# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	21	1.45187e-46	9.097693966666666e-44	2.092636	465	0.02525527	121	3.3939138164462813e-13	1.346038	191	213	0.01526901	
GO Biological Process	rRNA processing	24	4.158216e-45	2.279915181e-42	2.030621	484	0.0262872	106	4.530954053773584e-15	1.340249	225	252	0.01798705	
GO Biological Process	rRNA metabolic process	25	9.194447e-45	4.839589122919999e-42	2.00768	494	0.02683033	100	2.4943831948e-15	1.3388	231	259	0.0184667	
GO Biological Process	nuclear-transcribed mRNA catabolic process	29	2.186985e-44	9.923632970689656e-42	2.125056	427	0.0231914	102	3.072700035588236e-15	1.37978	182	198	0.01454952	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	34	1.178482e-38	4.5610719523529414e-36	2.54638	255	0.01384966	220	4.954922159363637e-8	1.361148	107	118	0.008553841	
GO Biological Process	cotranslational protein targeting to membrane	48	2.051549e-32	5.624236102291666e-30	2.546426	212	0.01151423	170	8.718131642352941e-10	1.424494	93	98	0.007434647	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	51	1.772526e-31	4.5734646341176474e-29	2.577852	201	0.01091679	196	6.3939205028571426e-9	1.419499	87	92	0.006954992	
GO Biological Process	protein targeting to ER	53	4.341739e-31	1.0779800660566037e-28	2.462534	216	0.01173148	177	2.3625207663276834e-9	1.411906	95	101	0.007594532	
GO Biological Process	translational initiation	54	6.561301e-31	1.5988918492407406e-28	2.124633	293	0.01591353	180	2.6850193823333334e-9	1.35412	129	143	0.01031257	
GO Biological Process	viral gene expression	66	6.713551e-29	1.3385396607424243e-26	2.224776	246	0.01336085	187	3.3652291795721926e-9	1.371064	116	127	0.009273323	
GO Biological Process	multi-organism metabolic process	78	1.629321e-27	2.7487480819230767e-25	2.019213	293	0.01591353	169	8.285599388757396e-10	1.358119	133	147	0.01063234	
GO Biological Process	protein localization to endoplasmic reticulum	80	2.899012e-27	4.7685123635e-25	2.126612	256	0.01390398	199	8.239914522613065e-9	1.367919	113	124	0.009033496	
GO Biological Process	endoplasmic reticulum unfolded protein response	86	2.100964e-26	3.214719218139535e-24	2.102925	254	0.01379535	555	0.00666663628990991	1.224565	93	114	0.007434647	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	89	4.371007e-26	6.462705743033708e-24	2.21839	222	0.01205735	190	3.964225626263158e-9	1.401007	98	105	0.007834359	
GO Biological Process	viral transcription	95	1.606668e-25	2.2254888644210526e-23	2.186209	224	0.01216598	235	2.197368214042553e-7	1.354956	102	113	0.008154129	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	102	8.956118e-24	1.1554270270784315e-21	2.00568	255	0.01384966	370	0.0002975654628162162	1.275253	96	113	0.007674474	
GO Biological Process	mitochondrial translational termination	114	7.985752e-22	9.217939523508772e-20	2.351881	162	0.00879861	191	4.4460430421989525e-9	1.432064	83	87	0.006635223	
GO Biological Process	translational elongation	118	1.249562e-21	1.3934734201694917e-19	2.090246	208	0.01129698	179	2.5736283983240227e-9	1.393859	104	112	0.008314014	
GO Biological Process	mitochondrial translation	123	3.485028e-21	3.7284132887804884e-19	2.13248	194	0.01053661	164	3.110140883292683e-10	1.416907	101	107	0.008074187	
GO Biological Process	mitochondrial transmembrane transport	125	5.232993e-21	5.50887639096e-19	2.168491	185	0.01004779	334	0.00007342150726047904	1.338312	74	83	0.005915741	
GO Cellular Component	ribosomal subunit	27	3.448723e-35	2.20718272e-33	2.113097	340	0.01846622	39	7.141934769230769e-14	1.371256	169	185	0.01351027	
GO Cellular Component	large ribosomal subunit	43	1.511093e-24	6.072485358139535e-23	2.194766	213	0.01156854	48	6.574752e-11	1.409709	108	115	0.008633784	
GO Cellular Component	mitochondrial ribosome	48	5.266788e-21	1.8960436800000002e-19	2.453035	143	0.007766674	69	0.0000011351908173913042	1.377461	78	85	0.00623551	
GO Cellular Component	cytosolic large ribosomal subunit	63	7.943659e-15	2.1788321828571428e-13	2.131363	131	0.007114925	73	0.0000019893263868493152	1.427256	58	61	0.004636662	
GO Cellular Component	mitochondrial large ribosomal subunit	81	1.301527e-11	2.7765909333333333e-10	2.337728	81	0.004399305	110	0.00029050664727272733	1.383348	47	51	0.003757295	
GO Cellular Component	mitochondrial small ribosomal subunit	83	2.413229e-11	5.024168327710843e-10	2.759833	58	0.003150119	142	0.0020864565633802817	1.447469	27	28	0.002158446	
GO Cellular Component	INO80-type complex	120	2.194673e-8	3.1603291200000003e-7	2.73823	41	0.002226809	131	0.0011482970235114503	1.501079	23	23	0.001838676	
GO Cellular Component	Ino80 complex	133	6.80871e-8	8.846203669172932e-7	3.121368	31	0.001683685	173	0.014984706589595375	1.501079	16	16	0.001279079	
GO Cellular Component	MKS complex	146	1.731258e-7	0.0000020490505643835617	2.678961	37	0.002009559	211	0.04160158362085308	1.501079	13	13	0.001039252	
GO Cellular Component	ESCRT complex	178	0.000001980758	0.00001922893159550562	2.07853	51	0.002769933	170	0.012770499388235296	1.393859	26	28	0.002078503	
GO Molecular Function	structural constituent of ribosome	9	8.805806e-31	4.130901436888889e-28	2.079247	307	0.01667391	15	4.768506938666666e-12	1.380622	149	162	0.01191142	
GO Molecular Function	unfolded protein binding	11	2.324301e-22	8.921089838181818e-20	2.182889	195	0.01059092	141	0.04334922031205674	1.203696	85	106	0.006795108	
GO Molecular Function	rRNA binding	18	9.732138e-18	2.2827270353333332e-15	2.71302	99	0.005376928	74	0.00030099436756756754	1.375989	55	60	0.004396834	
GO Molecular Function	snRNA binding	62	4.369268e-8	0.0000029753305638709677	2.230984	58	0.003150119	84	0.0019299973311904762	1.422075	36	38	0.002877928	
GO Molecular Function	O-methyltransferase activity	101	0.000001152341	0.00004817013566336634	2.156833	49	0.002661308	106	0.007821689149056604	1.501079	21	21	0.001678791	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	310	0.000797415	0.017165000951612903	2.027087	26	0.001412123	210	0.02113791910714286	1.501079	18	18	0.001438964	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	11	1.059789e-15	8.822261702727272e-13	2.097883	145	0.007875299	127	0.0018354543158267717	1.350971	54	60	0.004316892