# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of interleukin-8 production 67 4.881659e-14 9.58772399716418e-12 4.945519 35 0.01330798 201 0.02688284189154229 2.423327 16 45 0.005807623 GO Biological Process positive regulation of T cell activation 119 1.10144e-11 1.2179705008403361e-9 2.035704 109 0.04144487 190 0.024086566037894736 1.627608 48 201 0.01742287 GO Biological Process regulation of CD4-positive, alpha-beta T cell activation 131 2.128604e-11 2.1381908424427484e-9 3.109521 48 0.01825095 263 0.04641873274638783 2.271869 16 48 0.005807623 GO Biological Process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 244 8.816873e-9 4.7549685166803276e-7 3.334908 32 0.0121673 155 0.013414259130967743 2.806427 14 34 0.00508167 GO Biological Process negative regulation of tissue remodeling 365 2.625574e-7 0.00000946573377150685 3.745811 22 0.008365019 239 0.039036531380753144 3.228446 9 19 0.003266788 GO Biological Process cytokine production involved in immune response 420 6.506055e-7 0.000020384089939285715 3.826634 20 0.007604563 251 0.04347758764621514 2.963308 10 23 0.003629764 GO Biological Process negative regulation of transcription from RNA polymerase II promoter in response to stress 470 0.000001281663 0.0000358838370574468 5.07571 14 0.005323194 149 0.012088599249664428 4.19422 8 13 0.002903811 GO Biological Process regulation of bone remodeling 492 0.000001696458 0.00004537335532926829 2.45346 36 0.01368821 187 0.021525829971122998 2.478403 16 44 0.005807623 GO Biological Process regulation of ATPase activity 558 0.000003640291 0.00008584693417383512 2.336891 37 0.01406844 171 0.019699715578947365 2.118365 23 74 0.008348457 GO Biological Process JAK-STAT cascade 603 0.000006489119 0.0001416091491227197 2.408639 33 0.01254753 241 0.03902207535145228 2.320207 16 47 0.005807623 GO Biological Process 4-hydroxyproline metabolic process 605 0.000006506478 0.00014151858512727273 4.12568 15 0.005703422 226 0.03390784918451327 3.975771 7 12 0.002540835 GO Biological Process placenta blood vessel development 672 0.00001604316 0.00031415467625 2.804251 23 0.008745247 258 0.04588343874844961 2.6383 12 31 0.004355717 GO Biological Process cellular response to growth hormone stimulus 1671 0.006137078 0.04832903016277677 2.122588 15 0.005703422 164 0.016372660489634146 3.407804 10 20 0.003629764 GO Biological Process positive regulation of growth hormone secretion 1674 0.006196865 0.04871239339008364 3.295604 7 0.002661597 223 0.03295669779730942 4.543739 6 9 0.002177858 GO Molecular Function S100 protein binding 44 6.297918e-7 0.0000604313859 5.868292 13 0.004942966 20 0.028895325779999998 4.19422 8 13 0.002903811 Mouse Phenotype Single KO abnormal hemopoiesis 3 4.256301e-41 1.2991649419e-37 2.053349 393 0.1494297 3 3.100984474333333e-7 1.594945 172 735 0.06243194 Mouse Phenotype Single KO abnormal cytokine secretion 14 4.832028e-33 3.160491456857143e-30 2.242823 264 0.1003802 37 0.000027522328697297298 1.551715 130 571 0.04718693 Mouse Phenotype Single KO abnormal myeloid cell number 21 1.743585e-29 7.602860878571429e-27 2.15083 257 0.09771863 133 0.018380391692481204 1.414847 93 448 0.03375681 Mouse Phenotype Single KO abnormal T cell physiology 22 3.268037e-29 1.3602461276818182e-26 2.149312 255 0.09695817 21 0.000003044017905238095 1.635746 126 525 0.04573503 Mouse Phenotype Single KO abnormal interleukin secretion 30 1.150855e-25 3.512793078333333e-23 2.24559 204 0.07756654 46 0.00010919049659565218 1.614223 99 418 0.03593466 Mouse Phenotype Single KO abnormal granulocyte morphology 31 2.910375e-25 8.596872217741935e-23 2.136507 223 0.08479087 71 0.0022882285430985915 1.489992 101 462 0.03666062 Mouse Phenotype Single KO abnormal granulocyte number 32 1.002612e-24 2.86903690125e-22 2.164908 212 0.08060837 98 0.009146077941530613 1.453788 93 436 0.03375681 Mouse Phenotype Single KO abnormal platelet activation 43 1.218968e-21 2.5958348781395346e-19 3.882357 73 0.02775665 145 0.02311272269241379 2.004591 25 85 0.00907441 Mouse Phenotype Single KO abnormal erythropoiesis 48 9.713751e-21 1.8531003730625e-18 3.025893 97 0.03688213 39 0.000035506056184615386 2.354483 38 110 0.0137931 Mouse Phenotype Single KO decreased erythroid progenitor cell number 49 1.002563e-20 1.8735651818367346e-18 3.915141 69 0.02623574 180 0.033032366595 2.271869 17 51 0.006170599 Mouse Phenotype Single KO abnormal platelet morphology 50 1.1273e-20 2.06453722e-18 2.347501 149 0.05665399 144 0.022803028479166668 1.537355 60 266 0.02177858 Mouse Phenotype Single KO abnormal platelet physiology 57 4.971692e-19 7.986979586666667e-17 3.160486 83 0.03155894 154 0.025448337622077925 1.858802 30 110 0.01088929 Mouse Phenotype Single KO abnormal neutrophil cell number 59 9.909181e-19 1.5379384816440678e-16 2.385638 130 0.04942966 157 0.025682550412738852 1.525882 60 268 0.02177858 Mouse Phenotype Single KO autoimmune response 63 5.95417e-18 8.654338839682541e-16 2.21759 144 0.05475285 137 0.020948936775912412 1.482549 72 331 0.0261343 Mouse Phenotype Single KO abnormal self tolerance 66 1.10113e-17 1.527734456060606e-15 2.193859 145 0.05513308 125 0.0164049193376 1.494112 73 333 0.02649728 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 67 1.375457e-17 1.8798596640298508e-15 2.370593 123 0.04676806 108 0.009781702410185186 1.59292 61 261 0.02214156 Mouse Phenotype Single KO abnormal immune tolerance 70 2.201658e-17 2.880083186571429e-15 2.175276 145 0.05513308 143 0.022843372374825175 1.47201 73 338 0.02649728 Mouse Phenotype Single KO abnormal neutrophil morphology 74 2.234848e-16 2.7654733967567568e-14 2.205319 132 0.05019011 162 0.027436813866666666 1.50917 62 280 0.02250454 Mouse Phenotype Single KO decreased susceptibility to autoimmune disorder 75 6.837899e-16 8.348618819066667e-14 2.738193 85 0.03231939 109 0.010179341245871559 1.767009 42 162 0.01524501 Mouse Phenotype Single KO decreased interleukin-2 secretion 77 8.821397e-16 1.0490588614155845e-13 3.588933 57 0.021673 95 0.007291935012421051 2.434146 20 56 0.007259528 Mouse Phenotype abnormal myeloid cell number 19 5.963812e-33 3.001052975368421e-30 2.088088 306 0.1163498 160 0.005322203552625001 1.394102 117 572 0.04246824 Mouse Phenotype increased myeloid cell number 20 1.406697e-32 6.7247150085e-30 2.647118 192 0.0730038 193 0.009178129011917098 1.543605 65 287 0.02359347 Mouse Phenotype abnormal cytokine secretion 25 5.393541e-30 2.06270582004e-27 2.010197 304 0.1155894 63 0.00004171315573333334 1.46929 155 719 0.05626134 Mouse Phenotype abnormal interleukin secretion 36 2.110223e-24 5.604400584166667e-22 2.032273 241 0.09163498 91 0.000540234638934066 1.482205 117 538 0.04246824 Mouse Phenotype decreased erythroid progenitor cell number 38 4.55461e-24 1.1459638476315788e-21 3.688093 87 0.03307985 107 0.0014559723123364486 2.331655 26 76 0.009437387 Mouse Phenotype abnormal erythrocyte cell number 40 1.391398e-23 3.3257890694999998e-21 2.206041 194 0.07376426 192 0.0088291403078125 1.519403 70 314 0.02540835 Mouse Phenotype abnormal platelet physiology 45 8.034046e-23 1.7069669734666665e-20 3.249386 97 0.03688213 142 0.0035105541152112675 1.910436 37 132 0.01343013 Mouse Phenotype decreased myeloid cell number 46 9.890178e-23 2.0556519969130434e-20 2.099479 208 0.07908745 325 0.036778931196923076 1.387401 80 393 0.02903811 Mouse Phenotype abnormal platelet activation 47 3.13429e-22 6.375946104255318e-20 3.80328 77 0.02927757 301 0.030369477813289036 1.840214 27 100 0.009800363 Mouse Phenotype decreased inflammatory response 49 5.97171e-22 1.1652146797959185e-19 2.529461 138 0.05247148 215 0.012389126012093021 1.512072 67 302 0.02431942 Mouse Phenotype abnormal erythropoiesis 50 9.339154e-22 1.7858330278799999e-19 2.832038 113 0.04296578 41 0.0000037468066551219515 2.241374 49 149 0.01778584 Mouse Phenotype abnormal platelet aggregation 51 1.653783e-21 3.100356718235294e-19 3.774792 75 0.02851711 355 0.04903734556901409 1.812662 25 94 0.00907441 Mouse Phenotype increased circulating interferon-gamma level 54 2.931363e-21 5.1901410450000005e-19 6.040156 46 0.01749049 212 0.012094949124056602 2.359249 18 52 0.006533575 Mouse Phenotype abnormal CD4-positive, alpha-beta T cell physiology 58 2.529166e-20 4.169199332068965e-18 2.666439 116 0.04410646 230 0.014614005127826088 1.666038 44 180 0.01597096 Mouse Phenotype abnormal erythroid progenitor cell morphology 59 2.886543e-20 4.677667393728813e-18 2.880495 102 0.03878327 88 0.00043398389423863635 2.119139 37 119 0.01343013 Mouse Phenotype decreased erythrocyte cell number 60 2.98694e-20 4.759688890000001e-18 2.36225 144 0.05475285 298 0.028703158309731542 1.534249 52 231 0.01887477 Mouse Phenotype abnormal T cell activation 63 9.0309e-20 1.3705465857142856e-17 2.027704 195 0.07414449 132 0.0027903655365909092 1.499767 90 409 0.03266788 Mouse Phenotype altered susceptibility to autoimmune disorder 71 1.093006e-18 1.471863431830986e-16 2.219784 150 0.05703422 189 0.008870832385714286 1.501057 74 336 0.02686025 Mouse Phenotype abnormal platelet morphology 75 3.607358e-18 4.5986599784e-16 2.091164 166 0.06311787 255 0.020244412657647058 1.456154 72 337 0.0261343 Mouse Phenotype decreased T cell proliferation 82 2.250069e-17 2.6235255742682927e-15 2.299178 129 0.04904943 103 0.0012488838110679612 1.759899 55 213 0.0199637