# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	protein folding	6	1.03236e-18	2.26413754e-15	2.484638	121	0.03545268	147	0.0005539768022517007	1.602637	76	226	0.01928934	
GO Biological Process	cellular response to topologically incorrect protein	18	2.902347e-14	2.1217768985e-11	2.731298	76	0.0222678	72	1.8156420844583333e-8	2.16001	63	139	0.01598985	
GO Biological Process	response to topologically incorrect protein	19	1.036869e-13	7.181136405789474e-11	2.424764	90	0.02636976	71	1.5678077411267604e-8	2.0122	76	180	0.01928934	
GO Biological Process	ribosome biogenesis	24	9.636431e-13	5.283574813708334e-10	2.008761	125	0.03662467	90	9.788085288e-7	1.652515	112	323	0.0284264	
GO Biological Process	rRNA metabolic process	28	3.521565e-12	1.6550097798214286e-9	2.170538	99	0.02900674	120	0.00007997749605416667	1.619246	88	259	0.02233503	
GO Biological Process	protein transmembrane transport	31	1.406683e-11	5.971142450645162e-9	3.355291	44	0.01289188	282	0.025799922703900708	1.891165	25	63	0.006345178	
GO Biological Process	rRNA processing	33	1.565326e-11	6.24185601030303e-9	2.150165	95	0.02783475	138	0.0002930476879275362	1.588579	84	252	0.0213198	
GO Biological Process	mitochondrial transport	34	1.758943e-11	6.8076267461764716e-9	2.039416	107	0.03135072	95	0.000003552309449263158	1.734808	87	239	0.02208122	
GO Biological Process	viral gene expression	36	2.287964e-11	8.363143965555556e-9	2.780934	57	0.01670085	143	0.00038867176972027975	1.838749	49	127	0.01243655	
GO Biological Process	endoplasmic reticulum unfolded protein response	37	2.920372e-11	1.0386263553513514e-8	2.679822	60	0.01757984	75	4.9402693337333333e-8	2.257454	54	114	0.01370558	
GO Biological Process	multi-organism metabolic process	40	4.583677e-11	1.5079151410750004e-8	2.490886	67	0.01963082	118	0.00006663874838898305	1.847938	57	147	0.01446701	
GO Biological Process	translational initiation	45	1.00563e-10	2.9406855933333333e-8	2.503578	64	0.01875183	117	0.000057653245524786325	1.866302	56	143	0.0142132	
GO Biological Process	viral transcription	50	2.837981e-10	7.4689983958e-8	2.737862	52	0.01523586	141	0.0003584806510921986	1.897859	45	113	0.01142132	
GO Biological Process	cotranslational protein targeting to membrane	54	6.605657e-10	1.6097007493148147e-7	2.915899	45	0.01318488	130	0.00023673860906923077	1.993828	41	98	0.01040609	
GO Biological Process	cellular response to unfolded protein	55	8.696147e-10	2.0805926976909093e-7	2.426446	61	0.01787284	82	2.1172092812195122e-7	2.166244	55	121	0.01395939	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	56	8.712967e-10	2.0473916563035714e-7	2.975056	43	0.01259889	136	0.0002682575356102941	2.020258	39	92	0.009898477	
GO Biological Process	response to unfolded protein	57	9.851495e-10	2.2743126790350875e-7	2.188205	75	0.0219748	78	9.831222177051283e-8	2.025438	68	160	0.01725888	
GO Biological Process	mRNA catabolic process	64	2.506925e-9	5.15447282421875e-7	2.039317	84	0.02461178	173	0.0013083871998265896	1.588579	71	213	0.0180203	
GO Biological Process	protein targeting to ER	66	3.128551e-9	6.237667061969697e-7	2.767615	45	0.01318488	145	0.0005267258202	1.934606	41	101	0.01040609	
GO Biological Process	nuclear-transcribed mRNA catabolic process	72	1.371926e-8	0.000002507385310277778	2.040425	76	0.0222678	213	0.003977940370469484	1.564509	65	198	0.01649746	
GO Cellular Component	ribosomal subunit	20	8.220568e-13	7.102570751999999e-11	2.548114	76	0.0222678	38	0.000010856833010526317	1.777491	69	185	0.01751269	
GO Cellular Component	ribosome	25	2.267567e-10	1.5673423104e-8	2.097169	89	0.02607677	39	0.000013030879015384615	1.676085	83	236	0.02106599	
GO Cellular Component	chromatin silencing complex	32	6.978219e-9	3.76823826e-7	9.873772	12	0.003515968	59	0.003412562766101695	4.170019	7	8	0.00177665	
GO Cellular Component	large ribosomal subunit	33	2.160329e-8	0.0000011312268218181818	2.557002	46	0.01347788	54	0.0028449088	1.74053	42	115	0.0106599	
GO Cellular Component	endoplasmic reticulum chaperone complex	41	1.654048e-7	0.000006971207180487806	8.290451	11	0.003222971	110	0.04132268509090909	3.032741	7	11	0.00177665	
GO Cellular Component	methylosome	43	2.735556e-7	0.000010993118065116279	7.874222	11	0.003222971	87	0.016177083144827586	3.177157	8	12	0.002030457	
GO Cellular Component	small nuclear ribonucleoprotein complex	44	4.735265e-7	0.00001859667709090909	2.785317	32	0.009375916	108	0.040373280000000004	1.726716	25	69	0.006345178	
GO Cellular Component	membrane coat	50	7.843429e-7	0.000027106890624000003	2.106994	53	0.01552886	84	0.015625925485714287	1.687865	34	96	0.008629442	
GO Cellular Component	cytosolic ribosome	55	0.000001703408	0.00005351798225454545	2.119421	49	0.01435687	40	0.000047044540799999995	1.957356	46	112	0.01167513	
GO Cellular Component	methyltransferase complex	58	0.000003710633	0.0001105512728275862	2.177241	43	0.01259889	65	0.006487799926153846	1.780605	34	91	0.008629442	
GO Cellular Component	catalytic step 2 spliceosome	61	0.000007388045	0.00020928756983606557	2.159842	41	0.01201289	84	0.015625925485714287	1.687865	34	96	0.008629442	
GO Cellular Component	small ribosomal subunit	65	0.00001004906	0.00026715039507692307	2.477083	30	0.008789921	90	0.01836215232	1.787151	27	72	0.006852792	
GO Cellular Component	U5 snRNP	66	0.00001036418	0.0002713530763636364	4.215081	14	0.004101963	82	0.01163043676097561	2.599492	12	22	0.003045685	
GO Cellular Component	vesicle coat	68	0.00001190432	0.00030250977882352944	2.33792	33	0.009668913	107	0.03657135970093458	1.868916	20	51	0.005076142	
GO Cellular Component	cytosolic small ribosomal subunit	81	0.00004892094	0.0010436467199999998	2.673118	22	0.006445942	83	0.015371184578313254	2.057931	19	44	0.004822335	
GO Cellular Component	pICln-Sm protein complex	85	0.00006456914	0.001312652634352941	7.289514	7	0.002050982	105	0.03308298788571428	3.971447	5	6	0.001269036	
GO Cellular Component	proton-transporting two-sector ATPase complex	99	0.0002179006	0.003803355927272727	2.400922	22	0.006445942	99	0.026630591999999998	1.888311	21	53	0.005329949	
GO Cellular Component	Seh1-associated complex	101	0.0002416631	0.004134592443564356	3.747401	11	0.003222971	62	0.004796512722580645	3.177157	10	15	0.002538071	
GO Cellular Component	mitochondrial nucleoid	103	0.0002509924	0.004210823953398058	2.569037	19	0.00556695	94	0.020669067574468084	2.042458	18	42	0.004568528	
GO Cellular Component	cytosolic large ribosomal subunit	107	0.0003220472	0.005200911790654206	2.194274	25	0.007324934	70	0.007624210011428572	1.953171	25	61	0.006345178	
GO Molecular Function	structural constituent of ribosome	8	3.671773e-11	1.93777820075e-8	2.484514	68	0.01992382	18	0.000012971159123333333	1.88276	64	162	0.01624365	
GO Molecular Function	unfolded protein binding	10	2.202869e-10	9.300512918e-8	2.898698	48	0.01406387	31	0.0031572606296774194	1.843351	41	106	0.01040609	
GO Molecular Function	RNA polymerase III regulatory region DNA binding	19	0.000002935504	0.0006522998888421052	7.981755	9	0.002636976	52	0.03967627747692307	4.084917	6	7	0.001522843	
GO Molecular Function	RNA polymerase III type 1 promoter DNA binding	23	0.00000917411	0.001684047496521739	8.118172	8	0.002343979	49	0.03497846868163265	4.765736	5	5	0.001269036	
GO Molecular Function	RNA polymerase III type 2 promoter DNA binding	23	0.00000917411	0.001684047496521739	8.118172	8	0.002343979	49	0.03497846868163265	4.765736	5	5	0.001269036	
GO Molecular Function	DNA replication origin binding	25	0.000009287479	0.00156846945352	4.257416	14	0.004101963	40	0.018164848905	3.177157	10	15	0.002538071	
GO Molecular Function	mitogen-activated protein kinase binding	39	0.0000460673	0.004987080528205129	2.844336	20	0.005859947	24	0.0004780874935833333	3.000649	17	27	0.004314721	
Human Phenotype	Increased serum lactate	21	2.239672e-10	7.116824407619047e-8	2.789783	51	0.01494287	29	0.006704303273103449	1.858637	39	100	0.009898477	
Human Phenotype	Lactic acidosis	38	4.783051e-7	0.00008399289295526316	2.03383	60	0.01757984	45	0.02974698837333333	1.634961	47	137	0.01192893	
Mouse Phenotype Single KO	abnormal mortality induced by ionizing radiation	59	0.0002750685	0.042691563635593226	2.109031	28	0.008203926	15	0.017703368507333336	2.329915	22	45	0.005583756