# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA processing	22	1.057476e-51	6.325148492727272e-49	2.087898	515	0.04449628	59	1.598926894474576e-30	1.580048	311	396	0.03332262	
GO Biological Process	translation	28	2.703514e-46	1.2705550259285716e-43	2.002941	509	0.04397788	47	5.217129131489362e-40	1.676578	310	372	0.03321547	
GO Biological Process	rRNA processing	32	5.671223e-42	2.33211323303125e-39	2.282585	342	0.02954899	123	8.072509441626016e-19	1.57279	197	252	0.0211079	
GO Biological Process	rRNA metabolic process	34	4.342655e-41	1.6807352101470586e-38	2.24344	347	0.02998099	131	5.128039196412214e-18	1.553586	200	259	0.02142934	
GO Biological Process	regulation of gene expression, epigenetic	36	1.050663e-39	3.840465115833333e-37	2.126642	377	0.03257301	311	0.000004569020590675241	1.330446	164	248	0.01757206	
GO Biological Process	ribosome biogenesis	37	5.239884e-39	1.8635576636756754e-36	2.009264	424	0.03663383	101	9.271989047425742e-22	1.544735	248	323	0.02657238	
GO Biological Process	nuclear-transcribed mRNA catabolic process	41	4.149279e-35	1.3317161551463415e-32	2.272175	287	0.02479696	127	1.9817567975590555e-18	1.635933	161	198	0.01725062	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	43	4.366922e-34	1.3363796883255815e-31	2.875273	181	0.0156385	150	5.348472040933334e-16	1.756144	103	118	0.01103611	
GO Biological Process	translational elongation	44	1.751898e-33	5.2393694959090905e-31	2.861571	179	0.0154657	132	5.307487258787879e-18	1.814297	101	112	0.01082182	
GO Biological Process	mRNA catabolic process	46	1.490551e-32	4.263947958478261e-30	2.147729	300	0.02592017	126	1.776581968888889e-18	1.615182	171	213	0.01832208	
GO Biological Process	RNA catabolic process	47	2.013195e-32	5.6365176606382984e-30	2.048218	334	0.02885778	144	1.0468880043055555e-16	1.552748	186	241	0.01992928	
GO Biological Process	viral gene expression	50	1.13719e-31	2.992856642e-29	2.690359	187	0.0161569	159	5.21379028836478e-15	1.710901	108	127	0.01157184	
GO Biological Process	mitochondrial translational elongation	52	3.151549e-31	7.975237171346153e-29	3.239948	138	0.01192328	140	4.6746783542857145e-17	1.893547	80	85	0.008571735	
GO Biological Process	translational initiation	55	1.14078e-30	2.7293680036363637e-28	2.457047	213	0.01840332	139	3.241536938705036e-17	1.71644	122	143	0.0130719	
GO Biological Process	mitochondrial translational termination	56	1.524014e-30	3.581160754642857e-28	3.187109	138	0.01192328	157	1.942778835095541e-15	1.850017	80	87	0.008571735	
GO Biological Process	mitochondrial translation	57	5.453171e-30	1.2589171436666667e-27	2.832798	162	0.01399689	124	1.2263752904032257e-18	1.842669	98	107	0.01050038	
GO Biological Process	multi-organism metabolic process	63	5.017075e-29	1.0479315861111112e-26	2.368022	216	0.01866252	145	1.1451134228275862e-16	1.697107	124	147	0.01328619	
GO Biological Process	cotranslational protein targeting to membrane	66	2.174151e-28	4.3347959104545455e-26	2.866183	150	0.01296008	170	1.274827664764706e-13	1.765539	86	98	0.009214615	
GO Biological Process	translational termination	69	7.903117e-28	1.5072045884492753e-25	2.85238	148	0.01278728	155	1.5122721814838707e-15	1.821293	86	95	0.009214615	
GO Biological Process	viral transcription	71	1.282449e-27	2.3768656888732394e-25	2.623903	169	0.01460169	161	8.479863932298136e-15	1.744828	98	113	0.01050038	
GO Cellular Component	ribosomal subunit	19	8.21142e-50	7.4680704e-48	2.788093	282	0.02436496	32	5.8540914e-27	1.772641	163	185	0.01746491	
GO Cellular Component	ribosome	22	1.554972e-43	1.2213598254545455e-41	2.341672	337	0.02911699	33	1.359441687272727e-26	1.687944	198	236	0.02121504	
GO Cellular Component	mitochondrial ribosome	24	7.781805e-35	5.602899599999999e-33	3.629416	133	0.01149127	49	2.848264163265306e-14	1.822539	77	85	0.008250295	
GO Cellular Component	large ribosomal subunit	29	1.645728e-31	9.806268910344829e-30	2.819386	172	0.0148609	40	3.478626e-21	1.854441	106	115	0.01135755	
GO Cellular Component	spliceosomal complex	36	1.032295e-28	4.955016e-27	2.071992	286	0.02471056	44	1.5457890763636363e-17	1.633311	151	186	0.01617915	
GO Cellular Component	catalytic step 2 spliceosome	47	6.129524e-22	2.2535781855319148e-20	2.407812	155	0.01339209	60	1.8237579840000002e-10	1.676578	80	96	0.008571735	
GO Cellular Component	mitochondrial large ribosomal subunit	48	2.361722e-21	8.5021992e-20	3.62705	79	0.006825644	66	2.282067490909091e-8	1.814649	46	51	0.004928747	
GO Cellular Component	mitochondrial protein complex	49	2.390457e-21	8.430019787755102e-20	2.05015	214	0.01848972	51	2.2795864094117647e-12	1.574525	126	161	0.01350048	
GO Cellular Component	small ribosomal subunit	50	6.182454e-21	2.1366561024e-19	2.775729	114	0.009849663	70	3.36866688e-7	1.648635	59	72	0.006321654	
GO Cellular Component	inner mitochondrial membrane protein complex	55	1.338235e-17	4.204491054545454e-16	2.028666	178	0.0153793	62	6.505145187096775e-10	1.556647	106	137	0.01135755	
GO Cellular Component	cytosolic ribosome	57	3.703482e-17	1.1227398063157894e-15	2.079033	163	0.01408329	53	6.094711426415094e-12	1.67059	93	112	0.009964642	
GO Cellular Component	methyltransferase complex	58	1.79897e-16	5.359689931034482e-15	2.150074	144	0.01244168	85	0.000005895757101176471	1.525501	69	91	0.007393121	
GO Cellular Component	mitochondrial small ribosomal subunit	68	8.514825e-15	2.1637672941176473e-13	3.784795	50	0.004320028	79	0.000001989255445063291	1.94004	27	28	0.00289296	
GO Cellular Component	cytosolic large ribosomal subunit	71	2.027258e-13	4.933946230985915e-12	2.381176	92	0.007948851	52	5.461350646153846e-12	1.879966	57	61	0.006107361	
GO Cellular Component	proton-transporting ATP synthase complex	73	5.85002e-12	1.3847718575342463e-10	3.727863	40	0.003456022	175	0.00686885628342857	1.676578	20	24	0.002142934	
GO Cellular Component	mitochondrial proton-transporting ATP synthase complex	74	8.6271e-12	2.0145444324324326e-10	3.754976	39	0.003369622	182	0.011194325802197803	1.661999	19	23	0.002035787	
GO Cellular Component	histone methyltransferase complex	75	9.141216e-12	2.1061361663999998e-10	2.015233	115	0.009936064	118	0.0005092906576271187	1.487052	51	69	0.005464481	
GO Cellular Component	spliceosomal snRNP complex	78	4.820068e-11	1.0678304492307691e-9	2.342107	76	0.006566442	126	0.0009816552685714287	1.492695	46	62	0.004928747	
GO Cellular Component	proton-transporting two-sector ATPase complex	83	5.589004e-10	1.163590230361446e-8	2.284897	71	0.006134439	195	0.02103833796923077	1.404529	37	53	0.003964427	
GO Cellular Component	nuclear ubiquitin ligase complex	85	5.926055e-10	1.2047321223529412e-8	2.576648	56	0.004838431	112	0.00027373926857142855	1.659812	33	40	0.003535841	
GO Molecular Function	structural constituent of ribosome	6	8.836645e-37	6.218052531666666e-34	2.564261	238	0.02056333	8	1.3137676562499999e-24	1.800769	145	162	0.01553627	
GO Molecular Function	rRNA binding	9	5.437564e-19	2.5508216897777777e-16	3.356805	77	0.006652843	60	0.0000042848754313333335	1.676578	50	60	0.005357334	
GO Molecular Function	unfolded protein binding	10	4.083122e-18	1.7238941084000001e-15	2.350653	132	0.01140487	132	0.0074665718166666666	1.347589	71	106	0.007607415	
GO Molecular Function	ribonucleoprotein complex binding	11	3.682318e-17	1.4133405996363638e-14	2.112267	157	0.01356489	74	0.000042048603916216224	1.452062	83	115	0.008893175	
GO Molecular Function	snRNA binding	13	3.679536e-15	1.1950000763076923e-12	3.487874	57	0.004924832	71	0.000014652986183098593	1.800115	34	38	0.003642987	
GO Molecular Function	O-methyltransferase activity	20	2.139407e-10	4.516288177e-8	3.080993	44	0.003801624	159	0.017953308847798742	1.72448	18	21	0.00192864	
GO Molecular Function	proton-transporting ATP synthase activity, rotational mechanism	22	2.465556e-10	4.731626105454546e-8	3.542969	36	0.00311042	115	0.0024027989408695652	1.900121	17	18	0.001821494	
GO Molecular Function	adenyl-nucleotide exchange factor activity	29	3.412825e-9	4.968602465517242e-7	5.652889	19	0.001641611	191	0.04085050256544503	2.011893	9	9	0.0009643202	
GO Molecular Function	U6 snRNA binding	31	4.672601e-9	6.363781103870969e-7	5.541661	19	0.001641611	150	0.0128376243	2.011893	11	11	0.001178614	
GO Molecular Function	NF-kappaB binding	32	1.064878e-8	0.00000140497341125	2.483328	51	0.004406428	145	0.011801104373793104	1.652627	23	28	0.002464374	
GO Molecular Function	RNA cap binding	52	2.011182e-7	0.000016329250776923078	2.849879	33	0.002851218	175	0.026090850217142855	1.7752	15	17	0.0016072	
GO Molecular Function	mannosyltransferase activity	73	0.000002427755	0.00014041070698630136	2.494548	34	0.002937619	124	0.004197903956451613	1.760407	21	24	0.00225008	
GO Molecular Function	endoribonuclease activity, producing 5'-phosphomonoesters	82	0.00000416601	0.00021449871000000001	2.054224	49	0.004233627	133	0.0076500830571428575	1.665015	24	29	0.00257152	
GO Molecular Function	thyroid hormone receptor binding	89	0.000008223132	0.0003900905989213483	2.110498	43	0.003715224	188	0.03758399696808511	1.580773	22	28	0.002357227	
GO Molecular Function	NADH dehydrogenase activity	90	0.000008507963	0.0003991179976222222	2.067659	45	0.003888025	152	0.012930644403947368	1.498218	35	47	0.003750134	
GO Molecular Function	mRNA 5'-UTR binding	151	0.0001825079	0.005102969230463576	2.047875	32	0.002764818	144	0.011308489198611112	1.737544	19	22	0.002035787	
Human Phenotype	Increased serum lactate	1	2.880883e-14	1.9224132259000001e-10	2.09699	130	0.01123207	74	0.0000055369785606756755	1.529039	76	100	0.008143148	
Human Phenotype	Increased CSF lactate	9	7.036017e-11	5.2168157156666666e-8	2.368601	73	0.00630724	81	0.000014242579337037036	1.665015	48	58	0.005143041	
Human Phenotype	Abnormal CSF metabolite level	10	1.678228e-10	1.1198815444000001e-7	2.262568	77	0.006652843	103	0.00007529424481553399	1.596741	50	63	0.005357334	
Human Phenotype	Exercise intolerance	15	5.846335e-9	0.0000026008395636666664	2.069862	78	0.006739243	246	0.012189856635772359	1.408325	49	70	0.005250188	
Human Phenotype	Leukodystrophy	20	4.720475e-8	0.0000157498648375	2.039268	71	0.006134439	165	0.0015062873926666668	1.569277	39	50	0.004178721	
Human Phenotype	Abnormal glycosylation	36	0.000003220145	0.0005968896551388889	2.687887	29	0.002505616	241	0.010679549497510373	1.737544	19	22	0.002035787	
Human Phenotype	Abnormal mitochondria in muscle tissue	39	0.000004052289	0.0006933570383846154	2.513253	32	0.002764818	160	0.00121764733375	1.836946	21	23	0.00225008	
Human Phenotype	Abnormal protein N-linked glycosylation	53	0.000008289772	0.0010437292180377358	2.604385	28	0.002419215	268	0.01683486849328358	1.72448	18	21	0.00192864	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	54	0.00001054256	0.0013027870903703704	2.622382	27	0.002332815	247	0.012151724814979756	1.877767	14	15	0.001500054	
Human Phenotype	Abnormal isoelectric focusing of serum transferrin	61	0.00002051336	0.002244027070163934	2.522152	27	0.002332815	294	0.02672141567346939	1.710109	17	20	0.001821494	
Human Phenotype	Progressive macrocephaly	74	0.00004351046	0.003923585129459459	2.288097	30	0.002592017	271	0.01712894339889299	1.676578	20	24	0.002142934	
Human Phenotype	Acute necrotizing encephalopathy	77	0.00004967358	0.004304828562857143	2.348203	28	0.002419215	146	0.0008154031215068494	1.911299	19	20	0.002035787	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	84	0.00006515439	0.005175895767499999	2.35195	27	0.002332815	316	0.04089672640822785	1.760407	14	16	0.001500054	
Human Phenotype	CNS hypomyelination	93	0.0001068288	0.007665253574193549	2.034466	35	0.003024019	201	0.004727534988557215	1.676578	25	30	0.002678667	
Human Phenotype	Inverted nipples	106	0.0001440077	0.009065692283962264	2.166032	29	0.002505616	277	0.020449933667509027	1.868187	13	14	0.001392907	
Mouse Phenotype Single KO	abnormal sternebra number	19	1.46781e-7	0.00007074071668421053	3.508378	25	0.002160014	159	0.006481341877358491	2.011893	13	13	0.001392907	
Mouse Phenotype Single KO	increased embryonic neuroepithelium apoptosis	85	0.000052744	0.005682080094117648	2.086587	36	0.00311042	161	0.007100440176397517	1.893547	16	17	0.001714347	
Mouse Phenotype	early cellular replicative senescence	1	4.190859e-19	4.0068802899e-15	2.366769	138	0.01192328	271	0.0052681533365313655	1.433129	52	73	0.005571628	
Mouse Phenotype	abnormal cellular replicative senescence	2	8.561652e-19	4.0928977386e-15	2.260996	149	0.01287368	298	0.008025397523154362	1.389164	58	84	0.006214508	
Mouse Phenotype	increased fibroblast apoptosis	16	1.600119e-9	9.561711099375e-7	2.100797	81	0.006998445	203	0.0012002041046305417	1.592749	38	48	0.004071574	
Mouse Phenotype	increased neural tube apoptosis	23	2.168102e-8	0.000009012705748695652	2.058258	73	0.00630724	195	0.0008562302067692308	1.637588	35	43	0.003750134	
Mouse Phenotype	abnormal sternebra number	32	1.46781e-7	0.00004385541065625	3.508378	25	0.002160014	251	0.004286851476095617	2.011893	13	13	0.001392907	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	42	0.000001155656	0.0002630768337142857	2.24015	45	0.003888025	478	0.04697909361715481	1.542452	23	30	0.002464374	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	58	0.000003704056	0.0006105944726896551	2.099669	47	0.004060826	234	0.0028255198366666672	1.770466	22	25	0.002357227	
Mouse Phenotype	increased incidence of tumors by ionizing radiation induction	110	0.00006956174	0.006046179964909091	2.30114	28	0.002419215	461	0.04220362281995662	1.694226	16	19	0.001714347	
Mouse Phenotype	increased fibroma incidence	201	0.0008299717	0.03947940011791045	2.324332	19	0.001641611	439	0.04024865203872437	2.011893	9	9	0.0009643202