# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process	27	9.589553e-43	4.673663997296296e-40	2.100514	422	0.02292357	120	1.5389439534166665e-14	1.387087	179	198	0.01462657	
GO Biological Process	mRNA catabolic process	32	1.586053e-40	6.5221473209375e-38	2.007457	446	0.02422728	118	1.2828129211864406e-14	1.375845	191	213	0.01560713	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	39	4.929967e-37	1.6634214295641026e-34	2.506845	251	0.01363464	195	1.5436883633846155e-9	1.404292	108	118	0.008824971	
GO Biological Process	viral gene expression	47	6.763723e-33	1.893698531e-30	2.324637	257	0.01396056	197	2.0787619644162437e-9	1.389344	115	127	0.00939696	
GO Biological Process	endoplasmic reticulum unfolded protein response	50	3.070261e-32	8.0803128998e-30	2.244037	271	0.01472106	327	0.000019400188951070336	1.318976	98	114	0.008007844	
GO Biological Process	cotranslational protein targeting to membrane	52	3.370382e-31	8.529010911153847e-29	2.510801	209	0.01135314	213	6.827574950704225e-9	1.424725	91	98	0.007435856	
GO Biological Process	protein targeting to ER	54	1.057526e-30	2.5770341914814817e-28	2.451533	215	0.01167907	161	4.672405361801243e-11	1.458363	96	101	0.007844419	
GO Biological Process	multi-organism metabolic process	57	4.641349e-30	1.0715002015964911e-27	2.074683	301	0.0163507	143	3.115374845804196e-12	1.409069	135	147	0.01103121	
GO Biological Process	cellular response to topologically incorrect protein	58	5.846087e-30	1.3263561867758622e-27	2.052165	308	0.01673095	395	0.0002830676131240506	1.258363	114	139	0.009315248	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	60	7.744423e-30	1.6984810376166668e-27	2.526963	197	0.01070129	192	1.1829605171354167e-9	1.450932	87	92	0.007109005	
GO Biological Process	viral transcription	61	8.270317e-30	1.784083629557377e-27	2.303702	236	0.01281982	215	7.752383091627907e-9	1.398539	103	113	0.008416408	
GO Biological Process	translational initiation	65	5.987456e-29	1.212137438523077e-26	2.081465	287	0.0155902	208	5.023238844759615e-9	1.362647	127	143	0.01037751	
GO Biological Process	protein localization to endoplasmic reticulum	69	2.834597e-27	5.405864046811594e-25	2.126959	256	0.01390624	159	3.7464037148427677e-11	1.422957	115	124	0.00939696	
GO Biological Process	protein targeting to membrane	73	1.301178e-26	2.3455070276712326e-24	2.024359	281	0.01526427	178	2.1809504819101127e-10	1.396918	122	134	0.009968949	
GO Biological Process	cellular response to unfolded protein	75	3.439319e-26	6.034399829466667e-24	2.028054	275	0.01493835	363	0.00007611894238842975	1.293393	102	121	0.008334695	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	79	2.142731e-25	3.5691388897468355e-23	2.198763	220	0.01195068	167	8.951697356886229e-11	1.446644	99	105	0.008089557	
GO Biological Process	regulation of mitochondrial membrane permeability	118	8.331231e-21	9.290734638050847e-19	2.054215	208	0.01129882	261	9.694124381226055e-7	1.429229	68	73	0.005556463	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	120	1.342766e-20	1.4724548161666666e-18	2.190589	177	0.009614862	651	0.00814123073778802	1.289718	58	69	0.004739336	
GO Biological Process	regulation of viral transcription	138	4.933615e-19	4.704452158333334e-17	2.180844	164	0.008908686	649	0.00814864688120185	1.29827	55	65	0.004494198	
GO Biological Process	regulation of release of cytochrome c from mitochondria	145	2.758863e-18	2.5037157391034483e-16	2.331072	136	0.007387691	404	0.0003401578699752475	1.432031	42	45	0.003431933	
GO Cellular Component	ribosomal subunit	31	1.073922e-30	5.986249083870968e-29	2.026418	326	0.01770873	39	9.316060061538462e-14	1.385034	167	185	0.01364602	
GO Cellular Component	large ribosomal subunit	50	5.832947e-19	2.0158664831999998e-17	2.019926	196	0.01064697	45	4.21581696e-10	1.414242	106	115	0.008661546	
GO Cellular Component	mitochondrial ribosome	51	2.556013e-18	8.66037345882353e-17	2.333336	136	0.007387691	55	5.463826036363636e-8	1.426014	79	85	0.006455303	
GO Cellular Component	small ribosomal subunit	62	6.015431e-14	1.676558833548387e-12	2.051305	134	0.007279048	103	0.000270586345631068	1.342529	63	72	0.0051479	
GO Cellular Component	mitochondrial large ribosomal subunit	82	1.291553e-11	2.7217116878048777e-10	2.338109	81	0.004400022	115	0.0006139340577391304	1.383896	46	51	0.003758784	
GO Cellular Component	U12-type spliceosomal complex	106	1.022664e-8	1.667135275471698e-7	2.438164	53	0.002879027	170	0.015957022870588235	1.416295	24	26	0.001961105	
GO Cellular Component	COPI-coated vesicle	114	3.930026e-8	5.957092042105262e-7	2.294703	55	0.002987669	212	0.036764626415094336	1.4009	21	23	0.001715967	
GO Cellular Component	INO80-type complex	128	1.646589e-7	0.00000222289515	2.605082	39	0.002118529	212	0.036764626415094336	1.4009	21	23	0.001715967	
GO Cellular Component	MLL1 complex	131	3.066152e-7	0.000004044511951145038	2.114859	57	0.003096312	191	0.025186314722513085	1.375597	26	29	0.00212453	
GO Cellular Component	mitochondrial small ribosomal subunit	154	0.000001630542	0.000018295951792207793	2.18919	46	0.002498778	127	0.0013408471785826773	1.479522	27	28	0.002206243	
GO Cellular Component	exon-exon junction complex	181	0.000007589312	0.00007245486815469613	2.118451	43	0.002335814	130	0.001647297083076923	1.534319	21	21	0.001715967	
GO Cellular Component	proteasome regulatory particle	189	0.0000163089	0.00014910994285714286	2.069684	42	0.002281493	168	0.015601073142857145	1.461257	20	21	0.001634254	
GO Cellular Component	U2 snRNP	198	0.00002854081	0.00024908343272727273	2.239135	33	0.001792601	199	0.02832132952763819	1.453566	18	19	0.001470829	
GO Cellular Component	methylosome	233	0.0001171711	0.0008689770849785409	2.654306	20	0.001086425	225	0.045035612159999995	1.534319	12	12	0.0009805524	
GO Molecular Function	rRNA binding	11	8.267241e-24	3.173117409272727e-21	3.069776	112	0.006083981	88	0.0004739452158181818	1.380887	54	60	0.004412486	
GO Molecular Function	O-methyltransferase activity	126	0.000002518188	0.00008437928361904761	2.113161	48	0.00260742	156	0.04105004591025641	1.461257	20	21	0.001634254	
Human Phenotype	Abnormal CSF metabolite level	5	3.796925e-14	5.067376104999999e-11	2.179948	118	0.006409908	105	0.001058409614190476	1.363839	56	63	0.004575911	
Human Phenotype	Increased CSF lactate	13	2.457291e-11	1.2613463725384614e-8	2.080763	102	0.005540768	82	0.0003124310806707317	1.40205	53	58	0.004330773	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	138	0.000003182356	0.00015388305498550723	2.24544	41	0.002227171	219	0.03219146610958904	1.534319	16	16	0.001307403	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	139	0.000003430762	0.0001647012577410072	2.320434	38	0.002064208	242	0.04471682082644628	1.534319	15	15	0.00122569	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	2	1.902512e-22	8.710651192e-19	2.373164	164	0.008908686	216	0.022097430756944442	1.304171	51	60	0.004167348	
Mouse Phenotype	abnormal cellular replicative senescence	1	1.775678e-28	1.6977257358e-24	2.251535	236	0.01281982	189	0.0010254986955555555	1.315131	72	84	0.005883314	
Mouse Phenotype	early cellular replicative senescence	4	2.174224e-24	5.196938916e-21	2.22125	206	0.01119018	205	0.001990141738390244	1.324139	63	73	0.0051479	
Mouse Phenotype	decreased cellular sensitivity to ultraviolet irradiation	295	0.000007427317	0.00024072060283728816	2.268724	37	0.002009886	424	0.03656811905660377	1.534319	15	15	0.00122569