# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process	31	4.864166e-46	2.0647600127096776e-43	2.008247	510	0.02191663	138	2.8997048438405797e-16	1.335581	189	198	0.01408346	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	34	1.072537e-45	4.151033642058824e-43	2.302649	370	0.0159003	331	0.000002359608669093656	1.287741	104	113	0.007749627	
GO Biological Process	regulation of DNA-templated transcription in response to stress	39	1.898773e-42	6.406654847948718e-40	2.162176	393	0.0168887	304	5.413846345394737e-7	1.29336	110	119	0.008196721	
GO Biological Process	endoplasmic reticulum unfolded protein response	41	7.595674e-42	2.437840833317073e-39	2.273129	347	0.0149119	575	0.001749820427947826	1.215078	99	114	0.007377049	
GO Biological Process	cellular response to topologically incorrect protein	45	3.741793e-41	1.0941834241555557e-38	2.113683	401	0.01723249	497	0.0006665316802414487	1.207925	120	139	0.008941878	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	54	3.583046e-36	8.731352280370371e-34	2.29922	291	0.01250537	248	4.5026755189516126e-9	1.328036	112	118	0.008345753	
GO Biological Process	cellular response to unfolded protein	58	1.342419e-35	3.045670969137931e-33	2.082806	357	0.01534164	635	0.002668512573858268	1.202601	104	121	0.007749627	
GO Biological Process	positive regulation of mRNA catabolic process	68	3.116957e-33	6.031770171029412e-31	2.960297	169	0.00726257	934	0.03471766865952891	1.343213	24	25	0.001788376	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	74	2.162369e-32	3.845218063648649e-30	3.468796	131	0.005629566	986	0.044360897455375255	1.340881	23	24	0.00171386	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	79	2.05749e-30	3.4271532797468355e-28	2.261779	251	0.01078642	587	0.0018894250392674618	1.255675	70	78	0.005216095	
GO Biological Process	viral gene expression	87	5.100954e-28	7.71533950413793e-26	2.053703	287	0.01233348	223	3.708860609461883e-10	1.333077	121	127	0.009016393	
GO Biological Process	cotranslational protein targeting to membrane	97	3.728268e-27	5.057760681649484e-25	2.214398	233	0.01001289	220	2.2124160905e-10	1.370626	96	98	0.007153502	
GO Biological Process	positive regulation of mRNA metabolic process	99	4.81042e-27	6.393971391919192e-25	2.28907	216	0.009282338	816	0.014416429531617649	1.264644	47	52	0.003502235	
GO Biological Process	protein targeting to ER	116	2.793342e-25	3.1687575325862067e-23	2.12885	236	0.01014181	212	8.839353416509433e-11	1.371474	99	101	0.007377049	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	122	9.094201e-25	9.809064832704919e-23	2.191898	216	0.009282338	233	1.400745052746781e-9	1.368763	90	92	0.006706408	
GO Biological Process	regulation of mRNA catabolic process	124	3.486289e-24	3.6996836250806457e-22	2.353103	181	0.007778255	728	0.007209217799313187	1.354045	30	31	0.002235469	
GO Biological Process	translational elongation	132	2.026378e-23	2.020083947121212e-21	2.00373	252	0.01082939	225	4.2032232165333335e-10	1.34921	108	112	0.00804769	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	144	4.416614e-22	4.035987751805555e-20	2.098614	211	0.009067469	364	0.000020179109593406593	1.33653	64	67	0.004769001	
GO Biological Process	mitochondrial transmembrane transport	157	6.40984e-21	5.372425768152866e-19	2.021841	218	0.009368285	434	0.00019583423913824884	1.281177	76	83	0.005663189	
GO Biological Process	mitochondrial translational termination	161	8.961935e-21	7.324851097204969e-19	2.148061	187	0.008036098	338	0.0000033031967071301775	1.318768	82	87	0.006110283	
GO Cellular Component	mitochondrial ribosome	41	8.690481e-26	3.66271979707317e-24	2.44312	180	0.007735281	87	0.0000029491875310344825	1.316876	80	85	0.005961252	
GO Cellular Component	PcG protein complex	47	3.053214e-22	1.1225433599999999e-20	2.131576	205	0.008809626	130	0.0004698719113846154	1.338346	44	46	0.003278689	
GO Cellular Component	mitochondrial large ribosomal subunit	49	2.706447e-19	9.544368195918367e-18	2.626101	115	0.004941985	137	0.0006980065541605839	1.316876	48	51	0.003576751	
GO Cellular Component	nuclear ubiquitin ligase complex	50	6.144722e-19	2.1236159232e-17	2.608909	114	0.004899012	196	0.009832875428571428	1.294242	37	40	0.002757079	
GO Cellular Component	cleavage furrow	51	7.237858e-19	2.4523565929411764e-17	2.012668	197	0.008465836	94	0.000010136751319148935	1.372273	51	52	0.003800298	
GO Cellular Component	endopeptidase complex	57	2.838238e-17	8.604342568421053e-16	2.043758	172	0.007391491	135	0.000671260288	1.277512	63	69	0.004694486	
GO Cellular Component	outer mitochondrial membrane protein complex	59	1.178728e-16	3.4522745491525425e-15	3.846553	56	0.002406532	234	0.04778069907692308	1.39918	15	15	0.001117735	
GO Cellular Component	proteasome complex	61	2.331101e-16	6.603512340983606e-15	2.009245	169	0.00726257	141	0.0008254163336170213	1.275723	62	68	0.00461997	
GO Cellular Component	MLL1 complex	94	3.374515e-11	6.203363744680851e-10	2.318822	79	0.003394929	188	0.006755870604255319	1.350933	28	29	0.002086438	
GO Cellular Component	endoribonuclease complex	113	1.795393e-9	2.7455213309734513e-8	2.142889	77	0.003308982	139	0.0007251685018705036	1.39918	29	29	0.002160954	
GO Cellular Component	DNA-directed RNA polymerase III complex	152	6.079212e-8	6.911104168421054e-7	2.846093	36	0.001547056	204	0.01428017505882353	1.39918	19	19	0.001415797	
GO Cellular Component	U12-type spliceosomal complex	158	1.192337e-7	0.0000013040242632911392	2.147202	59	0.002535453	205	0.015378036760975608	1.345366	25	26	0.001862891	
GO Cellular Component	CCR4-NOT complex	161	1.443201e-7	0.0000015489759801242238	2.201682	55	0.002363558	223	0.03582211415246637	1.39918	16	16	0.00119225	
GO Cellular Component	very-low-density lipoprotein particle	199	0.000004029185	0.00003498709386934674	2.0094	52	0.002234637	200	0.01040600736	1.39918	20	20	0.001490313	
GO Molecular Function	unfolded protein binding	13	6.144883e-25	1.9956689250769233e-22	2.108039	238	0.01022776	113	0.0006381665088495574	1.240783	94	106	0.007004471	
GO Molecular Function	rRNA binding	14	1.095694e-23	3.3043000485714284e-21	2.797127	129	0.005543618	100	0.00018070675084	1.329221	57	60	0.004247392	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	28	1.138635e-14	1.7168989178571428e-12	2.285277	111	0.00477009	118	0.002087114213898305	1.39918	29	29	0.002160954	
GO Molecular Function	SUMO transferase activity	32	3.982076e-14	5.2538515225e-12	2.709051	77	0.003308982	198	0.0359478565050505	1.39918	19	19	0.001415797	
GO Molecular Function	snRNA binding	37	1.029413e-12	1.174643698918919e-10	2.465233	81	0.003480877	96	0.00012403545527083334	1.39918	38	38	0.002831595	
GO Molecular Function	NF-kappaB binding	48	3.628184e-11	3.1912901766666665e-9	2.179684	90	0.003867641	177	0.023764710114124295	1.34921	27	28	0.002011923	
Human Phenotype	Abnormal CSF metabolite level	31	1.007324e-14	2.1683461458064515e-12	2.060711	141	0.006059304	79	5.230846444303798e-8	1.39918	63	63	0.004694486	
Human Phenotype	Abnormal shape of the occiput	64	2.694856e-11	2.80980845125e-9	2.008242	111	0.00477009	439	0.04822101325740319	1.282582	33	36	0.002459016	
Human Phenotype	Increased muscle lipid content	204	7.167462e-7	0.000023445330355882352	2.333699	43	0.001847873	399	0.028194746220551382	1.39918	19	19	0.001415797	
Human Phenotype	Increased intramyocellular lipid droplets	372	0.00001982783	0.0003556750257795699	2.140411	38	0.001633004	445	0.04952811566741573	1.39918	17	17	0.001266766	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	482	0.00007622324	0.0010552648973443982	2.097406	34	0.001461109	414	0.0380347621763285	1.39918	18	18	0.001341282