# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	18	1.396903e-25	1.0212136987222222e-22	2.468488	174	0.01704545	344	0.012104902895348836	1.397636	65	113	0.008410973	
GO Biological Process	regulation of DNA-templated transcription in response to stress	20	4.713011e-23	3.10092558745e-20	2.282578	182	0.01782915	336	0.011874313461309524	1.388421	68	119	0.008799172	
GO Biological Process	activation of signaling protein activity involved in unfolded protein response	25	3.863404e-21	2.03354132944e-18	6.186687	45	0.004408307	414	0.02611099685169082	2.429736	8	8	0.001035197	
GO Biological Process	translational elongation	38	4.10991e-19	1.4232185707894736e-16	2.410715	133	0.013029	419	0.027416054168257757	1.366727	63	112	0.008152174	
GO Biological Process	regulation of cellular amino acid metabolic process	41	8.924641e-19	2.8643744126585363e-16	3.153579	83	0.008130878	437	0.03188248038443936	1.498337	37	60	0.004787785	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	55	2.635095e-17	6.304584564545455e-15	2.423897	118	0.01155956	379	0.01751963566965699	1.464072	47	78	0.006081781	
GO Biological Process	regulation of mitochondrial membrane permeability	71	6.351941e-16	1.1772562199859155e-13	2.244102	126	0.01234326	346	0.012260852611849709	1.497782	45	73	0.005822981	
GO Biological Process	RNA phosphodiester bond hydrolysis	76	1.049583e-15	1.8172977232894736e-13	2.054105	152	0.01489028	425	0.028673095644235296	1.333615	73	133	0.00944617	
GO Biological Process	positive regulation of mRNA catabolic process	81	1.706443e-15	2.7722325230864197e-13	2.954854	74	0.007249216	492	0.04736453669512195	1.74941	18	25	0.002329193	
GO Biological Process	regulation of translational fidelity	85	5.834141e-15	9.031936637529412e-13	5.045783	37	0.003624608	297	0.00667257887946128	2.046093	16	19	0.002070393	
GO Biological Process	regulation of membrane permeability	104	4.814919e-14	6.092261453942308e-12	2.067506	132	0.01293103	411	0.024042043692944035	1.439844	48	81	0.00621118	
GO Biological Process	negative regulation of ubiquitin protein ligase activity	105	6.670676e-14	8.359945284190476e-12	2.365193	97	0.009502351	293	0.006271503050853242	1.514641	48	77	0.00621118	
GO Biological Process	RNA phosphodiester bond hydrolysis, endonucleolytic	106	7.650856e-14	9.497888123018868e-12	2.437009	91	0.008914577	375	0.016978229560266667	1.492552	43	70	0.005564182	
GO Biological Process	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	137	1.128901e-12	1.084321770729927e-10	2.330126	90	0.008816614	343	0.012127764081632653	1.505752	44	71	0.005693582	
GO Biological Process	negative regulation of ubiquitin-protein transferase activity	141	1.322017e-12	1.2337887732624113e-10	2.191204	102	0.009992163	440	0.03243277795227273	1.417346	49	84	0.00634058	
GO Biological Process	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	143	1.53881e-12	1.4160280272727274e-10	2.316333	90	0.008816614	377	0.01713256773183024	1.484839	44	72	0.005693582	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	172	2.802651e-11	2.1441909598255815e-9	2.595149	64	0.006269592	203	0.0004974317859458128	2.112814	20	23	0.002587992	
GO Biological Process	anaphase-promoting complex-dependent catabolic process	178	4.530564e-11	3.3493085211235957e-9	2.080326	99	0.009698276	317	0.00923024979022082	1.488213	49	80	0.00634058	
GO Biological Process	positive regulation of endoplasmic reticulum unfolded protein response	229	1.254311e-9	7.20763251048035e-8	2.655696	51	0.004996082	490	0.04658970805102041	2.05593	11	13	0.001423395	
GO Biological Process	regulation of translational elongation	258	5.317586e-9	2.712174967984496e-7	2.625352	48	0.004702194	400	0.02124507391	1.759464	21	29	0.002717391	
GO Cellular Component	proteasome complex	47	3.459157e-12	1.271792190638298e-10	2.330775	86	0.008424765	50	0.0025464336768	1.572182	44	68	0.005693582	
GO Cellular Component	endopeptidase complex	48	3.55822e-12	1.2809592e-10	2.329459	86	0.008424765	53	0.003998233358490567	1.549397	44	69	0.005693582	
GO Cellular Component	preribosome	50	1.477145e-11	5.105013120000001e-10	2.21628	90	0.008816614	56	0.006626259771428571	1.5026	47	76	0.006081781	
GO Cellular Component	peptidase complex	52	2.196289e-11	7.298437292307692e-10	2.066021	104	0.01018809	52	0.003359747076923077	1.490974	54	88	0.006987578	
GO Cellular Component	spliceosomal snRNP complex	58	1.09185e-10	3.25296e-9	2.410932	69	0.006759404	89	0.04766326867415731	1.450004	37	62	0.004787785	
GO Cellular Component	proteasome accessory complex	78	4.19582e-8	9.295355076923077e-7	2.996966	34	0.003330721	73	0.019076544789041097	1.822302	18	24	0.002329193	
GO Cellular Component	aminoacyl-tRNA synthetase multienzyme complex	135	0.00001455406	0.000186291968	2.99725	21	0.00205721	61	0.012104458701639344	2.227258	11	12	0.001423395	
GO Cellular Component	Bcl-2 family protein complex	253	0.001186591	0.00810446343083004	2.644287	14	0.001371473	83	0.041577387180722895	2.429736	7	7	0.0009057971	
GO Molecular Function	rRNA binding	7	1.257799e-18	7.586324825714286e-16	3.509429	71	0.006955329	64	0.02824031150625	1.538833	38	60	0.004917184	
GO Molecular Function	ribonuclease activity	11	7.706164e-16	2.9577658552727277e-13	2.221835	128	0.01253918	80	0.0367917904325	1.398939	57	99	0.007375776	
GO Molecular Function	aminoacyl-tRNA editing activity	20	1.787919e-12	3.774297009e-10	4.901591	31	0.003036834	56	0.014291552932142857	2.242833	12	13	0.001552795	
GO Molecular Function	mRNA 5'-UTR binding	54	5.804435e-8	0.000004538208253703704	2.757273	38	0.003722571	77	0.03460831521038961	1.877523	17	22	0.002199793	
GO Molecular Function	protein transmembrane transporter activity	70	5.232673e-7	0.00003156049343714286	2.726681	33	0.003232759	60	0.021876356330000003	2.02478	15	18	0.001940994	
GO Molecular Function	quaternary ammonium group transmembrane transporter activity	257	0.0007843133	0.012884711099610896	2.764532	14	0.001371473	81	0.04281876299753087	2.429736	8	8	0.001035197	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	26	8.994831e-13	3.167910287192308e-10	3.236133	52	0.005094044	137	0.042187675891970804	1.877523	17	22	0.002199793	
Mouse Phenotype	absent segment of posterior cerebral artery	29	8.994831e-13	2.965502730724138e-10	3.236133	52	0.005094044	231	0.02612427772987013	1.877523	17	22	0.002199793	
Mouse Phenotype	abnormal cellular replicative senescence	31	1.491956e-12	4.6014810696774195e-10	2.047403	119	0.01165752	184	0.011843054814130435	1.475197	51	84	0.006599379	
Mouse Phenotype	early cellular replicative senescence	39	3.608216e-12	8.845680301538462e-10	2.100117	108	0.01057994	242	0.029490181498760332	1.464498	44	73	0.005693582	
Mouse Phenotype	abnormal cerebral artery morphology	64	1.940308e-10	2.898638248125e-8	2.715842	54	0.005289969	248	0.03106922898266129	1.822302	18	24	0.002329193	
Mouse Phenotype	abnormal umbilical vein morphology	315	0.0000289389	0.000878364517142857	2.303902	31	0.003036834	264	0.03466400668409091	2.208851	10	11	0.001293996	
Mouse Phenotype	increased prostaglandin level	356	0.00005064729	0.0013602211789044943	2.142594	34	0.003330721	261	0.03340778611149425	1.918213	15	19	0.001940994