# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA processing	31	6.156167e-49	2.613193598483871e-46	2.129869	469	0.02757202	127	3.8722305446456694e-17	1.452782	211	252	0.01949732	
GO Biological Process	rRNA metabolic process	34	1.929346e-47	7.467136474705882e-45	2.089574	475	0.02792475	132	1.3902174462878786e-16	1.440315	215	259	0.01986694	
GO Biological Process	nuclear-transcribed mRNA catabolic process	38	8.974478e-46	3.1077672632105267e-43	2.197856	408	0.02398589	131	1.326627096259542e-16	1.498475	171	198	0.01580115	
GO Biological Process	mRNA catabolic process	39	1.263075e-45	4.261744596153847e-43	2.128721	437	0.02569077	125	2.9408575376000003e-17	1.4907	183	213	0.01691	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	43	7.377011e-43	2.2575369243953486e-40	2.723831	252	0.01481481	151	2.158272949271523e-14	1.588036	108	118	0.009979671	
GO Biological Process	viral gene expression	49	3.35576e-40	9.01192772244898e-38	2.564774	262	0.0154027	150	1.8205897588e-14	1.571132	115	127	0.0106265	
GO Biological Process	multi-organism metabolic process	51	4.278534e-40	1.1039456648235294e-37	2.334831	313	0.01840094	154	2.1920877425974027e-14	1.534422	130	147	0.01201257	
GO Biological Process	translational initiation	56	9.349487e-39	2.196962489875e-36	2.346844	299	0.0175779	163	1.1684804495705521e-13	1.528809	126	143	0.01164295	
GO Biological Process	protein targeting to ER	62	4.130442e-36	8.76653004483871e-34	2.677842	217	0.0127572	145	1.152604070137931e-14	1.632003	95	101	0.008778414	
GO Biological Process	cotranslational protein targeting to membrane	65	1.105686e-35	2.2384187806153844e-33	2.717304	209	0.01228689	134	3.3180408679850745e-16	1.664257	94	98	0.00868601	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	67	5.720644e-35	1.1235515581492538e-32	2.76256	199	0.011699	143	6.72187945979021e-15	1.659639	88	92	0.008131584	
GO Biological Process	viral transcription	71	3.390469e-34	6.283828390281691e-32	2.482608	235	0.0138154	158	2.7044751581645574e-14	1.596885	104	113	0.009610054	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	84	4.886735e-32	7.655303079166667e-30	2.4445	226	0.0132863	164	1.3782022483536583e-13	1.60288	97	105	0.008963223	
GO Biological Process	translational elongation	102	3.971608e-28	5.1237636933333327e-26	2.338671	215	0.01263962	166	3.2040127733132526e-13	1.580159	102	112	0.009425245	
GO Biological Process	mitochondrial translational termination	108	7.88638e-27	9.608969853703703e-25	2.608586	166	0.009758965	207	6.679254119806763e-11	1.595473	80	87	0.007392349	
GO Biological Process	protein localization to endoplasmic reticulum	116	7.920199e-26	8.984646434568965e-24	2.140041	238	0.01399177	215	2.628707941023256e-10	1.497203	107	124	0.009887267	
GO Biological Process	mitochondrial translation	117	1.198755e-25	1.3482407730769232e-23	2.332039	196	0.01152263	171	4.2136264602923983e-13	1.589136	98	107	0.009055627	
GO Biological Process	mitochondrial translational elongation	119	1.850923e-25	2.046747542605042e-23	2.571959	161	0.009465021	211	1.680791586208531e-10	1.592188	78	85	0.00720754	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	120	2.059766e-25	2.2587050661666668e-23	2.246173	210	0.01234568	497	0.0008045362293963783	1.320501	86	113	0.007946775	
GO Biological Process	regulation of hematopoietic stem cell differentiation	129	3.118126e-24	3.1807302351937985e-22	2.298804	190	0.0111699	624	0.004586556797115384	1.297096	77	103	0.007115136	
GO Cellular Component	ribosomal subunit	28	5.017706e-45	3.0966414171428573e-43	2.347809	349	0.02051734	33	3.67209058909091e-21	1.566258	167	185	0.01543153	
GO Cellular Component	ribosome	33	4.56936e-40	2.3926830545454544e-38	2.028302	429	0.02522046	35	2.3725094400000004e-20	1.499812	204	236	0.01885049	
GO Cellular Component	large ribosomal subunit	40	7.661124e-32	3.309605568e-30	2.46489	221	0.01299236	40	5.435951039999999e-15	1.599288	106	115	0.009794862	
GO Cellular Component	mitochondrial ribosome	50	1.319377e-23	4.559766912e-22	2.636651	142	0.008348031	54	6.3522176e-10	1.571775	77	85	0.007115136	
GO Cellular Component	mitochondrial large ribosomal subunit	59	4.232143e-18	1.2395157803389828e-16	2.874044	92	0.005408583	80	0.00000766123704	1.564971	46	51	0.004250601	
GO Cellular Component	cytosolic large ribosomal subunit	64	2.432603e-17	6.568028099999999e-16	2.307034	131	0.007701352	58	1.1963718620689657e-8	1.621301	57	61	0.005267049	
GO Cellular Component	small ribosomal subunit	65	3.816545e-17	1.0146138092307691e-15	2.253151	136	0.007995297	68	9.305038588235293e-7	1.518192	63	72	0.005821475	
GO Cellular Component	spliceosomal snRNP complex	85	4.34264e-14	8.828331670588236e-13	2.264623	108	0.006349206	112	0.0005199028971428572	1.427241	51	62	0.004712622	
GO Cellular Component	endopeptidase complex	94	7.416767e-13	1.3634226995744682e-11	2.031903	125	0.007348618	125	0.00127701785088	1.383032	55	69	0.00508224	
GO Cellular Component	small nuclear ribonucleoprotein complex	99	1.325519e-12	2.3136331636363634e-11	2.060813	118	0.006937096	90	0.000046504224	1.45847	58	69	0.005359453	
GO Cellular Component	proteasome complex	102	2.998056e-12	5.0790595764705885e-11	2.000522	123	0.007231041	132	0.0016887783272727273	1.377855	54	68	0.004989836	
GO Cellular Component	mitochondrial nucleoid	114	9.957493e-11	1.5093463073684211e-9	2.224655	82	0.004820694	93	0.00006103673187096774	1.569831	38	42	0.003511366	
GO Cellular Component	cytosolic small ribosomal subunit	115	1.248204e-10	1.875562184347826e-9	2.145409	88	0.005173427	150	0.007033212288	1.419608	36	44	0.003326557	
GO Cellular Component	nuclear ubiquitin ligase complex	121	3.283413e-10	4.689039391735537e-9	2.285436	73	0.004291593	179	0.024303779396648042	1.388061	32	40	0.00295694	
GO Cellular Component	methylosome	140	6.476001e-9	7.99323552e-8	3.878026	27	0.001587302	166	0.013947260530120482	1.735077	12	12	0.001108852	
GO Cellular Component	MLL1 complex	152	2.457985e-8	2.794340842105263e-7	2.288797	57	0.00335097	108	0.00043882192	1.615416	27	29	0.002494918	
GO Cellular Component	mitochondrial small ribosomal subunit	156	3.239702e-8	3.588592984615385e-7	2.472252	48	0.002821869	97	0.00007560372321649484	1.67311	27	28	0.002494918	
GO Cellular Component	sex chromosome	183	4.77041e-7	0.000004504518295081967	2.069546	58	0.003409759	187	0.03081841796791444	1.468142	22	26	0.002032896	
GO Cellular Component	pronucleus	191	9.386789e-7	0.000008492341042931938	2.45632	38	0.00223398	184	0.028960190608695653	1.619405	14	15	0.001293661	
GO Cellular Component	proteasome accessory complex	201	0.000001356551	0.000011662289194029849	2.274614	43	0.002527925	143	0.0036328263608391607	1.590487	22	24	0.002032896	
GO Molecular Function	structural constituent of ribosome	8	3.236094e-40	1.7078486085e-37	2.323933	317	0.0186361	10	2.2566243796e-17	1.563711	146	162	0.01349104	
GO Molecular Function	chromatin DNA binding	11	2.40455e-30	9.229100090909092e-28	2.118738	289	0.01699001	108	0.001136979908888889	1.334674	80	104	0.007392349	
GO Molecular Function	rRNA binding	16	6.408462e-21	1.6910329102500002e-18	2.995959	101	0.005937684	100	0.0008406200434	1.445897	50	60	0.004620218	
GO Molecular Function	ribonucleoprotein complex binding	18	1.221828e-20	2.8658654533333333e-18	2.004807	219	0.01287478	27	1.2282348423703703e-9	1.508762	100	115	0.009240436	
GO Molecular Function	unfolded protein binding	23	2.167427e-18	3.978642084347826e-16	2.096234	173	0.01017049	88	0.00028940941611363635	1.358598	83	106	0.007669562	
GO Molecular Function	snRNA binding	30	2.207955e-16	3.10732867e-14	3.081036	74	0.004350382	63	0.000021595958901587303	1.643757	36	38	0.003326557	
GO Molecular Function	insulin-like growth factor I binding	63	6.415976e-11	4.299722328888889e-9	2.636408	60	0.003527337	162	0.0349185722345679	1.735077	12	12	0.001108852	
GO Molecular Function	translation elongation factor activity	200	0.000003475026	0.00007335779886000001	2.733485	28	0.001646091	171	0.04654029112280702	1.626634	15	16	0.001386065	
Human Phenotype	Increased serum lactate	5	8.266717e-20	1.1032760508199999e-16	2.085383	190	0.0111699	45	1.201680809577778e-7	1.492166	86	100	0.007946775	
Human Phenotype	Abnormal CSF metabolite level	13	1.340056e-14	6.878610529230769e-12	2.259272	113	0.006643151	129	0.0003268159168837209	1.459668	53	63	0.004897431	
Human Phenotype	Increased CSF lactate	17	1.287209e-13	5.052673915882353e-11	2.273974	103	0.006055262	141	0.0005299474166666667	1.465841	49	58	0.004527814	
Human Phenotype	Exercise intolerance	20	3.527536e-13	1.1769623863999998e-10	2.112574	117	0.006878307	215	0.005877007315348837	1.363275	55	70	0.00508224	
Human Phenotype	Focal segmental glomerulosclerosis	23	2.639793e-12	7.658842908260869e-10	2.166719	102	0.005996473	314	0.031547308802547774	1.487209	24	28	0.002217705	
Human Phenotype	Steppage gait	49	6.460758e-10	8.798497578367347e-8	2.134625	82	0.004820694	261	0.016558315725670496	1.503733	26	30	0.002402513	
Human Phenotype	Prolonged neonatal jaundice	103	1.420208e-7	0.000009201017460194175	2.373113	47	0.002763081	268	0.0173671498	1.638684	17	18	0.001570874	
Human Phenotype	Flat occiput	180	0.000002867518	0.00010630526452222222	2.121478	47	0.002763081	205	0.005010348809756098	1.652454	20	21	0.001848087	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	243	0.00003407753	0.0009357998258847737	2.133762	36	0.002116402	334	0.03766011441017964	1.626634	15	16	0.001386065	
Mouse Phenotype Single KO	decreased cellular sensitivity to gamma-irradiation	281	0.000002497159	0.00008137539132740214	2.113724	48	0.002821869	222	0.05025563713963964	1.569831	19	21	0.001755683	
Mouse Phenotype Single KO	pale placenta	341	0.00001243197	0.00033384032049853376	2.116035	41	0.002410347	198	0.035695896020707066	1.735077	13	13	0.001201257	
Mouse Phenotype	enlarged liver sinusoidal spaces	52	5.304392e-14	9.752940752307693e-12	2.018855	140	0.008230453	232	0.005666260712068966	1.481163	35	41	0.003234153	
Mouse Phenotype	decreased cellular sensitivity to gamma-irradiation	311	3.897769e-7	0.000011982819745659165	2.16515	53	0.003115814	258	0.011140907074418603	1.590487	22	24	0.002032896	
Mouse Phenotype	decreased thoracic vertebrae number	345	0.000001055313	0.000029245935052173916	2.002884	59	0.003468548	396	0.045510867022727275	1.626634	15	16	0.001386065	
Mouse Phenotype	pale placenta	414	0.000004231571	0.00009772475925362319	2.149205	44	0.002586714	251	0.009755804422709163	1.735077	15	15	0.001386065