# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process translation 48 3.243565e-13 8.892098298958332e-11 2.25219 99 0.04945055 103 0.0001606948973398058 1.684607 81 372 0.03337454 GO Biological Process protein-DNA complex subunit organization 51 7.578145e-13 1.9553100010784313e-10 2.392258 85 0.04245754 75 0.000016783816739733335 1.949651 63 250 0.02595797 GO Biological Process DNA conformation change 54 2.066205e-12 5.035035480555555e-10 2.305113 88 0.04395604 174 0.007443145589137931 1.624434 59 281 0.02430985 GO Biological Process protein-DNA complex assembly 57 5.710236e-12 1.318263079368421e-9 2.43296 76 0.03796204 95 0.00009488924426526316 1.94301 55 219 0.02266172 GO Biological Process peptide biosynthetic process 73 6.579979e-11 1.1861088172739726e-8 2.035927 100 0.04995005 121 0.0006119876792892562 1.618394 82 392 0.03378657 GO Biological Process mRNA splicing, via spliceosome 82 2.487561e-10 3.991928682804878e-8 2.136268 84 0.04195804 132 0.0011118228509848485 1.710221 63 285 0.02595797 GO Biological Process RNA splicing, via transesterification reactions 83 2.828951e-10 4.4850802661445784e-8 2.130347 84 0.04195804 138 0.0015037924025362319 1.692406 63 288 0.02595797 GO Biological Process regulation of adaptive immune response 89 8.572191e-10 1.267432150213483e-7 2.507516 57 0.02847153 140 0.0015844911687857143 2.06706 35 131 0.0144211 GO Biological Process translational elongation 91 1.104773e-9 1.5975503194505496e-7 3.327158 36 0.01798202 192 0.01075740025625 2.003256 29 112 0.01194891 GO Biological Process chromatin assembly or disassembly 93 1.315568e-9 1.8614579905376347e-7 2.500914 56 0.02797203 151 0.0026077573741059602 1.868981 43 178 0.01771735 GO Biological Process chromatin assembly 97 2.700437e-9 3.66340726628866e-7 2.577296 51 0.02547453 157 0.0034559607422929937 1.909695 39 158 0.01606922 GO Biological Process nucleosome organization 98 2.849203e-9 3.8257818650000007e-7 2.518742 53 0.02647353 149 0.002136032467114094 1.900245 42 171 0.01730532 GO Biological Process mitochondrial translational elongation 99 4.807619e-9 6.390248325353536e-7 3.800462 28 0.01398601 188 0.009468992417021278 2.184483 24 85 0.009888752 GO Biological Process mitochondrial translational termination 103 6.788077e-9 8.672262644951456e-7 3.738482 28 0.01398601 207 0.012728160354589372 2.134265 24 87 0.009888752 GO Biological Process multi-organism metabolic process 109 9.835384e-9 0.0000011873744775779817 2.725334 43 0.02147852 253 0.02400635378893281 1.789444 34 147 0.01400906 GO Biological Process nucleotide-excision repair, preincision complex assembly 111 1.036052e-8 0.0000012282349790990991 4.976475 20 0.00999001 265 0.030153272483396224 2.934615 11 29 0.004532344 GO Biological Process DNA packaging 115 1.401718e-8 0.0000016039310575652176 2.292166 58 0.02897103 214 0.013525521193457945 1.71063 44 199 0.01812938 GO Biological Process mitochondrial translation 117 1.711294e-8 0.0000019246938244444446 3.234968 32 0.01598402 196 0.011178691347959183 2.02456 28 107 0.01153688 GO Biological Process positive regulation of interferon-gamma production 118 1.915366e-8 0.0000021359577283050847 2.868155 38 0.01898102 71 0.000011777594127323944 3.119642 25 62 0.01030078 GO Biological Process translational termination 121 2.338956e-8 0.00000254366297553719 3.342614 30 0.01498501 240 0.018169234420833336 2.035977 25 95 0.01030078 GO Cellular Component nuclear chromatin 29 8.368752e-12 4.98662188137931e-10 2.023157 111 0.05544456 24 0.000029100117600000002 1.787278 73 316 0.03007829 GO Cellular Component ribosomal subunit 34 1.351492e-10 6.8687593411764706e-9 2.857903 50 0.02497502 30 0.002101465152 1.840083 44 185 0.01812938 GO Cellular Component protein-DNA complex 37 2.570269e-10 1.2003850897297296e-8 2.497948 61 0.03046953 44 0.023655974399999998 1.646924 43 202 0.01771735 GO Cellular Component large ribosomal subunit 45 6.856121e-9 2.6327504639999997e-7 3.221991 34 0.01698302 33 0.005517912436363637 2.018273 30 115 0.01236094 GO Cellular Component ribosome 54 1.050854e-7 0.0000033627327999999996 2.20942 55 0.02747253 41 0.020210119024390242 1.606351 49 236 0.02018953 GO Cellular Component retromer complex 98 0.0003452387 0.006087474220408163 3.587578 11 0.005494505 46 0.025307360139130437 3.315734 9 21 0.003708282 GO Cellular Component SWI/SNF superfamily-type complex 112 0.000688609 0.010624253142857143 2.113034 24 0.01198801 43 0.024046213060465116 2.149087 20 72 0.008240626 GO Molecular Function structural constituent of ribosome 10 6.711382e-10 2.8335454803999995e-7 2.86525 46 0.02297702 19 0.007293576107368422 1.910299 40 162 0.01648125 Mouse Phenotype Single KO abnormal T cell activation 25 3.296552e-12 1.20746106656e-9 2.096414 106 0.05294705 14 0.000029728782623571425 1.900715 71 289 0.02925422 Mouse Phenotype Single KO abnormal T cell proliferation 32 3.690862e-11 1.0561632291875001e-8 2.085041 97 0.04845155 16 0.000055411004370625005 1.926767 65 261 0.02678204 Mouse Phenotype Single KO decreased T cell proliferation 65 1.399848e-8 0.0000019720627901538462 2.204224 63 0.03146853 19 0.00011586978631578947 2.217857 43 150 0.01771735 Mouse Phenotype Single KO abnormal interleukin-6 secretion 67 2.137246e-8 0.0000029210091973134326 2.245312 59 0.02947053 37 0.0015259365867297296 2.020415 41 157 0.01689328 Mouse Phenotype Single KO abnormal immune organ physiology 77 1.142948e-7 0.000013592175111688311 2.167948 57 0.02847153 90 0.043072289622222225 1.833887 32 135 0.013185 Mouse Phenotype Single KO abnormal IgG2a level 87 4.350218e-7 0.00004578729451264368 2.162189 52 0.02597403 75 0.024612782857333333 1.86559 34 141 0.01400906 Mouse Phenotype Single KO abnormal white fat cell number 114 0.000004486005 0.0003603363840789474 4.01719 16 0.007992008 72 0.02040023167916667 3.868356 9 18 0.003708282 Mouse Phenotype Single KO abnormal thymocyte activation 211 0.0002214501 0.009610514529383886 3.526059 12 0.005994006 82 0.03013646869512195 3.664758 9 19 0.003708282 Mouse Phenotype abnormal interleukin-6 secretion 29 6.923066e-15 2.282463242275862e-12 2.671496 82 0.04095904 67 0.0012850460622985075 1.893883 47 192 0.01936547 Mouse Phenotype abnormal erythroid progenitor cell morphology 46 2.301786e-12 4.784212162173914e-10 2.596909 70 0.03496503 162 0.02802399922222222 1.885417 29 119 0.01194891 Mouse Phenotype decreased immunoglobulin level 48 3.656378e-12 7.283047928749999e-10 2.000379 118 0.05894106 61 0.0007149154679016393 1.667395 75 348 0.03090235 Mouse Phenotype decreased erythroid progenitor cell number 49 3.939279e-12 7.686417656938776e-10 3.007239 54 0.02697303 163 0.02799242011472393 2.137776 21 76 0.008652658 Mouse Phenotype decreased T cell apoptosis 61 8.586934e-11 1.345896327442623e-8 3.942421 33 0.01648352 130 0.019035414113076923 2.637515 15 44 0.00618047 Mouse Phenotype decreased T cell proliferation 62 1.12095e-10 1.7286133790322582e-8 2.107255 90 0.04495504 19 1.479730306263158e-7 2.252001 62 213 0.02554594 Mouse Phenotype abnormal B cell activation 80 1.207708e-8 0.0000014433620235000002 2.038742 76 0.03796204 87 0.005938376662758621 1.773783 47 205 0.01936547 Mouse Phenotype abnormal IgG2a level 91 6.5112e-8 0.0000068410530989010986 2.15549 60 0.02997003 106 0.009344713944339623 1.820403 40 170 0.01648125 Mouse Phenotype increased IgG1 level 94 7.482907e-8 0.000007611071683723405 2.469319 45 0.02247752 99 0.008156085413333333 2.131543 27 98 0.01112485 Mouse Phenotype abnormal IgG2 level 95 7.90087e-8 0.000007951601902105262 2.007875 70 0.03496503 93 0.006492692104516129 1.751708 48 212 0.0197775 Mouse Phenotype abnormal CD4-positive, alpha-beta T cell physiology 101 1.138073e-7 0.000010773382131683167 2.023206 67 0.03346653 120 0.0144963324275 1.762251 41 180 0.01689328 Mouse Phenotype abnormal single-positive T cell number 106 1.516347e-7 0.000013677163836792453 2.183522 55 0.02747253 77 0.002621482164155844 2.071246 34 127 0.01400906 Mouse Phenotype abnormal marginal zone B cell morphology 119 8.180738e-7 0.00006572776135966388 2.192029 48 0.02397602 143 0.022515412852447552 1.836773 33 139 0.01359703 Mouse Phenotype decreased marginal zone B cell number 122 8.868201e-7 0.00006949907357459015 2.386193 40 0.01998002 117 0.01436968452051282 2.047953 27 102 0.01112485 Mouse Phenotype abnormal spleen marginal zone morphology 124 9.350713e-7 0.0000720985217685484 2.071852 54 0.02697303 97 0.007326475033917525 1.862542 39 162 0.01606922 Mouse Phenotype abnormal spleen germinal center morphology 134 0.000001782342 0.00012717143180597016 2.129361 48 0.02397602 172 0.03096523849360465 1.807115 32 137 0.013185 Mouse Phenotype decreased IgG2 level 138 0.000002191621 0.0001518412201521739 2.132263 47 0.02347652 129 0.01910438256046512 1.903477 31 126 0.01277297 Mouse Phenotype abnormal spleen secondary B follicle morphology 140 0.000002693479 0.00018394537656428572 2.077991 49 0.02447552 153 0.024175057239215685 1.823654 33 140 0.01359703 Mouse Phenotype abnormal thymus physiology 146 0.000003518502 0.00023041368234246576 2.039986 50 0.02497502 160 0.026104039762499996 1.871785 30 124 0.01236094 Mouse Phenotype decreased B-1 B cell number 153 0.000005738892 0.0003586244863529412 2.229475 39 0.01948052 111 0.011652498897297298 2.184483 24 85 0.009888752