# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA metabolic process	18	8.667159e-31	6.336174737833334e-28	2.065252	310	0.02759972	105	1.544514440095238e-16	1.557276	193	259	0.02148024	
GO Biological Process	rRNA processing	19	2.020197e-30	1.3991459117368423e-27	2.076989	302	0.02688746	110	1.079527993309091e-15	1.550776	187	252	0.02081247	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	20	2.14156e-29	1.409039402e-26	2.5142	195	0.01736111	221	1.1943900321719457e-8	1.608974	87	113	0.009682805	
GO Biological Process	cellular response to topologically incorrect protein	23	8.049996e-29	4.605647711478261e-26	2.358785	216	0.01923077	156	9.788549901923076e-12	1.638777	109	139	0.01213133	
GO Biological Process	response to topologically incorrect protein	25	7.250025e-28	3.816123159e-25	2.128529	260	0.02314815	127	5.330526466771654e-14	1.613803	139	180	0.01547023	
GO Biological Process	endoplasmic reticulum unfolded protein response	27	1.698625e-27	8.278594953703703e-25	2.497191	184	0.01638177	203	2.092465744581281e-9	1.631523	89	114	0.009905398	
GO Biological Process	regulation of DNA-templated transcription in response to stress	38	9.988732e-25	3.4589927470526316e-22	2.26825	199	0.01771724	234	2.9137057068803417e-8	1.580533	90	119	0.01001669	
GO Biological Process	IRE1-mediated unfolded protein response	39	9.992571e-24	3.371595943307692e-21	3.217421	104	0.009259259	374	0.000029883501418983955	1.657441	46	58	0.005119644	
GO Biological Process	cellular response to unfolded protein	40	1.567852e-23	5.157841117e-21	2.272363	188	0.01673789	189	1.0504586014814814e-9	1.623494	94	121	0.01046188	
GO Biological Process	response to unfolded protein	42	3.42116e-23	1.0718820104761904e-20	2.056809	232	0.02065527	148	1.0666036341216217e-12	1.619608	124	160	0.01380078	
GO Biological Process	viral gene expression	59	7.485156e-21	1.669443522101695e-18	2.327527	157	0.01397792	207	2.641087584057971e-9	1.596159	97	127	0.01079577	
GO Biological Process	DNA-templated transcription, elongation	60	5.368588e-20	1.1774208248666666e-17	2.358811	146	0.01299858	242	4.612890712561983e-8	1.59586	84	110	0.009348915	
GO Biological Process	positive regulation of nuclease activity	61	1.740307e-19	3.754213084098361e-17	4.805881	52	0.00462963	599	0.005989548418530885	1.950495	14	15	0.001558152	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	62	2.425913e-19	5.148804704354839e-17	2.340792	143	0.01273148	322	0.0000031555568065217394	1.505376	85	118	0.009460211	
GO Biological Process	protein targeting to ER	69	1.412499e-18	2.6937788899999997e-16	2.410805	129	0.01148504	250	7.0553136492e-8	1.613918	78	101	0.008681135	
GO Biological Process	viral transcription	70	1.59867e-18	3.0052712185714285e-16	2.287829	143	0.01273148	221	1.1943900321719457e-8	1.608974	87	113	0.009682805	
GO Biological Process	multi-organism metabolic process	71	1.627847e-18	3.017019531408451e-16	2.056031	182	0.0162037	197	1.3522529064467002e-9	1.563808	110	147	0.01224263	
GO Biological Process	snRNA metabolic process	74	3.129194e-18	5.564468087297297e-16	2.52149	116	0.01032764	201	1.7155800746268657e-9	1.725314	71	86	0.007902059	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	78	3.820589e-17	6.4455295706410265e-15	2.235375	138	0.01228632	475	0.0006415707849263158	1.40554	76	113	0.008458542	
GO Biological Process	cotranslational protein targeting to membrane	80	8.9276e-17	1.468478605e-14	2.362764	120	0.01068376	297	8.863042855892255e-7	1.578025	74	98	0.008235949	
GO Cellular Component	ribosomal subunit	29	2.217143e-22	1.3211114151724137e-20	2.119082	208	0.01851852	52	2.609492676923077e-10	1.513705	134	185	0.01491375	
GO Cellular Component	large ribosomal subunit	34	1.738861e-20	8.837505317647057e-19	2.415397	143	0.01273148	50	1.6665239807999999e-10	1.653681	91	115	0.01012799	
GO Cellular Component	mitochondrial ribosome	43	7.505633e-16	3.016217168372093e-14	2.615137	93	0.008279915	74	0.000005066418940540541	1.573509	64	85	0.007122983	
GO Cellular Component	catalytic step 2 spliceosome	44	1.044499e-15	4.102032436363637e-14	2.160982	135	0.01201923	69	0.000001264182511304348	1.567362	72	96	0.008013356	
GO Cellular Component	mitochondrial large ribosomal subunit	45	1.434151e-15	5.5071398400000006e-14	3.169769	67	0.0059651	70	0.0000017017257600000002	1.762002	43	51	0.004785754	
GO Cellular Component	nuclear chromosome, telomeric region	47	8.95307e-15	3.2916819063829786e-13	2.026087	147	0.01308761	82	0.000015118843082926829	1.440707	91	132	0.01012799	
GO Cellular Component	DNA-directed RNA polymerase III complex	49	2.571157e-14	9.067263869387756e-13	5.405051	33	0.002938034	83	0.00001706461833253012	2.089816	19	19	0.002114636	
GO Cellular Component	preribosome	55	3.657431e-11	1.1490983214545455e-9	2.126127	95	0.008457977	66	6.497560145454545e-7	1.649855	60	76	0.006677796	
GO Cellular Component	proteasome core complex	58	5.537418e-11	1.6497686731034483e-9	4.031672	33	0.002938034	181	0.016422071867403316	1.654438	19	24	0.002114636	
GO Cellular Component	spliceosomal snRNP complex	59	7.386627e-11	2.1634053315254238e-9	2.34991	74	0.006588319	88	0.000035073431999999996	1.617922	48	62	0.005342237	
GO Cellular Component	endopeptidase complex	61	7.564801e-11	2.1429469062295077e-9	2.166321	88	0.007834758	61	6.622483514754099e-8	1.72637	57	69	0.006343907	
GO Cellular Component	proteasome complex	64	3.512239e-10	9.4830453e-9	2.118283	86	0.007656695	62	1.1321984206451612e-7	1.721025	56	68	0.00623261	
GO Cellular Component	small nuclear ribonucleoprotein complex	69	1.470743e-9	3.683252034782609e-8	2.115893	80	0.007122507	90	0.0000544473792	1.574934	52	69	0.005787423	
GO Cellular Component	ATP-binding cassette (ABC) transporter complex	72	4.175946e-9	1.00222704e-7	8.198615	14	0.001246439	204	0.02324569129411765	2.089816	8	8	0.0008903728	
GO Cellular Component	cytosolic large ribosomal subunit	80	2.084513e-8	4.50254808e-7	2.026952	76	0.006766382	92	0.00005475970017391304	1.610186	47	61	0.00523094	
GO Cellular Component	small-subunit processome	81	2.720095e-8	5.802869333333333e-7	2.543558	46	0.004095442	159	0.004196290415094339	1.612144	27	35	0.003005008	
GO Cellular Component	spliceosomal tri-snRNP complex	94	2.043192e-7	0.0000037559955063829784	2.619126	38	0.003383191	130	0.001516603126153846	1.729503	24	29	0.002671119	
GO Cellular Component	precatalytic spliceosome	100	5.294265e-7	0.00000914848992	2.678114	34	0.003027066	171	0.008908822231578947	1.641999	22	28	0.002448525	
GO Cellular Component	MLL1 complex	112	0.000001545232	0.00002384072228571429	2.371615	39	0.003472222	186	0.01859013987096774	1.585378	22	29	0.002448525	
GO Cellular Component	90S preribosome	122	0.000003443811	0.000048777913180327875	2.125044	46	0.004095442	138	0.0022842444521739133	1.685336	25	31	0.002782415	
GO Molecular Function	unfolded protein binding	4	2.071116e-29	2.186062938e-26	2.862632	156	0.01388889	50	0.0000015636616088000002	1.557505	79	106	0.008792432	
GO Molecular Function	rRNA binding	9	7.692318e-25	3.608551844e-22	3.863315	86	0.007656695	76	0.00026316675949999995	1.602193	46	60	0.005119644	
GO Molecular Function	ribonucleoprotein complex binding	12	1.185648e-14	4.17150488e-12	2.024084	146	0.01299858	39	3.018146497948718e-8	1.599164	88	115	0.009794101	
GO Molecular Function	RNA polymerase III activity	16	2.114846e-11	5.5805498825e-9	4.894505	28	0.002492877	77	0.00041140555228571423	2.089816	16	16	0.001780746	
GO Molecular Function	5'-3' RNA polymerase activity	23	2.092599e-10	3.8412839034782613e-8	2.62719	57	0.005074786	79	0.0005041038606329114	1.671853	36	45	0.004006678	
GO Molecular Function	DNA-directed 5'-3' RNA polymerase activity	27	4.79002e-10	7.490172014814815e-8	2.61857	55	0.004896724	95	0.001186292671368421	1.652413	34	43	0.003784085	
GO Molecular Function	endoribonuclease activity	34	6.211088e-9	7.712709863529412e-7	2.112765	74	0.006588319	142	0.023384712509859157	1.455408	39	56	0.004340568	
GO Molecular Function	mismatched DNA binding	37	1.278864e-8	0.0000014592875156756757	3.867432	26	0.002314815	175	0.04881428148571428	1.915665	11	12	0.001224263	
GO Molecular Function	snRNA binding	39	1.320613e-8	0.000001429648227179487	2.71132	43	0.003828348	151	0.03028482540397351	1.539865	28	38	0.003116305	
GO Molecular Function	protein binding involved in protein folding	49	5.973772e-8	0.000005147197017142857	2.599245	42	0.003739316	163	0.037996549496932513	1.625413	21	27	0.002337229	
GO Molecular Function	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	51	6.434143e-8	0.000005326461126666667	2.096636	65	0.005787037	114	0.005580332208771929	1.546464	37	50	0.004117974	
GO Molecular Function	mRNA 5'-UTR binding	78	0.000001490942	0.00008070201441025641	2.439953	37	0.00329416	153	0.031385961673202616	1.70985	18	22	0.002003339	
GO Molecular Function	mitogen-activated protein kinase binding	102	0.00000852817	0.0003529993503921569	2.031084	47	0.004184473	123	0.01185687944390244	1.702813	22	27	0.002448525	
GO Molecular Function	ubiquitin-specific protease binding	106	0.00001136696	0.00045274816150943397	2.798442	24	0.002136752	155	0.03299373149677419	1.828589	14	16	0.001558152	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	107	0.00001176742	0.0004643181985046729	2.004716	47	0.004184473	132	0.016805575045454546	1.657441	23	29	0.002559822	
GO Molecular Function	telomeric DNA binding	113	0.00001324751	0.0004949644886725664	2.011978	46	0.004095442	137	0.01942695671240876	1.598095	26	34	0.002893712	
GO Molecular Function	phosphate transmembrane transporter activity	132	0.00002662893	0.0008517222913636363	2.086485	39	0.003472222	127	0.012311119291338582	1.741514	20	24	0.002225932	
GO Molecular Function	snoRNA binding	169	0.00008653624	0.0021618698537278105	2.033911	36	0.003205128	158	0.03289082296202532	1.602193	23	30	0.002559822	
Human Phenotype	Exercise intolerance	6	2.076781e-16	2.3097266021666667e-13	2.625092	96	0.008547009	115	0.00002880523465304348	1.612144	54	70	0.006010017	
Human Phenotype	Increased serum lactate	7	1.583591e-15	1.5096146775714284e-12	2.177463	131	0.01166311	50	1.9112819945999998e-8	1.650955	79	100	0.008792432	
Human Phenotype	Abnormal CSF metabolite level	9	4.17349e-15	3.094410974444444e-12	2.634247	87	0.007745726	127	0.00005724614324409449	1.625413	49	63	0.005453534	
Human Phenotype	Increased CSF lactate	11	2.346124e-14	1.4232441319999999e-11	2.674764	80	0.007122507	124	0.000045706675829838706	1.657441	46	58	0.005119644	
Human Phenotype	Abnormality of the mitochondrion	15	4.364982e-11	1.9418349924e-8	2.073605	100	0.008903134	128	0.0000577260376875	1.589438	54	71	0.006010017	
Human Phenotype	Abnormality of mitochondrial metabolism	18	1.22192e-10	4.5299289777777783e-8	2.05854	97	0.00863604	138	0.00013712536284782607	1.574934	52	69	0.005787423	
Human Phenotype	Increased muscle lipid content	25	2.102669e-8	0.0000056124440948000005	3.373161	30	0.00267094	167	0.0007122892061676646	1.979826	18	19	0.002003339	
Human Phenotype	Leukodystrophy	30	3.246731e-8	0.000007221811987666667	2.071765	70	0.006232194	329	0.025421594665653496	1.462871	35	50	0.003895381	
Human Phenotype	Telangiectasia	31	3.443433e-8	0.000007412267228709678	2.163506	63	0.005608974	224	0.0036279879602678575	1.619608	31	40	0.003450195	
Human Phenotype	Increased intramyocellular lipid droplets	49	3.806862e-7	0.000051843245155102034	3.150769	27	0.002403846	210	0.002229460421666667	1.966886	16	17	0.001780746	
Human Phenotype	Axonal degeneration	53	4.63337e-7	0.000058336750962264146	3.502626	23	0.002047721	379	0.048318207015831144	2.089816	8	8	0.0008903728	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	60	7.849597e-7	0.00008730060130166667	3.195088	25	0.002225783	269	0.008635881555018588	1.857615	16	18	0.001780746	
Human Phenotype	Hypocholesterolemia	64	0.00000119318	0.0001244076584375	4.021755	18	0.001602564	379	0.048318207015831144	2.089816	8	8	0.0008903728	
Human Phenotype	Abnormal glycosylation	87	0.000005153079	0.00039524708237931034	2.674222	28	0.002492877	321	0.02364420599376947	1.70985	18	22	0.002003339	
Human Phenotype	Dysphonia	111	0.00001457555	0.0008762400463963963	2.122648	40	0.003561254	293	0.01483855879215017	1.72637	19	23	0.002114636	
Human Phenotype	Basal cell carcinoma	117	0.00001780481	0.0010154828814529914	2.202909	36	0.003205128	243	0.005668913964609054	1.804841	19	22	0.002114636	
Human Phenotype	Apathy	129	0.00002311788	0.001195857466976744	2.263334	33	0.002938034	325	0.02501902756923077	1.759845	16	19	0.001780746	
Human Phenotype	Flat occiput	156	0.00005685929	0.0024321925780128205	2.187448	32	0.002849003	351	0.03742815357834758	1.691756	17	21	0.001892042	
Human Phenotype	Abnormal protein N-linked glycosylation	172	0.00008937397	0.0034673982663372097	2.396148	25	0.002225783	351	0.03742815357834758	1.691756	17	21	0.001892042	
Human Phenotype	3-Methylglutaconic aciduria	178	0.0001049133	0.0039330699488764045	2.370933	25	0.002225783	356	0.037926070477528086	1.915665	11	12	0.001224263	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	64	2.289639e-7	0.0000327597255046875	2.500366	41	0.003650285	101	0.03357491113861386	1.741514	20	24	0.002225932	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	46	1.411981e-8	0.0000029347718132608696	2.513547	49	0.004362536	119	0.024964694962184876	1.671853	24	30	0.002671119	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	92	0.000001707157	0.00017741443561956525	2.163601	47	0.004184473	89	0.003551990995955056	1.839038	22	25	0.002448525