# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	11	3.92958e-58	4.700849383636364e-55	2.063804	591	0.06298625	50	4.5646570832e-28	1.527297	382	555	0.04514299	
GO Biological Process	ncRNA processing	16	1.928144e-51	1.585777931e-48	2.220377	444	0.04731962	52	1.4923262558076922e-24	1.585785	283	396	0.03344363	
GO Biological Process	rRNA processing	20	5.802053e-44	3.817460771350001e-41	2.486278	302	0.03218587	107	5.44398898317757e-16	1.59379	181	252	0.02138974	
GO Biological Process	rRNA metabolic process	22	1.233005e-42	7.375051270454544e-40	2.432353	305	0.0325056	119	5.070317511764706e-15	1.56785	183	259	0.02162609	
GO Biological Process	ribosome biogenesis	24	6.268467e-39	3.436948218875e-36	2.133565	365	0.03890014	110	1.3728270302727274e-15	1.518249	221	323	0.02611676	
GO Biological Process	nuclear-transcribed mRNA catabolic process	26	3.252006e-36	1.6458902674615383e-33	2.460947	252	0.02685708	84	3.917988857857143e-17	1.692252	151	198	0.01784448	
GO Biological Process	RNA catabolic process	30	7.334969e-35	3.2173619023666667e-32	2.231482	295	0.03143984	102	3.2937144712745097e-16	1.611292	175	241	0.02068069	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	31	6.481642e-34	2.7513524863870965e-31	3.115583	159	0.01694554	156	4.76358246224359e-12	1.748856	93	118	0.01099031	
GO Biological Process	mRNA catabolic process	34	1.040039e-32	4.0252568238235296e-30	2.296007	260	0.02770969	106	4.865447143867925e-16	1.646003	158	213	0.01867171	
GO Biological Process	cotranslational protein targeting to membrane	44	6.929107e-27	2.072275432113637e-24	3.040494	129	0.01374827	215	1.7623053039534882e-7	1.652913	73	98	0.008626802	
GO Biological Process	protein targeting to ER	45	7.95442e-27	2.326049172888889e-24	2.975359	133	0.01417457	175	6.844510980857142e-10	1.735637	79	101	0.009335854	
GO Biological Process	translational elongation	47	1.623393e-26	4.5451549972340425e-24	2.819871	143	0.01524033	150	1.4466741420000002e-12	1.783108	90	112	0.01063578	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	48	2.312574e-26	6.33982526375e-24	3.095468	123	0.01310881	197	2.075084792081218e-8	1.712473	71	92	0.008390451	
GO Biological Process	viral gene expression	50	3.396456e-26	8.938792900800001e-24	2.697454	152	0.01619951	183	2.0740654924590165e-9	1.642394	94	127	0.01110848	
GO Biological Process	translational initiation	58	1.519884e-24	3.448302337241379e-22	2.433166	171	0.01822445	189	3.573666216772487e-9	1.598286	103	143	0.01217206	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	63	4.744215e-24	9.90938495e-22	2.705972	138	0.01470745	181	1.3230851048066298e-9	1.711784	81	105	0.009572205	
GO Biological Process	viral transcription	65	3.73061e-23	7.55247646e-21	2.642907	138	0.01470745	196	1.498971230612245e-8	1.649506	84	113	0.009926731	
GO Biological Process	mitochondrial translation	68	1.076334e-22	2.0828645744117646e-20	2.739341	127	0.01353512	148	1.0652219391216216e-12	1.804217	87	107	0.01028126	
GO Biological Process	protein localization to endoplasmic reticulum	72	2.595667e-22	4.743941951805555e-20	2.461414	151	0.01609293	187	2.6274582336898394e-9	1.646339	92	124	0.01087213	
GO Biological Process	mitochondrial translational termination	73	3.609392e-22	6.506299907945206e-20	3.019712	106	0.01129703	165	1.882795302606061e-10	1.810891	71	87	0.008390451	
GO Cellular Component	ribosomal subunit	21	6.630924e-37	5.456303177142856e-35	2.683012	220	0.02344666	37	1.0822571416216217e-14	1.655238	138	185	0.0163082	
GO Cellular Component	ribosome	24	1.634002e-31	1.1764814399999999e-29	2.245635	262	0.02792284	35	1.418814390857143e-15	1.598417	170	236	0.02008981	
GO Cellular Component	large ribosomal subunit	29	1.317684e-26	7.851579144827587e-25	2.850932	141	0.01502718	43	2.7176256e-12	1.755888	91	115	0.01075396	
GO Cellular Component	mitochondrial ribosome	33	2.369224e-25	1.2406118399999998e-23	3.433421	102	0.01087072	45	5.5047206399999996e-11	1.827394	70	85	0.008272276	
GO Cellular Component	spliceosomal complex	39	3.931907e-21	1.7421372553846153e-19	2.001759	224	0.02387296	44	2.4552445090909092e-11	1.574759	132	186	0.01559915	
GO Cellular Component	mitochondrial large ribosomal subunit	43	1.315833e-17	5.287812613953489e-16	3.624501	64	0.006820846	67	0.000006319205731343284	1.783885	41	51	0.00484519	
GO Cellular Component	catalytic step 2 spliceosome	48	1.323149e-15	4.7633364e-14	2.280235	119	0.01268251	63	7.4759808e-7	1.618005	70	96	0.008272276	
GO Cellular Component	methyltransferase complex	49	1.625135e-15	5.731088326530611e-14	2.246945	122	0.01300224	51	7.227132988235294e-8	1.682523	69	91	0.008154101	
GO Cellular Component	nuclear chromosome, telomeric region	51	5.658641e-15	1.9172807152941176e-13	2.144862	130	0.01385484	162	0.026953770666666665	1.277594	76	132	0.008981328	
GO Cellular Component	small ribosomal subunit	55	2.89695e-13	9.101690181818182e-12	2.492826	83	0.008845785	95	0.0012283677170526316	1.510138	49	72	0.005790593	
GO Cellular Component	cytosolic ribosome	56	3.154839e-13	9.734931771428573e-12	2.029576	129	0.01374827	76	0.000052206335999999994	1.485923	75	112	0.008863153	
GO Cellular Component	cytosolic large ribosomal subunit	57	3.874697e-12	1.174644985263158e-10	2.458307	77	0.008206331	68	0.000008783360470588234	1.709705	47	61	0.005554242	
GO Cellular Component	histone methyltransferase complex	63	9.87723e-11	2.7091830857142857e-9	2.075107	96	0.01023127	81	0.00007584768	1.607956	50	69	0.005908769	
GO Cellular Component	telomerase holoenzyme complex	64	2.678799e-10	7.2327573e-9	3.693042	34	0.003623575	98	0.0013397362089795919	1.916391	19	22	0.002245332	
GO Cellular Component	spliceosomal snRNP complex	65	3.512575e-10	9.33804553846154e-9	2.432847	64	0.006820846	101	0.0016152680174257423	1.538969	43	62	0.005081541	
GO Cellular Component	preribosome	70	1.80279e-9	4.450315885714286e-8	2.11645	79	0.008419482	126	0.0068647858285714285	1.430657	49	76	0.005790593	
GO Cellular Component	mitochondrial proton-transporting ATP synthase complex	73	6.37386e-9	1.5087712438356162e-7	3.562916	30	0.003197272	142	0.015031008	1.736592	18	23	0.002127157	
GO Cellular Component	mitochondrial small ribosomal subunit	74	1.085091e-8	2.533834118918919e-7	3.174629	34	0.003623575	94	0.0011676070263829787	1.822733	23	28	0.002718034	
GO Cellular Component	small nuclear ribonucleoprotein complex	76	1.213577e-8	2.759290863157895e-7	2.152921	68	0.007247149	100	0.0015804936	1.511478	47	69	0.005554242	
GO Cellular Component	proton-transporting ATP synthase complex	77	1.297575e-8	2.9119605194805193e-7	3.44876	30	0.003197272	168	0.029397435428571428	1.664234	18	24	0.002127157	
GO Molecular Function	structural constituent of ribosome	7	1.564602e-26	9.436785205714286e-24	2.445372	184	0.01960993	21	3.4379605266666667e-11	1.629991	119	162	0.01406287	
GO Molecular Function	ribonucleoprotein complex binding	8	7.253016e-20	3.827779194e-17	2.37316	143	0.01524033	36	0.0000011877353855555556	1.582228	82	115	0.009690381	
GO Molecular Function	rRNA binding	9	2.26849e-19	1.0641738644444443e-16	3.710447	69	0.007353725	59	0.000042648017772881354	1.701217	46	60	0.005436067	
GO Molecular Function	snRNA binding	11	4.883177e-13	1.8742521176363634e-10	3.547526	47	0.005009059	96	0.0009082291635416667	1.751825	30	38	0.003545261	
GO Molecular Function	ribonuclease activity	14	8.013417e-11	2.4166176124285713e-8	2.001735	106	0.01129703	88	0.0005501836929545454	1.479319	66	99	0.007799575	
GO Molecular Function	DNA polymerase binding	16	1.654271e-10	4.36520760125e-8	4.986645	25	0.002664393	111	0.0022434814153153154	2.080293	15	16	0.001772631	
GO Molecular Function	telomeric DNA binding	19	1.045867e-9	2.3240265652631577e-7	2.670244	51	0.005435362	132	0.006199667960606061	1.696866	26	34	0.00307256	
GO Molecular Function	deoxyribonuclease activity	23	4.727419e-9	8.677896964347826e-7	2.058054	80	0.008526058	162	0.02564733909506173	1.417681	46	72	0.005436067	
GO Molecular Function	proton-transporting ATP synthase activity, rotational mechanism	27	1.451506e-8	0.000002269725308148148	3.520502	29	0.003090696	126	0.004898769846031746	1.972426	16	18	0.001890806	
GO Molecular Function	endodeoxyribonuclease activity	35	5.598833e-8	0.000006753792264571428	2.040811	70	0.007460301	135	0.007304232007407407	1.549099	37	53	0.004372489	
GO Molecular Function	RNA methyltransferase activity	36	6.200253e-8	0.000007271518935000001	2.071853	67	0.007140573	113	0.0025735821223008847	1.568589	41	58	0.00484519	
GO Molecular Function	endoribonuclease activity	40	8.811387e-8	0.000009300418978499998	2.118979	62	0.006607695	166	0.031056675927710845	1.466111	37	56	0.004372489	
GO Molecular Function	endoribonuclease activity, producing 5'-phosphomonoesters	42	1.760631e-7	0.00001769853352857143	2.378764	46	0.004902483	131	0.005657741054961832	1.75988	23	29	0.002718034	
GO Molecular Function	mRNA 5'-UTR binding	59	0.000001374098	0.0000983295212881356	2.605008	33	0.003516999	115	0.0027894720958260874	1.916391	19	22	0.002245332	
GO Molecular Function	single-stranded telomeric DNA binding	77	0.000005132435	0.00028141741000000005	3.022759	23	0.002451242	164	0.028144881756097563	2.034064	11	12	0.001299929	
GO Molecular Function	snoRNA binding	87	0.00001280996	0.0006216511622988505	2.299449	34	0.003623575	169	0.039962579041420115	1.627251	22	30	0.002599858	
GO Molecular Function	thyroid hormone receptor binding	127	0.0001067272	0.003548049121259842	2.058435	34	0.003623575	86	0.0005089807553488371	1.901982	24	28	0.002836209	
Human Phenotype	Abnormal CSF metabolite level	8	0.000001290076	0.0010760846435	2.029741	56	0.00596824	286	0.024933781160839164	1.444097	41	63	0.00484519	
Human Phenotype	Flat occiput	10	0.000001768056	0.0011798237687999998	2.618504	32	0.003410423	210	0.00466239967904762	1.901982	18	21	0.002127157	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	13	0.000002404982	0.0012344957604615385	2.995119	25	0.002664393	294	0.025455406850340135	1.923115	13	15	0.00153628	
Human Phenotype	Increased CSF lactate	16	0.000003182947	0.0013274878331875	2.041179	51	0.005435362	247	0.014470489653441295	1.492072	39	58	0.00460884	
Human Phenotype	Aplasia/Hypoplasia of the patella	55	0.00006100782	0.007401912415636363	2.121396	34	0.003623575	209	0.004667820970813397	1.972426	16	18	0.001890806	
Human Phenotype	Decreased plasma carnitine	102	0.0001541858	0.01008707689607843	4.308826	10	0.001065757	318	0.035635162993710695	2.218979	8	8	0.000945403	
Mouse Phenotype Single KO	abnormal white fat cell number	16	4.067851e-7	0.00023280819754375	2.357097	44	0.004689332	150	0.008924857840666668	1.972426	16	18	0.001890806	
Mouse Phenotype Single KO	thin interventricular septum	41	0.000005106688	0.0011405351711219513	2.307303	37	0.003943302	115	0.005826881772608696	1.985402	17	19	0.002008981	
Mouse Phenotype	abnormal DNA repair	3	6.406953e-13	2.0418959211e-9	2.02694	126	0.01342854	308	0.022013299171753247	1.32775	73	122	0.008626802	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	19	1.913816e-7	0.00009630523566315789	2.51762	41	0.004369605	374	0.04089344513101604	1.627251	22	30	0.002599858	
Mouse Phenotype	increased incidence of tumors by UV-induction	22	3.970143e-7	0.00017253880555909092	4.142067	19	0.002024939	285	0.017805805902105263	2.048288	12	13	0.001418104	
Mouse Phenotype	increased cellular sensitivity to alkylating agents	32	9.851776e-7	0.0002943525948	2.356945	41	0.004369605	370	0.04011875705675676	1.775183	16	20	0.001890806	
Mouse Phenotype	decreased cellular sensitivity to ultraviolet irradiation	103	0.0001556999	0.014452881008737865	2.526316	21	0.00223809	341	0.03144525981818182	1.923115	13	15	0.00153628	
Mouse Phenotype	abnormal prostate gland duct morphology	134	0.0003533879	0.025214490387313434	2.182662	25	0.002664393	379	0.04283993990501319	2.218979	8	8	0.000945403