402643	137	0.01542967	26	1.2849738192307692e-8	1.704881	83	115	0.01044156	
GO Molecular Function	O-methyltransferase activity	12	4.525443e-14	1.5922016955e-11	4.016152	44	0.004955513	102	0.0022449069388235294	2.024729	18	21	0.002264436	
GO Molecular Function	rRNA methyltransferase activity	16	8.840775e-12	2.332859503125e-9	4.009966	36	0.004054511	136	0.021036205027941176	1.889747	16	20	0.002012832	
GO Molecular Function	snRNA binding	17	1.313278e-11	3.261564538823529e-9	3.429839	43	0.004842888	88	0.0010266627804545454	1.802719	29	38	0.003648258	
GO Molecular Function	translation factor activity, RNA binding	18	3.396946e-11	7.967725562222222e-9	2.025425	107	0.01205091	46	5.204709966521739e-7	1.730437	63	86	0.007925525	
GO Molecular Function	methyl-CpG binding	22	5.201222e-10	9.981617856363638e-8	3.984617	30	0.003378759	127	0.011650279883464567	1.912244	17	21	0.002138634	
GO Molecular Function	tRNA binding	29	5.697467e-9	8.294726094482758e-7	2.226385	66	0.00743327	53	0.000006606200043773585	1.862491	41	52	0.005157881	
GO Molecular Function	ATP-dependent RNA helicase activity	31	7.606697e-9	0.0000010359830559354837	2.005025	83	0.0093479	49	0.0000016074903114285717	1.79808	51	67	0.006415901	
GO Molecular Function	translation initiation factor activity	35	1.538431e-8	0.000001855787337714286	2.263394	60	0.006757518	75	0.00017359282157333332	1.760059	38	51	0.004780476	
GO Molecular Function	RNA methyltransferase activity	37	1.832719e-8	0.0000020912809778378377	2.156779	66	0.00743327	94	0.001661737429148936	1.629092	40	58	0.00503208	
GO Molecular Function	translation elongation factor activity	42	5.6516e-8	0.000005681203619047619	4.114543	22	0.002477757	121	0.00906537372231405	2.066911	14	16	0.001761228	
GO Molecular Function	aminoacyl-tRNA ligase activity	48	1.058928e-7	0.000009314154199999999	2.260027	53	0.005969141	78	0.0003287003457948718	1.784761	34	45	0.004277268	
GO Molecular Function	ribosome binding	52	1.94249e-7	0.000015771524576923077	2.069127	62	0.006982768	84	0.0008392506678571428	1.675003	39	55	0.004906278	
GO Molecular Function	proton-transporting ATP synthase activity, rotational mechanism	62	7.319315e-7	0.00004984217408064516	3.207187	25	0.002815632	130	0.014608454512307693	1.968487	15	18	0.00188703	
GO Molecular Function	U6 snRNA binding	78	0.000004072303	0.00022042645212820512	4.942527	13	0.001464129	151	0.03487827752317881	2.14744	10	11	0.00125802	
GO Molecular Function	small ribosomal subunit rRNA binding	145	0.000119006	0.003465126427586207	4.451095	10	0.001126253	145	0.02997491884137931	2.362184	8	8	0.001006416	
GO Molecular Function	mRNA 5'-UTR binding	147	0.00012956	0.003721104217687075	2.252354	27	0.003040883	90	0.0012383346482222222	2.040068	19	22	0.002390238	
Human Phenotype	Increased serum lactate	1	9.074979e-11	6.055733486700001e-7	2.060623	98	0.01103728	46	0.000008829800639130436	1.629907	69	100	0.008680337	
Human Phenotype	Abnormality of the mitochondrion	6	2.054556e-9	0.0000022850086979999997	2.098501	80	0.009010024	80	0.00012759493347500001	1.66351	50	71	0.006290099	
Human Phenotype	Abnormality of mitochondrial metabolism	11	7.516335e-9	0.000004559682132272727	2.067147	77	0.008672148	76	0.0001149461127105263	1.677493	49	69	0.006164297	
Human Phenotype	Abnormal CSF metabolite level	16	2.121738e-8	0.00000884897354625	2.259864	59	0.006644892	165	0.009004748412121212	1.537294	41	63	0.005157881	
Human Phenotype	Increased intramyocellular lipid droplets	17	5.755812e-8	0.000022593254985882352	3.690505	25	0.002815632	227	0.026297331735242287	1.945328	14	17	0.001761228	
Human Phenotype	Increased CSF lactate	18	5.83981e-8	0.000021649473405555556	2.283928	54	0.006081766	152	0.004846138936184211	1.588365	39	58	0.004906278	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	23	2.756767e-7	0.00007998220083043478	3.291736	26	0.002928258	134	0.0026669057827611938	2.204705	14	15	0.001761228	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	36	0.000001976824	0.0003664262931111111	2.952277	26	0.002928258	169	0.010258580583431954	2.066911	14	16	0.001761228	
Human Phenotype	3-Methylglutaconic aciduria	175	0.0004181903	0.015946193553714287	2.399398	20	0.002252506	209	0.01828524604401914	2.165335	11	12	0.001383822	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	4	1.760047e-14	4.02918759475e-11	2.580171	86	0.009685775	86	0.012866532643023256	1.574789	40	60	0.00503208	
Mouse Phenotype Single KO	early cellular replicative senescence	5	5.000438e-13	9.1578021532e-10	2.585744	76	0.008559522	80	0.009101303692125	1.635358	36	52	0.004528872	
Mouse Phenotype Single KO	absent hypoglossal nerve	9	1.431169e-9	0.000001456134948111111	3.810404	30	0.003378759	130	0.03811937241461538	2.047226	13	15	0.001635426	
Mouse Phenotype	abnormal cellular replicative senescence	4	4.525123e-15	1.081617525075e-11	2.274735	115	0.01295191	58	0.00010799785801034482	1.631032	58	84	0.007296515	
Mouse Phenotype	early cellular replicative senescence	5	1.00031e-14	1.912792782e-11	2.347392	105	0.01182566	49	0.000029339528504081632	1.71501	53	73	0.006667505	
Mouse Phenotype	absent hypoglossal canal	6	2.490139e-11	3.9680364965e-8	6.336704	22	0.002477757	261	0.03771122151724138	2.362184	8	8	0.001006416	
Mouse Phenotype	absent hypoglossal nerve	11	1.431169e-9	0.0000012439460735454545	3.810404	30	0.003378759	219	0.023626265683561645	2.047226	13	15	0.001635426	
Mouse Phenotype	enlarged liver sinusoidal spaces	18	2.233572e-8	0.000011863989939999999	2.044321	74	0.008334272	171	0.012227149149122806	1.670813	29	41	0.003648258	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	54	0.00000520722	0.0009219672299999999	2.336073	36	0.004054511	230	0.023856544845652174	1.732268	22	30	0.002767644