# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	17	3.814992e-11	2.9530282192941176e-8	2.438065	70	0.02942413	92	0.0006304239465869565	1.774528	59	213	0.02012965	
GO Biological Process	nuclear-transcribed mRNA catabolic process	21	4.250251e-10	2.6632882337619046e-7	2.426551	63	0.02648172	111	0.0021102602246846846	1.747185	54	198	0.01842375	
GO Biological Process	regulation of gene expression, epigenetic	22	4.774033e-10	2.8555227385e-7	2.168049	79	0.03320723	82	0.00042665714556097564	1.730747	67	248	0.02285909	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	24	6.437216e-10	3.529471889333334e-7	3.474054	35	0.01471206	123	0.004051352266178862	2.089026	30	92	0.01023541	
GO Biological Process	translational initiation	25	7.426313e-10	3.9089141106800003e-7	2.749913	49	0.02059689	115	0.002550168429565218	1.881584	42	143	0.01432958	
GO Biological Process	RNA catabolic process	27	7.879756e-10	3.840359600148148e-7	2.207752	74	0.03110551	110	0.0019406737684545456	1.674688	63	241	0.02149437	
GO Biological Process	cotranslational protein targeting to membrane	30	9.749726e-10	4.2765548144666665e-7	3.346603	36	0.01513241	130	0.005544517319769231	2.026497	31	98	0.0105766	
GO Biological Process	protein targeting to ER	33	1.10505e-9	4.4064705909090907e-7	3.264651	37	0.01555275	124	0.004286996325322581	2.029733	32	101	0.01091778	
GO Biological Process	chromatin silencing	35	1.924906e-9	7.237096586857143e-7	3.650119	31	0.01303069	198	0.044063469760606065	1.849255	28	97	0.009553054	
GO Biological Process	cellular response to topologically incorrect protein	41	1.047262e-8	0.0000033612001604878053	2.526349	49	0.02059689	67	0.00012304183503880598	2.073997	45	139	0.01535312	
GO Biological Process	response to topologically incorrect protein	44	1.316162e-8	0.000003936221763181818	2.280451	59	0.02480034	71	0.00014559408580704225	1.921904	54	180	0.01842375	
GO Biological Process	gene silencing	49	2.461654e-8	0.000006610796935918367	2.315524	55	0.02311896	126	0.004679562849761904	1.74395	49	180	0.01671784	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	53	3.168796e-8	0.000007867582370566037	2.861496	37	0.01555275	139	0.008852916055035971	1.95241	32	105	0.01091778	
GO Biological Process	protein localization to endoplasmic reticulum	57	1.434068e-7	0.00003310684352982456	2.571668	40	0.01681379	163	0.01974888188588957	1.808243	35	124	0.01194132	
GO Biological Process	endoplasmic reticulum unfolded protein response	59	1.560504e-7	0.00003480452904406779	2.563047	40	0.01681379	79	0.0003420009108734177	2.135449	38	114	0.01296486	
GO Biological Process	negative regulation of protein ubiquitination	61	1.83724e-7	0.0000396331822295082	2.31594	48	0.02017654	161	0.01935232830310559	1.764066	38	138	0.01296486	
GO Biological Process	response to unfolded protein	68	8.275285e-7	0.0001601389342867647	2.13471	51	0.02143758	86	0.0004811701578604651	1.921904	48	160	0.01637666	
GO Biological Process	cellular response to unfolded protein	70	0.000001079563	0.00020294242167142858	2.339734	41	0.01723413	88	0.0005767317547954546	2.064855	39	121	0.01330604	
GO Biological Process	cell cycle G2/M phase transition	79	0.000006010827	0.0010012211707974685	2.001008	50	0.02101723	94	0.0007953776963723404	1.97843	42	136	0.01432958	
GO Biological Process	mitotic DNA integrity checkpoint	111	0.00005452277	0.006463649823693693	2.053261	37	0.01555275	149	0.012257299395973155	1.915917	32	107	0.01091778	
GO Cellular Component	ribosomal subunit	18	5.211477e-9	5.00301792e-7	2.501212	52	0.02185792	52	0.023263043815384615	1.592929	46	185	0.0156943	
GO Cellular Component	ribosome	19	2.211658e-8	0.0000020114447494736845	2.163541	64	0.02690206	48	0.007720210799999999	1.574441	58	236	0.01978847	
GO Cellular Component	heterochromatin	22	4.68359e-7	0.00003678747054545455	2.557572	37	0.01555275	24	0.00000269093376	2.720503	31	73	0.0105766	
GO Cellular Component	cytosolic ribosome	23	8.829531e-7	0.00006633665029565218	2.420068	39	0.01639344	37	0.002925122905945946	1.944784	34	112	0.01160014	
GO Cellular Component	nuclear heterochromatin	31	0.00001809535	0.0010086698322580646	3.042991	20	0.008406894	34	0.0012500468894117648	2.928615	16	35	0.005458888	
GO Cellular Component	COP9 signalosome	34	0.00002543201	0.0012925445082352942	3.190348	18	0.007566204	39	0.003251205858461538	2.826329	15	34	0.005117707	
GO Cellular Component	pericentric heterochromatin	50	0.0002035388	0.007034300928	3.347992	13	0.005464481	46	0.007514591165217391	3.371761	10	19	0.003411805	
GO Cellular Component	signal recognition particle	60	0.000303821	0.0087500448	6.818426	6	0.002522068	44	0.0068227291636363645	4.484442	7	10	0.002388263	
GO Cellular Component	cytoplasmic stress granule	79	0.0008714463	0.01906150894177215	2.3741	18	0.007566204	51	0.015688268047058824	2.383757	16	43	0.005458888	
GO Molecular Function	structural constituent of ribosome	7	6.315775e-9	0.0000038093145785714286	2.568446	49	0.02059689	34	0.014042620352941175	1.739995	44	162	0.01501194	
GO Molecular Function	RNA polymerase III type 1 promoter DNA binding	14	0.00008087237	0.024388796152857144	8.734969	6	0.002522068	32	0.01219172426875	6.406346	5	5	0.001705902	
GO Molecular Function	RNA polymerase III type 2 promoter DNA binding	14	0.00008087237	0.024388796152857144	8.734969	6	0.002522068	32	0.01219172426875	6.406346	5	5	0.001705902	
GO Molecular Function	rDNA binding	17	0.0002027101	0.05034364954117647	5.186596	8	0.003362757	38	0.019301972942105262	4.484442	7	10	0.002388263	
Human Phenotype	Increased serum lactate	1	1.895129e-7	0.0012646195817	2.746693	35	0.01471206	31	0.044789498887096775	1.921904	30	100	0.01023541