# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	36	1.715826e-38	6.271820648333333e-36	2.053344	399	0.02478107	88	1.9429921450000003e-22	1.573149	188	213	0.01784528	
GO Biological Process	nuclear-transcribed mRNA catabolic process	38	6.304818e-38	2.183292106894737e-35	2.10568	370	0.02297994	80	4.196512016875e-25	1.620313	180	198	0.0170859	
GO Biological Process	macromolecular complex disassembly	40	1.755455e-37	5.775008086249999e-35	2.049343	390	0.0242221	187	1.3407233627807487e-11	1.446405	155	191	0.01471286	
GO Biological Process	protein complex disassembly	62	5.935189e-31	1.2596960008225805e-28	2.047636	320	0.01987454	183	7.942930595628416e-12	1.490892	133	159	0.01262458	
GO Biological Process	cellular protein complex disassembly	70	4.007292e-29	7.533136489714285e-27	2.19185	256	0.01589963	197	5.798280896598985e-11	1.527724	108	126	0.01025154	
GO Biological Process	mitochondrial translational termination	75	1.86167e-28	3.266362070666667e-26	2.722653	164	0.0101857	231	1.757352549393939e-8	1.556991	76	87	0.007214048	
GO Biological Process	mitochondrial translation	80	5.140078e-28	8.454785800249999e-26	2.451127	195	0.01211105	198	7.352684293434343e-11	1.565798	94	107	0.008922639	
GO Biological Process	translational elongation	82	1.160719e-27	1.862670892804878e-25	2.367278	206	0.01279424	209	2.1024065042105263e-10	1.543638	97	112	0.009207404	
GO Biological Process	translational termination	84	1.312727e-27	2.056449356309524e-25	2.521434	182	0.01130365	218	2.7499931722018346e-9	1.557206	83	95	0.0078785	
GO Biological Process	mitochondrial translational elongation	87	5.296045e-27	8.010420247701149e-25	2.683408	159	0.009875163	228	7.936983594298246e-9	1.572657	75	85	0.007119127	
GO Biological Process	protein targeting to ER	91	1.134466e-26	1.6404877026373627e-24	2.437913	187	0.01161419	154	1.116712046103896e-14	1.658816	94	101	0.008922639	
GO Biological Process	negative regulation of gene expression, epigenetic	93	1.968079e-26	2.7847259743010753e-24	2.328283	203	0.01260791	878	0.020921491102505692	1.250768	80	114	0.007593735	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	99	1.798148e-25	2.3900837911111113e-23	2.295235	201	0.0124837	134	2.1306110065671643e-16	1.646403	109	118	0.01034646	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	102	3.46893e-25	4.475259791176471e-23	2.122665	236	0.01465747	405	0.00009323882555555556	1.372248	87	113	0.008258187	
GO Biological Process	DNA replication-dependent nucleosome assembly	105	6.726745e-25	8.430213090952381e-23	7.30677	47	0.002919073	787	0.011586265413595934	1.503853	27	32	0.002562886	
GO Biological Process	viral gene expression	107	9.312558e-25	1.145270567495327e-22	2.20282	213	0.01322899	153	8.569686081437909e-15	1.5999	114	127	0.01082107	
GO Biological Process	cytoplasmic translation	109	1.527403e-24	1.84395376853211e-22	3.452301	98	0.006086578	270	4.4771786830000005e-7	1.699445	41	43	0.003891789	
GO Biological Process	multi-organism metabolic process	112	3.196319e-24	3.755389439375e-22	2.017449	256	0.01589963	152	6.894814745986842e-15	1.564098	129	147	0.0122449	
GO Biological Process	regulation of DNA-templated transcription in response to stress	115	8.516197e-24	9.744750984608696e-22	2.011697	253	0.01571331	363	0.00003910619170523416	1.377947	92	119	0.008732795	
GO Biological Process	translational initiation	116	1.24638e-23	1.413889174137931e-21	2.031564	245	0.01521645	161	3.967553743416149e-14	1.557994	125	143	0.01186521	
GO Cellular Component	ribosomal subunit	24	2.390629e-43	1.72125288e-41	2.359537	332	0.02061984	34	3.391198983529412e-21	1.589659	165	185	0.01566208	
GO Cellular Component	ribosome	29	2.227157e-37	1.3270783779310342e-35	2.01794	404	0.02509161	36	5.934182399999999e-19	1.502909	199	236	0.01888942	
GO Cellular Component	large ribosomal subunit	35	2.252073e-29	1.1118806125714287e-27	2.439085	207	0.01285634	44	2.5002997527272727e-14	1.611859	104	115	0.009871856	
GO Cellular Component	mitochondrial ribosome	38	1.351706e-27	6.146705178947369e-26	2.863971	146	0.00906776	67	9.6683328e-8	1.530719	73	85	0.006929283	
GO Cellular Component	nuclear chromosome, telomeric region	45	2.000468e-22	7.68179712e-21	2.086434	217	0.01347742	83	0.00001638910982168675	1.363764	101	132	0.009587091	
GO Cellular Component	methyltransferase complex	54	6.465365e-18	2.0689168e-16	2.007073	187	0.01161419	86	0.000022482967813953486	1.429793	73	91	0.006929283	
GO Cellular Component	small ribosomal subunit	55	3.829972e-17	1.2033075665454547e-15	2.292842	131	0.008136141	72	2.18367888e-7	1.559551	63	72	0.005980066	
GO Cellular Component	mitochondrial large ribosomal subunit	60	2.889365e-16	8.321371199999999e-15	2.805279	85	0.005279175	113	0.0010662555185840708	1.467813	42	51	0.003986711	
GO Cellular Component	cytosolic large ribosomal subunit	63	2.053548e-15	5.6325888e-14	2.251229	121	0.007515061	53	1.746097050566038e-11	1.723907	59	61	0.00560038	
GO Cellular Component	DNA packaging complex	64	3.29237e-15	8.889399e-14	2.072342	144	0.008943544	193	0.020030349264248706	1.241276	78	112	0.007403892	
GO Cellular Component	pronucleus	69	2.938703e-14	7.359534469565217e-13	3.551044	52	0.003229613	191	0.019736537465968585	1.663522	14	15	0.001328904	
GO Cellular Component	mitochondrial small ribosomal subunit	73	4.03243e-14	9.54525895890411e-13	3.210369	59	0.003664369	89	0.000041166726471910106	1.718689	27	28	0.002562886	
GO Cellular Component	spliceosomal snRNP complex	83	2.800216e-12	5.829847286746987e-11	2.193102	99	0.006148686	74	6.40775558918919e-7	1.581112	55	62	0.005220693	
GO Cellular Component	small nuclear ribonucleoprotein complex	93	3.612917e-11	6.713032877419356e-10	2.011104	109	0.006769766	69	1.594704083478261e-7	1.575696	61	69	0.005790223	
GO Cellular Component	sex chromosome	101	4.995629e-10	8.546977140594059e-9	2.412563	64	0.003974908	189	0.019140479999999998	1.508138	22	26	0.002088277	
GO Cellular Component	spliceosomal tri-snRNP complex	102	9.253983e-10	1.567733590588235e-8	2.596396	54	0.003353829	117	0.0015561112615384617	1.597964	26	29	0.002467964	
GO Cellular Component	nuclear ubiquitin ligase complex	112	5.426483e-9	8.372288057142857e-8	2.216014	67	0.004161232	140	0.0049613360914285715	1.470434	33	40	0.003132416	
GO Cellular Component	clathrin adaptor complex	121	1.766861e-8	2.5232527338842976e-7	2.036467	76	0.004720204	135	0.00468347648	1.544699	26	30	0.002467964	
GO Cellular Component	U4/U6 x U5 tri-snRNP complex	135	1.535259e-7	0.00000196513152	2.392047	46	0.002856965	167	0.01127507583233533	1.559551	21	24	0.001993355	
GO Cellular Component	U12-type spliceosomal complex	141	2.755373e-7	0.00000337679754893617	2.366884	45	0.002794857	111	0.0010124225902702702	1.645241	24	26	0.002278121	
GO Molecular Function	structural constituent of ribosome	7	1.10716e-31	6.677756457142858e-29	2.184062	282	0.01751444	11	1.853662958909091e-16	1.573304	143	162	0.0135738	
GO Molecular Function	ribonucleoprotein complex binding	11	2.240061e-23	8.597761401818181e-21	2.11799	219	0.01360164	37	4.248277956216216e-8	1.48787	96	115	0.009112482	
GO Molecular Function	nucleosome binding	20	1.523989e-15	3.217140779e-13	2.064016	149	0.009254084	154	0.019978386112987013	1.350261	50	66	0.004746084	
GO Molecular Function	rRNA binding	25	1.311451e-14	2.2147784488e-12	2.63236	84	0.005217067	81	0.00037720489503703707	1.485287	50	60	0.004746084	
GO Molecular Function	snRNA binding	47	4.316121e-10	3.87716231106383e-8	2.5512	58	0.003602261	84	0.00046066825038095237	1.594729	34	38	0.003227337	
GO Molecular Function	death receptor binding	120	0.000002675458	0.00009413153063333335	2.212564	43	0.002670642	156	0.020845775873076924	1.677501	16	17	0.001518747	
GO Molecular Function	U6 snRNA binding	142	0.00001098452	0.00032659608056338026	3.564231	17	0.001055835	180	0.04058277876666667	1.782345	11	11	0.001044139	
GO Molecular Function	sequence-specific single stranded DNA binding	155	0.00002070755	0.0005640469425806452	2.276899	33	0.002049562	135	0.009542307952592591	1.782345	14	14	0.001328904	
GO Molecular Function	ribosomal small subunit binding	168	0.00003899596	0.0009800056138095238	2.07147	38	0.002360102	135	0.009542307952592591	1.782345	14	14	0.001328904	
GO Molecular Function	single-stranded telomeric DNA binding	256	0.0004790711	0.00790093040703125	2.067894	27	0.001676914	164	0.0249792519	1.782345	12	12	0.00113906	
Human Phenotype	Increased CSF lactate	8	2.181353e-11	1.8195210711249998e-8	2.169116	93	0.005776039	195	0.001972779028	1.444314	47	58	0.004461319	
Human Phenotype	Abnormal CSF metabolite level	10	7.663434e-11	5.1138095082e-8	2.069987	98	0.006086578	211	0.0029811270130805684	1.414559	50	63	0.004746084	
Human Phenotype	Renal Fanconi syndrome	209	0.00003951282	0.0012615743916746412	2.526617	25	0.001552699	248	0.008209910291935484	1.782345	14	14	0.001328904	
Human Phenotype	Increased hepatocellular lipid droplets	235	0.0000808067	0.0022945664217021273	2.464408	24	0.001490591	311	0.020819283663665596	1.782345	12	12	0.00113906	
Mouse Phenotype Single KO	decreased trophoblast giant cell number	13	2.496298e-12	1.7583539066153846e-9	2.025847	120	0.007452953	150	0.0012729920992666666	1.559551	35	40	0.003322259	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	52	2.098576e-8	0.0000036955116215384615	2.339843	55	0.003415937	232	0.006997775453017241	1.633816	22	24	0.002088277	
Mouse Phenotype Single KO	absent hypoglossal nerve	94	9.939178e-7	0.00009682239675106382	2.521526	36	0.002235886	230	0.00681159768347826	1.782345	15	15	0.001423825	
Mouse Phenotype	polyploidy	24	9.265378e-12	3.69109496075e-9	2.262281	88	0.005465499	492	0.030921265079268297	1.485287	25	30	0.002373042	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	38	1.494622e-9	3.7605476163157894e-7	2.325994	65	0.004037016	276	0.002261364948695652	1.60411	27	30	0.002562886	
Mouse Phenotype	absent hypoglossal nerve	113	9.939178e-7	0.00008409600075929202	2.521526	36	0.002235886	330	0.004956932319999999	1.782345	15	15	0.001423825	
Mouse Phenotype	increased incidence of tumors by ionizing radiation induction	191	0.00001628333	0.0008151042834031413	2.185835	37	0.002297994	508	0.038466820234251964	1.594729	17	19	0.001613669