# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of gene expression, epigenetic	13	1.044466e-40	1.0572406226153846e-37	2.427049	291	0.03717425	104	2.2436246834615386e-10	1.563349	151	248	0.02064816	
GO Biological Process	negative regulation of gene expression, epigenetic	17	7.101305e-37	5.49682779382353e-34	3.491431	148	0.01890649	190	0.000009578276806842107	1.621654	72	114	0.009845481	
GO Biological Process	DNA replication-dependent nucleosome assembly	18	9.7852e-35	7.153524822222222e-32	14.06962	44	0.005620848	330	0.0014737513764242426	1.925714	24	32	0.003281827	
GO Biological Process	chromatin silencing	21	4.962692e-32	3.109717334666666e-29	3.93624	110	0.01405212	281	0.0004819200433451957	1.561748	59	97	0.008067824	
GO Biological Process	gene silencing	32	6.565468e-28	2.699843544125e-25	2.456584	192	0.02452734	160	2.6723897579375e-7	1.554836	109	180	0.01490496	
GO Biological Process	response to topologically incorrect protein	34	5.909423e-26	2.2871205075588235e-23	2.325828	198	0.02529382	126	7.712773967301587e-9	1.611894	113	180	0.01545193	
GO Biological Process	endoplasmic reticulum unfolded protein response	35	3.788133e-25	1.4242297756285713e-22	2.745739	141	0.01801226	142	5.1394049873239435e-8	1.734269	77	114	0.01052919	
GO Biological Process	cellular response to topologically incorrect protein	38	8.984196e-25	3.111132504315789e-22	2.522707	161	0.02056719	144	5.575329399444445e-8	1.662487	90	139	0.01230685	
GO Biological Process	mRNA catabolic process	39	5.017793e-24	1.6930548227435897e-21	2.191095	207	0.02644354	147	6.249423940816327e-8	1.530928	127	213	0.01736633	
GO Biological Process	RNA catabolic process	41	1.579242e-23	5.0685964580487806e-21	2.076337	229	0.02925396	135	2.2169581386666664e-8	1.512871	142	241	0.01941748	
GO Biological Process	response to unfolded protein	43	2.147474e-23	6.5717698525581396e-21	2.302453	181	0.02312213	119	2.257500538487395e-9	1.668953	104	160	0.01422125	
GO Biological Process	positive regulation of gene expression, epigenetic	47	1.663516e-22	4.657490860425531e-20	3.266302	96	0.01226367	384	0.0037254808143229166	1.540572	48	80	0.006563654	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	50	4.57984e-22	1.2053222911999999e-19	2.794989	119	0.01520184	234	0.00013373278006837606	1.544923	71	118	0.009708738	
GO Biological Process	cellular response to unfolded protein	52	6.177474e-22	1.563257314730769e-19	2.497403	144	0.0183955	137	3.759861518321168e-8	1.71882	81	121	0.01107617	
GO Biological Process	nuclear-transcribed mRNA catabolic process	56	4.143383e-21	9.736210160178572e-19	2.165531	185	0.02363311	171	0.0000011900060770760233	1.504262	116	198	0.01586216	
GO Biological Process	nucleosome organization	59	1.136359e-20	2.5344657764406778e-18	2.175575	179	0.02286663	193	0.000011408927999481865	1.501532	100	171	0.01367428	
GO Biological Process	viral gene expression	63	4.450156e-20	9.29517504825397e-18	2.595142	122	0.01558508	198	0.000015597176613131312	1.576963	78	127	0.01066594	
GO Biological Process	chromatin assembly	66	2.050051e-19	4.08736683469697e-17	2.171284	168	0.02146142	187	0.000008939049437967916	1.527571	94	158	0.01285382	
GO Biological Process	chromatin assembly or disassembly	68	4.776544e-19	9.243315072941176e-17	2.078717	182	0.02324987	207	0.000031477243408695655	1.471332	102	178	0.01394776	
GO Biological Process	viral transcription	78	1.060182e-18	1.7885814023076925e-16	2.594013	113	0.01443536	197	0.000015150524474111673	1.613283	71	113	0.009708738	
GO Cellular Component	nucleosome	22	4.291706e-32	3.3709399854545455e-30	3.973927	109	0.01392437	68	0.000014876646776470588	1.613932	66	105	0.009025024	
GO Cellular Component	DNA packaging complex	26	3.474674e-29	2.309321796923077e-27	3.463273	117	0.01494635	54	0.00000153899072	1.650612	72	112	0.009845481	
GO Cellular Component	nuclear nucleosome	29	5.814932e-22	3.464897412413793e-20	6.167217	47	0.006004088	142	0.026294428394366194	1.604762	25	40	0.00341857	
GO Cellular Component	protein-DNA complex	37	7.033794e-19	3.2849719005405404e-17	2.021269	193	0.02465508	57	0.0000021745145936842108	1.474474	116	202	0.01586216	
GO Cellular Component	chromosome, telomeric region	39	8.171295e-18	3.620512246153846e-16	2.224479	145	0.01852325	112	0.005628811885714285	1.337622	87	167	0.01189662	
GO Cellular Component	COPI-coated vesicle	42	4.122858e-17	1.6962615771428572e-15	4.611487	47	0.006004088	127	0.009663612774803149	1.897806	17	23	0.002324627	
GO Cellular Component	nuclear chromosome, telomeric region	45	5.963955e-17	2.29015872e-15	2.373167	120	0.01532959	126	0.009451429028571429	1.361616	70	132	0.009571995	
GO Cellular Component	ribosomal subunit	47	1.655235e-14	6.085629957446808e-13	2.046533	140	0.01788452	116	0.0057891768827586215	1.318507	95	185	0.01299056	
GO Cellular Component	catalytic step 2 spliceosome	55	1.786986e-12	5.614385105454545e-11	2.227898	97	0.01239142	84	0.0008074230171428572	1.524524	57	96	0.007794339	
GO Cellular Component	methyltransferase complex	60	3.256919e-11	9.379926720000002e-10	2.119311	96	0.01226367	125	0.0095064897024	1.438995	51	91	0.006973882	
GO Cellular Component	small ribosomal subunit	73	2.702632e-9	6.39746314520548e-8	2.304012	64	0.008175779	151	0.03537418553642384	1.426455	40	72	0.005469711	
GO Cellular Component	intrinsic component of mitochondrial membrane	86	6.050217e-8	0.0000012156715088372093	2.112836	64	0.008175779	146	0.02925089753424658	1.461568	37	65	0.005059483	
GO Cellular Component	integral component of mitochondrial membrane	91	1.028314e-7	0.0000019526665846153845	2.094324	63	0.008048033	158	0.0403771151392405	1.444286	36	64	0.00492274	
GO Cellular Component	cytosolic large ribosomal subunit	92	1.124528e-7	0.0000021121569391304347	2.181278	57	0.007281553	132	0.015309870545454546	1.515316	36	61	0.00492274	
GO Cellular Component	clathrin adaptor complex	95	1.912861e-7	0.0000034793934821052633	2.425038	44	0.005620848	122	0.00791124291147541	1.797334	21	30	0.002871599	
GO Cellular Component	AP-type membrane coat adaptor complex	100	2.333043e-7	0.000004031498304	2.182525	54	0.006898314	128	0.0107741961	1.618717	29	46	0.003965541	
GO Cellular Component	INO80-type complex	103	2.729175e-7	0.000004578654757281554	3.612967	23	0.002938171	98	0.0025266339918367346	2.009441	18	23	0.00246137	
GO Cellular Component	nuclear heterochromatin	104	2.875958e-7	0.000004778514830769231	2.265742	49	0.006259581	93	0.0018299722529032257	1.834014	25	35	0.00341857	
GO Cellular Component	DNA-directed RNA polymerase I complex	113	0.000001174299	0.000017957421876106197	3.843958	19	0.002427184	150	0.03498027264	2.017415	11	14	0.001504171	
GO Cellular Component	endoribonuclease complex	141	0.00000995269	0.00012197339234042552	2.481851	30	0.003832397	156	0.037580544	1.682233	19	29	0.002598113	
GO Molecular Function	unfolded protein binding	7	5.268272e-18	3.177520626285714e-15	2.685637	102	0.01303015	59	0.00017900915047457626	1.574484	65	106	0.008888281	
GO Molecular Function	nucleosomal DNA binding	9	5.033214e-16	2.361136612e-13	3.205277	68	0.008686765	89	0.013060970471910113	1.674534	30	46	0.004102284	
GO Molecular Function	nucleosome binding	10	1.589163e-14	6.709446185999999e-12	2.535823	89	0.01136944	64	0.0003068601055625	1.711746	44	66	0.006016683	
GO Molecular Function	structural constituent of ribosome	13	1.304492e-13	4.236588633846154e-11	2.05498	129	0.01647931	82	0.008897432502439025	1.363057	86	162	0.01175988	
GO Molecular Function	ribonucleoprotein complex binding	14	1.868541e-13	5.634985787142857e-11	2.188137	110	0.01405212	55	0.00011809517403636364	1.562899	70	115	0.009571995	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	66	0.00001761766	0.0011269963715151514	2.20325	36	0.004598876	87	0.012845760142528737	1.859311	21	29	0.002871599	
GO Molecular Function	mitogen-activated protein kinase binding	96	0.00006833623	0.0030053704485416663	2.108217	34	0.004343383	106	0.037024343071698114	1.806843	19	27	0.002598113	
Human Phenotype	CNS hypomyelination	25	0.000001791574	0.00047820693208000005	2.664261	31	0.003960143	45	0.020578197399999998	1.882921	22	30	0.003008341	
Mouse Phenotype Single KO	increased cellular sensitivity to oxidative stress	2	7.571918e-13	3.4668026563e-9	3.125129	55	0.00702606	104	0.01788244115576923	1.783069	25	36	0.00341857	
Mouse Phenotype Single KO	abnormal platelet activation	5	1.148131e-11	2.1026871134e-8	2.019091	113	0.01443536	111	0.029665248187387385	1.480157	49	85	0.006700397	
Mouse Phenotype Single KO	abnormal embryonic erythrocyte morphology	6	4.60925e-11	7.034483708333334e-8	2.518948	66	0.008431272	46	0.0009439835842173913	1.980735	27	35	0.003692055	
Mouse Phenotype Single KO	abnormal cellular hemoglobin content	7	9.034548e-11	1.1818479433714286e-7	4.93291	26	0.00332141	130	0.040054817066153846	2.334199	10	11	0.001367428	
Mouse Phenotype Single KO	abnormal embryonic erythropoiesis	14	2.475425e-10	1.6191047660714285e-7	2.56347	59	0.007537046	82	0.006545217009146341	1.947849	22	29	0.003008341	
Mouse Phenotype	abnormal platelet activation	5	1.662257e-13	3.1785678354000003e-10	2.074352	125	0.01596832	231	0.03324156890909091	1.412191	55	100	0.007520853	
Mouse Phenotype	abnormal platelet aggregation	6	2.168798e-13	3.4559796130000004e-10	2.079897	123	0.01571283	207	0.02066429553333333	1.4477	53	94	0.007247368	
Mouse Phenotype	abnormal cellular hemoglobin content	14	9.034548e-11	6.169950959142857e-8	4.93291	26	0.00332141	215	0.025287724361860466	2.334199	10	11	0.001367428	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	19	5.550956e-10	2.7932994903157895e-7	2.298957	70	0.008942259	80	0.0001839633205125	1.975092	30	39	0.004102284	
Mouse Phenotype	abnormal embryonic erythropoiesis	34	1.071052e-8	0.000003011861227058824	2.286734	60	0.007664793	154	0.0044684972528571424	1.905008	23	31	0.003145084	
Mouse Phenotype	increased hemoglobin concentration distribution width	60	3.49897e-7	0.000055756086949999995	3.992905	20	0.002554931	262	0.04951375505725191	2.567619	7	7	0.0009571995	
Mouse Phenotype	increased mortality induced by gamma-irradiation	72	7.637982e-7	0.000101426035975	2.275196	45	0.005748595	223	0.028178950939910317	1.736919	23	34	0.003145084	
Mouse Phenotype	ruffled hair	84	0.000002457451	0.0002797105834642857	2.195562	44	0.005620848	254	0.045645945519685045	1.687293	23	35	0.003145084	
Mouse Phenotype	pancytopenia	132	0.00001789995	0.0012965259238636364	2.08027	41	0.005237609	187	0.013533886931550802	1.859311	21	29	0.002871599	
Mouse Phenotype	abnormal thrombopoiesis	282	0.0006803728	0.023067533123404253	2.049164	26	0.00332141	195	0.01586348372	2.11451	14	17	0.001914399