# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	11	2.665028e-68	3.1881003138181823e-65	2.646175	429	0.01827243	349	0.0000016543166767621777	1.336509	100	113	0.008043111	
GO Biological Process	endoplasmic reticulum unfolded protein response	13	1.945902e-66	1.9697018783076922e-63	2.668528	411	0.01750575	280	8.192685308214285e-8	1.364529	103	114	0.008284404	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	14	1.956517e-66	1.8389862287857142e-63	2.278991	555	0.02363915	648	0.0021627446020061726	1.208204	124	155	0.009973458	
GO Biological Process	regulation of DNA-templated transcription in response to stress	18	1.004469e-63	7.343226428333333e-61	2.470199	453	0.01929466	306	3.138514817091504e-7	1.345269	106	119	0.008525698	
GO Biological Process	IRE1-mediated unfolded protein response	20	3.111719e-60	2.04735551605e-57	3.566873	241	0.01026493	389	0.00000615552310899743	1.432138	55	58	0.004423711	
GO Biological Process	response to topologically incorrect protein	22	5.216902e-57	3.1204187917272725e-54	2.138429	546	0.02325581	257	1.528669253463035e-8	1.308888	156	180	0.01254725	
GO Biological Process	cellular response to topologically incorrect protein	23	7.671158e-57	4.388902961826087e-54	2.3405	448	0.01908169	323	6.775952055417957e-7	1.314682	121	139	0.009732164	
GO Biological Process	cellular response to unfolded protein	24	1.493101e-56	8.186548357916666e-54	2.417086	418	0.0178039	296	1.7699441820270272e-7	1.347996	108	121	0.00868656	
GO Biological Process	response to unfolded protein	26	5.172998e-53	2.6181338723846154e-50	2.141871	505	0.0215095	253	7.78140041027668e-9	1.330912	141	160	0.01134079	
GO Biological Process	positive regulation of nuclease activity	30	1.571849e-50	6.894653663666667e-48	5.526825	125	0.005324133	974	0.02777601449794661	1.510255	15	15	0.001206467	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	31	5.826296e-50	2.473168679483871e-47	2.410316	370	0.01575943	1023	0.03516706090029325	1.204991	75	94	0.006032333	
GO Biological Process	nuclear-transcribed mRNA catabolic process	38	5.936273e-46	2.0556688528157896e-43	2.002164	513	0.02185024	140	8.851879773642857e-16	1.388214	182	198	0.01463846	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	51	3.131153e-39	8.078988691568627e-37	2.357161	301	0.01282051	262	2.457592418816794e-8	1.369468	107	118	0.008606129	
GO Biological Process	regulation of nuclease activity	59	2.027219e-37	4.521385562881356e-35	3.685666	141	0.006005622	987	0.029000676133738603	1.394082	24	26	0.001930347	
GO Biological Process	liver regeneration	66	2.169474e-36	4.325470964545454e-34	2.881658	194	0.008263055	1008	0.03220519038888889	1.337654	31	35	0.002493364	
GO Biological Process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	70	5.052881e-35	9.498694439857141e-33	3.335485	150	0.00638896	896	0.01998449693080357	1.510255	16	16	0.001286898	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	71	1.246938e-34	2.3110503016901408e-32	2.357848	264	0.01124457	448	0.00004178731505580357	1.355357	70	78	0.005630178	
GO Biological Process	protein targeting to ER	74	2.527645e-34	4.4947676425675674e-32	2.351387	263	0.01120198	251	7.13693306494024e-9	1.405584	94	101	0.007560524	
GO Biological Process	cotranslational protein targeting to membrane	76	1.46266e-33	2.532518807894737e-31	2.373754	252	0.01073345	355	0.0000021043049899154932	1.356147	88	98	0.007077938	
GO Biological Process	positive regulation of mRNA catabolic process	79	2.512542e-32	4.185131668101266e-30	2.916709	168	0.007155635	761	0.007894402267674114	1.449845	24	25	0.001930347	
GO Cellular Component	mitochondrial ribosome	42	1.807624e-31	7.4370816e-30	2.623265	195	0.008305648	80	1.104288768e-7	1.403649	79	85	0.006354058	
GO Cellular Component	PcG protein complex	56	7.077619e-20	2.1839510057142855e-18	2.050857	199	0.00847602	177	0.0033989535457627116	1.346097	41	46	0.003297676	
GO Cellular Component	MLL1 complex	64	5.089834e-18	1.37425518e-16	2.792845	96	0.004088934	192	0.0069712272	1.406099	27	29	0.00217164	
GO Cellular Component	endopeptidase complex	66	1.472256e-17	3.854633890909091e-16	2.049205	174	0.007411193	129	0.00007050164986046512	1.357041	62	69	0.004986729	
GO Cellular Component	proteasome complex	68	2.894573e-17	7.3556208e-16	2.038579	173	0.0073686	130	0.00009544724972307693	1.354788	61	68	0.004906298	
GO Cellular Component	mitochondrial large ribosomal subunit	72	1.469556e-16	3.5269344e-15	2.467035	109	0.004642644	120	0.0000324635904	1.421416	48	51	0.003860693	
GO Cellular Component	ESCRT complex	101	1.562332e-12	2.672979897029703e-11	2.492991	78	0.003322259	242	0.03781879378512396	1.348442	25	28	0.002010778	
GO Cellular Component	DNA-directed RNA polymerase III complex	102	1.889836e-12	3.201604517647059e-11	3.526098	45	0.001916688	180	0.0037870089599999998	1.510255	19	19	0.001528191	
GO Cellular Component	mitochondrial small ribosomal subunit	110	7.222104e-12	1.1345268829090909e-10	2.574802	69	0.002938922	199	0.009511589306532663	1.40238	26	28	0.002091209	
GO Cellular Component	proteasome accessory complex	122	1.065134e-10	1.5086488131147542e-9	2.491127	65	0.002768549	189	0.0060736091428571426	1.447328	23	24	0.001849916	
GO Cellular Component	INO80-type complex	123	1.380888e-10	1.93997923902439e-9	2.775887	53	0.002257432	160	0.000817106508	1.510255	23	23	0.001849916	
GO Cellular Component	proteasome regulatory particle, base subcomplex	126	1.695654e-10	2.325468342857143e-9	3.857037	33	0.001405571	251	0.0488076009561753	1.510255	12	12	0.0009651733	
GO Cellular Component	COPI-coated vesicle	140	6.94625e-10	8.573657142857142e-9	2.289976	70	0.002981515	243	0.04242001066666667	1.378928	21	23	0.001689053	
GO Cellular Component	CCR4-NOT complex	147	1.122229e-9	1.3191916408163267e-8	2.420232	61	0.002598177	204	0.011526352941176472	1.510255	16	16	0.001286898	
GO Cellular Component	proteasome regulatory particle	149	1.206229e-9	1.3989018201342282e-8	2.395607	62	0.00264077	169	0.0017665282650887572	1.510255	21	21	0.001689053	
GO Cellular Component	Ino80 complex	176	6.946311e-9	6.820014436363636e-8	3.00059	38	0.001618537	204	0.011526352941176472	1.510255	16	16	0.001286898	
GO Cellular Component	cytoplasmic exosome (RNase complex)	184	1.322056e-8	1.2415830260869567e-7	3.538319	29	0.001235199	237	0.03421533326582278	1.510255	13	13	0.001045604	
GO Cellular Component	Fanconi anaemia nuclear complex	222	1.876098e-7	0.000001460314118918919	2.102149	60	0.002555584	237	0.03421533326582278	1.510255	13	13	0.001045604	
GO Cellular Component	DNA-directed RNA polymerase I complex	290	0.0000136485	0.00008132623448275862	2.293473	34	0.001448164	227	0.023645008070484582	1.510255	14	14	0.001126036	
GO Cellular Component	cytosolic proteasome complex	293	0.0000162352	0.0000957488928327645	2.378388	31	0.001320385	251	0.0488076009561753	1.510255	12	12	0.0009651733	
GO Molecular Function	unfolded protein binding	13	1.974571e-26	6.4127990476923074e-24	2.142036	244	0.01039271	120	0.0011562087733333333	1.268044	89	106	0.007158369	
GO Molecular Function	NF-kappaB binding	27	5.156294e-17	8.062916025185185e-15	2.54444	106	0.004514865	181	0.02555065761325967	1.40238	26	28	0.002091209	
GO Molecular Function	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	34	1.726747e-15	2.1442134805882352e-13	2.129535	138	0.005877843	111	0.0007722779702702703	1.389435	46	50	0.003699831	
GO Molecular Function	DNA polymerase binding	43	7.695797e-14	7.556198821860465e-12	3.746683	47	0.002001874	187	0.03072238770053476	1.510255	16	16	0.001286898	
GO Molecular Function	5'-3' RNA polymerase activity	69	1.787349e-11	1.0936503591304349e-9	2.13887	97	0.004131527	158	0.012613927775949368	1.342449	40	45	0.003217244	
GO Molecular Function	DNA-directed 5'-3' RNA polymerase activity	71	3.424875e-11	2.0365946830985913e-9	2.141042	94	0.004003748	173	0.02102376137919075	1.334644	38	43	0.003056382	
GO Molecular Function	RNA polymerase III activity	73	4.003785e-11	2.3156137356164384e-9	3.428709	41	0.001746316	187	0.03072238770053476	1.510255	16	16	0.001286898	
GO Molecular Function	oxidoreductase activity, acting on the CH-NH group of donors	119	3.290969e-9	1.1676026149579832e-7	2.009296	87	0.003705597	147	0.0061677503455782315	1.45432	26	27	0.002091209	
GO Molecular Function	telomerase RNA binding	171	4.615774e-8	0.000001139637299883041	2.008709	74	0.003151887	191	0.030945292680628272	1.441607	21	22	0.001689053	
Human Phenotype	Increased serum lactate	15	4.857461e-24	2.1609224835333333e-21	2.019804	254	0.01081864	50	3.6265592948000003e-9	1.41964	94	100	0.007560524	
Human Phenotype	Abnormal CSF metabolite level	20	1.925899e-18	6.4257620135e-16	2.216281	153	0.006516739	136	0.00007217261655882354	1.390393	58	63	0.004665004	
Human Phenotype	Exercise intolerance	25	2.221299e-17	5.9290912908e-15	2.106178	161	0.006857484	175	0.0006177417262285715	1.337654	62	70	0.004986729	
Human Phenotype	Aplasia/Hypoplasia involving the femoral head and neck	28	1.375729e-16	3.2786570060714286e-14	2.662557	95	0.004046341	380	0.03819793781052632	1.394082	24	26	0.001930347	
Human Phenotype	Increased CSF lactate	38	1.248478e-15	2.1923930773684212e-13	2.159361	135	0.005750064	162	0.00031756172653086423	1.380061	53	58	0.004262849	
Human Phenotype	Progressive external ophthalmoplegia	45	3.982722e-14	5.905934201333334e-12	3.139291	61	0.002598177	374	0.03668221253208556	1.510255	15	15	0.001206467	
Human Phenotype	Aplasia/hypoplasia of the femur	52	2.780525e-13	3.5681621778846154e-11	2.106448	119	0.005068575	326	0.02206073330674847	1.372959	30	33	0.002412933	
Human Phenotype	Supranuclear gaze palsy	137	1.255443e-9	6.115015429927007e-8	2.476617	58	0.002470398	374	0.03668221253208556	1.510255	15	15	0.001206467	
Mouse Phenotype Single KO	pale liver	27	6.729939e-31	2.282446349e-28	2.126233	293	0.01247977	98	0.0003034180359489796	1.340351	71	80	0.005710609	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	133	3.423797e-15	2.4612724148120297e-13	2.45407	100	0.004259307	210	0.0031259266084285716	1.459913	29	30	0.002332502