# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of gene expression, epigenetic	20	1.995269e-51	1.3127872385500001e-48	2.076873	523	0.03181072	254	1.9422621831496063e-8	1.283499	202	248	0.016952	
GO Biological Process	nuclear-transcribed mRNA catabolic process	24	3.830422e-43	2.100188462416667e-40	2.179174	391	0.02378201	103	4.488115856116505e-21	1.47232	185	198	0.01552534	
GO Biological Process	mRNA catabolic process	28	2.176665e-41	1.0229548119642857e-38	2.086478	414	0.02518095	93	1.3187873392903225e-23	1.479606	200	213	0.01678416	
GO Biological Process	rRNA processing	37	7.235851e-39	2.573420629972973e-36	2.006245	427	0.02597166	129	1.4528250054263566e-17	1.394441	223	252	0.01871433	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	46	1.138505e-35	3.256866803260869e-33	2.572074	230	0.01398942	154	4.778677178311688e-14	1.495656	112	118	0.009399127	
GO Biological Process	gene silencing	54	1.920908e-31	4.680968217037037e-29	2.028603	333	0.02025424	523	0.0012075780306309751	1.216853	139	180	0.01166499	
GO Biological Process	viral gene expression	57	2.204659e-29	5.089668031754386e-27	2.319313	229	0.01392859	216	1.5256587244907407e-10	1.426888	115	127	0.00965089	
GO Biological Process	translational initiation	61	6.251414e-29	1.3485632266557377e-26	2.151964	265	0.01611824	209	7.428633270334928e-11	1.410489	128	143	0.01074186	
GO Biological Process	positive regulation of gene expression, epigenetic	66	3.267595e-28	6.514891303787879e-26	2.689155	166	0.01009671	680	0.008091331704558825	1.280322	65	80	0.005454851	
GO Biological Process	multi-organism metabolic process	67	4.43984e-28	8.719978292537313e-26	2.099211	272	0.01654401	197	1.9360516074619287e-11	1.414987	132	147	0.01107754	
GO Biological Process	regulation of DNA-templated transcription in response to stress	68	5.565217e-28	1.0769513309264706e-25	2.102473	270	0.01642236	320	0.00000226880117184375	1.350669	102	119	0.008559919	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	71	2.265619e-27	4.199053580422535e-25	2.166852	246	0.01496259	331	0.000003976602093655589	1.352661	97	113	0.008140316	
GO Biological Process	cellular response to topologically incorrect protein	73	1.294227e-26	2.3329771360273974e-24	2.044156	274	0.01666565	485	0.0005398538083711341	1.258357	111	139	0.009315206	
GO Biological Process	cotranslational protein targeting to membrane	74	1.359406e-26	2.4173545343243245e-24	2.461609	183	0.01113071	191	1.2909137459162303e-11	1.495384	93	98	0.007804632	
GO Biological Process	endoplasmic reticulum unfolded protein response	75	1.579364e-26	2.7710467834666668e-24	2.178867	235	0.01429353	443	0.00020542511929571105	1.299328	94	114	0.007888553	
GO Biological Process	ribonucleoprotein complex export from nucleus	80	1.453658e-25	2.3910857027500003e-23	2.17846	226	0.01374612	290	3.873083478655172e-7	1.361474	108	125	0.009063444	
GO Biological Process	protein targeting to ER	83	6.689295e-25	1.0605353362048194e-22	2.361963	185	0.01125236	170	3.7260219378823535e-13	1.513373	97	101	0.008140316	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	86	1.83651e-24	2.810073847674419e-22	2.441651	170	0.01034	192	1.3951322580208334e-11	1.507268	88	92	0.007385029	
GO Biological Process	viral transcription	89	5.073442e-24	7.501283514382023e-22	2.21877	203	0.01234718	213	1.2842825679812206e-10	1.450276	104	113	0.008727761	
GO Biological Process	ribonucleoprotein complex localization	91	5.504073e-24	7.959131495274725e-22	2.110724	227	0.01380695	301	7.195516070431894e-7	1.352441	109	127	0.009147365	
GO Cellular Component	ribosomal subunit	30	1.64236e-28	9.4599936e-27	2.046259	294	0.01788212	42	1.1850331885714286e-14	1.413944	166	185	0.01393085	
GO Cellular Component	ficolin-1-rich granule lumen	37	1.484068e-23	6.93099865945946e-22	2.045861	240	0.01459765	150	0.0014768893439999998	1.245375	98	124	0.008224236	
GO Cellular Component	nuclear chromosome, telomeric region	44	1.881173e-20	7.387879418181818e-19	2.015038	214	0.01301624	162	0.0023261194666666664	1.229586	103	132	0.00864384	
GO Cellular Component	large ribosomal subunit	51	2.030101e-17	6.878459858823529e-16	2.030925	176	0.01070494	64	4.8111246e-9	1.411351	103	115	0.00864384	
GO Cellular Component	mitochondrial ribosome	56	5.29693e-16	1.6344812571428573e-14	2.305269	120	0.007298826	84	0.0000011329031314285714	1.408933	76	85	0.006377979	
GO Cellular Component	small ribosomal subunit	61	2.187216e-13	6.1959167999999995e-12	2.09116	122	0.007420473	91	0.000004126686171428571	1.42258	65	72	0.005454851	
GO Cellular Component	cytoplasmic stress granule	62	2.474728e-13	6.897306425806452e-12	2.156608	113	0.006873061	116	0.00012621629296551723	1.465842	40	43	0.003356831	
GO Cellular Component	spliceosomal snRNP complex	65	1.796315e-12	4.775434338461538e-11	2.191138	101	0.006143179	130	0.00039773615261538456	1.372454	54	62	0.004531722	
GO Cellular Component	endopeptidase complex	69	6.46565e-12	1.6192236521739132e-10	2.001318	119	0.007238003	119	0.00017385437042016807	1.370244	60	69	0.005035247	
GO Cellular Component	nuclear ubiquitin ligase complex	77	1.300323e-11	2.91812745974026e-10	2.429314	75	0.004561766	218	0.019174236770642204	1.339413	34	40	0.002853306	
GO Cellular Component	small nuclear ribonucleoprotein complex	85	2.820089e-11	5.733075049411765e-10	2.005652	111	0.006751414	119	0.00017385437042016807	1.370244	60	69	0.005035247	
GO Cellular Component	sex chromosome	86	2.899257e-11	5.82548383255814e-10	2.510338	68	0.004136001	244	0.03203369232786885	1.39396	23	26	0.001930178	
GO Cellular Component	retromer complex	89	6.59435e-11	1.280341213483146e-9	2.541701	64	0.003892707	253	0.0400893882687747	1.425706	19	21	0.001594495	
GO Cellular Component	mitochondrial large ribosomal subunit	93	4.783485e-10	8.888023741935485e-9	2.294775	71	0.004318472	164	0.002868502126829268	1.359497	44	51	0.003692514	
GO Cellular Component	mitochondrial nucleoid	105	1.245687e-8	2.0500448914285714e-7	2.077096	74	0.004500943	199	0.011327317869346735	1.350669	36	42	0.003021148	
GO Cellular Component	preribosome, large subunit precursor	114	1.164164e-7	0.0000017646275368421053	2.340933	49	0.002980354	200	0.01139718816	1.449718	23	25	0.001930178	
GO Cellular Component	nBAF complex	124	3.938916e-7	0.000005489070038709678	2.026471	62	0.00377106	209	0.01416592076555024	1.57578	14	14	0.001174891	
GO Cellular Component	mitochondrial small ribosomal subunit	125	4.735705e-7	0.0000065466385919999995	2.344662	44	0.002676236	135	0.000640867456	1.519503	27	28	0.002265861	
GO Cellular Component	endoribonuclease complex	127	5.169923e-7	0.000007034351924409449	2.127017	54	0.003284472	168	0.0029104714285714283	1.467106	27	29	0.002265861	
GO Cellular Component	npBAF complex	128	5.256446e-7	0.0000070962021	2.309864	45	0.00273706	237	0.031043272101265826	1.57578	12	12	0.001007049	
GO Molecular Function	unfolded protein binding	7	1.142732e-28	6.892306434285714e-26	2.469653	197	0.01198224	92	0.0003590983092391305	1.308195	88	106	0.007385029	
GO Molecular Function	ribonucleoprotein complex binding	9	1.263705e-23	5.9281805666666665e-21	2.112075	223	0.01356365	46	1.6354724686956523e-8	1.411351	103	115	0.00864384	
GO Molecular Function	rRNA binding	10	6.168755e-23	2.6044483609999998e-20	3.161024	103	0.006264826	136	0.006200519227941176	1.339413	51	60	0.00427996	
GO Molecular Function	nucleosome binding	11	9.210392e-17	3.535115911272727e-14	2.102728	155	0.00942765	201	0.04937811743283582	1.265399	53	66	0.004447801	
GO Molecular Function	snRNA binding	16	1.039037e-13	2.74175888375e-11	2.886131	67	0.004075178	182	0.030011715835164834	1.368441	33	38	0.002769386	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	22	8.201e-12	1.5738464545454545e-9	2.36031	81	0.004926708	141	0.008472820390070922	1.467106	27	29	0.002265861	
GO Molecular Function	O-methyltransferase activity	26	5.17152e-11	8.397752861538461e-9	2.760459	56	0.003406119	173	0.02264240296531792	1.500743	20	21	0.001678416	
GO Molecular Function	telomeric DNA binding	36	4.935127e-9	5.787807276111111e-7	2.151428	72	0.004379296	180	0.02891912847777778	1.390395	30	34	0.002517623	
GO Molecular Function	protein binding involved in protein folding	55	6.049981e-8	0.000004644185414909092	2.283077	54	0.003284472	155	0.016725033523870968	1.459056	25	27	0.002098019	
GO Molecular Function	mannosyltransferase activity	133	0.00001221633	0.00038779958842105264	2.11764	41	0.002493766	195	0.0416855814051282	1.444465	22	24	0.001846257	
GO Molecular Function	vitamin D receptor binding	202	0.00006885523	0.0014391424804950496	2.035821	37	0.002250471	175	0.02622076718857143	1.57578	15	15	0.001258812	
Human Phenotype	Basal cell carcinoma	104	0.00000943686	0.0006055016036538462	2.006616	48	0.00291953	151	0.0019831665468211922	1.57578	22	22	0.001846257	
Human Phenotype	Intestinal polyp	141	0.00003622893	0.0017145790772340424	2.015609	41	0.002493766	297	0.03849568321548821	1.57578	14	14	0.001174891	
Human Phenotype	Progressive macrocephaly	156	0.00005312811	0.002272588961730769	2.04029	38	0.002311295	302	0.04254185543377483	1.444465	22	24	0.001846257	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	6	4.845136e-15	7.394485058666666e-12	2.138749	132	0.008028709	100	0.0013037113923999998	1.391939	53	60	0.004447801	
Mouse Phenotype Single KO	early cellular replicative senescence	8	1.166787e-13	1.335533569875e-10	2.149778	117	0.007116355	166	0.010925531127108435	1.363656	45	52	0.003776435	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	28	4.658773e-10	1.5235851557500001e-7	2.499769	60	0.003649413	108	0.0015302160955555557	1.57578	24	24	0.002014099	
Mouse Phenotype	early cellular replicative senescence	12	4.939358e-16	3.9354334864999996e-13	2.004196	166	0.01009671	177	0.0006741250433898305	1.35992	63	73	0.005287009	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	35	1.594971e-11	4.357005066e-9	2.488159	71	0.004318472	123	0.00009118551121951219	1.57578	30	30	0.002517623	
Mouse Phenotype	increased acute lymphoblastic leukemia incidence	198	0.000009275004	0.0004478702689090909	2.37271	33	0.002007177	324	0.020343594805555556	1.57578	16	16	0.001342732