# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	79	2.871186e-29	4.7825236169620255e-27	2.180637	261	0.0118604	181	5.6374566412154696e-11	1.375143	113	118	0.008641786	
GO Biological Process	protein targeting to ER	84	1.140184e-26	1.7861525304761904e-24	2.203436	231	0.01049714	176	9.095964355681818e-12	1.407554	99	101	0.007571123	
GO Biological Process	viral gene expression	88	7.764686e-26	1.1610852622045454e-23	2.035464	269	0.01222394	179	2.826748747150838e-11	1.368148	121	127	0.009253594	
GO Biological Process	cotranslational protein targeting to membrane	90	2.605506e-25	3.809539272666667e-23	2.200894	219	0.009951831	178	2.5263904958426966e-11	1.406684	96	98	0.007341695	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	91	3.511799e-25	5.078215718791209e-23	2.242684	209	0.00949741	188	1.8758812450000002e-10	1.404772	90	92	0.006882839	
GO Biological Process	translational elongation	99	1.051896e-23	1.398171663030303e-21	2.043149	243	0.01104244	194	3.606374532371134e-10	1.371883	107	112	0.008182931	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	108	1.817559e-22	2.2145610074999998e-20	2.006578	240	0.01090612	180	3.453469891666667e-11	1.394961	102	105	0.007800551	
GO Biological Process	positive regulation of mRNA metabolic process	122	2.301273e-21	2.482168148114754e-19	2.151602	192	0.008724893	1059	0.04913990594523135	1.242683	45	52	0.003441419	
GO Biological Process	mitochondrial translational termination	126	8.084382e-21	8.44304624904762e-19	2.186416	180	0.008179587	255	9.273235026666667e-8	1.369967	83	87	0.006347507	
GO Biological Process	mitochondrial translational elongation	133	3.849631e-20	3.8088191224812035e-18	2.173272	176	0.007997819	265	1.6841642980377358e-7	1.368414	81	85	0.006194555	
GO Biological Process	translational termination	137	9.058504e-20	8.70079227270073e-18	2.037436	201	0.009133873	246	6.095553703658536e-8	1.360411	90	95	0.006882839	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	149	6.897112e-19	6.091214550872483e-17	2.029844	193	0.008770335	454	0.0001533328417797357	1.328826	62	67	0.004741511	
GO Biological Process	gene silencing by miRNA	211	1.287039e-14	8.026609573933649e-13	2.047803	142	0.006452786	990	0.03738180806969697	1.272809	39	44	0.002982563	
GO Biological Process	cytoplasmic translation	282	8.300084e-12	3.873078204113475e-10	2.268177	88	0.003998909	344	0.0000065469046979651165	1.43599	43	43	0.003288467	
GO Biological Process	cleavage involved in rRNA processing	286	1.220467e-11	5.61542841013986e-10	2.938894	54	0.002453876	662	0.003341549151208459	1.43599	24	24	0.001835424	
GO Biological Process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	299	2.393761e-11	1.0534950166889632e-9	3.31099	44	0.001999455	793	0.011885192206052964	1.43599	20	20	0.00152952	
GO Biological Process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	328	1.523516e-10	6.1121789768292685e-9	2.097116	92	0.004180678	847	0.018596121689492325	1.319558	34	37	0.002600184	
GO Biological Process	nuclear-transcribed mRNA poly(A) tail shortening	381	1.860188e-9	6.424728055643045e-8	2.007646	90	0.004089794	915	0.026686106845901638	1.340257	28	30	0.002141328	
GO Biological Process	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	434	1.874397e-8	5.683223530645161e-7	2.203032	63	0.002862856	611	0.002138083365466448	1.392475	32	33	0.002447232	
GO Biological Process	nuclear-transcribed mRNA catabolic process, exonucleolytic	515	1.926441e-7	0.0000049223373046601945	2.032391	65	0.00295374	742	0.007183469724797844	1.353933	33	35	0.002523708	
GO Cellular Component	mitochondrial ribosome	46	1.867369e-18	7.01481224347826e-17	2.210285	154	0.006998091	83	0.000016057823074698796	1.317732	78	85	0.005965127	
GO Cellular Component	mitochondrial large ribosomal subunit	67	1.256641e-13	3.2410084298507463e-12	2.34229	97	0.004407889	139	0.00569239873381295	1.295206	46	51	0.003517895	
GO Cellular Component	MLL1 complex	111	1.188901e-7	0.000001850829664864865	2.048517	66	0.002999182	137	0.004732944070072993	1.386473	28	29	0.002141328	
GO Cellular Component	mitochondrial small ribosomal subunit	125	3.793126e-7	0.000005243617382399999	2.149851	54	0.002453876	143	0.006306848358041958	1.384704	27	28	0.002064852	
GO Cellular Component	INO80-type complex	157	0.000004625025	0.000050904733757961786	2.235146	40	0.001817686	131	0.0031859492152671756	1.43599	23	23	0.001758948	
GO Cellular Component	Ino80 complex	220	0.0001117792	0.0008779748072727273	2.27461	27	0.001226938	190	0.027743321936842105	1.43599	16	16	0.001223616	
GO Molecular Function	rRNA binding	28	2.208113e-12	3.3295189592857144e-10	2.224075	97	0.004407889	88	0.00036261477006818184	1.340257	56	60	0.004282655	
GO Molecular Function	snRNA binding	74	1.515238e-7	0.000008645047075675675	2.05972	64	0.002908298	148	0.02565420135945946	1.322622	35	38	0.00267666	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	65	2.371417e-8	0.000003340779302923077	2.116629	68	0.003090066	251	0.0061328514992031865	1.43599	24	24	0.001835424	
Mouse Phenotype Single KO	spontaneous chromosome breakage	72	5.566244e-8	0.000007079180042777779	2.009426	73	0.003317277	235	0.004559052090638298	1.43599	25	25	0.0019119	
Mouse Phenotype	pancytopenia	34	1.67574e-12	4.712279452941177e-10	2.075599	115	0.005225847	426	0.008421741763380283	1.386473	28	29	0.002141328	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	73	5.008333e-9	6.559544083972603e-7	2.068398	79	0.00358993	264	0.0006917807226136365	1.43599	30	30	0.00229428	
Mouse Phenotype	increased adrenal gland tumor incidence	92	2.910799e-8	0.0000030250162216304345	2.337484	54	0.002453876	614	0.033066671785016294	1.43599	17	17	0.001300092