# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	interferon-gamma-mediated signaling pathway	56	1.776331e-49	4.1740606480357143e-47	2.915996	262	0.0126938	769	0.011767544410143044	1.27149	55	64	0.00433378	
GO Biological Process	nuclear-transcribed mRNA catabolic process	58	5.703826e-48	1.2940801092068968e-45	2.104321	474	0.02296512	140	3.5344444247857145e-15	1.367465	183	198	0.01441967	
GO Biological Process	mRNA catabolic process	66	1.703237e-45	3.3958932853030306e-43	2.011267	501	0.02427326	131	1.0613496922900763e-15	1.361466	196	213	0.01544402	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	73	1.42483e-43	2.5684024616438355e-41	2.556561	287	0.01390504	177	2.4761275431073447e-11	1.404321	112	118	0.008825152	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	75	6.879594e-43	1.20704769928e-40	2.06454	442	0.02141473	293	0.000002353623680238908	1.279097	134	155	0.01055866	
GO Biological Process	multi-organism metabolic process	94	2.714025e-38	3.7993462739361705e-36	2.163956	352	0.01705426	189	1.412269135820106e-10	1.358773	135	147	0.01063746	
GO Biological Process	cellular response to topologically incorrect protein	100	1.721869e-37	2.2658074171e-35	2.127478	358	0.01734496	331	0.000012303104450453173	1.277311	120	139	0.00945552	
GO Biological Process	viral gene expression	104	5.674798e-37	7.180256430961539e-35	2.331526	289	0.01400194	216	2.177877248935185e-9	1.363052	117	127	0.009219132	
GO Biological Process	protein targeting to ER	118	3.559454e-34	3.969394507288136e-32	2.450964	241	0.01167636	173	8.781175646242775e-12	1.435605	98	101	0.007722008	
GO Biological Process	tumor necrosis factor-mediated signaling pathway	119	4.263905e-34	4.7150189827731096e-32	2.148269	317	0.01535853	506	0.0008285785400395257	1.236813	107	128	0.008431172	
GO Biological Process	endoplasmic reticulum unfolded protein response	121	1.635376e-33	1.7785051887603305e-31	2.193501	297	0.01438953	380	0.00006414139850526317	1.284874	99	114	0.007800804	
GO Biological Process	cotranslational protein targeting to membrane	128	1.269873e-32	1.305488969296875e-30	2.453703	229	0.01109496	196	2.7146714880102043e-10	1.419163	94	98	0.007406824	
GO Biological Process	translational elongation	134	1.460546e-31	1.43427797119403e-29	2.285943	255	0.01235465	168	2.1612858560714286e-12	1.426711	108	112	0.008509968	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	136	2.891763e-31	2.7979933321323527e-29	2.471195	216	0.01046512	193	2.0693850218134716e-10	1.431306	89	92	0.007012844	
GO Biological Process	viral transcription	137	3.664913e-31	3.5201890632846715e-29	2.254938	259	0.01254845	223	5.384196039058296e-9	1.374805	105	113	0.00827358	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	140	7.232585e-31	6.798113286785714e-29	2.256621	256	0.0124031	540	0.0013545457898333333	1.243872	95	113	0.00748562	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	141	1.334231e-30	1.24518764035461e-28	2.097895	299	0.01448643	432	0.00022272216712962962	1.270058	97	113	0.007643212	
GO Biological Process	translational initiation	142	2.212462e-30	2.050266722394366e-28	2.044065	316	0.01531008	203	4.5448068030049264e-10	1.355394	131	143	0.01032228	
GO Biological Process	positive regulation of gene expression, epigenetic	157	1.65256e-28	1.3850979006369428e-26	2.490483	193	0.009350775	790	0.014392054933670885	1.239125	67	80	0.005279332	
GO Biological Process	regulation of hematopoietic stem cell differentiation	158	4.361947e-28	3.632839276772152e-26	2.273411	228	0.01104651	565	0.0018577135569557521	1.249719	87	103	0.006855252	
GO Cellular Component	ribosomal subunit	25	4.903294e-54	3.3891568128000006e-52	2.345159	423	0.02049419	42	4.1880507428571425e-16	1.383581	173	185	0.01363171	
GO Cellular Component	large ribosomal subunit	32	3.205712e-42	1.73108448e-40	2.555316	278	0.01346899	57	2.822721044210526e-11	1.402358	109	115	0.008588764	
GO Cellular Component	ficolin-1-rich granule lumen	41	6.363004e-35	2.681773393170732e-33	2.166078	319	0.01545543	152	0.0020282206736842107	1.217051	102	124	0.008037192	
GO Cellular Component	mitochondrial ribosome	44	2.06923e-33	8.126430545454545e-32	2.815637	184	0.008914729	63	1.036917394285714e-9	1.427333	82	85	0.006461272	
GO Cellular Component	mitochondrial large ribosomal subunit	60	3.547234e-23	1.021603392e-21	2.960725	115	0.005571705	114	0.00008165213810526316	1.39252	48	51	0.003782208	
GO Cellular Component	cytosolic large ribosomal subunit	67	1.996105e-21	5.1481633432835823e-20	2.336702	161	0.007800388	85	0.0000036384483388235295	1.406788	58	61	0.004570168	
GO Cellular Component	small ribosomal subunit	90	5.393766e-16	1.0356030720000001e-14	2.075341	152	0.007364341	100	0.00002173777344	1.356256	66	72	0.005200536	
GO Cellular Component	sex chromosome	107	3.592323e-13	5.801433779439252e-12	2.470137	84	0.004069767	204	0.028048523294117646	1.365741	24	26	0.001891104	
GO Cellular Component	MLL1 complex	114	4.999629e-12	7.578385010526315e-11	2.481923	75	0.003633721	151	0.001970440688741722	1.428533	28	29	0.002206288	
GO Cellular Component	mitochondrial small ribosomal subunit	136	6.084625e-10	7.73105294117647e-9	2.504368	59	0.002858527	128	0.0002304018	1.479552	28	28	0.002206288	
GO Cellular Component	Sin3 complex	235	0.000005904874	0.00004341966924255319	2.062217	47	0.002277132	223	0.047498349632286996	1.479552	13	13	0.001024348	
GO Cellular Component	Prp19 complex	257	0.000017233	0.00011587013229571984	2.085519	41	0.001986434	223	0.047498349632286996	1.479552	13	13	0.001024348	
GO Molecular Function	structural constituent of ribosome	8	1.58613e-37	8.370801074999999e-35	2.138761	354	0.01715116	14	2.0096376208571432e-15	1.406488	154	162	0.01213458	
GO Molecular Function	unfolded protein binding	10	1.559368e-28	6.583651695999999e-26	2.286777	229	0.01109496	94	0.0006244989265957446	1.270182	91	106	0.007170436	
GO Molecular Function	rRNA binding	11	3.182493e-25	1.221498676909091e-22	3.006867	123	0.005959302	93	0.00046226904989247304	1.356256	55	60	0.00433378	
GO Molecular Function	polyubiquitin binding	30	2.538929e-15	3.5731194126666666e-13	2.220164	124	0.006007752	138	0.006463340482608696	1.348037	41	45	0.003230636	
GO Molecular Function	snRNA binding	60	9.814356e-11	6.9060351719999995e-9	2.401916	70	0.003391473	183	0.03933355933333334	1.32381	34	38	0.002679064	
GO Molecular Function	O-methyltransferase activity	93	1.631959e-9	7.408742901075269e-8	2.395199	61	0.002955426	144	0.007799860601388889	1.479552	21	21	0.001654716	
GO Molecular Function	telomeric DNA binding	99	3.625803e-9	1.5462767945454546e-7	2.023167	85	0.004118217	178	0.031173824853932587	1.349004	31	34	0.002442676	
GO Molecular Function	mRNA 5'-UTR binding	115	1.706283e-8	6.26428419652174e-7	2.224943	62	0.003003876	195	0.04500864182564103	1.4123	21	22	0.001654716	
Human Phenotype	Abnormality of fatty-acid metabolism	168	0.000004382951	0.0001740918572797619	2.034461	50	0.002422481	252	0.019083530136507935	1.42037	24	25	0.001891104	
Mouse Phenotype Single KO	abnormal B cell activation	40	6.123935e-54	1.401921819875e-51	2.05145	568	0.02751938	134	0.000022431773061940298	1.265407	130	152	0.01024348	
Mouse Phenotype Single KO	decreased B cell proliferation	69	2.253087e-35	2.9900750230434777e-33	2.161112	325	0.01574612	437	0.035628294478260866	1.223827	67	81	0.005279332	
Mouse Phenotype Single KO	abnormal interferon level	89	4.247756e-30	4.370415920449438e-28	2.148228	278	0.01346899	463	0.045558210974082074	1.189173	86	107	0.006776456	
Mouse Phenotype Single KO	abnormal circulating interferon level	91	1.055386e-29	1.0619966595604395e-27	2.282103	240	0.01162791	424	0.02998658339622642	1.216521	74	90	0.005830904	
Mouse Phenotype Single KO	abnormal class switch recombination	98	2.305578e-27	2.154303851632653e-25	2.184182	242	0.01172481	135	0.000023544458051111113	1.388503	61	65	0.004806556	
Mouse Phenotype Single KO	abnormal marginal zone B cell morphology	99	2.648586e-27	2.449808283030303e-25	2.038799	284	0.01375969	282	0.003419480325886525	1.263438	76	89	0.005988496	
Mouse Phenotype Single KO	abnormal circulating interferon-gamma level	104	5.083387e-26	4.475824496057692e-24	2.327972	200	0.009689922	394	0.023327341294416243	1.250326	60	71	0.00472776	
Mouse Phenotype Single KO	increased circulating interferon-gamma level	112	2.978274e-24	2.4350049123214283e-22	2.693116	141	0.006831395	431	0.03309380167285383	1.307511	38	43	0.002994248	
Mouse Phenotype Single KO	increased B cell derived lymphoma incidence	136	2.798413e-21	1.8841961647794117e-19	2.182579	185	0.008963178	205	0.0006548496778536585	1.38708	45	48	0.00354582	
Mouse Phenotype Single KO	abnormal transitional stage B cell morphology	159	1.880493e-19	1.08299839e-17	2.060484	192	0.009302326	409	0.026991589630806844	1.28414	46	53	0.003624616	
Mouse Phenotype Single KO	abnormal B cell apoptosis	174	1.894816e-18	9.971741443678161e-17	2.017166	191	0.009253876	178	0.0002310866693258427	1.441615	38	39	0.002994248	
Mouse Phenotype Single KO	decreased T cell apoptosis	191	9.022112e-17	4.325417779267015e-15	2.159087	146	0.007073643	387	0.021347647847803616	1.380916	28	30	0.002206288	
Mouse Phenotype Single KO	increased interleukin-1 beta secretion	280	6.595447e-12	2.1569467206785713e-10	2.057733	111	0.005377907	443	0.03691223906772009	1.345048	30	33	0.00236388	
Mouse Phenotype Single KO	abnormal Peyer's patch germinal center morphology	394	7.183226e-9	1.6694619411675127e-7	2.316229	60	0.002906977	449	0.038555742244988866	1.479552	16	16	0.001260736	
Mouse Phenotype Single KO	abnormal DNA replication	470	1.90053e-7	0.0000037027985553191488	2.058989	63	0.003052326	426	0.03143997912676056	1.415224	22	23	0.001733512	
Mouse Phenotype	abnormal marginal zone B cell morphology	66	4.705834e-48	6.817042253636363e-46	2.104035	475	0.02301357	194	0.000004828201997474227	1.287956	121	139	0.009534316	
Mouse Phenotype	abnormal follicular B cell morphology	73	4.710343e-46	6.169258825068494e-44	2.20426	409	0.01981589	129	2.7637019188372095e-8	1.379	96	103	0.007564416	
Mouse Phenotype	decreased susceptibility to experimental autoimmune encephalomyelitis	88	5.699529e-39	6.192408723750001e-37	2.213063	341	0.01652132	465	0.006643282994838711	1.225915	87	105	0.006855252	
Mouse Phenotype	decreased marginal zone B cell number	94	6.466777e-37	6.577537755e-35	2.100422	363	0.01758721	265	0.00014246950729811318	1.290982	89	102	0.007012844	
Mouse Phenotype	decreased follicular B cell number	102	3.418431e-35	3.204276352058823e-33	2.263381	292	0.01414729	214	0.00001768142089766355	1.35169	74	81	0.005830904	
Mouse Phenotype	abnormal class switch recombination	111	3.496342e-32	3.0115789064864868e-30	2.07153	325	0.01574612	148	1.355034017027027e-7	1.38306	86	92	0.006776456	
Mouse Phenotype	abnormal circulating interferon-gamma level	118	4.77344e-31	3.8676999864406783e-29	2.363361	234	0.01133721	660	0.03708753910454546	1.207451	71	87	0.005594516	
Mouse Phenotype	increased B cell proliferation	128	1.074754e-27	8.027908589062499e-26	2.078685	275	0.01332364	397	0.0020998190913853903	1.278626	70	81	0.00551572	
Mouse Phenotype	increased B cell derived lymphoma incidence	138	8.069095e-26	5.590479514130434e-24	2.019565	274	0.01327519	204	0.000009004737270588236	1.365741	72	78	0.005673312	
Mouse Phenotype	abnormal lymph node cortex morphology	157	1.111118e-23	6.766496304458598e-22	2.073596	234	0.01133721	411	0.0029554563080291976	1.300213	58	66	0.004570168	
Mouse Phenotype	decreased T cell apoptosis	189	3.585399e-21	1.8137566052380954e-19	2.166931	187	0.009060078	459	0.0059681490895424835	1.345048	40	44	0.00315184	
Mouse Phenotype	increased dendritic cell number	197	3.063016e-20	1.4865733997969543e-18	2.097842	192	0.009302326	681	0.04302722369162996	1.240915	52	62	0.004097392	
Mouse Phenotype	abnormal lymph node B cell domain morphology	202	4.767601e-20	2.256585800049505e-18	2.029552	206	0.00998062	338	0.0007259706901775148	1.349767	52	57	0.004097392	
Mouse Phenotype	increased marginal zone B cell number	209	1.820019e-19	8.325933808133972e-18	2.329027	146	0.007073643	647	0.03479176968315302	1.286567	40	46	0.00315184	
Mouse Phenotype	increased follicular B cell number	222	2.455978e-18	1.0577299845945944e-16	2.215981	152	0.007364341	381	0.0014598151368503938	1.433316	31	32	0.002442676	
Mouse Phenotype	lymph node hyperplasia	223	3.594245e-18	1.5410123966367714e-16	2.061282	178	0.008624031	459	0.0059681490895424835	1.345048	40	44	0.00315184	
Mouse Phenotype	abnormal lymph node secondary follicle morphology	252	1.871973e-16	7.102354703571429e-15	2.245484	131	0.006346899	580	0.021665423813793105	1.349004	31	34	0.002442676	
Mouse Phenotype	abnormal Peyer's patch follicle morphology	290	1.361309e-14	4.4880949479310347e-13	2.318708	107	0.005184109	517	0.011990481538491296	1.384097	29	31	0.002285084	
Mouse Phenotype	abnormal lymph node germinal center morphology	294	2.380407e-14	7.741180723469388e-13	2.171673	121	0.005862403	653	0.03543603825574273	1.340844	29	32	0.002285084	
Mouse Phenotype	salivary gland inflammation	320	1.152529e-12	3.4435405528124994e-11	2.250577	97	0.004699612	609	0.026765917453201973	1.32381	34	38	0.002679064