# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	interferon-gamma-mediated signaling pathway	105	1.405117e-62	1.7609461526666667e-60	2.572446	414	0.01119827	811	0.008803995687422935	1.170918	62	64	0.003990988	
GO Biological Process	endoplasmic reticulum unfolded protein response	153	3.12065e-47	2.6839629640522875e-45	2.053387	498	0.01347038	470	0.00016731730095319148	1.16628	110	114	0.007080785	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	183	3.832759e-42	2.7560259934972676e-40	2.237046	363	0.009818772	916	0.017568213137554585	1.156138	66	69	0.004248471	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	185	1.028328e-41	7.314469271351352e-40	2.088737	420	0.01136056	517	0.0004079404536750483	1.157474	113	118	0.007273898	
GO Biological Process	cotranslational protein targeting to membrane	220	3.317645e-38	1.984404116136364e-36	2.14754	359	0.009710576	613	0.0015092872829200652	1.159356	94	98	0.006050853	
GO Biological Process	lymphocyte costimulation	235	2.897376e-36	1.6224072674042554e-34	2.026056	391	0.01057614	692	0.0033098954401734105	1.174642	69	71	0.004441584	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	241	1.763443e-35	9.628691467634855e-34	2.139727	335	0.009061401	467	0.00014715732242184153	1.182414	90	92	0.00579337	
GO Biological Process	T cell costimulation	243	2.280822e-35	1.23511673654321e-33	2.030032	379	0.01025156	740	0.005050443760675675	1.17314	66	68	0.004248471	
GO Biological Process	protein targeting to ER	252	7.304552e-35	3.8143095146031744e-33	2.055363	362	0.009791723	411	0.000035985990939172754	1.184756	99	101	0.006372707	
GO Biological Process	liver regeneration	378	1.189639e-25	4.141391428835978e-24	2.169603	230	0.00622126	924	0.01860595727813853	1.20869	35	35	0.002252977	
GO Biological Process	regulation of T cell receptor signaling pathway	401	3.900003e-24	1.2798039769825435e-22	2.203706	208	0.005626183	892	0.01593950260089686	1.20869	36	36	0.002317348	
GO Biological Process	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	444	7.129935e-22	2.1131264564189188e-20	2.012646	232	0.006275358	868	0.01354661593076037	1.20869	37	37	0.002381719	
GO Biological Process	cytoplasmic translation	743	1.251284e-14	2.2161031165545087e-13	2.086531	136	0.003678658	1060	0.035474926018867925	1.180581	42	43	0.002703573	
GO Biological Process	GPI anchor biosynthetic process	993	2.569572e-11	3.405135745015106e-10	2.055936	105	0.002840141	1018	0.029853802617878195	1.20869	32	32	0.002059865	
GO Cellular Component	mitochondrial ribosome	82	3.385186e-24	7.133660253658537e-23	2.067448	242	0.006545848	114	0.000258208067368421	1.18025	83	85	0.005342774	
GO Cellular Component	mitochondrial large ribosomal subunit	122	9.101875e-17	1.289183606557377e-15	2.141642	149	0.004030295	203	0.03592579247290641	1.16129	49	51	0.003154168	
GO Molecular Function	rRNA binding	12	3.919986e-36	1.379181741e-33	2.784194	204	0.005517988	139	0.03126876985611511	1.1684	58	60	0.003733505	
Mouse Phenotype Single KO	abnormal B cell activation	43	3.821545e-116	8.138113387209302e-114	2.179709	1081	0.02923992	189	0.0003951964494074074	1.145075	144	152	0.009269392	
Mouse Phenotype Single KO	abnormal B cell proliferation	51	8.076839e-104	1.4501885239803918e-101	2.143652	1003	0.02713011	255	0.001980446873058824	1.138621	130	138	0.008368201	
Mouse Phenotype Single KO	decreased B cell proliferation	75	8.794291e-78	1.0737243024933332e-75	2.327672	627	0.0169597	415	0.019043918812289156	1.149002	77	81	0.00495655	
Mouse Phenotype Single KO	decreased IgM level	93	2.594194e-61	2.5543047804301073e-59	2.046085	657	0.01777117	482	0.035280021207468884	1.125741	95	102	0.006115224	
Mouse Phenotype Single KO	abnormal spleen secondary B follicle morphology	99	1.631942e-57	1.5094639286868686e-55	2.031958	626	0.01693265	239	0.0014666812876569038	1.16129	98	102	0.006308336	
Mouse Phenotype Single KO	spleen hyperplasia	114	2.030952e-50	1.6313532863157896e-48	2.073905	520	0.01406546	346	0.008264457153179191	1.162202	75	78	0.004827808	
Mouse Phenotype Single KO	abnormal class switch recombination	125	2.360475e-47	1.729189566e-45	2.181833	433	0.0117122	259	0.002253682302818533	1.190095	64	65	0.00411973	
Mouse Phenotype Single KO	abnormal lymph node cortex morphology	156	2.393138e-39	1.4047413247435899e-37	2.171402	361	0.009764674	284	0.0035633820640845067	1.20869	48	48	0.003089797	
Mouse Phenotype Single KO	abnormal lymph node B cell domain morphology	187	1.350343e-34	6.612348048663102e-33	2.129172	330	0.008926156	338	0.007743332586982248	1.20869	43	43	0.002767943	
Mouse Phenotype Single KO	absent mature B cells	208	1.148409e-30	5.055760198557693e-29	2.134071	289	0.007817149	446	0.02682374792600897	1.20869	35	35	0.002252977	
Mouse Phenotype	abnormal B cell activation	45	2.553489e-139	5.425312962e-137	2.084564	1435	0.03881526	192	0.000013473605204687502	1.143834	194	205	0.01248793	
Mouse Phenotype	abnormal B cell proliferation	46	2.284148e-135	4.747551962608696e-133	2.10511	1363	0.03686773	213	0.000029936676025352115	1.144738	179	189	0.01152237	
Mouse Phenotype	decreased B cell proliferation	82	2.115681e-90	2.46683244402439e-88	2.107122	908	0.02456045	338	0.0006109264018934912	1.156591	111	116	0.007145156	
Mouse Phenotype	abnormal marginal zone B cell morphology	83	3.481466e-88	4.010397159759036e-86	2.131704	862	0.0233162	517	0.008258298030754351	1.121734	129	139	0.00830383	
Mouse Phenotype	abnormal spleen germinal center morphology	91	7.376645e-80	7.750340971978022e-78	2.051543	854	0.02309981	278	0.00014693740308992806	1.155755	131	137	0.008432572	
Mouse Phenotype	abnormal spleen secondary B follicle morphology	92	1.316727e-79	1.3683942225e-77	2.023196	881	0.02383013	257	0.0001018303047548638	1.156889	134	140	0.008625684	
Mouse Phenotype	decreased IgM level	95	3.372366e-78	3.3940201395789475e-76	2.018751	870	0.02353259	420	0.002781379127857143	1.135436	124	132	0.007981976	
Mouse Phenotype	abnormal follicular B cell morphology	96	3.080926e-77	3.068409738125e-75	2.172386	722	0.01952935	288	0.00019684608413541668	1.173485	100	103	0.006437078	
Mouse Phenotype	decreased marginal zone B cell number	116	7.561817e-64	6.232632098017242e-62	2.093318	648	0.01752773	676	0.026265113618343196	1.125741	95	102	0.006115224	
Mouse Phenotype	decreased follicular B cell number	141	1.538624e-56	1.0433180187234042e-54	2.202688	509	0.01376792	452	0.0041552909800884955	1.163924	78	81	0.005020921	
Mouse Phenotype	abnormal class switch recombination	145	4.142523e-55	2.731493958827586e-53	2.060377	579	0.01566135	202	0.000024528144387623758	1.195552	91	92	0.005857741	
Mouse Phenotype	abnormal lymph node cortex morphology	146	6.909437e-55	4.524734736780822e-53	2.27576	460	0.01244252	680	0.026844461880882353	1.15375	63	66	0.004055359	
Mouse Phenotype	absent spleen germinal center	148	1.078754e-54	6.968896617567567e-53	3.652351	212	0.005734379	648	0.02330819827314815	1.20869	34	34	0.002188606	
Mouse Phenotype	abnormal lymph node B cell domain morphology	158	4.457073e-51	2.697093351455696e-49	2.299162	418	0.01130646	659	0.024022991813353566	1.16628	55	57	0.003540393	
Mouse Phenotype	increased follicular B cell number	250	8.279879e-34	3.1665569247600006e-32	2.270842	279	0.007546659	705	0.031321225723404254	1.20869	32	32	0.002059865