# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	RNA processing	1	2.238343e-70	2.9454355537e-66	2.088887	670	0.1266301	16	2.705077536375e-56	1.838014	500	893	0.08741259	
GO Biological Process	ncRNA metabolic process	5	9.394617e-56	2.47247530206e-52	2.433758	393	0.07427707	40	7.93469606375e-29	1.768514	299	555	0.05227273	
GO Biological Process	mRNA metabolic process	8	1.78516e-50	2.936365055e-47	2.05621	504	0.0952561	23	8.734635249565219e-43	1.858034	373	659	0.06520979	
GO Biological Process	ncRNA processing	9	8.084429e-50	1.1820333467888889e-46	2.660535	300	0.05670006	52	3.4334209742307692e-25	1.856876	224	396	0.03916084	
GO Biological Process	ribonucleoprotein complex biogenesis	19	2.533315e-37	1.7545206360526317e-34	2.1817	327	0.06180306	45	1.0235660892888889e-26	1.822111	252	454	0.04405594	
GO Biological Process	translation	20	1.008758e-36	6.6371232610000005e-34	2.358559	274	0.05178605	41	7.866703751463414e-28	1.932553	219	372	0.03828671	
GO Biological Process	rRNA processing	22	1.737505e-35	1.0392649224999999e-32	2.81776	193	0.03647704	85	1.5013316740235293e-16	1.875824	144	252	0.02517483	
GO Biological Process	rRNA metabolic process	23	4.154553e-35	2.3769462142173912e-32	2.771959	196	0.03704404	89	4.446965766853933e-16	1.850475	146	259	0.02552448	
GO Biological Process	RNA splicing	24	1.624524e-34	8.907129715e-32	2.099295	329	0.06218106	39	6.09801219e-29	1.916961	233	399	0.04073427	
GO Biological Process	RNA splicing, via transesterification reactions	25	2.743366e-34	1.44399812776e-31	2.389443	249	0.04706105	55	2.439836508e-24	1.994692	175	288	0.03059441	
GO Biological Process	mRNA splicing, via spliceosome	26	2.708145e-33	1.3706338482692307e-30	2.367216	246	0.04649405	57	5.4458452242105264e-24	1.992652	173	285	0.03024476	
GO Biological Process	ribosome biogenesis	27	2.093645e-32	1.0203805390740741e-29	2.404943	232	0.04384804	72	1.0419363822638888e-18	1.819201	179	323	0.03129371	
GO Biological Process	nuclear-transcribed mRNA catabolic process	28	3.989408e-32	1.874879281142857e-29	2.892159	167	0.03156303	73	1.1839231614520549e-18	2.055828	124	198	0.02167832	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	30	1.151226e-31	5.049660978e-29	3.857173	111	0.02097902	114	1.59000197e-13	2.169915	78	118	0.01363636	
GO Biological Process	peptide biosynthetic process	32	2.992771e-30	1.2306835496562501e-27	2.133872	277	0.05235305	53	4.6443424256603775e-25	1.859076	222	392	0.03881119	
GO Biological Process	mRNA catabolic process	33	1.394499e-29	5.560670406363637e-27	2.693595	172	0.03250803	77	1.2263909439350647e-17	1.988109	129	213	0.02255245	
GO Biological Process	RNA catabolic process	34	7.747044e-29	2.998333882235294e-26	2.521931	188	0.03553204	83	6.267511207951808e-17	1.906958	140	241	0.02447552	
GO Biological Process	viral gene expression	36	3.727655e-28	1.3625614484722224e-25	3.493312	111	0.02097902	152	5.501417758947368e-10	1.964446	76	127	0.01328671	
GO Biological Process	viral transcription	37	2.133089e-27	7.586302202972973e-25	3.566121	105	0.01984502	145	1.0077398154482759e-10	2.062577	71	113	0.01241259	
GO Biological Process	cotranslational protein targeting to membrane	41	3.065394e-25	9.838419425853659e-23	3.761845	90	0.01701002	187	1.995797382406417e-8	2.009812	60	98	0.01048951	
GO Cellular Component	ribonucleoprotein complex	13	4.935296e-66	6.56014729846154e-64	2.179393	576	0.1088641	16	3.09025152e-45	1.779967	443	817	0.07744755	
GO Cellular Component	intracellular ribonucleoprotein complex	14	1.757603e-65	2.169384274285714e-63	2.174594	574	0.1084861	18	6.07786656e-45	1.778461	441	814	0.0770979	
GO Cellular Component	ribosomal subunit	20	3.240365e-36	2.79967536e-34	3.330616	154	0.02910603	34	3.275776207058823e-19	2.093825	118	185	0.02062937	
GO Cellular Component	ribosome	22	8.677019e-31	6.815404014545454e-29	2.70559	178	0.03364203	32	1.26961668e-19	1.975179	142	236	0.02482517	
GO Cellular Component	spliceosomal complex	27	3.115439e-26	1.99388096e-24	2.583184	163	0.03080703	40	8.33847696e-18	2.04727	116	186	0.02027972	
GO Cellular Component	large ribosomal subunit	33	4.062933e-24	2.127499461818182e-22	3.442255	96	0.01814402	47	9.24475220425532e-12	2.083796	73	115	0.01276224	
GO Cellular Component	mitochondrial ribosome	34	1.14516e-23	5.820107294117647e-22	4.29797	72	0.01360801	45	1.063681152e-12	2.317195	60	85	0.01048951	
GO Cellular Component	catalytic step 2 spliceosome	41	1.716903e-18	7.236118009756097e-17	2.990331	88	0.01663202	49	4.2290084571428575e-11	2.154267	63	96	0.01101399	
GO Cellular Component	mitochondrial protein complex	42	5.09035e-18	2.0943154285714285e-16	2.47286	118	0.02230202	42	5.024834742857143e-14	1.998161	98	161	0.01713287	
GO Cellular Component	inner mitochondrial membrane protein complex	45	1.01484e-15	3.8969856e-14	2.493081	100	0.01890002	48	3.34966752e-11	1.964823	82	137	0.01433566	
GO Cellular Component	mitochondrial membrane part	47	2.100119e-15	7.721288578723404e-14	2.126011	136	0.02570403	46	1.922650935652174e-12	1.811675	117	212	0.02045455	
GO Cellular Component	small ribosomal subunit	48	2.435918e-15	8.7693048e-14	3.302247	62	0.01171801	53	3.6814127094339623e-8	2.142869	47	72	0.008216783	
GO Cellular Component	cytosolic ribosome	50	4.558494e-14	1.5754155264e-12	2.483188	89	0.01682102	59	3.591138386440678e-7	1.846514	63	112	0.01101399	
GO Cellular Component	cytosolic large ribosomal subunit	51	2.582991e-13	8.751781270588236e-12	3.17057	56	0.01058401	77	0.000006110017246753247	2.044956	38	61	0.006643357	
GO Cellular Component	mitochondrial large ribosomal subunit	54	2.412165e-12	7.718928e-11	3.916849	39	0.007371007	81	0.000009868669866666666	2.124095	33	51	0.005769231	
GO Cellular Component	methyltransferase complex	55	7.878057e-12	2.475142272e-10	2.449615	75	0.01417501	58	3.159737379310345e-7	1.947971	54	91	0.009440559	
GO Cellular Component	mitochondrial small ribosomal subunit	56	1.42864e-11	4.4083748571428567e-10	4.801932	29	0.005481005	61	6.487795829508197e-7	2.696497	23	28	0.004020979	
GO Cellular Component	nuclear ubiquitin ligase complex	58	1.319317e-10	3.930654786206896e-9	3.623392	36	0.006804007	89	0.00013214060656179774	2.13375	26	40	0.004545455	
GO Cellular Component	protein acetyltransferase complex	59	5.165229e-10	1.512799273220339e-8	2.187267	78	0.01474201	55	1.0925201454545454e-7	1.991746	54	89	0.009440559	
GO Cellular Component	respiratory chain	60	8.538576e-10	2.4591098880000002e-8	2.303538	68	0.01285201	68	0.0000020733974682352944	1.834446	57	102	0.009965035	
GO Molecular Function	structural constituent of ribosome	6	4.851045e-30	3.413518665e-27	3.18174	135	0.02551503	8	8.2922454875e-17	2.127671	105	162	0.01835664	
GO Molecular Function	ribonucleoprotein complex binding	9	2.412794e-15	1.131868474222222e-12	2.619298	89	0.01682102	18	3.283200771111111e-9	1.998161	70	115	0.01223776	
GO Molecular Function	rRNA binding	11	9.94486e-15	3.817018083636364e-12	4.195983	44	0.008316008	76	0.00038450137313157895	1.914904	35	60	0.006118881	
GO Molecular Function	O-methyltransferase activity	14	3.831356e-12	1.1554275022857141e-9	4.748379	31	0.005859006	88	0.0009863196513636362	2.501099	16	21	0.002797203	
GO Molecular Function	unfolded protein binding	16	3.247538e-10	8.569440897500001e-8	2.454148	63	0.01190701	61	0.0002249448377704918	1.703284	55	106	0.009615385	
GO Molecular Function	NADH dehydrogenase activity	19	6.229857e-9	0.0000013843398028421053	3.316852	33	0.006237006	119	0.011986169302521008	1.815957	26	47	0.004545455	
GO Molecular Function	sequence-specific single stranded DNA binding	24	3.568071e-8	0.000006276831567500001	4.409244	21	0.003969004	116	0.010378294741379312	2.579258	11	14	0.001923077	
GO Molecular Function	NADH dehydrogenase (ubiquinone) activity	26	4.901216e-8	0.00000795882075076923	3.164946	31	0.005859006	140	0.03438113322857143	1.750769	24	45	0.004195804	
GO Molecular Function	RNA polymerase core enzyme binding	29	1.686112e-7	0.000024547465048275866	2.637056	38	0.007182007	99	0.003182467262828283	2.063407	22	35	0.003846154	
GO Molecular Function	aminoacyl-tRNA ligase activity	34	5.95703e-7	0.00007397229605882354	2.576123	36	0.006804007	122	0.013873744627868854	1.823718	25	45	0.004370629	
GO Molecular Function	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	35	6.671545e-7	0.00008047789425714286	2.982348	28	0.005292005	99	0.003182467262828283	2.063407	22	35	0.003846154	
GO Molecular Function	RNA polymerase binding	37	8.791239e-7	0.00010031516502162162	2.194868	48	0.009072009	85	0.0007154382649411764	1.969615	30	50	0.005244755	
GO Molecular Function	ATP-dependent RNA helicase activity	38	0.000001015961	0.00011287861426315789	2.108004	52	0.00982801	38	0.00007462822754736843	1.959816	40	67	0.006993007	
GO Molecular Function	telomeric DNA binding	39	0.000001077566	0.00011665342697435897	2.785519	30	0.005670006	128	0.018459329446875	1.930995	20	34	0.003496503	
GO Molecular Function	RNA helicase activity	40	0.000001352505	0.00014275690274999998	2.086696	52	0.00982801	44	0.00011058060895454547	1.930995	40	68	0.006993007	
GO Molecular Function	RNA polymerase II core binding	44	0.000001402388	0.00013456550309090908	2.600393	33	0.006237006	113	0.008407455414159293	2.110302	18	28	0.003146853	
GO Molecular Function	RNA-dependent ATPase activity	47	0.000001782142	0.00016008943668085107	2.066186	52	0.00982801	44	0.00011058060895454547	1.930995	40	68	0.006993007	
GO Molecular Function	proton-transporting ATP synthase activity, rotational mechanism	50	0.000001971703	0.00016649060132000002	3.875101	18	0.003402003	94	0.0021279401012765957	2.553205	14	18	0.002447552	
GO Molecular Function	RNA methyltransferase activity	54	0.00000298058	0.00023303719925925928	2.248391	41	0.007749008	54	0.0001831534874074074	1.980935	35	58	0.006118881	
GO Molecular Function	small ribosomal subunit rRNA binding	60	0.00001144369	0.0008052543196666667	6.722576	9	0.001701002	97	0.003216814052783505	3.282692	8	8	0.001398601	
Human Phenotype	Mood swings	1	2.463022e-16	1.6435745805999999e-12	12.38456	21	0.003969004	231	0.04117027232900433	2.872356	7	8	0.001223776	
Human Phenotype	Increased serum lactate	2	2.899444e-14	9.673994906e-11	2.716999	77	0.01455301	48	0.00001333116091625	1.838308	56	100	0.00979021	
Human Phenotype	Lactic acidosis	3	4.176475e-13	9.289872558333333e-10	2.230294	102	0.01927802	36	0.000001406815206	1.773133	74	137	0.01293706	
Human Phenotype	Hypertrophic cardiomyopathy	7	1.425339e-9	0.0000013587553067142858	2.101871	81	0.01530902	116	0.002004059520862069	1.585707	57	118	0.009965035	
Human Phenotype	Abnormal CSF metabolite level	8	2.590011e-9	0.0000021603929253750003	2.828195	44	0.008316008	228	0.040331436394736846	1.615293	31	63	0.00541958	
Human Phenotype	Increased CSF lactate	17	3.456756e-8	0.000013568783992941177	2.768085	39	0.007371007	229	0.041265861139737986	1.641346	29	58	0.00506993	
Human Phenotype	Abnormality of the mitochondrion	21	9.155431e-8	0.00002909247193476191	2.289016	52	0.00982801	118	0.0024022636002542373	1.756934	38	71	0.006643357	
Human Phenotype	Abnormality of mitochondrial metabolism	23	1.081278e-7	0.00003137116562608696	2.297614	51	0.00963901	119	0.0028333670151260504	1.760284	37	69	0.006468531	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	24	1.329529e-7	0.00003696644590416666	4.249208	20	0.003780004	138	0.005199427521739131	2.626154	12	15	0.002097902	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	26	7.060295e-7	0.00018120518667307694	3.81101	20	0.003780004	167	0.012395061537724551	2.462019	12	16	0.002097902	
Human Phenotype	Central hypotonia	83	0.00007575773	0.006090738943253012	5.251969	9	0.001701002	204	0.026092614130392155	3.282692	6	6	0.001048951	
Human Phenotype	Prominent fingertip pads	88	0.00009642381	0.007311773683295455	3.869079	12	0.002268002	231	0.04117027232900433	2.872356	7	8	0.001223776	
Human Phenotype	Emotional lability	116	0.0003297788	0.018970809762068965	2.1186	27	0.005103005	134	0.0044458050784328355	1.953984	25	42	0.004370629	
Mouse Phenotype Single KO	abnormal thymus development	17	7.122095e-7	0.0003836295524411765	3.12355	26	0.004914005	54	0.006777446718333333	2.667187	13	16	0.002272727	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	19	8.35814e-7	0.00040281835778947366	2.26563	45	0.008505009	94	0.04667197234787234	1.696058	31	60	0.00541958	
Mouse Phenotype Single KO	absent hypoglossal nerve	33	0.000008841636	0.0024534200258181822	3.623472	17	0.003213003	63	0.01562881876190476	2.626154	12	15	0.002097902	
Mouse Phenotype	absent hypoglossal nerve	30	0.000008841636	0.0028178293932000003	3.623472	17	0.003213003	87	0.011816736620689655	2.626154	12	15	0.002097902