# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of gene expression, epigenetic	32	5.594824e-49	2.30069653175e-46	2.003776	544	0.03069111	358	0.000006815027721508381	1.231473	197	248	0.01626486	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	42	1.46482e-43	4.589420566666667e-41	2.170188	399	0.02251058	225	6.356106967555556e-10	1.370248	137	155	0.0113111	
GO Biological Process	nuclear-transcribed mRNA catabolic process	54	6.856837e-38	1.6709095941296295e-35	2.047163	396	0.02234133	161	6.126486304409938e-14	1.385857	177	198	0.01461361	
GO Biological Process	DNA replication-dependent nucleosome assembly	63	1.072845e-34	2.240883707142857e-32	8.47316	60	0.003385049	1111	0.04077473086768677	1.356496	28	32	0.002311757	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	66	1.327223e-33	2.6462011298484846e-31	2.442975	238	0.01342736	545	0.0005750825858348624	1.275895	93	113	0.007678336	
GO Biological Process	cellular response to topologically incorrect protein	89	2.414633e-30	3.570129847977528e-28	2.082917	301	0.01698166	297	2.6194814923569025e-7	1.338372	120	139	0.00990753	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	93	1.307934e-29	1.8506562909677418e-27	2.344262	226	0.01275035	242	2.709048223842975e-9	1.405763	107	118	0.008834214	
GO Biological Process	multi-organism metabolic process	96	4.517948e-29	6.192883097083334e-27	2.075999	290	0.01636107	239	1.8511073628033474e-9	1.370997	130	147	0.01073316	
GO Biological Process	regulation of hematopoietic stem cell differentiation	97	5.867636e-29	7.960022899381443e-27	2.41507	208	0.01173484	652	0.0022564879630368097	1.264307	84	103	0.006935271	
GO Biological Process	viral gene expression	98	1.156585e-28	1.5530104096938774e-26	2.245245	239	0.01348378	255	1.4021807247843138e-8	1.379384	113	127	0.00932959	
GO Biological Process	translational initiation	100	1.748091e-28	2.3003129469e-26	2.093996	278	0.01568406	235	1.5971380677021276e-9	1.376823	127	143	0.01048547	
GO Biological Process	endoplasmic reticulum unfolded protein response	103	2.464391e-28	3.148438948446602e-26	2.175832	253	0.01427362	311	7.4087962585209e-7	1.359895	100	114	0.008256275	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	106	7.546147e-28	9.36790078990566e-26	2.165812	251	0.01416079	327	0.0000013860712729357797	1.385357	84	94	0.006935271	
GO Biological Process	translational elongation	123	1.425108e-25	1.5246338351219512e-23	2.233894	214	0.01207334	228	7.334514939473683e-10	1.425705	103	112	0.008503963	
GO Biological Process	positive regulation of gene expression, epigenetic	127	7.661661e-25	7.938566700708661e-23	2.494352	166	0.009365303	656	0.0022868877660060976	1.29836	67	80	0.005531704	
GO Biological Process	cellular response to unfolded protein	130	2.019184e-24	2.0438801735384616e-22	2.006744	262	0.01478138	324	0.0000011754861594444444	1.345285	105	121	0.008669089	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	131	2.309629e-24	2.3200311458778626e-22	2.042566	250	0.01410437	442	0.00009230526430316742	1.303333	95	113	0.007843461	
GO Biological Process	protein targeting to ER	138	3.178843e-23	3.0311880461594204e-21	2.250074	190	0.01071932	263	3.1496967115969584e-8	1.412137	92	101	0.007595773	
GO Biological Process	cotranslational protein targeting to membrane	139	4.345074e-23	4.113440918417266e-21	2.28329	183	0.0103244	258	1.6085122966666667e-8	1.423727	90	98	0.007430647	
GO Biological Process	protein refolding	140	8.525549e-23	8.013407092214286e-21	5.520893	54	0.003046544	934	0.01766411185867238	1.476458	20	21	0.001651255	
GO Cellular Component	ribosomal subunit	28	3.442373e-36	2.1244359085714283e-34	2.156263	334	0.01884344	47	8.258196561702127e-12	1.365923	163	185	0.01345773	
GO Cellular Component	large ribosomal subunit	37	5.428969e-28	2.535475251891892e-26	2.322646	217	0.0122426	67	7.974180967164179e-8	1.375032	102	115	0.0084214	
GO Cellular Component	mitochondrial ribosome	49	1.269059e-21	4.4753754122448975e-20	2.512473	141	0.007954866	82	0.000003135137795121951	1.386133	76	85	0.006274769	
GO Cellular Component	mitochondrial large ribosomal subunit	68	1.047937e-15	2.6629928470588236e-14	2.668171	89	0.005021157	146	0.0014611991671232877	1.367895	45	51	0.003715324	
GO Cellular Component	uropod	69	1.13884e-15	2.8520514782608694e-14	3.865599	52	0.002933709	226	0.025533333238938055	1.550281	13	13	0.001073316	
GO Cellular Component	cytosolic large ribosomal subunit	77	2.675173e-14	6.003505122077922e-13	2.129469	126	0.007108604	129	0.0002714512520930232	1.37238	54	61	0.004458388	
GO Cellular Component	MLL1 complex	78	2.960407e-14	6.558440123076923e-13	2.813023	73	0.004118477	105	0.00004889680457142857	1.550281	29	29	0.00239432	
GO Cellular Component	spliceosomal snRNP complex	92	1.149216e-11	2.1585274434782608e-10	2.09278	104	0.005867419	123	0.00020577024	1.375249	55	62	0.004540951	
GO Cellular Component	nuclear ubiquitin ligase complex	128	3.991075e-9	5.3879512499999995e-8	2.163201	72	0.004062059	231	0.026939168415584414	1.317739	34	40	0.002807133	
GO Cellular Component	mitochondrial small ribosomal subunit	140	4.329397e-8	5.343712868571429e-7	2.421953	49	0.002764457	140	0.0009355590719999999	1.494914	27	28	0.002229194	
GO Cellular Component	spliceosomal tri-snRNP complex	159	2.825917e-7	0.0000030711852679245288	2.22748	51	0.002877292	138	0.0006322878469565217	1.496823	28	29	0.002311757	
GO Cellular Component	INO80-type complex	166	4.719063e-7	0.000004912374014457832	2.566862	37	0.002087447	232	0.027944039172413792	1.415474	21	23	0.001733818	
GO Cellular Component	BLOC complex	178	0.000001006794	0.000009773820404494383	2.187497	48	0.002708039	232	0.027944039172413792	1.415474	21	23	0.001733818	
GO Cellular Component	U2 snRNP	192	0.000002241591	0.000020174318999999996	2.466484	35	0.001974612	224	0.021228449142857146	1.468687	18	19	0.001486129	
GO Cellular Component	npBAF complex	200	0.000003592321	0.00003103765344	2.142537	45	0.002538787	239	0.037443916317991634	1.550281	12	12	0.000990753	
GO Cellular Component	NuA4 histone acetyltransferase complex	207	0.000007193869	0.00006005316730434782	2.028511	48	0.002708039	171	0.0037602138947368424	1.550281	18	18	0.001486129	
GO Cellular Component	SAGA-type complex	208	0.000007775157	0.000064593612	2.005819	49	0.002764457	159	0.0027660954566037736	1.488269	24	25	0.001981506	
GO Cellular Component	ribonuclease P complex	226	0.00001818244	0.00013902325805309734	2.491286	28	0.00157969	226	0.025533333238938055	1.550281	13	13	0.001073316	
GO Cellular Component	U4/U6 x U5 tri-snRNP complex	229	0.00002007125	0.00015145467248908295	2.031173	43	0.002425952	173	0.003796597789595376	1.485686	23	24	0.001898943	
GO Cellular Component	STAGA complex	260	0.00009220967	0.000612839652923077	2.498422	23	0.001297602	239	0.037443916317991634	1.550281	12	12	0.000990753	
GO Molecular Function	unfolded protein binding	10	1.272342e-25	5.371827924e-23	2.314008	199	0.01122708	85	0.00011635404832941177	1.316276	90	106	0.007430647	
GO Molecular Function	ribonucleoprotein complex binding	13	2.67624e-22	8.691604061538461e-20	2.029357	231	0.01303244	51	2.559559353333333e-7	1.375032	102	115	0.0084214	
GO Molecular Function	rRNA binding	17	6.838521e-18	1.698366803647059e-15	2.761241	97	0.005472496	108	0.0010939280185185186	1.369415	53	60	0.004375826	
GO Molecular Function	nucleosome binding	20	5.597504e-16	1.1816330944e-13	2.025906	161	0.009083216	144	0.006002241483333334	1.31539	56	66	0.004623514	
GO Molecular Function	nucleosomal DNA binding	21	9.806908e-16	1.9716555036190476e-13	2.352337	113	0.006375176	204	0.0415789803627451	1.314368	39	46	0.003219947	
GO Molecular Function	RNA polymerase core enzyme binding	32	2.263292e-12	2.9861308825000003e-10	2.154371	104	0.005867419	192	0.028779350958333335	1.373106	31	35	0.002559445	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	38	2.2734e-11	2.525867052631579e-9	2.270415	84	0.004739069	158	0.011153030267088608	1.443365	27	29	0.002229194	
GO Molecular Function	H4 histone acetyltransferase activity	49	9.472096e-11	8.161467206530612e-9	3.027979	47	0.002651622	171	0.01424997341871345	1.550281	17	17	0.001403567	
GO Molecular Function	telomeric DNA binding	88	4.260723e-8	0.0000020441786938636364	2.023295	73	0.004118477	121	0.0021957596158677685	1.459088	32	34	0.002642008	
GO Molecular Function	NF-kappaB binding	102	1.080038e-7	0.000004470510231372549	2.066686	65	0.003667137	124	0.002580786366290322	1.494914	27	28	0.002229194	
GO Molecular Function	snRNA binding	128	7.436104e-7	0.0000245275242875	2.117674	53	0.002990127	202	0.04064801563366337	1.346296	33	38	0.002724571	
GO Molecular Function	K63-linked polyubiquitin binding	158	0.000003522186	0.00009411816007594937	2.003914	53	0.002990127	190	0.02785995583157895	1.476458	20	21	0.001651255	
GO Molecular Function	sequence-specific single stranded DNA binding	165	0.000004626427	0.0001183804532969697	2.318986	37	0.002087447	206	0.04413135678640777	1.550281	14	14	0.001155878	
Human Phenotype	Increased intramyocellular lipid droplets	177	0.00003190606	0.001202876488022599	2.292373	31	0.001748942	269	0.014317288639033456	1.550281	17	17	0.001403567	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	185	0.0000451836	0.0016297846637837836	2.156296	34	0.001918195	304	0.030475810506578948	1.550281	15	15	0.001238441	
Human Phenotype	Renal Fanconi syndrome	368	0.0009155804	0.016602358720652174	2.111514	23	0.001297602	322	0.044623283562111794	1.550281	14	14	0.001155878	
Mouse Phenotype Single KO	abnormal B cell activation	29	2.592595e-47	8.186342212068964e-45	2.060782	490	0.02764457	152	0.000024284550754605262	1.285101	126	152	0.01040291	
Mouse Phenotype Single KO	decreased B cell proliferation	52	1.905068e-34	3.3547514761538456e-32	2.245512	290	0.01636107	370	0.015605735579459459	1.263192	66	81	0.005449141	
Mouse Phenotype Single KO	decreased IgM level	62	8.908739e-30	1.3157632745645162e-27	2.033133	313	0.01765867	378	0.018614335065079368	1.231105	81	102	0.006687583	
Mouse Phenotype Single KO	increased circulating interferon-gamma level	123	4.440525e-18	3.3058445060975603e-16	2.535504	114	0.006431594	425	0.03205992820705882	1.333962	37	43	0.003054822	
Mouse Phenotype Single KO	abnormal circulating interferon-gamma level	131	4.7035e-17	3.287782404580153e-15	2.114442	156	0.008801128	406	0.026648178142857144	1.266426	58	71	0.004788639	
Mouse Phenotype Single KO	abnormal Peyer's patch follicle morphology	217	4.886706e-12	2.0620998544700462e-10	2.448792	77	0.004344147	441	0.03787943590249433	1.426258	23	25	0.001898943	
Mouse Phenotype Single KO	delayed embryo turning	276	4.424878e-10	1.4680655016666667e-8	2.299351	71	0.004005642	383	0.02017233305613577	1.479813	21	22	0.001733818	
Mouse Phenotype Single KO	increased lactate dehydrogenase level	364	4.332104e-8	0.0000010898097892307692	2.150379	63	0.003554302	383	0.02017233305613577	1.479813	21	22	0.001733818	
Mouse Phenotype Single KO	abnormal Peyer's patch germinal center morphology	371	5.136529e-8	0.0000012677950418598383	2.33753	52	0.002933709	391	0.020964405827109973	1.550281	16	16	0.001321004	
Mouse Phenotype Single KO	thin hypoglossal nerve	413	2.524259e-7	0.0000055967650515738495	2.349037	46	0.002595205	416	0.030561003235576922	1.550281	15	15	0.001238441	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	491	0.000003243509	0.00006049045196130346	2.111366	47	0.002651622	344	0.009905118914244187	1.550281	18	18	0.001486129	
Mouse Phenotype	abnormal B cell activation	32	1.661644e-60	4.9646807137500005e-58	2.014875	665	0.03751763	144	3.114589368125e-8	1.300723	172	205	0.01420079	
Mouse Phenotype	abnormal B cell proliferation	37	7.249299e-56	1.873258047e-53	2.003699	622	0.03509168	167	2.3504911253892216e-7	1.296002	158	189	0.01304491	
Mouse Phenotype	abnormal marginal zone B cell morphology	63	2.928988e-40	4.445087979047619e-38	2.083839	404	0.02279267	142	2.8704316990140843e-8	1.360678	122	139	0.01007266	
Mouse Phenotype	decreased B cell proliferation	65	1.921898e-39	2.8269641196923077e-37	2.032902	420	0.02369535	257	0.000050577950416342415	1.30972	98	116	0.008091149	
Mouse Phenotype	abnormal follicular B cell morphology	76	1.170107e-33	1.4720253982894736e-31	2.089812	333	0.01878702	141	2.1159483004255318e-8	1.414819	94	103	0.007760898	
Mouse Phenotype	decreased marginal zone B cell number	89	1.971248e-30	2.117651924494382e-28	2.06853	307	0.01732017	184	5.783578804891303e-7	1.383094	91	102	0.00751321	
Mouse Phenotype	decreased follicular B cell number	90	3.257748e-30	3.460814292e-28	2.256516	250	0.01410437	235	0.000022611309326808512	1.378027	72	81	0.005944518	
Mouse Phenotype	arrested B cell differentiation	96	3.247448e-29	3.2342552425e-27	2.060069	297	0.01675599	272	0.00008492582855514706	1.378027	64	72	0.005284016	
Mouse Phenotype	absent spleen germinal center	132	2.185254e-21	1.582819204090909e-19	3.269951	91	0.005133992	595	0.02912796411932773	1.367895	30	34	0.002476882	
Mouse Phenotype	lymph node hyperplasia	161	3.090621e-19	1.835368160310559e-17	2.198004	163	0.009196051	457	0.006032633247045952	1.374112	39	44	0.003219947	
Mouse Phenotype	peritoneal inflammation	230	5.51436e-14	2.2922954765217393e-12	2.848377	70	0.003949224	644	0.040854509310559006	1.468687	18	19	0.001486129	
Mouse Phenotype	increased pre-B cell number	247	1.465874e-13	5.674178669635627e-12	2.001655	138	0.007785614	518	0.012477701178185327	1.382683	33	37	0.002724571	
Mouse Phenotype	increased circulating interleukin-4 level	261	5.138348e-13	1.8822890891954025e-11	4.694993	34	0.001918195	656	0.04867115955640244	1.550281	13	13	0.001073316	
Mouse Phenotype	decreased splenocyte number	284	3.361072e-12	1.1315214574647886e-10	2.058435	114	0.006431594	565	0.022147201932743363	1.373106	31	35	0.002559445	
Mouse Phenotype	abnormal Peyer's patch follicle morphology	312	2.347453e-11	7.193589145192307e-10	2.22059	88	0.004964739	556	0.019389088942446044	1.400254	28	31	0.002311757	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	329	6.68086e-11	1.9415107130699087e-9	2.372929	73	0.004118477	456	0.0060173495394736844	1.446929	28	30	0.002311757	
Mouse Phenotype	increased lactate dehydrogenase level	378	1.991556e-9	5.0373722e-8	2.040717	86	0.004851904	348	0.0009232060388793102	1.498605	29	30	0.00239432	
Mouse Phenotype	reduced sympathetic cervical ganglion size	457	4.694162e-8	9.820762118599562e-7	2.739288	39	0.002200282	656	0.04867115955640244	1.550281	13	13	0.001073316	
Mouse Phenotype	abnormal Peyer's patch germinal center morphology	467	6.281056e-8	0.0000012859352551605995	2.260854	55	0.003102962	471	0.007553484340764332	1.550281	18	18	0.001486129	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	485	1.173361e-7	0.000002313093715670103	2.012794	69	0.003892807	601	0.029021357585690518	1.426258	23	25	0.001898943