# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	RNA processing	1	2.964268e-69	3.9006802612e-65	2.164873	605	0.1312364	16	3.896220347125e-51	1.85993	462	893	0.08845491	
GO Biological Process	ncRNA metabolic process	9	4.55791e-49	6.664170854444445e-46	2.4379	343	0.07440347	44	1.0760386452045456e-23	1.748948	270	555	0.05169443	
GO Biological Process	mRNA metabolic process	10	5.839199e-48	7.683801964100001e-45	2.107106	450	0.09761388	20	5.864505734999999e-38	1.871177	343	659	0.06567107	
GO Biological Process	ncRNA processing	15	1.750358e-43	1.5355307281333335e-40	2.656593	261	0.05661605	48	1.997501657625e-21	1.852001	204	396	0.03905801	
GO Biological Process	ribonucleoprotein complex biogenesis	16	5.219872e-41	4.2930184780000004e-38	2.350837	307	0.06659436	32	1.719185517875e-26	1.884635	238	454	0.04556768	
GO Biological Process	rRNA processing	21	2.192524e-34	1.3738773007619047e-31	2.932389	175	0.03796095	70	8.190731196714286e-17	1.954457	137	252	0.02623014	
GO Biological Process	ribosome biogenesis	22	6.828775e-33	4.084538646590909e-30	2.534156	213	0.0462039	56	5.418692913928571e-19	1.892137	170	323	0.03254834	
GO Biological Process	rRNA metabolic process	23	8.89291e-33	5.087904464782609e-30	2.840571	175	0.03796095	77	1.727568206753247e-15	1.901634	137	259	0.02623014	
GO Biological Process	RNA splicing	24	1.695185e-32	9.294558089583334e-30	2.145765	293	0.06355748	33	6.324327052121212e-26	1.937188	215	399	0.04116408	
GO Biological Process	translation	25	2.429761e-32	1.2789289999599998e-29	2.36119	239	0.05184382	38	6.630508439473685e-25	1.952156	202	372	0.03867509	
GO Biological Process	RNA splicing, via transesterification reactions	26	4.000805e-32	2.024868961346154e-29	2.445046	222	0.04815618	40	1.1386647187499998e-24	2.084636	167	288	0.03197396	
GO Biological Process	mitochondrion organization	27	1.971548e-31	9.608740789629629e-29	2.021261	325	0.07049892	30	4.305003256566666e-28	1.830818	275	540	0.05265173	
GO Biological Process	mRNA splicing, via spliceosome	28	4.409026e-31	2.072084754785714e-28	2.418709	219	0.04750542	41	2.9045292616341465e-24	2.081351	165	285	0.03159104	
GO Biological Process	nuclear-transcribed mRNA catabolic process	30	2.046373e-29	8.976074102333333e-27	2.941739	148	0.03210412	69	6.167655720724637e-17	2.08804	115	198	0.022018	
GO Biological Process	mRNA catabolic process	32	7.287321e-28	2.99668303246875e-25	2.767971	154	0.03340564	71	2.9507463592957745e-16	2.025386	120	213	0.0229753	
GO Biological Process	peptide biosynthetic process	33	7.291853e-28	2.907681625060606e-25	2.166165	245	0.05314534	46	4.6575107632608696e-23	1.889241	206	392	0.03944093	
GO Biological Process	RNA catabolic process	34	1.929383e-25	7.467279675588236e-23	2.524969	164	0.03557484	86	1.1896421492093022e-14	1.90941	128	241	0.02450699	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	35	6.440757e-24	2.4215406103714283e-21	3.58943	90	0.01952278	113	2.1211597646902655e-11	2.16313	71	118	0.01359372	
GO Biological Process	mitochondrial translation	36	9.944078e-24	3.6348367333888886e-21	3.73166	85	0.01843818	65	2.1439189404615383e-17	2.519902	75	107	0.01435956	
GO Biological Process	RNA 3'-end processing	40	7.000151e-23	2.302874675225e-20	3.583886	86	0.0186551	125	1.6572244583200001e-9	2.116718	63	107	0.01206203	
GO Cellular Component	intracellular ribonucleoprotein complex	8	1.121554e-68	2.42255664e-66	2.304512	530	0.1149675	15	1.891752192e-49	1.881444	426	814	0.08156232	
GO Cellular Component	ribonucleoprotein complex	9	1.67824e-68	3.2222207999999996e-66	2.301578	530	0.1149675	16	2.13713748e-49	1.878936	427	817	0.08175378	
GO Cellular Component	ribosomal subunit	19	9.060518e-33	8.24030268631579e-31	3.375822	136	0.02950108	25	2.1441341952e-21	2.2542	116	185	0.02220946	
GO Cellular Component	ribosome	22	1.823104e-27	1.4319653236363638e-25	2.721469	156	0.03383948	29	7.971746648275863e-21	2.086963	137	236	0.02623014	
GO Cellular Component	mitochondrial ribosome	25	2.533784e-24	1.7513515008e-22	4.658827	68	0.01475054	40	1.2345747840000001e-14	2.53769	60	85	0.01148765	
GO Cellular Component	spliceosomal complex	27	4.447103e-23	2.84614592e-21	2.582813	142	0.0308026	37	1.885676263783784e-16	2.087454	108	186	0.02067777	
GO Cellular Component	large ribosomal subunit	30	6.922965e-21	3.9876278400000004e-19	3.415755	83	0.01800434	42	2.71034784e-13	2.25082	72	115	0.01378518	
GO Cellular Component	catalytic step 2 spliceosome	35	1.745156e-18	8.616084480000001e-17	3.159065	81	0.0175705	49	1.972703843265306e-10	2.209464	59	96	0.01129619	
GO Cellular Component	mitochondrial protein complex	36	4.514406e-18	2.16691488e-16	2.597635	108	0.02342733	45	2.157879552e-12	2.009661	90	161	0.01723148	
GO Cellular Component	mitochondrial membrane part	40	1.197735e-16	5.174215200000001e-15	2.278595	127	0.02754881	47	2.6546411029787233e-11	1.831446	108	212	0.02067777	
GO Cellular Component	inner mitochondrial membrane protein complex	44	1.585585e-15	6.227024727272727e-14	2.603842	91	0.0197397	48	9.011206799999999e-11	2.020581	77	137	0.01474249	
GO Cellular Component	small ribosomal subunit	46	1.2185e-14	4.577321739130435e-13	3.423283	56	0.01214751	50	6.3150935040000004e-9	2.296844	46	72	0.008807199	
GO Cellular Component	mitochondrial large ribosomal subunit	49	3.79336e-14	1.3377400163265306e-12	4.495455	39	0.00845987	58	2.564874273103448e-7	2.396707	34	51	0.006509669	
GO Cellular Component	methyltransferase complex	50	9.181661e-14	3.1731820416000003e-12	2.736505	73	0.01583514	65	0.0000012064834855384617	1.975308	50	91	0.009573042	
GO Cellular Component	MLL1 complex	52	8.629527e-12	2.867658203076923e-10	4.593011	31	0.006724512	72	0.000018415092	2.60332	21	29	0.004020678	
GO Cellular Component	mitochondrial small ribosomal subunit	53	1.647495e-11	5.371455396226415e-10	5.131196	27	0.005856833	53	1.095264760754717e-7	2.953085	23	28	0.004403599	
GO Cellular Component	respiratory chain	55	5.258345e-11	1.6520763927272726e-9	2.527183	65	0.01409978	62	6.608097754838709e-7	1.938513	55	102	0.01053035	
GO Cellular Component	respiratory chain complex	56	1.27534e-10	3.935334857142858e-9	2.605828	59	0.01279826	63	9.549133714285714e-7	2.001795	49	88	0.009381581	
GO Cellular Component	preribosome	57	2.593158e-10	7.8613632e-9	2.780942	51	0.01106291	91	0.0006337626092307693	1.79753	38	76	0.007275512	
GO Cellular Component	cytosolic ribosome	58	2.623337e-10	7.815735062068967e-9	2.305626	72	0.01561822	61	6.573691593442623e-7	1.893826	59	112	0.01129619	
GO Molecular Function	structural constituent of ribosome	6	4.535054e-24	3.1911663313333337e-21	3.056654	113	0.02451193	7	1.7171404765714287e-15	2.17479	98	162	0.01876316	
GO Molecular Function	ribonucleoprotein complex binding	7	3.257954e-14	1.965011684e-11	2.668449	79	0.01713666	17	0.0000023756622788235296	1.906945	61	115	0.01167911	
GO Molecular Function	rRNA binding	8	1.834497e-13	9.681557917499999e-11	4.268571	39	0.00845987	18	0.000010272048596666668	2.216954	37	60	0.007084051	
GO Molecular Function	NADH dehydrogenase activity	10	1.367434e-11	5.7733063479999996e-9	4.037542	35	0.007592191	43	0.0004967576726046512	2.141738	28	47	0.005360904	
GO Molecular Function	NADH dehydrogenase (ubiquinone) activity	11	1.513248e-10	5.80812096e-8	3.866833	33	0.007158351	53	0.001874389560754717	2.077146	26	45	0.004977982	
GO Molecular Function	ATP-dependent helicase activity	12	2.226567e-9	7.833804895e-7	2.216586	70	0.01518438	28	0.000033205622878571426	1.890186	51	97	0.009764503	
GO Molecular Function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	14	1.447789e-8	0.00000436611797	2.960137	37	0.00802603	76	0.015359930428947366	1.79753	29	58	0.005552365	
GO Molecular Function	snRNA binding	24	3.932055e-7	0.000069171400875	3.533428	23	0.004989154	103	0.043336575533980584	1.892137	20	38	0.003829217	
GO Molecular Function	RNA-dependent ATPase activity	25	4.102996e-7	0.000069291396448	2.234596	49	0.01062907	23	0.000014960009014782609	2.114741	40	68	0.007658434	
GO Molecular Function	ATP-dependent RNA helicase activity	28	0.000001238705	0.00018677901821428572	2.186768	47	0.01019523	26	0.000028334329153846154	2.092647	39	67	0.007466973	
GO Molecular Function	RNA helicase activity	29	0.000001617926	0.00023554770937931035	2.164664	47	0.01019523	31	0.000040796409696774194	2.061873	39	68	0.007466973	
GO Molecular Function	small ribosomal subunit rRNA binding	51	0.00003022087	0.002501813983137255	6.858356	8	0.001735358	95	0.03456907381263158	3.145678	7	8	0.001340226	
GO Molecular Function	translation initiation factor activity	69	0.0000990429	0.0060602771565217385	2.179683	30	0.006507592	101	0.0432965263960396	1.762284	25	51	0.004786521	
GO Molecular Function	RNA methyltransferase activity	80	0.0002385624	0.01259013066	2.014071	32	0.006941432	94	0.03246630415957447	1.735546	28	58	0.005360904	
GO Molecular Function	DNA replication origin binding	91	0.0007110176	0.03298809128791209	2.926825	13	0.002819957	78	0.0175470542	2.636378	11	15	0.002106069	
GO Molecular Function	ribosomal small subunit binding	103	0.00109764	0.044992583300970876	2.665477	14	0.003036876	98	0.03731326053061224	2.5679	10	14	0.001914608	
Human Phenotype	Increased serum lactate	14	2.11349e-7	0.00010073799121428571	2.186902	54	0.01171367	214	0.024178140579906544	1.545876	43	100	0.008232816	
Human Phenotype	Abnormal glycosylation	15	6.702526e-7	0.00029817303998666664	4.188592	18	0.003904555	132	0.004807111916969697	2.451177	15	22	0.002871913	
Human Phenotype	Abnormal protein N-linked glycosylation	22	0.000002730784	0.0008282964378181818	3.969892	17	0.003687636	157	0.010045699962420383	2.396707	14	21	0.002680452	
Human Phenotype	Abnormal isoelectric focusing of serum transferrin	26	0.00001050371	0.0026958175703846155	3.752408	16	0.003470716	200	0.0191975103255	2.336789	13	20	0.002488991